Gianakos AL, Sun L, Patel JN, Adams DM, Liporace FA. Clinical application of concentrated bone marrow aspirate in orthopaedics: A systematic review. World J Orthop 2017; 8(6): 491-506 [PMID: 28660142 DOI: 10.5312/wjo.v8.i6.491]
Corresponding Author of This Article
Frank A Liporace, MD, Chairman, Division of Orthopedic Surgery, Department of Orthopedic Surgery, Jersey City Medical Center - RWJ Barnabas Health, 355 Grand Street, Jersey City, NJ 07302, United States. liporace33@gmail.com
Research Domain of This Article
Orthopedics
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Orthop. Jun 18, 2017; 8(6): 491-506 Published online Jun 18, 2017. doi: 10.5312/wjo.v8.i6.491
Clinical application of concentrated bone marrow aspirate in orthopaedics: A systematic review
Arianna L Gianakos, Li Sun, Jay N Patel, Donald M Adams, Frank A Liporace
Arianna L Gianakos, Li Sun, Jay N Patel, Donald M Adams, Frank A Liporace, Division of Orthopedic Surgery, Department of Orthopedic Surgery, Jersey City Medical Center - RWJ Barnabas Health, Jersey City, NJ 07302, United States
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: Disclosures for Frank A Liporace include AO: Unpaid consultant, Biomet: IP royalties; Paid consultant; Medtronic: Paid consultant, Stryker: Paid consultant, Synthes: Paid consultant.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at algianakos@gmail.com, who will provide a permanent, citable and open-access home for the dataset.
Correspondence to: Frank A Liporace, MD, Chairman, Division of Orthopedic Surgery, Department of Orthopedic Surgery, Jersey City Medical Center - RWJ Barnabas Health, 355 Grand Street, Jersey City, NJ 07302, United States. liporace33@gmail.com
Telephone: +1-201-3092427 Fax: +1-201-9152025
Received: January 23, 2017 Peer-review started: February 2, 2017 First decision: March 28, 2017 Revised: April 5, 2017 Accepted: May 3, 2017 Article in press: May 15, 2017 Published online: June 18, 2017 Processing time: 144 Days and 3.8 Hours
Core Tip
Core tip: With the widespread use of orthobiologics in everyday practice, attention must be directed to substantiate the evidence for their current use and to direct future practice guidelines. The use of concentrated bone marrow aspirate (cBMA) has become an increasingly popular alternative and adjunct in the treatment of cartilaginous lesions, bony defects, and tendinous injuries. This systematic review demonstrates the potential benefits of utilizing cBMA for the repair of different tissue types in the clinical setting. This systematic review also highlights discrepancies between the literature with regards to various methods of centrifugation, variable cell count concentrations, variable methods of application of cBMA, and the lack of standardized outcome measures.
