Observational Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Sep 18, 2015; 6(8): 641-648
Published online Sep 18, 2015. doi: 10.5312/wjo.v6.i8.641
Standardized quantitative measurements of wrist cartilage in healthy humans using 3T magnetic resonance imaging
Jean-Vincent Zink, Philippe Souteyrand, Sandrine Guis, Christophe Chagnaud, Yann Le Fur, Daniela Militianu, Jean-Pierre Mattei, Michael Rozenbaum, Itzhak Rosner, Maxime Guye, Monique Bernard, David Bendahan
Jean-Vincent Zink, Philippe Souteyrand, Christophe Chagnaud, Department of Radiology, Conception Hospital, Aix-Marseille University, APHM, 13005 Marseille, France
Sandrine Guis, Jean-Pierre Mattei, Department of Rheumatology, Ste marguerite Hospital, Aix-Marseille University, APHM, 13009 Marseille, France
Yann Le Fur, Monique Bernard, David Bendahan, Faculté de Médecine de Marseille, Aix-Marseille Université - CRMBM-CNRS, 13005 Marseille, France
Daniela Militianu, Department of Medical Imaging, Rambam - Health Care Campus, Haifa 35254, Israel
Michael Rozenbaum, Itzhak Rosner, Department of Rheumatology, Bnai Zion Medical Center, Technion, Haifa 31048, Israel
Maxime Guye, Aix-Marseille Université - CEMEREM-CNRS, AP-HM Pôle Imagerie, 13005 Marseille, France
Author contributions: Zink JV, Souteyrand P, Guis S, Chagnaud C and Bendahan D designed the study and took part to the data acquisition; Statistical analyses were conducted by Zink JV, Fur YL, Mattei JP and Bendahan D; Fur YL, Militianu D, Rozenbaum M, Rosner I, Guye M and Bernard M made substantial contribution to analysis and interpretation of the data; Zink JV, Souteyrand P and Guis S drafted sections of the manuscript; all authors revised it critically for important intellectual content and approved the final version of the manuscript.
Supported by Aix-Marseille University and APHM (Assistance Publique Hôpitaux de Marseille), No. CNRS (UMR #7339).
Institutional review board statement: The study was reviewed and approved by Aix-Marseille Université - CRMBM-CNRS Institutional Review Board.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: None.
Data sharing statement: Technical appendix, statistical code and dataset available from the corresponding author at drgargpankaj@yahoo.com. No cosent was obtained but the presented data ara anonymized and risk of identification is low.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: David Bendahan, Director, Faculté de Médecine de Marseille, Aix-Marseille Université - CRMBM-CNRS, 27 boulevard Jean Moulin 13385, 13005 Marseille, France. david.bendahan@univ-amu.fr
Telephone: +33-491-324803 Fax: +33-491-256539
Received: February 5, 2015
Peer-review started: February 6, 2015
First decision: June 3, 2015
Revised: June 17, 2015
Accepted: July 29, 2015
Article in press: August 3, 2015
Published online: September 18, 2015
Processing time: 225 Days and 18.4 Hours
Core Tip

Core tip: Wrist cartilage cross-sectional area has been quantified in wrists of healthy subjects using 3T magnetic resonance imaging. Based on a semi-automatic segmentation method, the reproducibility of the measurements is high as compared to previous studies. A standardized quantitative index has been proposed. This standardized index can be used for future follow-up studies. The measurements performed in a small group of subjects should be further confirmed in a larger group.