Published online Jul 18, 2015. doi: 10.5312/wjo.v6.i6.457
Peer-review started: February 12, 2015
First decision: April 10, 2015
Revised: May 2, 2015
Accepted: June 1, 2015
Article in press: June 2, 2015
Published online: July 18, 2015
Processing time: 152 Days and 8.9 Hours
Core tip: Teriparatide contains the biologically active component of Parathyroid Hormone. It is utilised in osteoporosis for its ability to increase bone mass and prevent fractures. Research suggests Teriparatide may improve callus volume, callus mineralisation, bone mineral content and successful union. However most research come from animal models. Human research, whilst supporting Teriparatide use, mostly comprises low level evidence such as case series. Currently many United States physicians use Teriparatide “off license” for fractures and non-unions. We suggest more, well designed, human randomised controlled trials are required before Teriparatide can become a mainstream option in the conservative management of fractures and non-unions.
