Biological response to prosthetic debris

doi:10.5312/wjo.v6.i2.172

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 6, Issue 2

This Article

Peer-Review Report of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (15700)

All Articles published online

The chart showing PDF series, WORD series, HTML series.

Item

Count

PDF

2962

WORD

323

HTML

9203

Sum=12488

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1361

Download

1854

Sum=3215

Mar 18, 2015 (publication date) through Feb 28, 2026

Times Cited of This Article

Times Cited (198)

Journal Information of This Article

Publication Name

World Journal of Orthopedics

ISSN

2218-5836

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Review

World J Orthop. Mar 18, 2015; 6(2): 172-189
Published online Mar 18, 2015. doi: 10.5312/wjo.v6.i2.172

Biological response to prosthetic debris

Diana Bitar, Javad Parvizi

Diana Bitar, Javad Parvizi, the Rothman Institute at Thomas Jefferson University, Department of Orthopaedic Surgery, Philadelphia, PA 19107, United States

Author contributions: Both authors were involved in the design, acquisition of data, and analysis of this study; both contributed to the writing of this manuscript.

Correspondence to: Javad Parvizi, MD, FRCS, the Rothman Institute at Thomas Jefferson University, Department of Orthopaedic Surgery, 125 S 9^th St. Suite 1000, Philadelphia, PA 19107, United States. research@rothmaninstitute.com

Telephone: +1-267-3397813 Fax: +1-215-5035651

Received: April 12, 2014
Peer-review started: April 12, 2014
First decision: April 28, 2014
Revised: September 24, 2014
Accepted: October 14, 2014
Article in press: October 16, 2014
Published online: March 18, 2015
Processing time: 341 Days and 16.1 Hours

Core Tip

Core tip: After a comprehensive review of joint arthroplasty history, this article outlines the fundamental pathophysiology of the debris-induced biological reaction common to all particles types. Furthermore, specific characteristics of polyethylene, metal, ceramic, and polymethylmethacrylate particles are stated separately with their associated clinical relevance. Lastly, future therapeutic strategies to down-regulate periprosthetic osteolysis are enumerated, including anti-inflammatory agents used to modulate the cytokines release, anti-osteolytic agents used to disintegrate osteoclasts morphology, and antioxidants used to demolish the free oxygen radicals produced by the activated macrophages. The reader will find an extensive literature review encompassing all aspects of the debris-induced hostile cellular reaction.