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Observational Study
Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Orthop. Aug 18, 2026; 17(8): 123460
Published online Aug 18, 2026. doi: 10.5312/wjo.123460
New paradigms for identifying predisposition to bone injuries in young athletes: Significant keys for rapid diagnostics
Maria V Sankova, Evgeny E Achkasov, Vladimir N Nikolenko, Marine V Oganesyan, Negoriya A Rizaeva, Aleksey V Sankov, Lucas A S Pires, Tatyana S Zharikova, Yury O Zharikov
Maria V Sankova, Vladimir N Nikolenko, Marine V Oganesyan, Negoriya A Rizaeva, Aleksey V Sankov, Tatyana S Zharikova, Yury O Zharikov, Department of Human Anatomy and Histology, Sechenov First Moscow State Medical University (Sechenov University), Moscow 125009, Russia
Maria V Sankova, Evgeny E Achkasov, Department of Sports Medicine and Medical Rehabilitation, Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia
Lucas A S Pires, Department of Morphology, Fluminense Federal University, Rio de Janeiro 24020-140, Brazil
Author contributions: Sankova MV, Oganesyan MV, Achkasov EE, Nikolenko VN conceptualized the manuscript; Sankova MV, Rizaeva NA, Sankov AV, and Zharikov YO contributed to the methodology; Sankova MV, Oganesyan MV, Pires LAS, and Zharikova TS provided resources; Sankova MV analyzed data; Sankova MV, Pires LAS, and Zharikov YO wrote the original draft; Sankova MV, Oganesyan MV, Zharikova TS and Zharikov YO performed manuscript review and editing; Nikolenko VN, Oganesyan MV, Achkasov EE, Rizaeva NA, and Zharikov YO were involved in project administration; all authors have read and agreed to the published manuscript version.
AI contribution statement: No AI tools were used in the preparation of this manuscript.
Institutional review board statement: The study protocol was reviewed and approved by the Local Ethics Committee of I.M. Sechenov First Moscow State Medical University (Sechenov University) (No. 29-24) and was conducted in strict accordance with the principles of the Declaration of Helsinki.
Informed consent statement: All participants were enrolled on a voluntary basis and provided written informed consent prior to participation.
Conflict-of-interest statement: The authors declare no conflicts of interest in the writing and preparation of this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement- checklist of items.
Data sharing statement: The raw data supporting the findings of this study are available from the corresponding author upon reasonable request.
Corresponding author: Yury O Zharikov, MD, PhD, Associate Professor, Department of Human Anatomy and Histology, Sechenov First Moscow State Medical University (Sechenov University), Mokhovaya Street 11s10, Moscow 125009, Russia. dr_zharikov@mail.ru
Received: May 20, 2026
Revised: July 5, 2026
Accepted: July 17, 2026
Published online: August 18, 2026
Processing time: 87 Days and 16.6 Hours
Core Tip

Core Tip: Recurrent bone injuries in young athletes may reflect underlying connective tissue dysplasia (CTD) rather than isolated traumatic events. Although individual dysplastic features [e.g., arachnodactyly, chest deformities, and a high-arched (gothic) palate] lack sufficient diagnostic accuracy, their cumulative severity defines a DRIT threshold of 44.2 points on the CTD scale, representing a novel indicator of susceptibility to recurrent bone injury. This threshold enables rapid risk stratification without the need for molecular genetic testing, supporting individualized sports participation and targeted injury prevention strategies. A composite phenotype comprising ten readily identifiable external dysplastic features provides a practical screening tool for sports physicians to identify at-risk athletes and help preserve musculoskeletal health.

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