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World J Orthop. May 18, 2026; 17(5): 116844
Published online May 18, 2026. doi: 10.5312/wjo.v17.i5.116844
Published online May 18, 2026. doi: 10.5312/wjo.v17.i5.116844
Effect of liposomal bupivacaine for iliac fascia block on postoperative cognitive dysfunction in patients with femoral neck fractures
Hui Liu, Tong Jia, Shi-Chao Shuai, Ji-Bo Zhao, Department of Anesthesiology, The First Affiliated Hospital, Hebei North University, Zhangjiakou 075000, Hebei Province, China
Author contributions: Liu H and Zhao JB designed the research study, Liu H, Jia T and Shuai SC performed the research; Shuai SC analyzed the data and designed the tables; Jia T executed the study and collected most of the data; Liu H wrote the manuscript; all authors contributed to drafting the article and revised the manuscript for important intellectual content; all authors had access to the study data and approved the final manuscript.
Supported by Hebei Provincial Medical Science Research Project Plan for 2023, No. 20231435.
Institutional review board statement: The study was reviewed and approved by the First Affiliated Hospital of Hebei North University (No. K2023384).
Clinical trial registration statement: This study is registered at the Chinese Clinical Trial Registry. The registration identification number is ChiCTR2400082621.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrollment.
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Data sharing statement: The datasets generated and analyzed during the current study are not publicly available because individual privacy could be compromised. However, they are available from the corresponding author upon reasonable request.
Corresponding author: Ji-Bo Zhao, Professor, Department of Anesthesiology, The First Affiliated Hospital, Hebei North University, No. 12 Changqing Road, Zhangjiakou 075000, Hebei Province, China. zhaojibo@hbbfyfy.com
Received: November 28, 2025
Revised: January 12, 2026
Accepted: February 6, 2026
Published online: May 18, 2026
Processing time: 177 Days and 23 Hours
Revised: January 12, 2026
Accepted: February 6, 2026
Published online: May 18, 2026
Processing time: 177 Days and 23 Hours
Core Tip
Core Tip: This study employed an innovative approach by utilizing a bupivacaine liposome solution for preoperative iliofascial block in patients with femoral neck fractures. By assessing cognitive function scores, plasma cortisol levels, sleep quality evaluation scales, and resting and exercise visual analog scale scores, we found that patients receiving this anesthetic technique experienced enhanced postoperative recovery quality. Consequently, this approach also mitigated the severity of postoperative cognitive dysfunction.