Animal models for study on rotator cuff healing

doi:10.5312/wjo.v16.i9.110320

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Sep 18, 2025 (publication date) through Sep 13, 2025

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World Journal of Orthopedics

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2218-5836

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Orthop. Sep 18, 2025; 16(9): 110320
Published online Sep 18, 2025. doi: 10.5312/wjo.v16.i9.110320

Animal models for study on rotator cuff healing

Qi-Long Jiang

Qi-Long Jiang, Department of Orthopaedic Surgery, Chongqing Orthopedic Hospital of Traditional Chinese Medicine, Chongqing 400043, China

Author contributions: Jiang QL contributed to the manuscript writing, final reviewing, and editing the manuscript as the corresponding author; Jiang QL approved the final version of the article for publication.

Conflict-of-interest statement: The author declares that they have no conflict of interest.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Qi-Long Jiang, MD, PhD, Department of Orthopaedic Surgery, Chongqing Orthopedic Hospital of Traditional Chinese Medicine, No. 19 Fuhua Road, Chongqing 400043, China. jys19870607@qq.com

Received: June 4, 2025
Revised: June 21, 2025
Accepted: August 13, 2025
Published online: September 18, 2025
Processing time: 98 Days and 16.7 Hours

Core Tip

Core Tip: Animal models are crucial tools for studying rotator cuff healing. Different models, including rodent, rabbit, and large-animal models, offer distinct advantages, such as cost-effectiveness, ease of genetic manipulation, or anatomical similarity. However, they also have limitations like anatomical disparities and high costs. These models help in understanding the repair mechanisms and evaluating new treatments. Second-look arthroscopic studies support the effectiveness of current surgical procedures, and future research using animal models can focus on the local microenvironment of the rotator cuff to enhance healing.