Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Sep 18, 2025; 16(9): 108629
Published online Sep 18, 2025. doi: 10.5312/wjo.v16.i9.108629
Published online Sep 18, 2025. doi: 10.5312/wjo.v16.i9.108629
Therapeutic potential of traditional Chinese medicine for inflammatory bone diseases: Elucidating molecular mechanisms and insights
Jing-Shun Lu, Department of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, Wuhu 241000, Anhui Province, China
Min Yang, Department of Traditional Chinese Medicine, Meilong Community Health Service Center of Minhang District, Shanghai 200233, China
Zeng-Gao Han, Yunnan Southern Central Hospital, Honghe Hani and Yi Autonomous Pre
Chen-Yu Song, Trauma Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China
Nurjamal Sarbay, Kirgiz Institute of Ethnic Medicine, People’s Hospital of Kizilsu Kirgiz Autonomous Prefecture, Atushi 845350, Xinjiang Uygur Autonomous Region, China
Kai-Yang Wang, Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China
Co-first authors: Jing-Shun Lu and Min Yang.
Co-corresponding authors: Nurjamal Sarbay and Kai-Yang Wang.
Author contributions: Lu JS and Yang M wrote and edited the manuscript, they contributed equally to this article, they are the co-first authors of this manuscript; Han ZG and Song CY contributed to review and edit; Sarbay N and Wang KY conceived, reviewed, and revised this paper, they contributed equally to this article, they are the co-corresponding authors of this manuscript; and all authors thoroughly reviewed and endorsed the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kai-Yang Wang, MD, Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600 Yishan Road, Shanghai 200233, China. ortho_wang@163.com
Received: April 21, 2025
Revised: May 24, 2025
Accepted: August 22, 2025
Published online: September 18, 2025
Processing time: 144 Days and 20.6 Hours
Revised: May 24, 2025
Accepted: August 22, 2025
Published online: September 18, 2025
Processing time: 144 Days and 20.6 Hours
Core Tip
Core Tip: This article aims to investigate the therapeutic effects of traditional Chinese medicine (TCM) on inflammatory bone diseases. By systematically elucidating molecular mechanisms, we demonstrate that TCM mitigates immune-mediated inflammation, thereby decelerating disease progression in rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. Simultaneously, we summarize the key targets critically involved in the initiation of inflammation in inflammatory bone diseases. This provides novel insights for developing TCM-based therapeutic strategies targeting these convergent molecular pathways.