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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Nov 18, 2025; 16(11): 110155
Published online Nov 18, 2025. doi: 10.5312/wjo.v16.i11.110155
Published online Nov 18, 2025. doi: 10.5312/wjo.v16.i11.110155
Internal diseases and molecular mechanisms causing slipped capital femoral epiphysis in children
Yi-Fan Chen, Yu-Yin Xie, Zhong-Wen Tang, Jie Wen, Sheng Xiao, Department of Pediatric Orthopedics, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410013, Hunan Province, China
Ke Ning, Can Liu, Yi-Tong Ding, Yu-Fei Li, Department of Anatomy, Hunan Normal University, Changsha 410013, Hunan Province, China
Co-first authors: Yi-Fan Chen and Ke Ning.
Co-corresponding authors: Zhong-Wen Tang and Jie Wen.
Author contributions: Chen YF was responsible for the conceptualization of the work; Ning K carried out the investigation; Chen YF and Ning K contributed equally to this article, they are the co-first authors of this manuscript; Xie YY conducted the formal analysis; Liu C developed the methodology; Ding YT handled data curation; Tang ZW provided the necessary resources; Wen J performed validation; Tang ZW and Wen J contributed equally to this article, they are the co-corresponding authors of this manuscript; Xiao S was in charge of visualization; Li YF oversaw the work as the supervisor; and all authors thoroughly reviewed and endorsed the final manuscript.
Supported by the Science Project of Hunan Provincial Healthy Commission, No. 20230844.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jie Wen, Editor, Department of Pediatric Orthopedics, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, No. 61 West Jiefang Road, Changsha 410013, Hunan Province, China. cashwj@qq.com
Received: May 30, 2025
Revised: July 6, 2025
Accepted: October 24, 2025
Published online: November 18, 2025
Processing time: 168 Days and 15.7 Hours
Revised: July 6, 2025
Accepted: October 24, 2025
Published online: November 18, 2025
Processing time: 168 Days and 15.7 Hours
Core Tip
Core Tip: Slipped capital femoral epiphysis is an adolescent hip disorder causing hip pain, abnormal gait, and potential avascular necrosis. Although its exact cause is unknown, risk factors include endocrine disorders (e.g., hypothyroidism, growth hormone abnormalities), metabolic conditions (e.g., obesity, renal osteodystrophy), and genetic diseases (e.g., COL2A1 mutations). This article summarizes these associated conditions and explores potential mechanisms involving growth plate chondrocyte dysfunction, hormonal imbalances, and inflammatory/metabolic factors, aiming to support slipped capital femoral epiphysis prevention and treatment.