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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Nov 18, 2025; 16(11): 109855
Published online Nov 18, 2025. doi: 10.5312/wjo.v16.i11.109855
Published online Nov 18, 2025. doi: 10.5312/wjo.v16.i11.109855
Prophylactic fixation in elderly fractures: Preventive breakthrough or unnecessary intervention?
Mohamed Sameer, Department of Orthopaedics, Sri Ramachandra Institute of Higher Education and Research, Chennai 600116, Tamil Nādu, India
Sathish Muthu, Central Research Laboratory, Meenakshi Medical College Hospital and Research Institute, Meenakshi Academy of Higher Education and Research, Kanchipuram 631552, Tamil Nadu, India
Sathish Muthu, Department of Orthopaedics, Orthopaedic Research Group, Coimbatore 641045, Tamil Nādu, India
Srujun Vadranapu, Department of Orthopaedics, Royal Care Super Speciality Hospital, Coimbatore 641062, Tamil Nadu, India
Co-first authors: Mohamed Sameer and Sathish Muthu.
Author contributions: Sameer M, Muthu S, and Vadranapu S contributed significantly to the development and execution of this study; Muthu S conceptualised the study framework, led the manuscript drafting, and coordinated the research design; Sameer M performed data analysis, conducted literature synthesis, and contributed to critical revisions of the manuscript; Vadranapu S provided expertise in surgical methodologies, refined the discussion on feasibility, and ensured alignment with current orthopaedic practices; all authors reviewed and approved the final manuscript, ensuring accuracy, coherence, and relevance to the field of preventive orthopaedic care.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sathish Muthu, MD, PhD, Assistant Professor, Central Research Laboratory, Meenakshi Medical College Hospital and Research Institute, Meenakshi Academy of Higher Education and Research, Karrapettai Post, Enathur, Kanchipuram 631552, Tamil Nadu, India. drsathishmuthu@gmail.com
Received: May 26, 2025
Revised: June 14, 2025
Accepted: October 24, 2025
Published online: November 18, 2025
Processing time: 174 Days and 23.5 Hours
Revised: June 14, 2025
Accepted: October 24, 2025
Published online: November 18, 2025
Processing time: 174 Days and 23.5 Hours
Core Tip
Core Tip: Prophylactic fixation (ProFix) represents a paradigm shift in orthopaedic care, proactively addressing fracture risk in elderly osteoporotic patients before injury occurs. By integrating predictive analytics, minimally invasive techniques, and ethical considerations, ProFix has the potential to enhance mobility, reduce hospitalisation rates, and optimise healthcare resources. This review explores the feasibility, efficacy, and strategic implementation of ProFix, balancing innovation with patient safety to redefine preventive orthopaedic interventions.