©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Aug 18, 2024; 15(8): 704-712
Published online Aug 18, 2024. doi: 10.5312/wjo.v15.i8.704
Published online Aug 18, 2024. doi: 10.5312/wjo.v15.i8.704
Intra-articular interventions in osteoarthritis: Navigating the landscape of hyaluronic acid, mesenchymal stem cells, and platelet-rich plasma
Somar Soufan, Joenne Al Khoury, Zahi Hamdan, Department of Medicine, University of Bala
Mohamad Ali Rida, Department of Internal Medicine, Clemenceau Medical Center, Beirut 12345, Lebanon
Author contributions: Soufan S, Hamdan Z and Al Khoury J designed and wrote the manuscript; Soufan S, Hamdan Z, Al Khoury J and Rida MA did the literature review; All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Mohamad Ali Rida, MD, Assistant Professor, Department of Internal Medicine, Clemenceau Medical Center, Clemenceau, Beirut 12345, Lebanon.
Received: April 25, 2024
Revised: July 13, 2024
Accepted: July 29, 2024
Published online: August 18, 2024
Processing time: 109 Days and 14.9 Hours
Revised: July 13, 2024
Accepted: July 29, 2024
Published online: August 18, 2024
Processing time: 109 Days and 14.9 Hours
Core Tip
Core tip: Osteoarthritis significantly affects patients by causing pain, functional decline, and reduced quality of life. Traditional treatments mainly manage symptoms, with no disease-modifying interventions established. This review examines intra-articular treatments, including hyaluronic acid (HA), mesenchymal stem cells (MSCs), and platelet-rich plasma (PRP). HA injections show varied outcomes, requiring detailed understanding. MSCs, especially adipose-derived MSCs, demonstrate sustained benefits over 6 mo, while bone-marrow-derived MSCs are less effective. PRP is effective for long-term pain relief and quality of life improvement. Personalized, evidence-based approaches are crucial to enhance treatment efficacy and patient outcomes.