Is there sufficient evidence to support the use of antibiotic holiday just before the second stage of an infected total hip or knee arthroplasty revision surgery?

doi:10.5312/wjo.v15.i5.483

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May 18, 2024 (publication date) through Nov 5, 2024

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World Journal of Orthopedics

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2218-5836

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Orthop. May 18, 2024; 15(5): 483-485
Published online May 18, 2024. doi: 10.5312/wjo.v15.i5.483

Is there sufficient evidence to support the use of antibiotic holiday just before the second stage of an infected total hip or knee arthroplasty revision surgery?

Konstantinos Tsikopoulos, Konstantinos Sidiropoulos

Konstantinos Tsikopoulos, Department of Orthopaedics, Portsmouth Hospitals NHS University Trust, Portsmouth University Hospitals, Portsmouth PO6 3LY, United Kingdom

Konstantinos Sidiropoulos, Emergency Department, Papageorgiou General Hospital of Thessaloniki, Thessaloniki 54635, Greece

Konstantinos Sidiropoulos, Medical School, University of Patras, Patras 26504, Greece

Author contributions: Tsikopoulos K had the original idea; Sidiropoulos K performed the related research and wrote the letter; Tsikopoulos K revised the letter.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Konstantinos Tsikopoulos, PhD, Senior Researcher, Department of Orthopaedics, Portsmouth Hospitals NHS University Trust, Portsmouth University Hospitals, Cosham, Portsmouth PO6 3LY, United Kingdom. kostastsikop@gmail.com

Received: January 14, 2024
Revised: April 1, 2024
Accepted: April 19, 2024
Published online: May 18, 2024
Processing time: 121 Days and 19.2 Hours

Core Tip

Core Tip: Optimising the outcomes of the two-stage revision process for infected hip and knee arthroplasty patients is a crucial topic to address. We wish to highlight that there is no evidence against the use of continuous antibiotic treatment in two-stage septic hip and knee joint arthroplasty. Furthermore, the optimal duration of antibiotic holidays has yet to be determined.