Letter to the Editor
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Feb 18, 2024; 15(2): 192-200
Published online Feb 18, 2024. doi: 10.5312/wjo.v15.i2.192
Adenylate cyclase activates the cAMP signalling pathway to enhance platelet-rich plasma-treated Achilles tendon disease, a theoretical bioinformatics-based study
Jing-Yi Sun, Cai Li, Feng-Ying Du
Jing-Yi Sun, Cai Li, College of Basic Medical Science, Qilu Medical University, Zibo 255300, Shandong Province, China
Feng-Ying Du, Department of Gastroenterological Surgery, Shandong Provincial Hospital of Shandong First Medical University, Jinan 250021, Shandong Province, China
Author contributions: Du FY designed the study; Du FY and Sun JY performed the research; Du FY and Sun JY analysed the data; Sun JY and Li C wrote the manuscript; Du FY and Li C revised the manuscript.
Conflict-of-interest statement: All the authors declare no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Feng-Ying Du, MD, Doctor, Department of Gastroenterological Surgery, Shandong Provincial Hospital of Shandong First Medical University, No. 324 Jingwu Road, Jinan 250021, Shandong Province, China. sdudfy@126.com
Received: October 26, 2023
Peer-review started: October 26, 2023
First decision: December 12, 2023
Revised: December 29, 2023
Accepted: January 16, 2024
Article in press: January 16, 2024
Published online: February 18, 2024
Processing time: 104 Days and 1.4 Hours
Core Tip

Core Tip: The cAMP signalling pathway may be the key to enhancing the effectiveness of platelet-rich plasma (PRP) in the treatment of Achilles tendon disease. ADCY1-9 may be the key to activating the cAMP signalling network and is expected to be a complementary target for enhancing the effectiveness of PRP in the treatment of Achilles tendon disease.