Wen RM, Wang HX, Liu ZJ, Duan ZQ. Nanofiber scaffold for bone tissue engineering: Mechanism, challenge and future prospect. World J Orthop 2025; 16(12): 112998 [DOI: 10.5312/wjo.v16.i12.112998]
Corresponding Author of This Article
Zi-Qiang Duan, MD, Department of Rehabilitation, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang No. 1 People’s Hospital, No. 48 Taling South Road, Jiujiang 332000, Jiangxi Province, China. dzq10353@163.com
Research Domain of This Article
Orthopedics
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Minireviews
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dec 18, 2025 (publication date) through Dec 17, 2025
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Journal Information of This Article
Publication Name
World Journal of Orthopedics
ISSN
2218-5836
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Wen RM, Wang HX, Liu ZJ, Duan ZQ. Nanofiber scaffold for bone tissue engineering: Mechanism, challenge and future prospect. World J Orthop 2025; 16(12): 112998 [DOI: 10.5312/wjo.v16.i12.112998]
Rui-Ming Wen, Hai-Xia Wang, School of Physical Education and Sports Science, South China Normal University, Guangzhou 510006, Guangdong Province, China
Zhi-Jun Liu, School of Sport and Health, Guangzhou Sport University, Guangzhou 510500, Guangdong Province, China
Zi-Qiang Duan, Department of Rehabilitation, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang No. 1 People’s Hospital, Jiujiang 332000, Jiangxi Province, China
Author contributions: Wen RM contributed to writing - original draft. Wang HX, Liu ZJ, and Duan ZQ contributed to writing - review & editing; Liu ZJ contributed to conceptualization and investigation; Duan ZQ contributed to funding acquisition and providing resources. All author approval the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zi-Qiang Duan, MD, Department of Rehabilitation, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang No. 1 People’s Hospital, No. 48 Taling South Road, Jiujiang 332000, Jiangxi Province, China. dzq10353@163.com
Received: August 13, 2025 Revised: August 30, 2025 Accepted: October 29, 2025 Published online: December 18, 2025 Processing time: 126 Days and 22.7 Hours
Abstract
Nanofiber scaffold has built a bionic microenvironment for bone marrow mesenchymal stem cells by highly simulating the topological structure of natural extracellular matrix. Its ordered fiber network effectively guides the directional migration and spatial arrangement of cells through the mechanical signal transduction mediated by integrin. Surface functionalization can synergistically activate the osteogenic transcription network and significantly enhance the osteogenic differentiation potential of cells. The precise design of scaffold stiffness affects the cell fate choice by regulating the nuclear translocation of mechanical sensitive factors. This triple cooperative strategy of “physical topology-biochemical signal-mechanical microenvironment” effectively overcomes the biological inertia of traditional scaffolds and provides a dynamic and adjustable platform for bone defect repair. Looking forward to the future, breaking through the bottleneck of clinical transformation such as long-term intelligent slow release of functional factors and in situ efficient construction of vascular network is the key to promoting nanofiber scaffolds from basic research to precise bone regeneration treatment.
Core Tip: Nanofiber scaffold accurately mimics the topological structure of natural bone extracellular matrix, and regulates the behavior of bone marrow mesenchymal stem cells through physical topological guidance, biochemical signal activation and mechanical microenvironment programming, providing a dynamic adjustable platform for bone defect repair. However, clinical transformation is restricted by bottlenecks such as functional factor delivery, vascularization and mechanical adaptation. This review analyzes the triple coordinated regulation network and dynamic interaction mechanism, evaluates the transformation prospects of intelligent materials and bionic design, and provides theoretical support for the research and development of precise bone regeneration strategies.
