Meta-Analysis
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. May 18, 2024; 15(5): 469-476
Published online May 18, 2024. doi: 10.5312/wjo.v15.i5.469
Meta-analysis of new intervention measures for preventing side effects of artificial joint replacement
Wei Jiang, Ting-Biao Zhu
Wei Jiang, Department of Orthopaedics, Traditional Chinese Medicine Hospital of Pingshan, Yibin 645350, Sichuan Province, China
Ting-Biao Zhu, Department of Orthopaedics, The First People's Hospital of Qujing, Qujing 655099, Yunnan Province, China
Author contributions: Jiang W and Zhu TB designed the research study, performed the research, analyzed the data and wrote the manuscript; All authors have read and approve the final manuscript.
Conflict-of-interest statement: All authors declare that the research was conducted in the absence of any commercial or financial relationships.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ting-Biao Zhu, PhD, Deputy Director, Doctor, Department of Orthopaedics, The First People's Hospital of Qujing, No. 1 Yuanlin Road, Qujing 655099, Yunnan Province, China. 13308748558@163.com
Received: January 11, 2024
Revised: February 23, 2024
Accepted: April 12, 2024
Published online: May 18, 2024
Processing time: 125 Days and 2.5 Hours
Abstract
BACKGROUND

Intertrochanteric fracture of the femur occurs mostly among older people, and seriously affects daily life and quality of life. At present, physical intervention, drug treatment, routine intervention and rehabilitation training are widely used for prevention of side effects, but it is still inconclusive which intervention has the best effect.

AIM

To compare the effects of new intervention measures for preventing side effects of artificial joint replacement.

METHODS

We searched the Chinese and English literatures for comparative studies on the prevention of side effects of new interventions for artificial joint replacement from July 2013 to June 2023 in China HowNet, PubMed, Wanfang, Weipu and other databases. Study quality was evaluated by improved Jadad scoring standard, and the effects of different interventions on preventing different complications were analyzed by meta-analysis of evidence-based medicine with Review Manager 5.0 software.

RESULTS

Ten articles, including 869 cases, were finally included. The preventive effects of different interventions on the side effects of artificial joint replacement were studied, and valid data were extracted. There were two articles on the preventive effects of drug intervention, four on comparison of the preventive effects of combined and single interventions, and three on the preventive effects of physical intervention, rehabilitation training and routine intervention. Meta-analysis showed that the preventive effect of rivaroxaban was significantly better than low molecular weight heparin calcium [mean difference (MD) = -0.16, 95%CI: -0.28 to -0.04, P < 0.05]. The effect of combined intervention was significantly better than that of single intervention (MD = -0.08, 95%CI: -0.16 to -0.01, P < 0.001). Physical intervention was significantly better than routine intervention and rehabilitation training (MD = 0.26, 95%CI: 0.16–0.36, P < 0.001).

CONCLUSION

Rivaroxaban combined with rehabilitation training is preferred for preventing deep vein thrombosis after artificial joint replacement. In the prevention of pulmonary embolism, rivaroxaban drug intervention is given priority. The effect of combined intervention is better than that of single intervention.

Keywords: Artificial joint replacement; Venous thromboembolism; Side effects; Interventions; Meta-analysis

Core Tip: Physical intervention, drug therapy, routine intervention and rehabilitation training are widely used clinically to prevent side effects of artificial joint replacement, but it is still inconclusive which intervention method is best. This meta-analysis assessed new methods of intervention for prevention of side effects of artificial joint replacement for intertrochanteric fracture.