• Edge loading
• Hip contact force
• Implant testing
• Joint reconstruction
• Musculoskeletal modelling
• Total hip replacement

• Dynamic modelling
• Edge loading
• Finite element analysis
• Mass-scaling
• Total hip replacement
• UHMWPE

• Finite Element Analysis
• Arthroplasty, Replacement, Hip
• Hip Prosthesis
• Polyethylene
• Acetabulum

• arthroplasty
• daily activities
• fluoroscopy
• hip
• kinematics

• European Commission

• Fretting
• modular junction
• pull-off force
• taper connection
• total hip arthroplasty

Estimation of the accuracy of 2D‐3D registration is paramount for a correct evaluation of its outcome in both research and clinical studies. Publicly available datasets with standardized evaluation methodology are necessary for validation and comparison of 2D‐3D registration techniques. Given the large use of 2D‐3D registration in biomechanics, we introduced the first gold standard validation dataset for computed tomography (CT)‐to‐x‐ray registration of the hip joint, based on fluoroscopic images with large rotation angles. As the ground truth computed with fiducial markers is affected by localization errors in the image datasets, we proposed a new methodology based on uncertainty propagation to estimate the accuracy of a gold standard dataset.

The gold standard dataset included a 3D CT scan of a female hip phantom and 19 2D fluoroscopic images acquired at different views and voltages. The ground truth transformations were estimated based on the corresponding pairs of extracted 2D and 3D fiducial locations. These were assumed to be corrupted by Gaussian noise, without any restrictions of isotropy. We devised the multiple projective points criterion (MPPC) that jointly optimizes the transformations and the noisy 3D fiducial locations for all views. The accuracy of the transformations obtained with the MPPC was assessed in both synthetic and real experiments using different formulations of the target registration error (TRE), including a novel formulation of the TRE (uTRE) derived from the uncertainty analysis of the MPPC.

The proposed MPPC method was statistically more accurate compared to the validation methods for 2D‐3D registration that did not optimize the 3D fiducial positions or wrongly assumed the isotropy of the noise. The reported results were comparable to previous published works of gold standard datasets. However, a formulation of the TRE commonly found in these gold standard datasets was found to significantly miscalculate the true TRE computed in synthetic experiments with known ground truths. In contrast, the uncertainty‐based uTRE was statistically closer to the true TRE.

We proposed a new gold standard dataset for the validation of CT‐to‐X‐ray registration of the hip joint. The gold standard transformations were derived from a novel method modeling the uncertainty in extracted 2D and 3D fiducials. Results showed that considering possible noise anisotropy and including corrupted 3D fiducials in the optimization resulted in improved accuracy of the gold standard. A new uncertainty‐based formulation of the TRE also appeared as a good alternative to the unknown true TRE that has been replaced in previous works by an alternative TRE not fully reflecting the gold standard accuracy.

• 2D-3D registration
• CT-to-X-ray image registration
• gold standard dataset
• uncertainty propagation

• Computational modelling
• Edge loading
• Hip replacements
• Joint kinematics
• Pre-clinical testing

• Hip abductor strength
• Hip offset
• Limb length discrepancy
• Replaced hip
• Treadmill

• effective dose
• hip joint
• image registration
• kinematics
• total hip arthroplasty
• video fluoroscopy

• Activities of Daily Living
• Arthroplasty, Replacement, Hip
• Biomechanical Phenomena
• Female
• Fluoroscopy/methods
• Hip Joint/diagnostic imaging
• Hip Joint/physiology
• Humans
• Male
• Motion
• Radiation Dosage
• Range of Motion, Articular
• Video Recording
• X-Rays

• gait
• hip arthroplasty
• osteoarthritis
• prevention

• anterolateral
• approach
• arthroplasty
• hip
• replacement

Squeaking is a well-recognized complication for hard-on-hard bearings. The nature of squeaking is not yet completely understood however it is considered a multifactorial phenomenon. Patient, implant, and surgical factors play a role in squeaking. It is believed that mechanisms damaging the fluid film lubrication in which these bearings function optimally have a critical role. Such mechanisms include edge loading, stripe wear, impingement, third body particles and ceramic fracture. The resonance of metallic parts can produce noise in the human audible range hence the implant metallurgic composition and design may play a role. Implant positioning can facilitate impingement and edge loading enhancing the occurrence of squeaking. The recent introduction of large heads (> 36 mm) 4^th generation ceramic-on-ceramic bearing may accentuate the conditions facilitating noise formation; however the current literature is insufficient. Clinically, squeaking may manifest in extreme hip positions or during normal gait cycle however it is rarely associated with pain. Evaluations of patients with squeaking include clinical and radiographic assessments. Computer tomography is recommended as it can better reveal ceramic breakage and implant malposition. The treatments for most squeaking patients include reassurance and activity modification. However for some, noise can be a problem, requiring further surgical intervention. In the occurrence of ceramic fracture, implant failure, extreme components malposition, instability and impingement, surgery should be advised. This review will aim to discuss the current literature regarding squeaking.

• Squeaking
• Total hip arthroplasty
• Ceramic-on-ceramic
• Lubrication
• Edge loading
• Metal-on-metal

To understand the progression of recovery in postural stability and physical functioning after patients received the minimally invasive total hip arthroplasty (MTHA), we monitor the pain level, functional capacity, and postural stability before and after operation within one year. In total of 23 subjects in our study, we found out that MTHA was effective in relieving pain in first 2 weeks and restoring the hip joint integrity, but the postural stability was influenced especially in tandem stand in both anterior-posterior and medial-lateral directions. The recovery of postural stability and functional capacity in one year duration fluctuated and no consistent improvement tendency was found. We suggested clinicians designing postsurgery rehabilitation program for consistent and progressive long-term recovery of postural stability and fall prevention to optimize surgical results and prevent undesired postoperative consequences.

Model-based Roentgen Stereophotogrammetric Analysis (MBRSA) allows the accurate in vivo measurement of the relative motion between an implant and the surrounding bone (migration), using pose-estimation algorithms and three dimensional geometric surface models of the implant. The goal of this study was thus to investigate the effect of surface model resolution on the accuracy of the MBRSA method.

Four different implant geometries (knee femoral and tibial components, and two different hip stems) were investigated, for each of which two reversed engineering (RE) models of differing spatial digitizing resolution were generated. Accuracy of implant migration measurement using MBRSA was assessed in dependence on surface model resolution using an experimental phantom-model set up.

When using the lower quality RE models, the worst bias observed ranged from -0.048 to 0.037 mm, and -0.057 to 0.078 deg for translation and rotation respectively. For higher quality reverse engineering models, bias ranged from -0.042 to 0.048 mm, and -0.449 to 0.029 deg. The pair-wise comparisons of digitizing resolution (higher vs. lower quality) within the different implant type revealed significant differences only for the hip stems (p < 0.001).

The data suggest that the application of lower resolution RE models for MBRSA is a viable alternative method for the in vivo measurement of implant migration, in particular for implants with non symmetrical geometries (total knee arthroplasty). Implants with larger length to width aspect ratio (total hip arthroplasty) may require high resolution RE models in order to achieve acceptable accuracy. Conversely, for some axis the bias for translation are clearly worse for translation, and are marginally better for rotations using the lower resolution RE models instead of the higher ones. However, performed box plots ranges were well within what has been reported in the literature. The observed lower accuracy and precision of the measurements for hip stem components for rotations about the superior-inferior direction is presumably the result of the nature of the MBRSA method. This well known effect within MBRSA for rotations about the axis of symmetry of axially-symmetric objects do not change the contour of the projected image to as large a degree as motion about a non-symmetric axes. It is not possible to detected this small motion as accurately using pose-estimation methods. This may affect the “higher” accuracy for the applied lower resolution RE models.

• Ceramics
• Hip Prosthesis
• Humans
• Materials Testing
• Models, Theoretical
• Polyethylene
• Weight-Bearing

• R21 AR056374 NIAMS NIH HHS
• R21 AR056374-01A1 NIAMS NIH HHS
• R21AR056374 NIAMS NIH HHS