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van Kouswijk HW, Yazid H, Schoones JW, Witlox MA, Nelissen RGHH, de Witte PB. Current and Emerging Applications of Artificial Intelligence in Medical Imaging for Paediatric Hip Disorders-A Scoping Review. CHILDREN (BASEL, SWITZERLAND) 2025; 12:645. [PMID: 40426824 DOI: 10.3390/children12050645] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 03/14/2025] [Revised: 05/02/2025] [Accepted: 05/15/2025] [Indexed: 05/29/2025]
Abstract
INTRODUCTION Paediatric hip disorders present unique challenges for artificial intelligence (AI)-aided assessments of medical imaging due to disease-related and age-dependent changes in hip morphology. This scoping review aimed to describe current and emerging applications of AI in medical imaging for paediatric hip disorders. METHODS A descriptive synthesis of articles identified through PubMed, Embase, Cochrane Library, Web of Science, Emcare, and Academic Search Premier databases was performed including articles published up until June 2024. Original research articles' titles and abstracts were screened, followed by full-text screening. Two reviewers independently conducted article screening and data extraction (i.e., data on the article and the model and its performance). RESULTS Out of 871 unique articles, 40 were included. The first article was dated from 2017, with annual publication rates increasing thereafter. Research contributions were primarily from China (17 [43%]) and Canada (10 [25%]). Articles mainly focused on developing novel AI models (19 [47.5%]), applied to ultrasound images or radiographs of developmental dysplasia of the hip (DDH; 37 [93%]). The three remaining articles addressed Legg-Calvé-Perthes disease, neuromuscular hip dysplasia in cerebral palsy, or hip arthritis/osteomyelitis. External validation was performed in eight articles (20%). Models were mainly applied to the diagnosis/grading of the disorder (22 [55%]), or on screening/detection (17 [42.5%]). AI models were 17 to 124 times faster (median 30) in performing a specific task than experienced human assessors, with an accuracy of 86-100%. CONCLUSIONS Research interest in AI applied to medical imaging of paediatric hip disorders has expanded significantly since 2017, though the scope remains restricted to developing novel models for DDH imaging. Future studies should focus on (1) the external validation of existing models, (2) implementation into clinical practice, addressing the current lack of implementation efforts, and (3) paediatric hip disorders other than DDH.
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Affiliation(s)
- Hilde W van Kouswijk
- Department of Orthopaedics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
- Department of Orthopaedic Surgery, Care and Public Health Research Institute (CAPHRI), Maastricht University, 6229 HX Maastricht, The Netherlands
| | - Hizbillah Yazid
- Department of Orthopaedics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
- Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya 60286, Indonesia
| | - Jan W Schoones
- Directorate of Research Policy, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
| | - M Adhiambo Witlox
- Department of Orthopaedic Surgery, Care and Public Health Research Institute (CAPHRI), Maastricht University, 6229 HX Maastricht, The Netherlands
| | - Rob G H H Nelissen
- Department of Orthopaedics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
| | - Pieter Bas de Witte
- Department of Orthopaedics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
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Minty R, Mahomed N, van Wyk N, Mndebele G, Lockhat Z, Ranchod A. Comparison of bone age assessment using manual Greulich and Pyle method versus automated BoneXpert method in South African children. SA J Radiol 2025; 29:3033. [PMID: 40356794 PMCID: PMC12067538 DOI: 10.4102/sajr.v29i1.3033] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/14/2024] [Accepted: 01/29/2025] [Indexed: 05/15/2025] Open
Abstract
Background The Greulich and Pyle (GP) method is the most commonly used manual bone age assessment method but it is associated with interrater variability. The BoneXpert method is fully automated, eliminates interrater variability and has been validated for use in various populations. Objectives To compare the manual GP method with the automated BoneXpert method in performing bone age assessment of children with various paediatric endocrinology diagnoses. Method Three manual readers performed manual bone age assessment, and BoneXpert software performed automated bone age assessment on 260 left hand-wrist radiographs. Images where the average of three manual readers (Manual BA) deviated from BoneXpert BA by > 1.5 years, were re-read by an external reader, producing a Reference BA. Manual BA was compared to Carpal BA that was produced by the software. A composite bone age (Comp BA) for the software was defined to estimate the weighting on carpal and tubular bones to achieve the best agreement with Manual BA. Results The interclass correlation (ICC) between each manual reader was > 0.9, indicating a high positive correlation. The ICC between Manual BA and BoneXpert BA was 0.982. The Comp BA for BoneXpert that would achieve the best fit with Manual BA, places a 50% weighting on Carpal BA and 50% weighting on Tubular BA. Conclusion The BoneXpert method is efficient, well-validated and shows a positive correlation with the manual GP method. An estimated weightage of 50% to carpal bones and 50% to tubular bones resulted in an automated Comp BA with the best agreement with Manual BA. Contribution This original research article compares manual and automated bone age assessment methods to evaluate the use of artificial intelligence tools in the South African context.
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Affiliation(s)
- Radhiya Minty
- Department of Radiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
| | - Nasreen Mahomed
- Department of Radiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
| | - Nicole van Wyk
- Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
| | - Gopolang Mndebele
- Department of Radiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
| | - Zarina Lockhat
- Department of Radiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa
| | - Ashesh Ranchod
- Department of Radiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
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Tan MB, Chua YR, Fan Q, Fortier MV, Chang PP. Use of deep learning model for paediatric elbow radiograph binomial classification: initial experience, performance and lessons learnt. Singapore Med J 2025; 66:208-214. [PMID: 40258236 PMCID: PMC12063939 DOI: 10.4103/singaporemedj.smj-2022-078] [Citation(s) in RCA: 1] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/02/2022] [Accepted: 11/15/2022] [Indexed: 04/23/2025]
Abstract
INTRODUCTION In this study, we aimed to compare the performance of a convolutional neural network (CNN)-based deep learning model that was trained on a dataset of normal and abnormal paediatric elbow radiographs with that of paediatric emergency department (ED) physicians on a binomial classification task. METHODS A total of 1,314 paediatric elbow lateral radiographs (patient mean age 8.2 years) were retrospectively retrieved and classified based on annotation as normal or abnormal (with pathology). They were then randomly partitioned to a development set (993 images); first and second tuning (validation) sets (109 and 100 images, respectively); and a test set (112 images). An artificial intelligence (AI) model was trained on the development set using the EfficientNet B1 network architecture. Its performance on the test set was compared to that of five physicians (inter-rater agreement: fair). Performance of the AI model and the physician group was tested using McNemar test. RESULTS The accuracy of the AI model on the test set was 80.4% (95% confidence interval [CI] 71.8%-87.3%), and the area under the receiver operating characteristic curve (AUROC) was 0.872 (95% CI 0.831-0.947). The performance of the AI model vs. the physician group on the test set was: sensitivity 79.0% (95% CI: 68.4%-89.5%) vs. 64.9% (95% CI: 52.5%-77.3%; P = 0.088); and specificity 81.8% (95% CI: 71.6%-92.0%) vs. 87.3% (95% CI: 78.5%-96.1%; P = 0.439). CONCLUSION The AI model showed good AUROC values and higher sensitivity, with the P-value at nominal significance when compared to the clinician group.
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Affiliation(s)
- Mark Bangwei Tan
- Department of Diagnostic Radiology, Singapore General Hospital, Singapore
| | | | - Qiao Fan
- Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore
| | - Marielle Valerie Fortier
- Department of Diagnostic and Interventional Imaging, KK Women’s and Children’s Hospital, Singapore
- Duke-NUS Medical School, Singapore
- Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore
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Dubreucq Guerif E, Agut S, Rousseau A, Bompard R, Goulet H. Evaluation of the use of artificial intelligence in the detection of appendicular skeletal fractures in adult patients consulting in an emergency department, a retrospective study. Eur J Emerg Med 2025; 32:144-146. [PMID: 40009538 DOI: 10.1097/mej.0000000000001193] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/28/2025]
Affiliation(s)
| | | | - Alexandra Rousseau
- Unité de Recherche Clinique (URC) de l'Est Parisien Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France
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Rodriguez-Merchan EC. Some artificial intelligence tools may currently be useful in orthopedic surgery and traumatology. World J Orthop 2025; 16:102252. [PMID: 40027961 PMCID: PMC11866107 DOI: 10.5312/wjo.v16.i2.102252] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/12/2024] [Revised: 01/05/2025] [Accepted: 01/14/2025] [Indexed: 02/12/2025] Open
Abstract
Artificial intelligence (AI) can help in diagnosing fractures and demonstrating effusions, dislocations, and focal bone lesions in both adult and pediatric aged individuals and also aid in early tumor discovery (bone osteosarcoma) and in robot-assisted surgery. A recent AI model [Mask R-CNN (region-based convolutional neural network)] has shown to be dependable for detecting surgical target zones in pediatric hip and periarticular infections, offering a more convenient and quicker alternative to conventional methods. It can help inexperienced physicians in pre-treatment evaluations, diminishing the risk of missed diagnosis and misdiagnosis. AI has some very interesting applications in orthopedic surgery, which orthopedic surgeons should be aware of and if possible use. Although some interesting advances have been made recently on AI in orthopedic surgery, its usefulness in clinical practice is still very limited. Ethical concerns, such as transparency in AI decision-making, data privacy, and the potential loss of human intuition cannot be forgotten. Besides, it is paramount to explore how to gain trust from both healthcare professionals and patients in the utilization of AI.
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Gao C, Hu C, Qian Q, Li Y, Xing X, Gong P, Lin M, Ding Z. Artificial intelligence model system for bone age assessment of preschool children. Pediatr Res 2024; 96:1822-1828. [PMID: 38802611 PMCID: PMC11772234 DOI: 10.1038/s41390-024-03282-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/11/2023] [Revised: 05/04/2024] [Accepted: 05/07/2024] [Indexed: 05/29/2024]
Abstract
BACKGROUD Our study aimed to assess the impact of inter- and intra-observer variations when utilizing an artificial intelligence (AI) system for bone age assessment (BAA) of preschool children. METHODS A retrospective study was conducted involving a total sample of 53 female individuals and 41 male individuals aged 3-6 years in China. Radiographs were assessed by four mid-level radiology reviewers using the TW3 and RUS-CHN methods. Bone age (BA) was analyzed in two separate situations, with/without the assistance of AI. Following a 4-week wash-out period, radiographs were reevaluated in the same manner. Accuracy metrics, the correlation coefficient (ICC)and Bland-Altman plots were employed. RESULTS The accuracy of BAA by the reviewers was significantly improved with AI. The results of RMSE and MAE decreased in both methods (p < 0.001). When comparing inter-observer agreement in both methods and intra-observer reproducibility in two interpretations, the ICC results were improved with AI. The ICC values increased in both two interpretations for both methods and exceeded 0.99 with AI. CONCLUSION In the assessment of BA for preschool children, AI was found to be capable of reducing inter-observer variability and enhancing intra-observer reproducibility, which can be considered an important tool for clinical work by radiologists. IMPACT The RUS-CHN method is a special bone age method devised to be suitable for Chinese children. The preschool stage is a critical phase for children, marked by a high degree of variability that renders BA prediction challenging. The accuracy of BAA by the reviewers can be significantly improved with the aid of an AI model system. This study is the first to assess the impact of inter- and intra-observer variations when utilizing an AI model system for BAA of preschool children using both the TW3 and RUS-CHN methods.
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Affiliation(s)
- Chengcheng Gao
- Department of Radiology, Hangzhou First People's Hospital, Hangzhou, China
| | - Chunfeng Hu
- Department of Radiology, Hangzhou First People's Hospital, Hangzhou, China
- The Fourth School of Clinical Medicine, Zhejiang Chinese Medicine University, Hangzhou, China
| | - Qi Qian
- Department of Radiology, The Third Affiliated Hospital of Zhejiang Chinese Medicine University, Hangzhou, China
| | - Yangsheng Li
- Department of Radiology, Hangzhou First People's Hospital, Hangzhou, China
| | - Xiaowei Xing
- Rehabilitation Medicine Center, Department of Radiology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China
| | | | - Min Lin
- Department of Radiology, The Third Affiliated Hospital of Zhejiang Chinese Medicine University, Hangzhou, China.
- College of Humanities and Management, Zhejiang Chinese Medical University, Hangzhou, China.
| | - Zhongxiang Ding
- Department of Radiology, Hangzhou First People's Hospital, Hangzhou, China.
- Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Hangzhou, China.
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Alomran AK, Alomar MF, Akhdher AA, Al Qanber AR, Albik AK, Alumran A, Abdulwahab AH. Artificial intelligence awareness and perceptions among pediatric orthopedic surgeons: A cross-sectional observational study. World J Orthop 2024; 15:1023-1035. [PMID: 39600858 PMCID: PMC11586741 DOI: 10.5312/wjo.v15.i11.1023] [Citation(s) in RCA: 1] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/10/2024] [Revised: 09/06/2024] [Accepted: 10/10/2024] [Indexed: 11/15/2024] Open
Abstract
BACKGROUND Artificial intelligence (AI) is a branch of computer science that allows machines to analyze large datasets, learn from patterns, and perform tasks that would otherwise require human intelligence and supervision. It is an emerging tool in pediatric orthopedic surgery, with various promising applications. An evaluation of the current awareness and perceptions among pediatric orthopedic surgeons is necessary to facilitate AI utilization and highlight possible areas of concern. AIM To assess the awareness and perceptions of AI among pediatric orthopedic surgeons. METHODS This cross-sectional observational study was conducted using a structured questionnaire designed using QuestionPro online survey software to collect quantitative and qualitative data. One hundred and twenty-eight pediatric orthopedic surgeons affiliated with two groups: Pediatric Orthopedic Chapter of Saudi Orthopedics Association and Middle East Pediatric Orthopedic Society in Gulf Cooperation Council Countries were surveyed. RESULTS The pediatric orthopedic surgeons surveyed had a low level of familiarity with AI, with more than 60% of respondents rating themselves as being slightly familiar or not at all familiar. The most positively rated aspect of AI applications for pediatric orthopedic surgery was their ability to save time and enhance productivity, with 61.97% agreeing or strongly agreeing, and only 4.23% disagreeing or strongly disagreeing. Our participants also placed a high priority on patient privacy and data security, with over 90% rating them as quite important or highly important. Additional bivariate analyses suggested that physicians with a higher awareness of AI also have a more positive perception. CONCLUSION Our study highlights a lack of familiarity among pediatric orthopedic surgeons towards AI, and suggests a need for enhanced education and regulatory frameworks to ensure the safe adoption of AI.
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Affiliation(s)
- Ammar K Alomran
- Department of Orthopedic, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 31441, Eastern, Saudi Arabia
| | - Mohammed F Alomar
- College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 31441, Eastern, Saudi Arabia
| | - Ali A Akhdher
- College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 31441, Eastern, Saudi Arabia
| | - Ali R Al Qanber
- College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 31441, Eastern, Saudi Arabia
| | - Ahmad K Albik
- College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 31441, Eastern, Saudi Arabia
| | - Arwa Alumran
- Department of Health Information Management and Technology, Imam Abdulrahman Bin Faisal University, Dammam 34212, Eastern, Saudi Arabia
| | - Ahmed H Abdulwahab
- College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 31441, Eastern, Saudi Arabia
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Jeong S, Han K, Kang Y, Kim EK, Song K, Vasanawala S, Shin HJ. The Impact of Artificial Intelligence on Radiologists' Reading Time in Bone Age Radiograph Assessment: A Preliminary Retrospective Observational Study. JOURNAL OF IMAGING INFORMATICS IN MEDICINE 2024:10.1007/s10278-024-01323-3. [PMID: 39528879 DOI: 10.1007/s10278-024-01323-3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 05/30/2024] [Revised: 10/24/2024] [Accepted: 10/28/2024] [Indexed: 11/16/2024]
Abstract
To evaluate the real-world impact of artificial intelligence (AI) on radiologists' reading time during bone age (BA) radiograph assessments. Patients (<19 year-old) who underwent left-hand BA radiographs between December 2021 and October 2023 were retrospectively included. A commercial AI software was installed from October 2022. Radiologists' reading times, automatically recorded in the PACS log, were compared between the AI-unaided and AI-aided periods using linear regression tests and factors affecting reading time were identified. A total of 3643 radiographs (M:F=1295:2348, mean age 9.12 ± 2.31 years) were included and read by three radiologists, with 2937 radiographs (80.6%) in the AI-aided period. Overall reading times were significantly shorter in the AI-aided period compared to the AI-unaided period (mean 17.2 ± 12.9 seconds vs. mean 22.3 ± 14.7 seconds, p < 0.001). Staff reading times significantly decreased in the AI-aided period (mean 15.9 ± 11.4 seconds vs. mean 19.9 ± 13.4 seconds, p < 0.001), while resident reading times increased (mean 38.3 ± 16.4 seconds vs. 33.6 ± 15.3 seconds, p = 0.013). The use of AI and years of experience in radiology were significant factors affecting reading time (all, p≤0.001). The degree of decrease in reading time as experience increased was larger when utilizing AI (-1.151 for AI-unaided, -1.866 for AI-aided, difference =-0.715, p<0.001). In terms of AI exposure time, the staff's reading time decreased by 0.62 seconds per month (standard error 0.07, p<0.001) during the AI-aided period. The reading time of radiologists for BA assessment was influenced by AI. The time-saving effect of utilizing AI became more pronounced as the radiologists' experience and AI exposure time increased.
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Affiliation(s)
- Sejin Jeong
- Department of Radiology, Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, 16995, Yongin-si, Gyeonggi-do, Republic of Korea
| | - Kyunghwa Han
- Department of Radiology, Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
| | - Yaeseul Kang
- Department of Radiology, Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, 16995, Yongin-si, Gyeonggi-do, Republic of Korea
| | - Eun-Kyung Kim
- Department of Radiology, Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, 16995, Yongin-si, Gyeonggi-do, Republic of Korea
| | - Kyungchul Song
- Department of Pediatrics, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, Republic of Korea
| | | | - Hyun Joo Shin
- Department of Radiology, Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, 16995, Yongin-si, Gyeonggi-do, Republic of Korea.
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van Roessel IMAA, Gorter JE, Bakker B, van den Heuvel-Eibrink MM, Lequin MH, van der Lugt J, Meijer L, Schouten-van Meeteren AYN, van Santen HM. Bone health in childhood low-grade glioma: an understudied problem. Endocr Connect 2024; 13:e240224. [PMID: 39140359 PMCID: PMC11466249 DOI: 10.1530/ec-24-0224] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/08/2024] [Accepted: 08/14/2024] [Indexed: 08/15/2024]
Abstract
Objective Children with a supratentorial midline low-grade glioma (LGG) may be at risk for impaired bone health due to hypothalamic-pituitary dysfunction, obesity, exposure to multiple treatment modalities, and/or decreased mobility. The presence of impaired bone health and/or its severity in this population has been understudied. We aimed to identify the prevalence and risk factors for bone problems in children with supratentorial midline LGG. Materials and methods A retrospective study was performed in children with supratentorial midline (suprasellar or thalamic) LGG between 1 January 2003 and 1 January 2022, visiting the Princess Máxima Center for Pediatric Oncology. Impaired bone health was defined as the presence of vertebral fractures and/or very low bone mineral density (BMD). Results In total, 161 children were included, with a median age at tumor diagnosis of 4.7 years (range: 0.1-17.9) and a median follow-up of 6.1 years (range: 0.1-19.9). Five patients (3.1%) had vertebral fractures. In 99 patients, BMD was assessed either by Dual Energy X-ray Absorptiometry (n = 12) or Bone Health Index (n = 95); 34 patients (34.3%) had a low BMD (≤ -2.0). Impaired visual capacity was associated with bone problems in multivariable analysis (OR: 6.63, 95% CI: 1.83-24.00, P = 0.004). Conclusion In this retrospective evaluation, decreased BMD was prevalent in 34.3% of children with supratentorial midline LGG. For the risk of developing bone problems, visual capacity seems highly relevant. Surveillance of bone health must be an aspect of awareness in the care and follow-up of children with a supratentorial midline LGG. Significance statement Patients with supratentorial midline LGG may encounter various risk factors for impaired bone health. Bone problems in survivors of childhood supratentorial midline LGG are, however, understudied. This is the first paper to address the prevalence of bone problems in this specific patient population, revealing visual problems as an important risk factor. Diencephalic syndrome historyand/or weight problems associated with hypothalamic dysfunction were related to bone problems in univariate analyses. The results of this study can be used in the development of guidelines to adequately screen and treat these patients to subsequently minimizing bone problems as one of the endocrine complications.
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Affiliation(s)
- I M A A van Roessel
- Department of Pediatric Neuro-oncology, Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands
- Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
| | - J E Gorter
- Department of Pediatric Neuro-oncology, Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands
- Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
| | - B Bakker
- Department of Pediatric Neuro-oncology, Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands
- Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
| | - M M van den Heuvel-Eibrink
- Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands
- Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
| | - M H Lequin
- Department of Radiology, Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands
- Department of Radiology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
| | - J van der Lugt
- Department of Pediatric Neuro-oncology, Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands
| | - L Meijer
- Department of Pediatric Neuro-oncology, Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands
| | | | - H M van Santen
- Department of Pediatric Neuro-oncology, Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands
- Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Franco PN, Maino C, Mariani I, Gandola DG, Sala D, Bologna M, Talei Franzesi C, Corso R, Ippolito D. Diagnostic performance of an AI algorithm for the detection of appendicular bone fractures in pediatric patients. Eur J Radiol 2024; 178:111637. [PMID: 39053306 DOI: 10.1016/j.ejrad.2024.111637] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/30/2024] [Revised: 07/15/2024] [Accepted: 07/16/2024] [Indexed: 07/27/2024]
Abstract
PURPOSE To evaluate the diagnostic performance of an Artificial Intelligence (AI) algorithm, previously trained using both adult and pediatric patients, for the detection of acute appendicular fractures in the pediatric population on conventional X-ray radiography (CXR). MATERIALS AND METHODS In this retrospective study, anonymized extremities CXRs of pediatric patients (age <17 years), with or without fractures, were included. Six hundred CXRs (maintaining the positive-for-fracture and negative-for-fracture balance) were included, grouping them per body part (shoulder/clavicle, elbow/upper arm, hand/wrist, leg/knee, foot/ankle). Follow-up CXRs and/or second-level imaging were considered as reference standard. A deep learning algorithm interpreted CXRs for fracture detection on a per-patient, per-radiograph, and per-location level, and its diagnostic performance values were compared with the reference standard. AI diagnostic performance was computed by using cross-tables, and 95 % confidence intervals [CIs] were obtained by bootstrapping. RESULTS The final cohort included 312 male and 288 female with a mean age of 8.9±4.5 years. Three undred CXRs (50 %) were positive for fractures, according to the reference standard. For all fractures, the AI tool showed a per-patient 91.3% (95%CIs = 87.6-94.3) sensitivity, 76.7% (71.5-81.3) specificity, and 84% (82.1-86.0) accuracy. In the per-radiograph analysis the AI tool showed 85% (81.9-87.8) sensitivity, 88.5% (86.3-90.4) specificity, and 87.2% (85.7-89.6) accuracy. In the per-location analysis, the AI tool identified 606 bounding boxes: 472 (77.9 %) were correct, 110 (18.1 %) incorrect, and 24 (4.0 %) were not-overlapping. CONCLUSION The AI algorithm provides good overall diagnostic performance for detecting appendicular fractures in pediatric patients.
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Affiliation(s)
- Paolo Niccolò Franco
- Department of Diagnostic Radiology, Fondazione IRCCS San Gerardo dei Tintori, Via Pergolesi 33, 20900 Monza, MB, Italy
| | - Cesare Maino
- Department of Diagnostic Radiology, Fondazione IRCCS San Gerardo dei Tintori, Via Pergolesi 33, 20900 Monza, MB, Italy.
| | - Ilaria Mariani
- Department of Diagnostic Radiology, Fondazione IRCCS San Gerardo dei Tintori, Via Pergolesi 33, 20900 Monza, MB, Italy
| | - Davide Giacomo Gandola
- Department of Diagnostic Radiology, Fondazione IRCCS San Gerardo dei Tintori, Via Pergolesi 33, 20900 Monza, MB, Italy
| | - Davide Sala
- Synbrain The Human-Machine Cooperation - AI/ML solutions, Corso Milano 23, 20900 Monza, MB, Italy
| | - Marco Bologna
- Synbrain The Human-Machine Cooperation - AI/ML solutions, Corso Milano 23, 20900 Monza, MB, Italy
| | - Cammillo Talei Franzesi
- Department of Diagnostic Radiology, Fondazione IRCCS San Gerardo dei Tintori, Via Pergolesi 33, 20900 Monza, MB, Italy
| | - Rocco Corso
- Department of Diagnostic Radiology, Fondazione IRCCS San Gerardo dei Tintori, Via Pergolesi 33, 20900 Monza, MB, Italy
| | - Davide Ippolito
- Department of Diagnostic Radiology, Fondazione IRCCS San Gerardo dei Tintori, Via Pergolesi 33, 20900 Monza, MB, Italy; Department of Medicine and Surgery - University of Milano Bicocca, Via Cadore 33, 20090 Monza, MB, Italy
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11
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Kibrom BT, Manyazewal T, Demma BD, Feleke TH, Kabtimer AS, Ayele ND, Korsa EW, Hailu SS. Emerging technologies in pediatric radiology: current developments and future prospects. Pediatr Radiol 2024; 54:1428-1436. [PMID: 39012407 DOI: 10.1007/s00247-024-05997-3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/16/2023] [Revised: 07/02/2024] [Accepted: 07/03/2024] [Indexed: 07/17/2024]
Abstract
Radiological imaging is a crucial diagnostic tool for the pediatric population. However, it is associated with several unique challenges in this age group compared to adults. These challenges mainly come from the fact that children are not small-sized adults and differ in development, anatomy, physiology, and pathology compared to adults. This paper reviews relevant articles published between January 2015 and October 2023 to analyze challenges associated with imaging technologies currently used in pediatric radiology, emerging technologies, and their role in resolving the challenges and future prospects of pediatric radiology. In recent decades, imaging technologies have advanced rapidly, developing advanced ultrasound, computed tomography, magnetic resonance, nuclear imaging, teleradiology, artificial intelligence, machine learning, three-dimensional printing, radiomics, and radiogenomics, among many others. By prioritizing the unique needs of pediatric patients while developing such technologies, we can significantly alleviate the challenges faced in pediatric radiology.
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Affiliation(s)
- Bethlehem T Kibrom
- Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), College of Health Sciences, Addis Ababa University, P.O. Box 9086, Addis Ababa, Ethiopia.
| | - Tsegahun Manyazewal
- Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), College of Health Sciences, Addis Ababa University, P.O. Box 9086, Addis Ababa, Ethiopia
| | - Biruk D Demma
- College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
| | - Tesfahunegn H Feleke
- Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), College of Health Sciences, Addis Ababa University, P.O. Box 9086, Addis Ababa, Ethiopia
- Potomac Urology Clinic, Alexandria, VA, USA
| | | | - Nitsuh D Ayele
- College of Health Sciences, Wolkite University, Wolkite, Ethiopia
| | - Eyasu W Korsa
- Department of Radiology, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
| | - Samuel S Hailu
- Department of Radiology, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
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12
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Pape J, Hirsch FW, Deffaa OJ, DiFranco MD, Rosolowski M, Gräfe D. Applicability and robustness of an artificial intelligence-based assessment for Greulich and Pyle bone age in a German cohort. ROFO-FORTSCHR RONTG 2024; 196:600-606. [PMID: 38065542 DOI: 10.1055/a-2203-2997] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 05/24/2024]
Abstract
PURPOSE The determination of bone age (BA) based on the hand and wrist, using the 70-year-old Greulich and Pyle (G&P) atlas, remains a widely employed practice in various institutions today. However, a more recent approach utilizing artificial intelligence (AI) enables automated BA estimation based on the G&P atlas. Nevertheless, AI-based methods encounter limitations when dealing with images that deviate from the standard hand and wrist projections. Generally, the extent to which BA, as determined by the G&P atlas, corresponds to the chronological age (CA) of a contemporary German population remains a subject of continued discourse. This study aims to address two main objectives. Firstly, it seeks to investigate whether the G&P atlas, as applied by the AI software, is still relevant for healthy children in Germany today. Secondly, the study aims to assess the performance of the AI software in handling non-strict posterior-anterior (p. a.) projections of the hand and wrist. MATERIALS AND METHODS The AI software retrospectively estimated the BA in children who had undergone radiographs of a single hand using posterior-anterior and oblique planes. The primary purpose was to rule out any osseous injuries. The prediction error of BA in relation to CA was calculated for each plane and between the two planes. RESULTS A total of 1253 patients (aged 3 to 16 years, median age 10.8 years, 55.7 % male) were included in the study. The average error of BA in posterior-anterior projections compared to CA was 3.0 (± 13.7) months for boys and 1.7 (± 13.7) months for girls. Interestingly, the deviation from CA tended to be even slightly lower in oblique projections than in posterior-anterior projections. The mean error in the posterior-anterior projection plane was 2.5 (± 13.7) months, while in the oblique plane it was 1.8 (± 13.9) months (p = 0.01). CONCLUSION The AI software for BA generally corresponds to the age of the contemporary German population under study, although there is a noticeable prediction error, particularly in younger children. Notably, the software demonstrates robust performance in oblique projections. KEY POINTS · Bone age, as determined by artificial intelligence, aligns with the chronological age of the contemporary German cohort under study.. · As determined by artificial intelligence, bone age is remarkably robust, even when utilizing oblique X-ray projections.. CITATION FORMAT · Pape J, Hirsch F, Deffaa O et al. Applicability and robustness of an artificial intelligence-based assessment for Greulich and Pyle bone age in a German cohort. Fortschr Röntgenstr 2024; 196: 600 - 606.
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Affiliation(s)
- Johanna Pape
- Pediatric Radiology, University Hospital Leipzig, Germany
| | | | | | | | - Maciej Rosolowski
- Institute for Medical Informatics, Statistics and Epidemiology, Leipzig University, Leipzig, Germany
| | - Daniel Gräfe
- Pediatric Radiology, University Hospital Leipzig, Germany
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13
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Oza C, Antani M, Mondkar S, Bhor S, Kajale N, Kajale S, Goel P, Khadilkar V, Khadilkar A. Adaptation and validation of an artificial intelligence based digital radiogrammetry tool for assessing bone health of indian children and youth with type-1 diabetes. Endocrine 2024; 84:119-127. [PMID: 38123878 PMCID: PMC10987335 DOI: 10.1007/s12020-023-03630-1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/31/2023] [Accepted: 11/22/2023] [Indexed: 12/23/2023]
Abstract
BACKGROUND AND OBJECTIVES BoneXpert (BX) is an artificial intelligence software used primarily for bone age assessment. Besides, it can also be used to screen for bone health using the digital radiogrammetry tool called bone health index (BHI) for which normative reference values available are calculated from healthy European children. Due to ethnic difference in bone geometry, in a previous study, we generated reference curves based on healthy Indian children. The objectives of this study were: 1) To assess and compare bone health of Indian children with Type 1 diabetes (T1D) using both European and Indian BHI SDS reference data and 2) To identify determinants of poor bone health in Indian children and youth with T1D by using BHI tool (based on BHI-SDS Indian reference data) of BX. METHOD The BHI was assessed retrospectively in 1159 subjects with T1D using digitalised left-hand x-rays and SDS were computed using European and Indian data. The demographic, anthropometric, clinical, biochemistry, dual x-ray absorptiometry (DXA) data and peripheral quantitative computed tomography (pQCT) data collection were performed using standard protocols and were extracted from hospital records. RESULTS The BHI correlated well with DXA and pQCT parameters in subjects with T1D. BHI-SDS calculated using Indian reference data had better correlation with height and DXA parameters. 8.6% study participants had low (less than -2) BHI-SDS (Indian), with height SDS having significant effect. Subjects with low BHI-SDS were older, shorter and had higher duration of diabetes. They also had lower IGF1 and vitamin D concentrations, bone mineral density, and trabecular density. Female gender, increased duration of illness, poor glycaemic control, and vitamin D deficiency/insufficiency were significant predictors of poor BHI-SDS. CONCLUSION Our study highlights the utility of digital radiogrammetry AI tool to screen for bone health of children with T1D and demonstrates and highlights the necessity of interpretation using ethnicity specific normative data.
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Affiliation(s)
- Chirantap Oza
- Department of Paediatric growth and Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, India
- Consultant Paediatric Endocrinologist, Endogrow pediatric and adolescent endocrine centre, Ahmedabad, India
- Visiting consultant pediatric endocrinologist, Department of pediatrics, Narendra Modi Medical college, Ahmedabad, India
| | - Misha Antani
- Department of pathology, B.J. Medical college, Ahmedabad, India
| | - Shruti Mondkar
- Department of Paediatric growth and Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, India
| | - Shital Bhor
- Department of Paediatric growth and Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, India
| | - Neha Kajale
- Department of Paediatric growth and Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, India
- Interdisciplinary School of Health Sciences, Savitribai Phule University, Pune, India
| | - Shilpa Kajale
- Consultant Radiologist, Department of radiology, Jehangir Hospital, Pune, India
| | - Pranay Goel
- Department of Biology, Indian Institute of Science Education and Research Pune, Pune, India
| | - Vaman Khadilkar
- Department of Paediatric growth and Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, India
- Interdisciplinary School of Health Sciences, Savitribai Phule University, Pune, India
- Senior Consultant, Jehangir Hospital, Pune, India
| | - Anuradha Khadilkar
- Department of Paediatric growth and Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, India.
- Interdisciplinary School of Health Sciences, Savitribai Phule University, Pune, India.
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14
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Boitsios G, Saliba T, Aparisi Gómez MP, Simoni P. Does ethnicity influence bone health index in children? A pilot study. Pediatr Radiol 2024; 54:316-323. [PMID: 38227019 DOI: 10.1007/s00247-023-05844-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/08/2023] [Revised: 12/21/2023] [Accepted: 12/22/2023] [Indexed: 01/17/2024]
Abstract
BACKGROUND Several pathological conditions can lead to variations in bone mineral content during growth. When assessing bone age, bone mineral content can be estimated without supplementary cost and irradiation. Manual assessment of bone quality using the Exton-Smith index (ESI) and automated assessment of the bone health index (BHI) provided by the BoneXpert® software are available but still not validated in different ethnic groups. OBJECTIVE Our aim is to provide normative values of the ESI and BHI for healthy European Caucasian and first-generation children of North Africans living in Europe. MATERIALS AND METHODS A sex- and aged-match population of 214 girls (107 European-Caucasian and 107 North African) and 220 boys (111 European-Caucasian and 109 North African) were retrospectively and consecutively included in the study. Normal radiographs of the left hand and wrist from healthy children were retrieved from those performed in a single institution from 2008 to 2017 to rule out a left-hand fracture. Radiographs were processed by BoneXpert® to obtain the BHI and BHI standard deviation score (SDS). One radiologist, blinded to BHI values, manually calculated ESI for each patient. The variability for both methods was assessed and compared using the standard deviation (SD) of the median (%) for each class of age and sex, and ESI and BHI trends were compared by sex and ethnic group. RESULTS The final population comprised 434 children ages 3 to 15 years (214 girls). Overall, BHI was lower in North African children (mean = 4.23 for girls and 4.17 in boys) than in European Caucasians (mean = 4.50 for girls and 4.68 in boys) (P < 0.001). Regardless of ethnicity, 29 girls (13.6%) and 34 boys (15.5%) had BHI more than 2 SD from the mean. While correlated to BHI, ESI has a higher variability than BHI and is more pronounced from 8-12 years for both sexes (mean ESI in European Caucasian girls and boys 17.47 and 20.87, respectively) (P < 0.001). ESI showed more than 15% variability in European girls from 8-12 years and a plateau in North African boys from 12 years to 16 years. However, the BHI has less than 15% variability regardless of age and ethnic group. CONCLUSION BHI may be a reliable tool to detect children with abnormal bone mineral content, with lower variability compared to ESI and with specific trends depending on sex and ethnicity.
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Affiliation(s)
- Grammatina Boitsios
- Paediatric Imaging Department, Queen Fabiola Children's Hospital (HUDERF), Université Libre de Bruxelles, Avenue Jean Joseph Crocq 15, 1020, Brussels, Belgium.
| | - Thomas Saliba
- Paediatric Imaging Department, Queen Fabiola Children's Hospital (HUDERF), Université Libre de Bruxelles, Avenue Jean Joseph Crocq 15, 1020, Brussels, Belgium
| | | | - Paolo Simoni
- Paediatric Imaging Department, Queen Fabiola Children's Hospital (HUDERF), Université Libre de Bruxelles, Avenue Jean Joseph Crocq 15, 1020, Brussels, Belgium
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Tsai AY, Carter SR, Greene AC. Artificial intelligence in pediatric surgery. Semin Pediatr Surg 2024; 33:151390. [PMID: 38242061 DOI: 10.1016/j.sempedsurg.2024.151390] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/21/2024]
Abstract
Artificial intelligence (AI) is rapidly changing the landscape of medicine and is already being utilized in conjunction with medical diagnostics and imaging analysis. We hereby explore AI applications in surgery and examine its relevance to pediatric surgery, covering its evolution, current state, and promising future. The various fields of AI are explored including machine learning and applications to predictive analytics and decision support in surgery, computer vision and image analysis in preoperative planning, image segmentation, surgical navigation, and finally, natural language processing assist in expediting clinical documentation, identification of clinical indications, quality improvement, outcome research, and other types of automated data extraction. The purpose of this review is to familiarize the pediatric surgical community with the rise of AI and highlight the ongoing advancements and challenges in its adoption, including data privacy, regulatory considerations, and the imperative for interdisciplinary collaboration. We hope this review serves as a comprehensive guide to AI's transformative influence on surgery, demonstrating its potential to enhance pediatric surgical patient outcomes, improve precision, and usher in a new era of surgical excellence.
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Affiliation(s)
- Anthony Y Tsai
- Division of Pediatric Surgery, Penn State Health Children's Hospital, 500 University Drive, Hershey, PA 17033, United States.
| | - Stewart R Carter
- Division of Pediatric Surgery, University of Louisville School of Medicine, Louisville, KY, United States
| | - Alicia C Greene
- Division of Pediatric Surgery, Penn State Health Children's Hospital, 500 University Drive, Hershey, PA 17033, United States
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16
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Altmann-Schneider I, Kellenberger CJ, Pistorius SM, Saladin C, Schäfer D, Arslan N, Fischer HL, Seiler M. Artificial intelligence-based detection of paediatric appendicular skeletal fractures: performance and limitations for common fracture types and locations. Pediatr Radiol 2024; 54:136-145. [PMID: 38099929 PMCID: PMC10776701 DOI: 10.1007/s00247-023-05822-3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/06/2023] [Revised: 11/17/2023] [Accepted: 11/20/2023] [Indexed: 01/10/2024]
Abstract
BACKGROUND Research into artificial intelligence (AI)-based fracture detection in children is scarce and has disregarded the detection of indirect fracture signs and dislocations. OBJECTIVE To assess the diagnostic accuracy of an existing AI-tool for the detection of fractures, indirect fracture signs, and dislocations. MATERIALS AND METHODS An AI software, BoneView (Gleamer, Paris, France), was assessed for diagnostic accuracy of fracture detection using paediatric radiology consensus diagnoses as reference. Radiographs from a single emergency department were enrolled retrospectively going back from December 2021, limited to 1,000 radiographs per body part. Enrolment criteria were as follows: suspected fractures of the forearm, lower leg, or elbow; age 0-18 years; and radiographs in at least two projections. RESULTS Lower leg radiographs showed 607 fractures. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were high (87.5%, 87.5%, 98.3%, 98.3%, respectively). Detection rate was low for toddler's fractures, trampoline fractures, and proximal tibial Salter-Harris-II fractures. Forearm radiographs showed 1,137 fractures. Sensitivity, specificity, PPV, and NPV were high (92.9%, 98.1%, 98.4%, 91.7%, respectively). Radial and ulnar bowing fractures were not reliably detected (one out of 11 radial bowing fractures and zero out of seven ulnar bowing fractures were correctly detected). Detection rate was low for styloid process avulsions, proximal radial buckle, and complete olecranon fractures. Elbow radiographs showed 517 fractures. Sensitivity and NPV were moderate (80.5%, 84.7%, respectively). Specificity and PPV were high (94.9%, 93.3%, respectively). For joint effusion, sensitivity, specificity, PPV, and NPV were moderate (85.1%, 85.7%, 89.5%, 80%, respectively). For elbow dislocations, sensitivity and PPV were low (65.8%, 50%, respectively). Specificity and NPV were high (97.7%, 98.8%, respectively). CONCLUSIONS The diagnostic performance of BoneView is promising for forearm and lower leg fractures. However, improvement is mandatory before clinicians can rely solely on AI-based paediatric fracture detection using this software.
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Affiliation(s)
- Irmhild Altmann-Schneider
- Department of Diagnostic Imaging, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland.
- Paediatric Emergency Department, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland.
| | - Christian J Kellenberger
- Department of Diagnostic Imaging, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland
- Paediatric Emergency Department, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland
| | - Sarah-Maria Pistorius
- Department of Diagnostic Imaging, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland
- Paediatric Emergency Department, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland
| | - Camilla Saladin
- Department of Diagnostic Imaging, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland
- Paediatric Emergency Department, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland
| | - Debora Schäfer
- Children's Research Centre, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland
| | - Nidanur Arslan
- Children's Research Centre, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland
| | - Hanna L Fischer
- Children's Research Centre, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland
| | - Michelle Seiler
- Paediatric Emergency Department, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland
- Children's Research Centre, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland
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17
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Oza C, Antani M, Mondkar SA, Kajale N, Ojha V, Goel P, Khadilkar V, Khadilkar AV. BoneXpert-derived bone health index reference curves constructed on healthy Indian children and adolescents. Pediatr Radiol 2024; 54:127-135. [PMID: 38099931 DOI: 10.1007/s00247-023-05824-1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/31/2023] [Revised: 11/19/2023] [Accepted: 11/21/2023] [Indexed: 01/10/2024]
Abstract
BACKGROUND Artificial intelligence (AI)-based applications for the assessment of the paediatric musculoskeletal system like BoneXpert are not only useful to assess bone age (BA) but also to provide a bone health index (BHI) and a standard deviation score (SDS) for both. This allows comparison of the BHI with age- and sex-matched healthy Caucasian children. OBJECTIVE We conducted this study with the objective of generating BHI curves using BoneXpert in healthy Indian children with BA between 2 and 17 years. METHOD We retrospectively reviewed anthropometric parameters, BHI, and BHI SDS data of digitalized left-hand radiographs (joint photographic experts group [jpg] format) of a cohort of 788 paediatric patients from a previous study to which they were recruited to compare various methods of BA assessment. The recruited children represented all age groups for both sexes. The corrected BHI for jpg images was calculated using the formula corrected BHI=BHI*(stature/(avL*50))^0.33333 where stature is height of subject and avL is average length of metacarpal bones. The reference Indian BHI curves and centiles were generated using the Lambda-Mu-Sigma method. RESULT The mean BHI and BHI SDS of the study group were 4.02±0.57 and -1.73±1.09, respectively. The average increase in median BHI from each age group was between 2.5% and 3% in both sexes up to age of 14 years after which it increased to 4.5% to 5%. The mean BHI of Indian children was lower than that of Caucasian children with maximum differences noted in boys at 16 years (21.7%) and girls at 14 years (16%). We report 8.4% SD of BHI for our study sample. Reference percentile curves for BHI according to BA were derived separately for boys and girls. CONCLUSION Reference data has been provided for the screening of bone health status of Indian children and adolescents.
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Affiliation(s)
- Chirantap Oza
- Department of Paediatric Growth and Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Old Building Basement, Jehangir Hospital, 32, Sassoon Road, Pune, Maharashtra, 411001, India
- Endogrow Paediatric and Adolescent Endocrine Centre, Ahmedabad, India
- Department of Paediatrics, Narendra Modi Medical College, Ahmedabad, India
| | - Misha Antani
- Department of Pathology, B. J. Medical College, Ahmedabad, India
| | - Shruti A Mondkar
- Department of Paediatric Growth and Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Old Building Basement, Jehangir Hospital, 32, Sassoon Road, Pune, Maharashtra, 411001, India
| | - Neha Kajale
- Department of Paediatric Growth and Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Old Building Basement, Jehangir Hospital, 32, Sassoon Road, Pune, Maharashtra, 411001, India
- Interdisciplinary School of Health Sciences, Savitribai Phule University, Pune, India
| | - Vikas Ojha
- Department of Radiology, Jehangir Hospital, Pune, India
| | - Pranay Goel
- Department of Biology, Indian Institute of Science Education and Research, Pune, India
| | - Vaman Khadilkar
- Department of Paediatric Growth and Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Old Building Basement, Jehangir Hospital, 32, Sassoon Road, Pune, Maharashtra, 411001, India
- Interdisciplinary School of Health Sciences, Savitribai Phule University, Pune, India
- Jehangir Hospital, Pune, India
| | - Anuradha V Khadilkar
- Department of Paediatric Growth and Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Old Building Basement, Jehangir Hospital, 32, Sassoon Road, Pune, Maharashtra, 411001, India.
- Interdisciplinary School of Health Sciences, Savitribai Phule University, Pune, India.
- Jehangir Hospital, Pune, India.
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18
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Rassmann S, Keller A, Skaf K, Hustinx A, Gausche R, Ibarra-Arrelano MA, Hsieh TC, Madajieu YED, Nöthen MM, Pfäffle R, Attenberger UI, Born M, Mohnike K, Krawitz PM, Javanmardi B. Deeplasia: deep learning for bone age assessment validated on skeletal dysplasias. Pediatr Radiol 2024; 54:82-95. [PMID: 37953411 PMCID: PMC10776485 DOI: 10.1007/s00247-023-05789-1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/22/2023] [Revised: 10/04/2023] [Accepted: 10/05/2023] [Indexed: 11/14/2023]
Abstract
BACKGROUND Skeletal dysplasias collectively affect a large number of patients worldwide. Most of these disorders cause growth anomalies. Hence, evaluating skeletal maturity via the determination of bone age (BA) is a useful tool. Moreover, consecutive BA measurements are crucial for monitoring the growth of patients with such disorders, especially for timing hormonal treatment or orthopedic interventions. However, manual BA assessment is time-consuming and suffers from high intra- and inter-rater variability. This is further exacerbated by genetic disorders causing severe skeletal malformations. While numerous approaches to automate BA assessment have been proposed, few are validated for BA assessment on children with skeletal dysplasias. OBJECTIVE We present Deeplasia, an open-source prior-free deep-learning approach designed for BA assessment specifically validated on patients with skeletal dysplasias. MATERIALS AND METHODS We trained multiple convolutional neural network models under various conditions and selected three to build a precise model ensemble. We utilized the public BA dataset from the Radiological Society of North America (RSNA) consisting of training, validation, and test subsets containing 12,611, 1,425, and 200 hand and wrist radiographs, respectively. For testing the performance of our model ensemble on dysplastic hands, we retrospectively collected 568 radiographs from 189 patients with molecularly confirmed diagnoses of seven different genetic bone disorders including achondroplasia and hypochondroplasia. A subset of the dysplastic cohort (149 images) was used to estimate the test-retest precision of our model ensemble on longitudinal data. RESULTS The mean absolute difference of Deeplasia for the RSNA test set (based on the average of six different reference ratings) and dysplastic set (based on the average of two different reference ratings) were 3.87 and 5.84 months, respectively. The test-retest precision of Deeplasia on longitudinal data (2.74 months) is estimated to be similar to a human expert. CONCLUSION We demonstrated that Deeplasia is competent in assessing the age and monitoring the development of both normal and dysplastic bones.
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Affiliation(s)
- Sebastian Rassmann
- Institute for Genomic Statistics and Bioinformatics, University Hospital Bonn, Venusberg-Campus 1 Building 11, 2nd Floor, 53127, Bonn, Germany
| | | | - Kyra Skaf
- Medical Faculty, Otto-Von-Guericke-University Magdeburg, Magdeburg, Germany
| | - Alexander Hustinx
- Institute for Genomic Statistics and Bioinformatics, University Hospital Bonn, Venusberg-Campus 1 Building 11, 2nd Floor, 53127, Bonn, Germany
| | - Ruth Gausche
- CrescNet - Wachstumsnetzwerk, Medical Faculty, University Hospital Leipzig, Leipzig, Germany
| | - Miguel A Ibarra-Arrelano
- Institute for Genomic Statistics and Bioinformatics, University Hospital Bonn, Venusberg-Campus 1 Building 11, 2nd Floor, 53127, Bonn, Germany
| | - Tzung-Chien Hsieh
- Institute for Genomic Statistics and Bioinformatics, University Hospital Bonn, Venusberg-Campus 1 Building 11, 2nd Floor, 53127, Bonn, Germany
| | | | - Markus M Nöthen
- Institute of Human Genetics, University Hospital Bonn, Bonn, Germany
| | - Roland Pfäffle
- Department for Pediatrics, University Hospital Leipzig, Leipzig, Germany
| | - Ulrike I Attenberger
- Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, Germany
| | - Mark Born
- Division of Paediatric Radiology, Department of Radiology, University Hospital Bonn, Bonn, Germany
| | - Klaus Mohnike
- Medical Faculty, Otto-Von-Guericke-University Magdeburg, Magdeburg, Germany
| | - Peter M Krawitz
- Institute for Genomic Statistics and Bioinformatics, University Hospital Bonn, Venusberg-Campus 1 Building 11, 2nd Floor, 53127, Bonn, Germany
| | - Behnam Javanmardi
- Institute for Genomic Statistics and Bioinformatics, University Hospital Bonn, Venusberg-Campus 1 Building 11, 2nd Floor, 53127, Bonn, Germany.
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19
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Wang G, Meng X, Zhang F. Past, present, and future of global research on artificial intelligence applications in dermatology: A bibliometric analysis. Medicine (Baltimore) 2023; 102:e35993. [PMID: 37960748 PMCID: PMC10637496 DOI: 10.1097/md.0000000000035993] [Citation(s) in RCA: 4] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/06/2023] [Accepted: 10/17/2023] [Indexed: 11/15/2023] Open
Abstract
In recent decades, artificial intelligence (AI) has played an increasingly important role in medicine, including dermatology. Worldwide, numerous studies have reported on AI applications in dermatology, rapidly increasing interest in this field. However, no bibliometric studies have been conducted to evaluate the past, present, or future of this topic. This study aimed to illustrate past and present research and outline future directions for global research on AI applications in dermatology using bibliometric analysis. We conducted an online search of the Web of Science Core Collection database to identify scientific papers on AI applications in dermatology. The bibliometric metadata of each selected paper were extracted, analyzed, and visualized using VOS viewer and Cite Space. A total of 406 papers, comprising 8 randomized controlled trials and 20 prospective studies, were deemed eligible for inclusion. The United States had the highest number of papers (n = 166). The University of California System (n = 24) and Allan C. Halpern (n = 11) were the institution and author with the highest number of papers, respectively. Based on keyword co-occurrence analysis, the studies were categorized into 9 distinct clusters, with clusters 2, 3, and 7 containing keywords with the latest average publication year. Wound progression prediction using machine learning, the integration of AI into teledermatology, and applications of the algorithms in skin diseases, are the current research priorities and will remain future research aims in this field.
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Affiliation(s)
- Guangxin Wang
- Shandong Innovation Center of Intelligent Diagnosis, Jinan Central Hospital, Shandong University, Jinan, Shandong, China
| | - Xianguang Meng
- Department of Dermatology, Jinan Central Hospital, Shandong University, Jinan, Shandong, China
| | - Fan Zhang
- Shandong Innovation Center of Intelligent Diagnosis, Jinan Central Hospital, Shandong University, Jinan, Shandong, China
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Zech JR, Jaramillo D, Altosaar J, Popkin CA, Wong TT. Artificial intelligence to identify fractures on pediatric and young adult upper extremity radiographs. Pediatr Radiol 2023; 53:2386-2397. [PMID: 37740031 DOI: 10.1007/s00247-023-05754-y] [Citation(s) in RCA: 4] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/03/2023] [Revised: 08/09/2023] [Accepted: 08/21/2023] [Indexed: 09/24/2023]
Abstract
BACKGROUND Pediatric fractures are challenging to identify given the different response of the pediatric skeleton to injury compared to adults, and most artificial intelligence (AI) fracture detection work has focused on adults. OBJECTIVE Develop and transparently share an AI model capable of detecting a range of pediatric upper extremity fractures. MATERIALS AND METHODS In total, 58,846 upper extremity radiographs (finger/hand, wrist/forearm, elbow, humerus, shoulder/clavicle) from 14,873 pediatric and young adult patients were divided into train (n = 12,232 patients), tune (n = 1,307), internal test (n = 819), and external test (n = 515) splits. Fracture was determined by manual inspection of all test radiographs and the subset of train/tune radiographs whose reports were classified fracture-positive by a rule-based natural language processing (NLP) algorithm. We trained an object detection model (Faster Region-based Convolutional Neural Network [R-CNN]; "strongly-supervised") and an image classification model (EfficientNetV2-Small; "weakly-supervised") to detect fractures using train/tune data and evaluate on test data. AI fracture detection accuracy was compared with accuracy of on-call residents on cases they preliminarily interpreted overnight. RESULTS A strongly-supervised fracture detection AI model achieved overall test area under the receiver operating characteristic curve (AUC) of 0.96 (95% CI 0.95-0.97), accuracy 89.7% (95% CI 88.0-91.3%), sensitivity 90.8% (95% CI 88.5-93.1%), and specificity 88.7% (95% CI 86.4-91.0%), and outperformed a weakly-supervised model (AUC 0.93, 95% CI 0.92-0.94, P < 0.0001). AI accuracy on cases preliminary interpreted overnight was higher than resident accuracy (AI 89.4% vs. 85.1%, 95% CI 87.3-91.5% vs. 82.7-87.5%, P = 0.01). CONCLUSION An object detection AI model identified pediatric upper extremity fractures with high accuracy.
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Affiliation(s)
- John R Zech
- Department of Radiology, Columbia University Irving Medical Center, 622 W. 168th St., New York, NY, 10032, USA.
| | - Diego Jaramillo
- Department of Radiology, Columbia University Irving Medical Center, 622 W. 168th St., New York, NY, 10032, USA
| | | | - Charles A Popkin
- Department of Orthopedic Surgery, Columbia University Irving Medical Center, New York, NY, USA
| | - Tony T Wong
- Department of Radiology, Columbia University Irving Medical Center, 622 W. 168th St., New York, NY, 10032, USA
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Aryasomayajula S, Hing CB, Siebachmeyer M, Naeini FB, Ejindu V, Leitch P, Gelfer Y, Zweiri Y. Developing an artificial intelligence diagnostic tool for paediatric distal radius fractures, a proof of concept study. Ann R Coll Surg Engl 2023; 105:721-728. [PMID: 37642151 PMCID: PMC10618045 DOI: 10.1308/rcsann.2023.0017] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 03/02/2023] [Indexed: 08/31/2023] Open
Abstract
INTRODUCTION In the UK, 1 in 50 children sustain a fractured bone yearly, yet studies have shown that 34% of children sustaining an injury do not have a visible fracture on initial radiographs. Wrist fractures are particularly difficult to identify because the growth plate poses diagnostic challenges when interpreting radiographs. METHODS We developed Convolutional Neural Network (CNN) image recognition software to detect fractures in radiographs from children. A consecutive data set of 5,000 radiographs of the distal radius in children aged less than 19 years from 2014 to 2019 was used to train the CNN. In addition, transfer learning from a VGG16 CNN pretrained on non-radiological images was applied to improve generalisation of the network and the classification of radiographs. Hyperparameter tuning techniques were used to compare the model with the radiology reports that accompanied the original images to determine diagnostic test accuracy. RESULTS The training set consisted of 2,881 radiographs with a fracture and 1,571 without; 548 radiographs were outliers. With additional augmentation, the final data set consisted of 15,498 images. The data set was randomly split into three subsets: training (70%), validation (10%) and test (20%). After training for 20 epochs, the diagnostic test accuracy was 85%. DISCUSSION A CNN model is feasible in diagnosing paediatric wrist fractures. We demonstrated that this application could be utilised as a tool for improving diagnostic accuracy. Future work would involve developing automated treatment pathways for diagnosis, reducing unnecessary hospital visits and allowing staff redeployment to other areas.
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Affiliation(s)
| | - CB Hing
- St George’s University Hospitals NHS Foundation Trust, UK
| | - M Siebachmeyer
- St George’s University Hospitals NHS Foundation Trust, UK
| | | | - V Ejindu
- St George’s University Hospitals NHS Foundation Trust, UK
| | - P Leitch
- St George’s University London, UK
| | - Y Gelfer
- St George’s University Hospitals NHS Foundation Trust, UK
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22
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Oza C, Khadilkar A, Goel P, Karguppikar M, Shah N, Lohiya N, Mondkar S, Patil P, Prasad H, Maheshwari A, Ladkat D, Kajale N, More C, Khurjekar D, Khadilkar V. Utility of BoneXpert in assessing bone age and bone health in Indian children and youth with type 1 diabetes mellitus. Bone 2023; 178:116952. [PMID: 39492559 DOI: 10.1016/j.bone.2023.116952] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/24/2023] [Revised: 10/02/2023] [Accepted: 10/27/2023] [Indexed: 11/05/2024]
Abstract
INTRODUCTION BoneXpert (BX) performs digital radiogrammetry and reports metacarpal index (MCI) besides bone age (BA) evaluation. Its utility in subjects with type-1 diabetes (T1D) has not been reported. We conducted this study with following objectives: 1) To study the utility of BX in the assessment of BA in Indian children and youth (CY) with T1D and 2) To assess association of MCI (measured by BX) and bone health in Indian CY with T1D. METHODS The MCI and BA were assessed retrospectively in 1272 subjects with T1D using digitalised left-hand x-rays. The demographic, anthropometric, clinical, dietary, biochemistry, dual x-ray absorptiometry (DXA) data and peripheral quantitative computed tomography (pQCT) data collection were performed using standard protocols and were extracted from hospital records. RESULTS The root mean square error of BX with respect to reference and true bone age by TW-3 method were estimated to be 0.72 years and 0.67 years respectively in Indian CY with T1D. The BX provided MCI results were in concordance with the DXA derived bone mineral density (r = 0.551) and pQCT derived cortical density (r = 0.318) measurements; MCI correlated with trabecular density at the tibia (r = 0.212). 51.5 % subjects with T1D had significantly decreased MCI. Height, tanner stage, vitamin D concentrations showed positive correlation while HbA1c and disease duration had negative correlation with MCI. CONCLUSION BX may be used for accurate assessment of BA by TW-3 method and for screening for bone health in Indian CY with T1D.
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Affiliation(s)
- Chirantap Oza
- Department of Paediatric growth and Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, India; Endogrow Pediatric and Adolescent Endocrine Centre, Ahmedabad, India; Department of Pediatrics, Narendra Modi Medical College, GCS Medical College and B.J. Medical College, Ahmedabad, India
| | - Anuradha Khadilkar
- Department of Paediatric growth and Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, India; Interdisciplinary School of Health Sciences, Savitribai Phule University, Pune, India.
| | - Pranay Goel
- Department of Biology, Indian Institute of Science Education and Research Pune, India
| | - Madhura Karguppikar
- Department of Paediatric growth and Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, India; Jupiter Hospital and Sahyadri Hospital, Pune, SKN Medical College and Hospital, Pune, India
| | - Nikhil Shah
- Department of Paediatric growth and Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, India; Department of Paediatrics, Cloudnine Hospital, Malad, Mumbai, India
| | - Nikhil Lohiya
- Division of Growth & Endocrinology, Silver Lining Paediatric Super Speciality Centre for Growth Development & Endocrine Care, Lokmat Square, Nagpur, India
| | - Shruti Mondkar
- Department of Paediatric growth and Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, India
| | - Prashant Patil
- SRCC NH CHILDREN'S Hospital, Mumbai and Apollo Hospital, Navi Mumbai, India
| | | | - Ankita Maheshwari
- Paediatric Endocrinology, SAIMS, Indore, India; Coral Hospital and Research Centre, Indore, India
| | - Dipali Ladkat
- Department of Paediatric growth and Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, India
| | - Neha Kajale
- Department of Paediatric growth and Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, India; Interdisciplinary School of Health Sciences, Savitribai Phule University, Pune, India
| | - Chidvilas More
- Department of Paediatric growth and Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, India
| | | | - Vaman Khadilkar
- Department of Paediatric growth and Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, India; Interdisciplinary School of Health Sciences, Savitribai Phule University, Pune, India
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23
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Hussain A, Fareed A, Taseen S. Bone fracture detection-Can artificial intelligence replace doctors in orthopedic radiography analysis? Front Artif Intell 2023; 6:1223909. [PMID: 37593091 PMCID: PMC10427856 DOI: 10.3389/frai.2023.1223909] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/16/2023] [Accepted: 07/20/2023] [Indexed: 08/19/2023] Open
Affiliation(s)
- Aariz Hussain
- Karachi Medical and Dental College and Abbasi Shaheed Hospital, Karachi, Sindh, Pakistan
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Gasmi I, Calinghen A, Parienti JJ, Belloy F, Fohlen A, Pelage JP. Comparison of diagnostic performance of a deep learning algorithm, emergency physicians, junior radiologists and senior radiologists in the detection of appendicular fractures in children. Pediatr Radiol 2023; 53:1675-1684. [PMID: 36877239 DOI: 10.1007/s00247-023-05621-w] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/30/2021] [Revised: 11/21/2022] [Accepted: 01/30/2023] [Indexed: 03/07/2023]
Abstract
BACKGROUND Advances have been made in the use of artificial intelligence (AI) in the field of diagnostic imaging, particularly in the detection of fractures on conventional radiographs. Studies looking at the detection of fractures in the pediatric population are few. The anatomical variations and evolution according to the child's age require specific studies of this population. Failure to diagnose fractures early in children may lead to serious consequences for growth. OBJECTIVE To evaluate the performance of an AI algorithm based on deep neural networks toward detecting traumatic appendicular fractures in a pediatric population. To compare sensitivity, specificity, positive predictive value and negative predictive value of different readers and the AI algorithm. MATERIALS AND METHODS This retrospective study conducted on 878 patients younger than 18 years of age evaluated conventional radiographs obtained after recent non-life-threatening trauma. All radiographs of the shoulder, arm, elbow, forearm, wrist, hand, leg, knee, ankle and foot were evaluated. The diagnostic performance of a consensus of radiology experts in pediatric imaging (reference standard) was compared with those of pediatric radiologists, emergency physicians, senior residents and junior residents. The predictions made by the AI algorithm and the annotations made by the different physicians were compared. RESULTS The algorithm predicted 174 fractures out of 182, corresponding to a sensitivity of 95.6%, a specificity of 91.64% and a negative predictive value of 98.76%. The AI predictions were close to that of pediatric radiologists (sensitivity 98.35%) and that of senior residents (95.05%) and were above those of emergency physicians (81.87%) and junior residents (90.1%). The algorithm identified 3 (1.6%) fractures not initially seen by pediatric radiologists. CONCLUSION This study suggests that deep learning algorithms can be useful in improving the detection of fractures in children.
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Affiliation(s)
- Idriss Gasmi
- Department of Radiology, Caen University Medical Center, 14033 Cedex 9, Caen, France
| | - Arvin Calinghen
- Department of Radiology, Caen University Medical Center, 14033 Cedex 9, Caen, France
| | - Jean-Jacques Parienti
- GRAM 2.0 EA2656 UNICAEN Normandie, University Hospital, Caen, France
- Department of Clinical Research, Caen University Hospital, Caen, France
| | - Frederique Belloy
- Department of Radiology, Caen University Medical Center, 14033 Cedex 9, Caen, France
| | - Audrey Fohlen
- Department of Radiology, Caen University Medical Center, 14033 Cedex 9, Caen, France
- UNICAEN CEA CNRS ISTCT- CERVOxy, Normandie University, 14000, Caen, France
| | - Jean-Pierre Pelage
- Department of Radiology, Caen University Medical Center, 14033 Cedex 9, Caen, France.
- UNICAEN CEA CNRS ISTCT- CERVOxy, Normandie University, 14000, Caen, France.
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Madsen A, Juul A, Aksglaede L. Biochemical identification of prepubertal boys with Klinefelter syndrome by combined reproductive hormone profiling using machine learning. Endocr Connect 2023; 12:e220537. [PMID: 36892968 PMCID: PMC10160564 DOI: 10.1530/ec-22-0537] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/02/2023] [Accepted: 03/09/2023] [Indexed: 03/10/2023]
Abstract
Objective Klinefelter syndrome (KS) is the most common sex chromosome disorder and genetic cause of infertility in males. A highly variable phenotype contributes to the fact that a large proportion of cases are never diagnosed. Typical hallmarks in adults include small testes and azoospermia which may prompt biochemical evaluation that typically shows extremely high follicle-stimulating hormone and low/undetectable inhibin B serum concentrations. However, in prepubertal KS individuals, biochemical parameters are largely overlapping those of prepubertal controls. We aimed to characterize clinical profiles of prepubertal boys with KS in relation to controls and to develop a novel biochemical classification model to identify KS before puberty. Methods Retrospective, longitudinal data from 15 prepubertal boys with KS and data from 1475 controls were used to calculate age- and sex-adjusted standard deviation scores (SDS) for height and serum concentrations of reproductive hormones and used to infer a decision tree classification model for KS. Results Individual reproductive hormones were low but within reference ranges and did not discriminate KS from controls. Clinical and biochemical profiles including age- and sex-adjusted SDS from multiple reference curves provided input data to train a 'random forest' machine learning (ML) model for the detection of KS. Applied to unseen data, the ML model achieved a classification accuracy of 78% (95% CI, 61-94%). Conclusions Supervised ML applied to clinically relevant variables enabled computational classification of control and KS profiles. The application of age- and sex-adjusted SDS provided robust predictions irrespective of age. Specialized ML models applied to combined reproductive hormone concentrations may be useful diagnostic tools to improve the identification of prepubertal boys with KS.
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Affiliation(s)
- Andre Madsen
- Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway
- Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
| | - Anders Juul
- Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
- International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
- Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
| | - Lise Aksglaede
- Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
- International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
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Laborie LB, Naidoo J, Pace E, Ciet P, Eade C, Wagner MW, Huisman TAGM, Shelmerdine SC. European Society of Paediatric Radiology Artificial Intelligence taskforce: a new taskforce for the digital age. Pediatr Radiol 2023; 53:576-580. [PMID: 35731260 PMCID: PMC9214669 DOI: 10.1007/s00247-022-05426-3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/21/2022] [Revised: 05/26/2022] [Accepted: 06/03/2022] [Indexed: 11/08/2022]
Abstract
A new task force dedicated to artificial intelligence (AI) with respect to paediatric radiology was created in 2021 at the International Paediatric Radiology (IPR) meeting in Rome, Italy (a joint society meeting by the European Society of Pediatric Radiology [ESPR] and the Society for Pediatric Radiology [SPR]). The concept of a separate task force dedicated to AI was borne from an ESPR-led international survey of health care professionals' opinions, expectations and concerns regarding AI integration within children's imaging departments. In this survey, the majority (> 80%) of ESPR respondents supported the creation of a task force and helped define our key objectives. These include providing educational content about AI relevant for paediatric radiologists, brainstorming ideas for future projects and collaborating on AI-related studies with respect to collating data sets, de-identifying images and engaging in multi-case, multi-reader studies. This manuscript outlines the starting point of the ESPR AI task force and where we wish to go.
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Affiliation(s)
- Lene Bjerke Laborie
- grid.412008.f0000 0000 9753 1393Department of Radiology, Section for Paediatrics, Haukeland University Hospital, Bergen, Norway
- grid.7914.b0000 0004 1936 7443Department of Clinical Medicine, University of Bergen, Bergen, Norway
| | - Jaishree Naidoo
- Paediatric Diagnostic Imaging and Envisionit Deep AI, Johannesburg, South Africa
| | - Erika Pace
- grid.5072.00000 0001 0304 893XDepartment of Diagnostic Radiology, The Royal Marsden NHS Foundation Trust, London, UK
| | - Pierluigi Ciet
- grid.5645.2000000040459992XDepartment of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
- grid.5645.2000000040459992XDepartment of Pediatric Pulmonology and Allergology, Erasmus MC, Sophia’s Children’s Hospital, Rotterdam, The Netherlands
| | - Christine Eade
- grid.8391.30000 0004 1936 8024University of Exeter Medical School, Exeter, UK
| | - Matthias W. Wagner
- grid.42327.300000 0004 0473 9646Department of Diagnostic Imaging, Division of Neuroradiology, The Hospital for Sick Children, Toronto, Canada
- grid.17063.330000 0001 2157 2938Department of Medical Imaging, University of Toronto, Toronto, Ontario Canada
| | - Thierry A. G. M. Huisman
- grid.39382.330000 0001 2160 926XEdward B. Singleton Department of Radiology, Texas Children’s Hospital, Baylor College of Medicine, Houston, Texas USA
| | - Susan C. Shelmerdine
- grid.424537.30000 0004 5902 9895Department of Clinical Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, Great Ormond Street, WC1H 3JH London, UK
- grid.83440.3b0000000121901201UCL Great Ormond Street Institute of Child Health, London, UK
- grid.451056.30000 0001 2116 3923NIHR Great Ormond Street Hospital Biomedical Research Centre, London, UK
- grid.464688.00000 0001 2300 7844Department of Clinical Radiology, St. George’s Hospital, London, UK
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Hayashi D, Kompel AJ, Ventre J, Ducarouge A, Nguyen T, Regnard NE, Guermazi A. Automated detection of acute appendicular skeletal fractures in pediatric patients using deep learning. Skeletal Radiol 2022; 51:2129-2139. [PMID: 35522332 DOI: 10.1007/s00256-022-04070-0] [Citation(s) in RCA: 17] [Impact Index Per Article: 5.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/16/2022] [Revised: 04/28/2022] [Accepted: 04/28/2022] [Indexed: 02/02/2023]
Abstract
OBJECTIVE We aimed to perform an external validation of an existing commercial AI software program (BoneView™) for the detection of acute appendicular fractures in pediatric patients. MATERIALS AND METHODS In our retrospective study, anonymized radiographic exams of extremities, with or without fractures, from pediatric patients (aged 2-21) were included. Three hundred exams (150 with fractures and 150 without fractures) were included, comprising 60 exams per body part (hand/wrist, elbow/upper arm, shoulder/clavicle, foot/ankle, leg/knee). The Ground Truth was defined by experienced radiologists. A deep learning algorithm interpreted the radiographs for fracture detection, and its diagnostic performance was compared against the Ground Truth, and receiver operating characteristic analysis was done. Statistical analyses included sensitivity per patient (the proportion of patients for whom all fractures were identified) and sensitivity per fracture (the proportion of fractures identified by the AI among all fractures), specificity per patient, and false-positive rate per patient. RESULTS There were 167 boys and 133 girls with a mean age of 10.8 years. For all fractures, sensitivity per patient (average [95% confidence interval]) was 91.3% [85.6, 95.3], specificity per patient was 90.0% [84.0,94.3], sensitivity per fracture was 92.5% [87.0, 96.2], and false-positive rate per patient in patients who had no fracture was 0.11. The patient-wise area under the curve was 0.93 for all fractures. AI diagnostic performance was consistently high across all anatomical locations and different types of fractures except for avulsion fractures (sensitivity per fracture 72.7% [39.0, 94.0]). CONCLUSION The BoneView™ deep learning algorithm provides high overall diagnostic performance for appendicular fracture detection in pediatric patients.
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Affiliation(s)
- Daichi Hayashi
- Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA, 02118, USA. .,Department of Radiology, Stony Brook University Renaissance School of Medicine, HSc Level 4, Room 120, Stony Brook, NY, 11794, USA.
| | - Andrew J Kompel
- Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA, 02118, USA
| | - Jeanne Ventre
- Gleamer, 117-119 Quai de Valmy, 75010, Paris, France
| | | | - Toan Nguyen
- Gleamer, 117-119 Quai de Valmy, 75010, Paris, France.,Service de Radiopédiatrie, Hôpital Armand-Trousseau, AP-HP, Médecine Sorbonne Université, 26 avenue du Docteur Arnold-Netter, 75012, Paris, France
| | - Nor-Eddine Regnard
- Gleamer, 117-119 Quai de Valmy, 75010, Paris, France.,Réseau d'Imagerie Sud Francilien, 2 avenue de Mousseau, 91000, Evry, France
| | - Ali Guermazi
- Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA, 02118, USA.,Department of Radiology, VA Boston Healthcare System, 1400 VFW Parkway, Suite 1B105, West Roxbury, MA, 02132, USA
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Nguyen T, Maarek R, Hermann AL, Kammoun A, Marchi A, Khelifi-Touhami MR, Collin M, Jaillard A, Kompel AJ, Hayashi D, Guermazi A, Le Pointe HD. Assessment of an artificial intelligence aid for the detection of appendicular skeletal fractures in children and young adults by senior and junior radiologists. Pediatr Radiol 2022; 52:2215-2226. [PMID: 36169667 DOI: 10.1007/s00247-022-05496-3] [Citation(s) in RCA: 24] [Impact Index Per Article: 8.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/11/2022] [Revised: 07/07/2022] [Accepted: 08/25/2022] [Indexed: 10/14/2022]
Abstract
BACKGROUND As the number of conventional radiographic examinations in pediatric emergency departments increases, so, too, does the number of reading errors by radiologists. OBJECTIVE The aim of this study is to investigate the ability of artificial intelligence (AI) to improve the detection of fractures by radiologists in children and young adults. MATERIALS AND METHODS A cohort of 300 anonymized radiographs performed for the detection of appendicular fractures in patients ages 2 to 21 years was collected retrospectively. The ground truth for each examination was established after an independent review by two radiologists with expertise in musculoskeletal imaging. Discrepancies were resolved by consensus with a third radiologist. Half of the 300 examinations showed at least 1 fracture. Radiographs were read by three senior pediatric radiologists and five radiology residents in the usual manner and then read again immediately after with the help of AI. RESULTS The mean sensitivity for all groups was 73.3% (110/150) without AI; it increased significantly by almost 10% (P<0.001) to 82.8% (125/150) with AI. For junior radiologists, it increased by 10.3% (P<0.001) and for senior radiologists by 8.2% (P=0.08). On average, there was no significant change in specificity (from 89.6% to 90.3% [+0.7%, P=0.28]); for junior radiologists, specificity increased from 86.2% to 87.6% (+1.4%, P=0.42) and for senior radiologists, it decreased from 95.1% to 94.9% (-0.2%, P=0.23). The stand-alone sensitivity and specificity of the AI were, respectively, 91% and 90%. CONCLUSION With the help of AI, sensitivity increased by an average of 10% without significantly decreasing specificity in fracture detection in a predominantly pediatric population.
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Affiliation(s)
- Toan Nguyen
- Department of Pediatric Radiology, Armand Trousseau Hospital, 26 Av. du Dr Arnold Netter, 75012, Paris, France.
| | - Richard Maarek
- Department of Pediatric Radiology, Armand Trousseau Hospital, 26 Av. du Dr Arnold Netter, 75012, Paris, France
| | - Anne-Laure Hermann
- Department of Pediatric Radiology, Armand Trousseau Hospital, 26 Av. du Dr Arnold Netter, 75012, Paris, France
| | - Amina Kammoun
- Department of Pediatric Radiology, Armand Trousseau Hospital, 26 Av. du Dr Arnold Netter, 75012, Paris, France
| | - Antoine Marchi
- Department of Pediatric Radiology, Armand Trousseau Hospital, 26 Av. du Dr Arnold Netter, 75012, Paris, France
| | - Mohamed R Khelifi-Touhami
- Department of Pediatric Radiology, Armand Trousseau Hospital, 26 Av. du Dr Arnold Netter, 75012, Paris, France
| | - Mégane Collin
- Department of Pediatric Radiology, Armand Trousseau Hospital, 26 Av. du Dr Arnold Netter, 75012, Paris, France
| | - Aliénor Jaillard
- Department of Pediatric Radiology, Armand Trousseau Hospital, 26 Av. du Dr Arnold Netter, 75012, Paris, France
| | - Andrew J Kompel
- Department of Radiology, Boston University School of Medicine, Boston, MA, USA
| | - Daichi Hayashi
- Department of Radiology, Boston University School of Medicine, Boston, MA, USA.,Department of Radiology, Stony Brook University Renaissance School of Medicine, Stony Brook, NY, USA
| | - Ali Guermazi
- Department of Radiology, Boston University School of Medicine, Boston, MA, USA.,Department of Radiology, VA Boston Healthcare System, West Roxbury, MA, USA
| | - Hubert Ducou Le Pointe
- Department of Pediatric Radiology, Armand Trousseau Hospital, 26 Av. du Dr Arnold Netter, 75012, Paris, France
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Madsen A, Almås B, Bruserud IS, Oehme NHB, Nielsen CS, Roelants M, Hundhausen T, Ljubicic ML, Bjerknes R, Mellgren G, Sagen JV, Juliusson PB, Viste K. Reference Curves for Pediatric Endocrinology: Leveraging Biomarker Z-Scores for Clinical Classifications. J Clin Endocrinol Metab 2022; 107:2004-2015. [PMID: 35299255 PMCID: PMC9202734 DOI: 10.1210/clinem/dgac155] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/17/2021] [Indexed: 12/13/2022]
Abstract
CONTEXT Hormone reference intervals in pediatric endocrinology are traditionally partitioned by age and lack the framework for benchmarking individual blood test results as normalized z-scores and plotting sequential measurements onto a chart. Reference curve modeling is applicable to endocrine variables and represents a standardized method to account for variation with gender and age. OBJECTIVE We aimed to establish gender-specific biomarker reference curves for clinical use and benchmark associations between hormones, pubertal phenotype, and body mass index (BMI). METHODS Using cross-sectional population sample data from 2139 healthy Norwegian children and adolescents, we analyzed the pubertal status, ultrasound measures of glandular breast tissue (girls) and testicular volume (boys), BMI, and laboratory measurements of 17 clinical biomarkers modeled using the established "LMS" growth chart algorithm in R. RESULTS Reference curves for puberty hormones and pertinent biomarkers were modeled to adjust for age and gender. Z-score equivalents of biomarker levels and anthropometric measurements were compiled in a comprehensive beta coefficient matrix for each gender. Excerpted from this analysis and independently of age, BMI was positively associated with female glandular breast volume (β = 0.5, P < 0.001) and leptin (β = 0.6, P < 0.001), and inversely correlated with serum levels of sex hormone-binding globulin (SHBG) (β = -0.4, P < 0.001). Biomarker z-score profiles differed significantly between cohort subgroups stratified by puberty phenotype and BMI weight class. CONCLUSION Biomarker reference curves and corresponding z-scores provide an intuitive framework for clinical implementation in pediatric endocrinology and facilitate the application of machine learning classification and covariate precision medicine for pediatric patients.
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Affiliation(s)
- Andre Madsen
- Correspondence: André Madsen, PhD, Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, N-5021 Bergen, Norway.
| | - Bjørg Almås
- Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway
| | - Ingvild S Bruserud
- Faculty of Health, VID Specialized University, Bergen, Norway
- Department of Pediatrics, Haukeland University Hospital, Bergen, Norway
| | | | - Christopher Sivert Nielsen
- Department of Chronic Diseases and Ageing, Norwegian Institute of Public Health, Oslo, Norway
- Department of Pain Management and Research, Oslo University Hospital, Oslo, Norway
| | - Mathieu Roelants
- Environment and Health, Department of Public Health and Primary Care, KU Leuven, University of Leuven, Leuven, Belgium
| | - Thomas Hundhausen
- Department of Medical Biochemistry, Southern Norway Hospital Trust, Kristiansand, Norway
- Department of Natural Sciences, University of Agder, Kristiansand, Norway
| | - Marie Lindhardt Ljubicic
- Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, and International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen, Denmark
| | - Robert Bjerknes
- Department of Pediatrics, Haukeland University Hospital, Bergen, Norway
- Department of Clinical Science, University of Bergen, Bergen, Norway
| | - Gunnar Mellgren
- Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway
- Department of Clinical Science, University of Bergen, Bergen, Norway
- Mohn Nutrition Research Laboratory, University of Bergen, Bergen, Norway
| | - Jørn V Sagen
- Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway
- Department of Clinical Science, University of Bergen, Bergen, Norway
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30
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Wu Q, Ma H, Sun J, Liu C, Fang J, Xie H, Zhang S. Application of deep-learning-based artificial intelligence in acetabular index measurement. Front Pediatr 2022; 10:1049575. [PMID: 36741093 PMCID: PMC9891291 DOI: 10.3389/fped.2022.1049575] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/20/2022] [Accepted: 12/21/2022] [Indexed: 01/17/2023] Open
Abstract
OBJECTIVE To construct an artificial intelligence system to measure acetabular index and evaluate its accuracy in clinical application. METHODS A total of 10,219 standard anteroposterior pelvic radiographs were collected retrospectively from April 2014 to December 2018 in our hospital. Of these, 9,219 radiographs were randomly selected to train and verify the system. The remaining 1,000 radiographs were used to compare the system's and the clinicians' measurement results. All plain pelvic films were labeled by an expert committee through PACS system based on a uniform standard to measure acetabular index. Subsequently, eight other clinicians independently measured the acetabular index from 200 randomly selected radiographs from the test radiographs. Bland-Altman test was used for consistency analysis between the system and clinician measurements. RESULTS The test set included 1,000 cases (2,000 hips). Compared with the expert committee measurement, the 95% limits of agreement (95% LOA) of the system was -4.02° to 3.45° (bias = -0.27°, P < 0.05). The acetabular index measured by the system within all age groups, including normal and abnormal groups, also showed good credibility according to the Bland-Altman principle. Comparison of the measurement evaluations by the system and eight clinicians vs. that of, the expert committee, the 95% LOA of the clinician with the smallest measurement error was -2.76° to 2.56° (bias = -0.10°, P = 0.126). The 95% LOA of the system was -0.93° to 2.86° (bias = -0.03°, P = 0.647). The 95% LOA of the clinician with the largest measurement error was -3.41° to 4.25° (bias = 0.42°, P < 0.05). The measurement error of the system was only greater than that of a senior clinician. CONCLUSION The newly constructed artificial intelligence system could quickly and accurately measure the acetabular index of standard anteroposterior pelvic radiographs. There is good data consistency between the system in measuring standard anteroposterior pelvic radiographs. The accuracy of the system is closer to that of senior clinicians.
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Affiliation(s)
- Qingjie Wu
- Department of Pediatric Orthopedics, Anhui Provincial Children's Hospital, Hefei, China.,Fifth Clinical Medical College, Anhui Medical University, Hefei, China
| | - Hailong Ma
- Department of Pediatric Orthopedics, Anhui Provincial Children's Hospital, Hefei, China
| | - Jun Sun
- Department of Pediatric Orthopedics, Anhui Provincial Children's Hospital, Hefei, China.,Fifth Clinical Medical College, Anhui Medical University, Hefei, China
| | - Chuanbin Liu
- School of Information Science and Technology, University of Science and Technology of China, Hefei, China
| | - Jihong Fang
- Department of Pediatric Orthopedics, Anhui Provincial Children's Hospital, Hefei, China
| | - Hongtao Xie
- School of Information Science and Technology, University of Science and Technology of China, Hefei, China
| | - Sicheng Zhang
- Department of Pediatric Orthopedics, Anhui Provincial Children's Hospital, Hefei, China.,Fifth Clinical Medical College, Anhui Medical University, Hefei, China
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