|
1
|
Badaoui A, Fougerousse AC, Roussel A. Allergic contact dermatitis to octyl and butylcyanoacrylate as well as formaldehyde in Leukosan® surgical glue. Contact Dermatitis 2025; 92:73-75. [PMID: 39243145 DOI: 10.1111/cod.14689] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/18/2024] [Revised: 08/25/2024] [Accepted: 08/26/2024] [Indexed: 09/09/2024]
Affiliation(s)
- Antoine Badaoui
- Dermatology Department, Begin Hospital, Saint Mandé, France
- Private Practice, Paris, France
| | | | - Aude Roussel
- Dermatology Department, Begin Hospital, Saint Mandé, France
| |
Collapse
|
|
2
|
Doci RSA, Carvalho FFD, Gomes RC, Gianini RJ, Fanelli C, Noronha IDL, Santos NBD, Hausen MDA, Komatsu D, Randazzo-Moura P. Pharmacological effects of triamcinolone associated with surgical glue on cutaneous wound healing in rats. Acta Cir Bras 2024; 39:e399624. [PMID: 39661810 DOI: 10.1590/acb399624] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/05/2024] [Accepted: 09/30/2024] [Indexed: 12/13/2024] Open
Abstract
PURPOSE The surgical glue is widely used in closing cutaneous surgical wounds. Corticosteroids are indicated for their anti-inflammatory and immunomodulatory properties. The present work evaluated the pharmacological effects of triamcinolone (AT) incorporated into surgical glue (C) on the initial phase of the wound healing process in Wistar rats. METHODS Through in-vivo studies, the effects of the healing process, C or C+AT in the same rat were evaluated for seven and 14 days post-surgery. RESULTS The C+AT association did not change the physicochemical properties of the polymer. This association in wound healing confirmed the anti-inflammatory and immunomodulatory effects of the corticosteroid, with less neovascularization and fibrosis, in addition to the remodeling of the extracellular matrix carried out by the balance of myofibroblasts and less dense collagen fibers, culminating in tissue regeneration and possible reduction of side effects. CONCLUSION This association is a powerful and innovative pharmacological tool, promising in translational medicine.
Collapse
Affiliation(s)
- Rosana Soares Araújo Doci
- Pontifícia Universidade Católica de São Paulo - Faculty of Medical and Health Sciences - Program of Postgraduate in Biomaterials and Regenerative Medicine - São Paulo (SP) - Brazil
| | - Filipe Feitosa de Carvalho
- Pontifícia Universidade Católica de São Paulo - Faculty of Medical and Health Sciences - Program of Postgraduate in Biomaterials and Regenerative Medicine - São Paulo (SP) - Brazil
| | - Rodrigo César Gomes
- Pontifícia Universidade Católica de São Paulo - Faculty of Medical and Health Sciences - Biomaterials Laboratory - São Paulo (SP) - Brazil
| | - Reinaldo José Gianini
- Pontifícia Universidade Católica de São Paulo - Faculty of Medical and Health Sciences - Program of Postgraduate in Biomaterials and Regenerative Medicine - São Paulo (SP) - Brazil
| | - Camilla Fanelli
- Universidade de São Paulo - Medical School - Laboratory of Cellular, Genetic, and Molecular Nephrology - São Paulo (SP) - Brazil
| | - Irene de Lourdes Noronha
- Universidade de São Paulo - Medical School - Laboratory of Cellular, Genetic, and Molecular Nephrology - São Paulo (SP) - Brazil
| | - Nelson Brancaccio Dos Santos
- Pontifícia Universidade Católica de São Paulo - Faculty of Medical and Health Sciences - Pathology Laboratory - São Paulo (SP) - Brazil
| | - Moema de Alencar Hausen
- Pontifícia Universidade Católica de São Paulo - Faculty of Medical and Health Sciences - Program of Postgraduate in Biomaterials and Regenerative Medicine - São Paulo (SP) - Brazil
| | - Daniel Komatsu
- Pontifícia Universidade Católica de São Paulo - Faculty of Medical and Health Sciences - Program of Postgraduate in Biomaterials and Regenerative Medicine - São Paulo (SP) - Brazil
| | - Priscila Randazzo-Moura
- Pontifícia Universidade Católica de São Paulo - Faculty of Medical and Health Sciences - Program of Postgraduate in Biomaterials and Regenerative Medicine - São Paulo (SP) - Brazil
| |
Collapse
|
|
3
|
Ali E, Makhdom AM. Association of Surgical Adhesive and Glue System With Incidence of Allergic Dermatitis Post Unilateral and Staged Bilateral Total Knee Arthroplasty. Cureus 2024; 16:e58827. [PMID: 38654960 PMCID: PMC11037296 DOI: 10.7759/cureus.58827] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 04/22/2024] [Indexed: 04/26/2024] Open
Abstract
Background Skin closure is an important step in total knee arthroplasty (TKA). Several techniques are described in the literature with emerging interest in skin adhesives. This study aims to highlight the adverse reactions related to skin adhesives and to identify potential risk factors. Methods A retrospective review of 250 patients (295 knees, 45 being staged bilateral TKA) who underwent TKA was conducted at our facility. All patients underwent the same perioperative protocol with application of surgical glue over the wound edges. Postoperative adverse reactions were classified as allergic dermatitis (AD), cellulitis, and superficial infection. Results Incidence of adverse reactions in the form of AD was noted in 4.8% of patients. Demographics and comorbidities had no influence on this occurrence (p>0.05). However, in patients who had bilateral staged TKA, AD manifested after performing the second contralateral TKA in 22% of patients. This incidence of AD was significantly higher when compared to those who had single unilateral TKA (p =0.001) Conclusion The theory of allergic sensitization may explain the higher incidence of AD in bilateral staged TKA due to prior exposure to glue components in the first knee; thus, we recommend avoiding its use if there was previous exposure.
Collapse
Affiliation(s)
- Enji Ali
- Orthopaedic Surgery, Dr. Samir Abbas Hospital, Jeddah, SAU
| | - Asim M Makhdom
- Orthopaedic Surgery, King Abdulaziz University, Jeddah, SAU
| |
Collapse
|
|
4
|
Djordjevic I, Ellis E, Singh J, Ali N, Pena EM, Rajarethinam R, Manikandan L, Goh J, Lim S, Steele T. Color changing bioadhesive barrier for peripherally inserted central catheters. Biomater Sci 2024; 12:1502-1514. [PMID: 38284150 DOI: 10.1039/d3bm01347b] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/30/2024]
Abstract
Bacteria migration at catheter insertion sites presents a serious complication (bacteraemia) with high mortality rates. One strategy to mediate bacteraemia is a physical barrier at the skin-catheter interface. Herein a colorimetric biosensor adhesive (CathoGlu) is designed and evaluated for both colorimetric detection of bacterial infection and application as a bacteria barrier. The design intent combines viscous, hydrophobic bioadhesive with an organic pH indicator (bromothymol blue). Visual observation can then distinguish healthy skin at pH = ∼5 from an infected catheter insertion site at pH = ∼8. The liquid-to-biorubber transition of CathoGlu formulation occurs via a brief exposure to UVA penlight, providing an elastic barrier to the skin flora. Leachates from CathoGlu demonstrate no genotoxic and skin sensitization effect, assessed by OECD-recommended in vitro and in chemico assays. The CathoGlu formulation was found non-inferior against clinically approved 2-octyl-cyanoacrylate (Dermabond™), and adhesive tape (Micropore™) within an in vivo porcine model. CathoGlu skin adhesive provides new opportunities to prevent sepsis in challenging clinical situations.
Collapse
Affiliation(s)
- Ivan Djordjevic
- School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Ave, Block N4.1, Singapore 639798.
| | - Elizabeth Ellis
- School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Ave, Block N4.1, Singapore 639798.
| | - Juhi Singh
- NTU Institute for Health Technologies, Interdisciplinary Graduate Program, Nanyang Technological University, 61 Nanyang Drive, Singapore 637335
- School of Chemistry, Chemical Engineering and Biotechnology, 70 Nanyang Drive, Block N1.3, Nanyang Technological University, Singapore 637457
| | - Naziruddin Ali
- School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Ave, Block N4.1, Singapore 639798.
| | - Edgar M Pena
- National Large Animal Research Facility, SingHealth Experimental Medicine Centre, Academia 20 College Road, Singapore 169856
| | - Ravisankar Rajarethinam
- Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673
| | - Lakshmanan Manikandan
- Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673
| | - Jason Goh
- Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673
| | - Sierin Lim
- School of Chemistry, Chemical Engineering and Biotechnology, 70 Nanyang Drive, Block N1.3, Nanyang Technological University, Singapore 637457
| | - Terry Steele
- School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Ave, Block N4.1, Singapore 639798.
| |
Collapse
|
|
5
|
Koritz K, Canizares MF, Cook D, Shore BJ. Incidence of Skin Sensitivity Following Dermabond Application in Pediatric Orthopedic Surgery. J Pediatr Orthop 2024; 44:e203-e208. [PMID: 37820062 DOI: 10.1097/bpo.0000000000002549] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 10/13/2023]
Abstract
BACKGROUND Dermabond (Dermabond; Ethicon, Sommerville, NJ), is a skin adhesive commonly utilized in pediatric orthopedic surgery for postoperative wound care. Few studies have examined outcomes of Dermabond exposure in children. The purpose of this study is to estimate the incidence of skin reactions following Dermabond exposure in pediatric orthopedic surgery and investigate potential risk factors associated with Dermabond sensitivity. METHODS This was a retrospective study of a level-one pediatric trauma center. All orthopaedic surgeries in 2019 were screened for Dermabond application. Three surgeons with the highest rates of Dermabond application defined our cohort. Out of 2990 surgeries in 2019, the 3 surgeons performed 234 surgeries with Dermabond. Postoperative reactions and repeat Dermabond exposures were collected for these 234 patients. Subjects with known allergies to Dermabond were excluded. Reactions were defined. as discoloration, irritation, and wound dehiscence. Significant differences between patients with repeat Dermabond exposures and those without were determined using χ 2 analysis. Associations between patient characteristics and sensitivity were determined using logistic regression analysis. P values less than 0.05 were considered significant. RESULTS In all, 234 patients were included for analysis. The mean age at surgery was 12.5 years (SD 6.1), and 39% (92/234) of the cohort was male. Thirty-two patients (14%) experienced skin reactions during the study period (95% CI=7%-19%). Reactions most frequently included. erythema (10/32; 31%) and itchiness (10/32; 31%). Reactions were most frequently treated with oral antibiotics, Benadryl, or a dressing change. Of 144 patients with 1 Dermabond exposure, 17 (12%) experienced reactions (95% CI=7%-18%). Of 128 patients experiencing a repeat Dermabond exposure, 27 (21%) experienced reactions (95% CI=19%-34%, P =0.03). Age, surgical procedure, and surgical location were not, associated with a variable rate of sensitivity. CONCLUSIONS Sensitivity to Dermabond after pediatric orthopedic surgery occurred at a higher rate than seen in adults, and patients with multiple Dermabond exposures experienced significantly higher sensitivity than patients with a single exposure. Increased awareness of this potential complication is needed to help inform decisions regarding Dermabond's application in pediatric orthopedics.
Collapse
Affiliation(s)
| | | | - Danielle Cook
- Department of Orthopaedic Surgery, Boston Children's Hospital
| | - Benjamin J Shore
- Department of Orthopaedic Surgery, Boston Children's Hospital
- Harvard Medical School, Boston, MA
| |
Collapse
|
|
6
|
Alotaibi NN, Ahmad T, Rabah SM, Sheikh MT. Type IV Hypersensitivity Reaction to Dermabond (2-Octyl Cyanoacrylate) in Plastic Surgical Patients: A Retrospective Study. Plast Surg (Oakv) 2022; 30:222-226. [PMID: 35990393 PMCID: PMC9389055 DOI: 10.1177/22925503211015448] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/03/2020] [Revised: 02/27/2021] [Accepted: 03/22/2021] [Indexed: 08/03/2023] Open
Abstract
Background: The Dermabond (2-octyl cyanoacrylate) is a commonly used skin adhesive in plastic surgery. There are some reports in the literature regarding Dermabond associated contact dermatitis. In this retrospective cohort study, we evaluated the incidence and characteristics of contact dermatitis (type IV hypersensitivity reaction) post application of Dermabond (Trade name PRINEO manufactured by ETHICON) in patients who underwent plastic surgical breast procedures in our hospital. Methods: Sixty patients had undergone plastic surgical breast procedures (mastopexy and reduction mammoplasty) with Dermabond application over the period of last 3 years in our hospital. The records of these 60 patients were studied retrospectively. Results: Four patients (6.6%) out of the 60 patients taken for study had developed type IV hypersensitivity reaction to Dermabond. All of these patients presented with pruritus and skin rash in the second week of their post-operative period and none of them had any known past allergic history. Conclusion: We conclude that the incidence of type IV hypersensitivity allergic reaction post application of Dermabond (2-octyl cyanoacrylate) is significantly high and its possibility should be explained to the patients prior to its application.
Collapse
Affiliation(s)
- Nawaf Naif Alotaibi
- Plastic Surgery, King Abdullah bin Abdulaziz
University Hospital (Princess Nourah Bint Abdulrahman University), Riyadh, Saudi
Arabia
| | - Tawheed Ahmad
- Plastic Surgery, King Abdullah bin Abdulaziz
University Hospital (Princess Nourah Bint Abdulrahman University), Riyadh, Saudi
Arabia
| | - Sari Monzer Rabah
- Plastic Surgery, King Abdullah bin Abdulaziz
University Hospital (Princess Nourah Bint Abdulrahman University), Riyadh, Saudi
Arabia
| | - Mohammad Tafazul Sheikh
- Plastic Surgery, King Abdullah bin Abdulaziz
University Hospital (Princess Nourah Bint Abdulrahman University), Riyadh, Saudi
Arabia
| |
Collapse
|
|
7
|
Atwater AR, Bembry R, Liu B, Warshaw EM, DeKoven JG, Silverberg JI, Taylor JS, Zug KA, Houle MC, Belsito DV, Maibach HI, Reeder MJ, Sasseville D, Dunnick C, Fowler JF, Pratt MD, DeLeo VA. Medical Adhesive Allergens: Retrospective Analysis of Cross-Sectional Data from the North American Contact Dermatitis Group, 2001-2018. J Am Acad Dermatol 2021; 87:1024-1032. [PMID: 34875303 DOI: 10.1016/j.jaad.2021.11.055] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/30/2021] [Revised: 11/16/2021] [Accepted: 11/29/2021] [Indexed: 10/31/2022]
Abstract
BACKGROUND Identification of allergens causing medical adhesive contact allergy is difficult. OBJECTIVE Characterize the demographics, clinical characteristics, patch test results and occupational data for North American Contact Dermatitis Group (NACDG) patients with medical adhesive contact allergy. METHODS Retrospective study of 43,722 NACDG patients patch-tested 2001-2018, with: 1) medical adhesive (tapes/band aids/adhesive aids/suture glue) source, 2) positive patch test, and 3) final primary diagnosis of allergic contact dermatitis. RESULTS 313 (0.7%) patients met inclusion criteria. Compared to other patients with final primary diagnosis of allergic contact dermatitis, medical adhesive allergy patients were less likely male (odds ratio 0.58, 95% confidence interval [0.45-0.77]) and/or age >40 (0.76 [0.6-0.96]). The most common NACDG screening series allergens were colophony (80.7%), balsam of Peru (3.9%), 2-hydroxyethyl methacrylate (2.7%) and carba mix (2.7%). One-fourth (79/313, 25.2%) had positive patch test reactions to supplemental allergens/materials, and 17.3% (54/313) only had reactions to supplemental allergens/materials. LIMITATIONS Results of comprehensive patch testing may be prone to referral population selection bias and may not be representative of the general dermatology population. CONCLUSION Colophony was the most common allergen. Supplemental allergens and materials should be tested in the evaluation of suspected medical adhesive contact allergy.
Collapse
Affiliation(s)
- Amber Reck Atwater
- Department of Dermatology, Duke University Medical Center, Durham, North Carolina.
| | - Raina Bembry
- Department of Dermatology, Duke University Medical Center, Durham, North Carolina
| | - Beiyu Liu
- Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC
| | - Erin M Warshaw
- Departments of Dermatology, Minneapolis Veterans Affairs Medical Center, Park Nicollet Health Services, and University of Minnesota, Minneapolis, MN
| | - Joel G DeKoven
- Division of Dermatology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
| | - Jonathan I Silverberg
- Department of Dermatology, George Washington University School of Medicine and Health Sciences, Washington, DC
| | - James S Taylor
- Department of Dermatology, Cleveland Clinic Lerner College of Medicine, Cleveland, OH
| | - Kathryn A Zug
- Department of Dermatology, Dartmouth Hitchcock Medical Center, Lebanon, NH
| | - Marie-Claude Houle
- Division of Dermatology, CHU de Quebec, Laval University, Quebec, Canada
| | - Donald V Belsito
- Department of Dermatology, Columbia University Irving Medical Center, New York, NY
| | - Howard I Maibach
- Department of Dermatology, University of California Medical School, San Francisco, CA
| | - Margo J Reeder
- Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, WI
| | - Denis Sasseville
- Division of Dermatology, McGill University Health Centre, Montreal General Hospital, Montreal, QC, Canada
| | - Cory Dunnick
- Department of Dermatology, University of Colorado, Anschutz Medical Campus, Aurora, CO
| | - Joseph F Fowler
- Division of Dermatology, University of Louisville, Louisville, KY
| | - Melanie D Pratt
- Division of Dermatology, University of Ottawa, The Ottawa Hospital, Ottawa, Ontario, Canada
| | - Vincent A DeLeo
- Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA
| |
Collapse
|
|
8
|
Dermatologic Complications Following Cosmetic and Reconstructive Plastic Surgery: A Systematic Review of the Literature. Aesthetic Plast Surg 2021; 45:3005-3018. [PMID: 34231016 DOI: 10.1007/s00266-021-02362-9] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/22/2021] [Accepted: 05/15/2021] [Indexed: 10/20/2022]
Abstract
PURPOSE Plastic surgery procedures, including minimally invasive cosmetic procedures, continue to grow in popularity. Although dermatologic complications following plastic surgery procedures are rare, the authors have encountered several of these complications in their practice, including herpes simplex virus (HSV-1) and varicella zoster virus (VZV) infections, pyoderma gangrenosum (PG), contact dermatitis, and suture hypersensitivity. These cases prompted a systematic literature review of dermatologic complications following plastic surgery procedures. METHODS The authors conducted a systematic review of PubMed, MEDLINE, EMBASE, Scopus, Web of Science, and the Cochrane Library to identify relevant articles published from 1975 to 2021. Articles were independently reviewed by the authors to determine whether studies met inclusion criteria. RESULTS The majority of articles that met inclusion criteria represented level V evidence. The most robust evidence in the literature was for PG, for which there were 63 total studies. Pyoderma gangrenosum was most frequently reported following breast surgery (85.1%), while HSV-1 infections were frequently seen following minimally invasive procedures (84.6%). VZV reactivation was reported after a range of interventions, including pedicled flap surgeries and laser treatments. Other complications, such as suture hypersensitivity, were less frequently reported in the literature, usually as isolated case reports. CONCLUSIONS Dermatologic complications represent a rare but serious concern following plastic surgery procedures. While most dermatologic complications resolve with appropriate treatment, sequelae of these conditions can be devastating to the patient's overall outcome. Plastic surgeons performing procedures at a high risk of these complications should recognize the diagnostic criteria to facilitate appropriate treatment. LEVEL OF EVIDENCE III This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
Collapse
|
|
9
|
Robinson J, Smidt KP, Houk G, McKie J, Barton RS, Massey P. Allergic dermatitis after knee arthroscopy with repeated exposure to Dermabond Prineo™ in pediatric patients: Two case reports. World J Orthop 2021; 12:931-937. [PMID: 34888153 PMCID: PMC8613688 DOI: 10.5312/wjo.v12.i11.931] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/30/2021] [Revised: 08/09/2021] [Accepted: 09/19/2021] [Indexed: 02/06/2023] Open
Abstract
BACKGROUND Allergic contact dermatitis (ACD) secondary to Dermabond Prineo™ is rare, but documented. To our knowledge, there are no described reports of this ACD reaction within the pediatric population following arthroscopic surgery.
CASE SUMMARY We report two cases of pediatric ACD upon second exposure to Dermabond Prineo™ after knee arthroscopy. Both cases presented within two weeks of the inciting second exposure. The cases resolved with differing described combinations of sterile cleaning, diphenhydramine, and antibiotic administration. No long-term sequelae were found.
CONCLUSION This case report elucidates the rare complication of allergic dermatitis secondary to Dermabond Prineo™ repeat exposure use in pediatric arthroscopy.
Collapse
Affiliation(s)
- James Robinson
- Department of Orthopaedic Surgery, Louisiana State University, Shreveport, LA 71103, United States
| | - Kevin P Smidt
- Department of Orthopaedic Surgery, Louisiana State University, Shreveport, LA 71103, United States
| | - Garrett Houk
- School of Medicine, Louisiana State University, Shreveport, LA 71103, United States
| | - Janay McKie
- Department of Orthopaedic Surgery, Shriners Hospital for Children, Shreveport, LA 71103, United States
| | - R Shane Barton
- Department of Orthopaedic Surgery, Louisiana State University, Shreveport, LA 71103, United States
| | - Patrick Massey
- Department of Orthopaedic Surgery, Louisiana State University, Shreveport, LA 71103, United States
| |
Collapse
|
|
10
|
Lee GW, Kwak WK, Lee KB. Comparison of 2-octyl cyanoacrylate skin adhesive and interrupted polypropylene sutures for wound closure in total ankle arthroplasty. J Orthop Surg Res 2021; 16:636. [PMID: 34689815 PMCID: PMC8543931 DOI: 10.1186/s13018-021-02791-x] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/31/2021] [Accepted: 10/12/2021] [Indexed: 11/10/2022] Open
Abstract
BACKGROUND Adhesive skin materials have increasingly been used in orthopedic surgery. We aimed to compare the efficacy and safety of skin adhesive (2-octyl cyanoacrylate and polymer mesh, Dermabond Prineo) and interrupted polypropylene sutures for wound closure in patients undergoing total ankle arthroplasty (TAA). METHODS We prospectively enrolled 107 consecutive patients (108 ankles) undergoing TAA and divided them into two groups: skin adhesive group (36 ankles) and suture group (72 ankles). The primary outcome assessment included wound complications and patient satisfaction for wound cosmesis. The secondary outcome assessment included duration of surgery, length of hospital stay, and the Ankle Osteoarthritis Scale (AOS) pain and disability score. RESULTS There was one case of allergic contact dermatitis, three cases of wound dehiscence, and one case of superficial surgical site infection in the skin adhesive group. Among them, one case each with allergic contact dermatitis and wound dehiscence finally progressed to deep surgical site infection. Three cases of wound dehiscence were also reported in the suture group; however, there was no case of surgical site infection. Patient satisfaction for wound cosmesis was significantly higher in the skin adhesive group than in the suture group (p = 0.001). There was no statistically significant difference between the groups in terms of secondary outcomes (p > 0.05). CONCLUSIONS Although the use of Dermabond Prineo showed better patient satisfaction for wound cosmesis, it showed significantly high wound complication rates and no other clinical benefits compared to interrupted polypropylene suture in TAA. Our results suggest that awareness of the possibility of wound complications is necessary when Dermabond Prineo is used in TAA.
Collapse
Affiliation(s)
- Gun-Woo Lee
- Department of Orthopedic Surgery, Chonnam National University Medical School and Hospital, 42 Jebongro, Donggu, Gwangju, 61469, Republic of Korea
| | - Woo Kyoung Kwak
- Department of Orthopedic Surgery, Chonnam National University Medical School and Hospital, 42 Jebongro, Donggu, Gwangju, 61469, Republic of Korea
| | - Keun-Bae Lee
- Department of Orthopedic Surgery, Chonnam National University Medical School and Hospital, 42 Jebongro, Donggu, Gwangju, 61469, Republic of Korea.
| |
Collapse
|
|
11
|
Dear K, Nixon R, Ricciardo B. Post-operative rashes in the orthopaedic ward caused by allergic contact dermatitis to Dermabond Prineo. ANZ J Surg 2021; 90:1529. [PMID: 33448581 DOI: 10.1111/ans.16009] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/22/2020] [Revised: 04/17/2020] [Accepted: 05/03/2020] [Indexed: 11/29/2022]
Affiliation(s)
- Kate Dear
- Occupational Dermatology Research and Education Centre, Skin Health Institute, Melbourne, Victoria, Australia
| | - Rosemary Nixon
- Occupational Dermatology Research and Education Centre, Skin Health Institute, Melbourne, Victoria, Australia
| | - Bernadette Ricciardo
- Department of Dermatology, Fiona Stanley Hospital, Perth, Western Australia, Australia
| |
Collapse
|
|
12
|
Abstract
In more recent years, the use of medical adhesives in lieu of sutures or staples has become increasingly common for the closure of post-surgical and traumatic incisions in areas of the skin where tension is low. While medical adhesives possess many advantages and little risk of adverse side effects, there are increasing numbers of accounts in the medical literature of allergic contact dermatitis (ACD) caused by specific components contained within the medical adhesives. The goal of this paper is to provide physicians with a differential diagnosis when faced with complications after the use of medical adhesives for wound closure. Additionally, this paper aims to delineate the differences among the most commonly used adhesives, provide a rationale for assessing an individual’s personal risk of developing ACD, and to highlight the unique advantages and disadvantages of each adhesive. Dermabond® appears to be the most versatile adhesive with the lowest risk of ACD. However, because of its high cost, it may not be appropriate for all patients. While Mastisol® can only be utilized in combination with a dressing, such as Steri-Strips®, it is much more affordable than Dermabond and is still capable of providing an effective wound closure. Due to these factors, it is our recommendation that Dermabond is considered the first-line medical adhesive due to its versatility and strength, while Mastisol can be readily employed in situations with financial consideration. As the number of patients treated with medical adhesives continues to grow, physicians should anticipate an increase in the number of cases of ACD secondary to adhesive sensitization. It is imperative for physicians to be able to differentiate between a case of ACD and another potentially more serious complication, such as cellulitis. We hope that this paper will assist providers in distinguishing adhesive-induced ACD and other complications, identifying patients at risk of ACD from adhesive use, and provide a basis for which adhesives are most appropriate for any given patient.
Collapse
Affiliation(s)
| | | | - Andrew M Ferry
- Plastic and Reconstructive Surgery, Baylor College of Medicine, Houston, USA
| |
Collapse
|
|
13
|
Ricciardo BM, Nixon RL, Tam MM, Radic RR, Ricciardo BJ. Allergic Contact Dermatitis to Dermabond Prineo After Elective Orthopedic Surgery. Orthopedics 2020; 43:e515-e522. [PMID: 32882052 DOI: 10.3928/01477447-20200827-01] [Citation(s) in RCA: 13] [Impact Index Per Article: 2.6] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/27/2019] [Accepted: 10/08/2019] [Indexed: 02/03/2023]
Abstract
The Dermabond Prineo skin closure system (Ethicon, Somerville, New Jersey) is a wound closure device that combines a 2-octyl cyanoacrylate liquid adhesive and a self-adhesive polyester mesh. Although cyanoacrylates traditionally have been associated with low rates of sensitization, allergic contact dermatitis (ACD) to Dermabond products is being increasingly reported after orthopedic surgery. The authors describe the first case series of ACD to Dermabond Prineo where patch testing confirmed the diagnosis in all patients. Six patients who had suspected Dermabond Prineo ACD after lower limb orthopedic surgery were assessed. Of these patients, 5 had itching within 4 days of surgery and rash within 5 days. All 5 of these patients reported previous exposure to Dermabond products. All patients had removal of the adhesive and mesh earlier than planned and were treated with corticosteroids. In addition, 4 patients received systemic antibiotics; however, only 1 had a microbiologically confirmed superficial skin infection. In all patients, the dermatitis resolved within 2 weeks of dressing removal, with no adverse effect on the orthopedic outcome. Patch testing showed positive reactions to Dermabond Prineo glue for all patients. Orthopedic surgeons should be aware of the potential for ACD to Dermabond Prineo, especially among patients with previous exposure to Dermabond products. The authors discuss the risk factors for ACD to Dermabond Prineo in the orthopedic cohort and provide recommendations for prevention and management. [Orthopedics. 2020;43(6):e515-e522.].
Collapse
|
|
14
|
Asai C, Inomata N, Sato M, Koh N, Goda S, Ishikawa H, Tanaka M, Aihara M. Allergic contact dermatitis due to the liquid skin adhesive Dermabond® predominantly occurs after the first exposure. Contact Dermatitis 2020; 84:103-108. [PMID: 32909284 DOI: 10.1111/cod.13700] [Citation(s) in RCA: 15] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/26/2020] [Revised: 08/25/2020] [Accepted: 08/26/2020] [Indexed: 12/28/2022]
Abstract
BACKGROUND The clinical characteristics of patients with allergic contact dermatitis (ACD) due to a skin adhesive containing 2-octyl cyanoacrylate, Dermabond®, have not yet been elucidated. OBJECTIVE To investigate the clinical characteristics of patients with ACD caused by Dermabond® application. METHODS In this retrospective study, 577 patch tested patients were included. We identified patients with positive patch test results for Dermabond® and evaluated their results concerning (meth)acrylates and ethyl cyanoacrylate adhesive. RESULTS Nine patients had positive patch test results to Dermabond®; six had developed secondary generalization.The mean time between Dermabond® application and ACD onset was 34 days (range, 27-44) in six patients with ACD after the first use, whereas, in the other three patients, it was 5.6 days (range, 4-8) after the second use. The time was significantly different between the two groups (P < .01). Positive reactions to ethyl cyanoacrylate adhesive (Aron Alpha) occurred in seven of nine patients, to ethyl cyanoacrylate 10% pet. in four of eight patients tested, and to 2-hydroxyethyl methacrylate in one of eight patients tested. CONCLUSIONS Dermabond®-induced ACD is apparently characterized by a high prevalence of primary sensitization at first exposure to Dermabond®, secondary generalization is frequent, and most patients show cross-reactivity to ethyl cyanoacrylate.
Collapse
Affiliation(s)
- Chika Asai
- Department of Environmental Immuno-Dermatology, Yokohama City University School of Medicine, Yokohama, Japan
| | - Naoko Inomata
- Department of Environmental Immuno-Dermatology, Yokohama City University School of Medicine, Yokohama, Japan
| | - Megumi Sato
- Department of Environmental Immuno-Dermatology, Yokohama City University School of Medicine, Yokohama, Japan
| | - Nao Koh
- Department of Environmental Immuno-Dermatology, Yokohama City University School of Medicine, Yokohama, Japan
| | - Seiko Goda
- Department of Environmental Immuno-Dermatology, Yokohama City University School of Medicine, Yokohama, Japan
| | - Hideyuki Ishikawa
- Department of Environmental Immuno-Dermatology, Yokohama City University School of Medicine, Yokohama, Japan
| | - Masako Tanaka
- Department of Environmental Immuno-Dermatology, Yokohama City University School of Medicine, Yokohama, Japan
| | - Michiko Aihara
- Department of Environmental Immuno-Dermatology, Yokohama City University School of Medicine, Yokohama, Japan
| |
Collapse
|
|
15
|
Gardeen S, Hylwa S. A review of acrylates: Super glue, nail adhesives, and diabetic pump adhesives increasing sensitization risk in women and children. Int J Womens Dermatol 2020; 6:263-267. [PMID: 33015283 PMCID: PMC7522914 DOI: 10.1016/j.ijwd.2020.04.007] [Citation(s) in RCA: 11] [Impact Index Per Article: 2.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/25/2020] [Revised: 04/01/2020] [Accepted: 04/18/2020] [Indexed: 11/27/2022] Open
Abstract
Allergic contact dermatitis (ACD) is a cutaneous type IV hypersensitivity immune reaction mounted against substances in contact with the skin to which the patient has been sensitized. ACD is common, affecting approximately 72 million Americans per year, and is more common in women. One common contact allergen group is acrylates, which are monomers that are polymerized in the making of glues, adhesives, and plastic materials. It is the monomers that are sensitizing, whereas the final polymers are inert. Acrylates were the 2012 Contact Allergen of the Year with the specific acrylate, isobornyl acrylate, being the 2020 Contact Allergen of the Year. This article reviews the history of acrylate use, epidemiology, and both known and emerging sources of acrylates resulting in ACD.
Collapse
Affiliation(s)
- Samantha Gardeen
- Department of Medicine, Hennepin County Medical Center, Minneapolis, MN, United States
| | - Sara Hylwa
- Department of Dermatology, Hennepin County Medical Center, Minneapolis, MN, United States
- Park Nicollet Contact Dermatitis Clinic, Health Partners Institute, Minneapolis, MN, United States
- Department of Dermatology, University of Minnesota, Minneapolis, MN, United States
| |
Collapse
|
|
16
|
Should We Stick with Surgical Glues? The Incidence of Dermatitis after 2-Octyl Cyanoacrylate Exposure in 102 Consecutive Breast Cases. Plast Reconstr Surg 2020; 145:32-37. [DOI: 10.1097/prs.0000000000006321] [Citation(s) in RCA: 10] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/25/2022]
|
|
17
|
|
|
18
|
Liu T, Wan J, McKenna RA, Jackson OA, Treat JR. Allergic contact dermatitis caused by Dermabond in a paediatric patient undergoing skin surgery. Contact Dermatitis 2018; 80:61-62. [DOI: 10.1111/cod.13125] [Citation(s) in RCA: 15] [Impact Index Per Article: 2.1] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/14/2018] [Revised: 08/16/2018] [Accepted: 08/19/2018] [Indexed: 11/27/2022]
Affiliation(s)
- Tianyu Liu
- Section of Dermatology, Department of Pediatrics; Children's Hospital of Philadelphia; Philadelphia Pennsylvania
| | - Joy Wan
- Section of Dermatology, Department of Pediatrics; Children's Hospital of Philadelphia; Philadelphia Pennsylvania
| | - Rachel A. McKenna
- Division of Plastic and Reconstructive Surgery; Department of Surgery, Children's Hospital of Philadelphia; Philadelphia Pennsylvania
| | - Oksana A. Jackson
- Division of Plastic and Reconstructive Surgery; Department of Surgery, Children's Hospital of Philadelphia; Philadelphia Pennsylvania
| | - James R. Treat
- Section of Dermatology, Department of Pediatrics; Children's Hospital of Philadelphia; Philadelphia Pennsylvania
| |
Collapse
|
|
19
|
Contact Dermatitis Caused by Dermabond Advanced Use. PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN 2018; 6:e1841. [PMID: 30349768 PMCID: PMC6191225 DOI: 10.1097/gox.0000000000001841] [Citation(s) in RCA: 15] [Impact Index Per Article: 2.1] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/22/2018] [Accepted: 05/04/2018] [Indexed: 11/25/2022]
Abstract
Background: Dermabond Advanced (DBA) has been widely used globally; however, severe contact dermatitis (CD) can be a serious adverse effect of DBA use. In this study, we investigated the characterization and incidence rate of CD after using DBA and the safe use of DBA. Methods: One hundred consecutive patients who underwent skin closure with DBA were investigated. All patients were women undergoing breast reconstruction. DBA was applied to their trunk and limbs following reconstruction. Results: Seven patients (7%) presented with CD. Of these, 4 patients exhibited CD after the second DBA use; sensitization influence by the first DBA use was considered. One of 3 patients presenting with CD after the first DBA use was allergic to cosmetic glue, and the influence of immunological cross-reaction of acrylates was suggested. Conclusion: We consider that DBA use is inadequate for wounds with an improper margin and in dry and low-skin barrier areas such as the trunk and limbs because it may induce irritant CD and sensitization of DBA and subsequent allergic CD. Frequent use can also induce sensitization. If patients have a history of acrylate allergies, DBA use should be avoided because immunological cross-reaction from acetylates could result.
Collapse
|
|
20
|
Kanazawa A, Uno H, Nakada T, Shaw DW, Maibach HI. Contact dermatitis to Dermabond Advance®. Australas J Dermatol 2018; 60:63-64. [DOI: 10.1111/ajd.12843] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/16/2022]
Affiliation(s)
- Azusa Kanazawa
- Department of Dermatology; Showa University; Fujigaoka Hospital; Yokohama Japan
| | - Hirokazu Uno
- Department of Dermatology; Showa University; Fujigaoka Hospital; Yokohama Japan
| | - Tokio Nakada
- Department of Dermatology; Showa University; Fujigaoka Hospital; Yokohama Japan
| | - Daniel W Shaw
- Department of Dermatology; University of California; San Diego California USA
| | - Howard I Maibach
- Department of Dermatology; University of California; San Francisco California USA
| |
Collapse
|
|
21
|
Lake NH, Barlow BT, Toledano JE, Valentine J, McDonald LS. Contact Dermatitis Reaction to 2-Octyl Cyanoacrylate Following 3 Orthopedic Procedures. Orthopedics 2018; 41:e289-e291. [PMID: 28934541 DOI: 10.3928/01477447-20170918-08] [Citation(s) in RCA: 12] [Impact Index Per Article: 1.7] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/07/2017] [Accepted: 08/02/2017] [Indexed: 02/03/2023]
Abstract
Two-octyl cyanoacrylate is a popular skin adhesive used for closing surgical incisions. Since Food and Drug Administration approval in 1998, the few reports of adverse reactions following its use have primarily been limited to the nonorthopedic literature. The authors present a case series of contact dermatitis associated with 2-octyl cyanoacrylate following orthopedic surgery and a review of the literature on the diagnosis and treatment of this complication. All 3 patients presented with blistering around their incisions within 2 weeks of surgery and responded to treatment involving removal of the offending agent and use of oral diphenhydramine and hydroxyzine and topical triamcinolone. One case was complicated by a draining hematoma, requiring irrigation and debridement. Complete resolution occurred in all cases. This case series is intended to increase awareness in the orthopedic community of allergic contact dermatitis to 2-octyl cyanoacrylate and its appropriate treatment. [Orthopedics. 2018; 41(2):e289-e291.].
Collapse
|
|
22
|
Bitterman A, Sandhu K. Allergic contact dermatitis to 2-octyl cyanoacrylate after surgical repair: Humidity as a potential factor. JAAD Case Rep 2017; 3:480-481. [PMID: 28971138 PMCID: PMC5614641 DOI: 10.1016/j.jdcr.2017.07.006] [Citation(s) in RCA: 18] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/26/2022] Open
Affiliation(s)
- Avi Bitterman
- Sidney Kimmel Medical College, Philadelphia, Pennsylvania.,Jersey Shore University Medical Center, Neptune, New Jersey
| | | |
Collapse
|
|
23
|
Cook KA, Kelso JM. Surgery-Related Contact Dermatitis: A Review of Potential Irritants and Allergens. THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE 2017; 5:1234-1240. [PMID: 28396114 DOI: 10.1016/j.jaip.2017.03.001] [Citation(s) in RCA: 16] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Subscribe] [Scholar Register] [Received: 11/01/2016] [Revised: 02/06/2017] [Accepted: 03/01/2017] [Indexed: 11/29/2022]
Abstract
Surgical procedures utilize an increasing number of medical products including antiseptics, anesthetics, gloves, suture materials, tissue adhesives, topical antibiotics, and bandages. Many of these products have irritant potential. Allergic contact dermatitis has also been reported. This review covers preoperative, operative, and postoperative exposures that may result in contact dermatitis. Testing with standard patch panels such as T.R.U.E. Test and the North American Contact Dermatitis Group 65 allergen series does not evaluate for all relevant contactants. A thorough understanding of potential exposures is vital to effectively evaluate a patient with surgery-related contact dermatitis. A systematic approach is needed to ensure that standard patch panels and supplementary patches adequately address each encountered contactant.
Collapse
Affiliation(s)
- Kevin A Cook
- Division of Allergy, Asthma and Immunology, Scripps Clinic, San Diego, Calif.
| | - John M Kelso
- Division of Allergy, Asthma and Immunology, Scripps Clinic, San Diego, Calif
| |
Collapse
|
|
24
|
|
|
25
|
Lefèvre S, Valois A, Truchetet F. Utility of scratch tests for allergic contact dermatitis caused by Dermabond®. Contact Dermatitis 2017; 76:193-194. [DOI: 10.1111/cod.12727] [Citation(s) in RCA: 12] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/12/2016] [Revised: 10/14/2016] [Accepted: 10/16/2016] [Indexed: 12/01/2022]
Affiliation(s)
- Sébastien Lefèvre
- Department of Allergy, Unit of Allergy; Mercy Hospital; 57050 Metz France
- Laboratory of medical Hydrology and Climatology, EA 7299, Faculty of Medicine; Lorraine University; 54000 Nancy France
| | - Aude Valois
- Department of Dermatology, Military Health Service; Legouest Hospital; 57050 Metz France
| | | |
Collapse
|
|
26
|
Lefèvre S, Valois A, Truchetet F. Allergic contact dermatitis caused by Dermabond®. Contact Dermatitis 2016; 75:240-1. [DOI: 10.1111/cod.12597] [Citation(s) in RCA: 28] [Impact Index Per Article: 3.1] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/04/2016] [Revised: 03/13/2016] [Accepted: 03/13/2016] [Indexed: 11/29/2022]
Affiliation(s)
- Sébastien Lefèvre
- Allergy Department; Metz-Thionville Hospital; 57085 Metz France
- University of Lorraine; Faculty of Medicine; EA 7299 54500 Vandaeuvre-lès-Nancy France
| | - Aude Valois
- Department of Dermatology; Military Health Service, Legouest Hospital; 57070 Metz France
| | | |
Collapse
|
|
27
|
Hagen SL, Grey KR, Hylwa SA. Allergic contact dermatitis to Dermabond™: A case and review of the literature. ACTA ACUST UNITED AC 2016. [DOI: 10.1016/j.wndm.2016.07.003] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/27/2022]
|
|
28
|
Severe Allergic Contact Dermatitis to Dermabond Prineo, a Topical Skin Adhesive of 2-Octyl Cyanoacrylate Increasingly Used in Surgeries to Close Wounds. Dermatitis 2016; 27:75-6. [DOI: 10.1097/der.0000000000000163] [Citation(s) in RCA: 33] [Impact Index Per Article: 3.7] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/05/2023]
|
|
29
|
Rash with DERMABOND PRINEO Skin Closure System Use in Bilateral Reduction Mammoplasty: A Case Series. Case Rep Med 2015; 2015:642595. [PMID: 25922607 PMCID: PMC4397495 DOI: 10.1155/2015/642595] [Citation(s) in RCA: 28] [Impact Index Per Article: 2.8] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/02/2015] [Accepted: 03/25/2015] [Indexed: 12/03/2022] Open
Abstract
Background. Bilateral reduction mammoplasty is a common plastic surgery procedure that can be complicated by unfavorable scar formation along incision sites. Surgical adhesives can be utilized as an alternative or as an adjunct to conventional suture closures to help achieve good wound tension and provide an adequate barrier with excellent cosmesis. The recently introduced DERMABOND PRINEO Skin Closure System Skin Closure System combines the skin adhesive 2-octyl cyanoacrylate with a self-adhering polyester-based mesh. Proposed benefits of wound closure with DERMABOND PRINEO Skin Closure System, used with or without sutures, include its watertight seal, easy removal, microbial barrier, even distribution of tension, and reduction in wound closure time. Although allergic reactions to 2-octyl cyanoacrylate have been reported, few allergic reactions to DERMABOND PRINEO Skin Closure System have been noted in the literature. This case series describes three patients who experienced an allergic reaction to DERMABOND PRINEO Skin Closure System after undergoing elective bilateral reduction mammoplasties at our institution to further explore this topic. Methods. Retrospective chart review of bilateral reduction mammoplasty patients who received DERMABOND PRINEO Skin Closure System dressing at our institution was performed. Results. Three patients were identified as having a rash in reaction to DERMABOND PRINEO Skin Closure System after bilateral reduction mammoplasty. All three patients required systemic steroid treatment to resolve the rash. One patient was identified as having a prior adhesive reaction. Conclusions. DERMABOND PRINEO Skin Closure System has demonstrated its efficacy in optimizing scar healing and appearance. However, as we demonstrate these three allergic reactions to DERMABOND PRINEO Skin Closure System, caution must be utilized in its usage, namely, in patients with a prior adhesive allergy and in sites where moisture or friction may be apparent.
Collapse
|
|
30
|
McDonald BS, Buckley DA. Severe dermatitis from Dermabond ® surgical glue. Br J Dermatol 2014; 170:739-41. [PMID: 24125099 DOI: 10.1111/bjd.12684] [Citation(s) in RCA: 24] [Impact Index Per Article: 2.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/31/2023]
Affiliation(s)
- B S McDonald
- Department of Dermatology, Royal United Hospital, Combe Park, Bath BA1 3NG, U.K.
| | | |
Collapse
|
|
31
|
[Serious adverse events after microbial sealant application in paediatric patients]. ANNALES PHARMACEUTIQUES FRANÇAISES 2014; 72:409-14. [PMID: 25438651 DOI: 10.1016/j.pharma.2014.04.007] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/27/2014] [Accepted: 04/23/2014] [Indexed: 11/23/2022]
Abstract
BACKGROUND Integuseal(®) is a cyanoacrylate-based medical device (IIa class), used in surgery after skin preparation to reduce bacterial contamination. It is not officially contraindicated for children. OBJECTIVES To describe a case series of skin lesions in pediatric patients after using Integuseal(®) in cardiac surgery. METHODS Case series. RESULTS Between September 2012 and February 2013, 153 pediatric patients were treated by Integuseal(®) to prepare for a cardiac surgery in our center: 5 patients (2%) had serious cutaneous reactions. The average age of patients having had lesions is 16months (the youngest patient being 1month old and the oldest being 5years and 8months old). ISSUES The risk factor in the development of skin lesion seems to be particularly related to the patient's age and sternal location. Other medical literature reports instances of cyanoacrylate intolerance in a variety of other situations. CONCLUSION Using Integuseal(®) on children does not appear to be safe.
Collapse
|
|
32
|
Abstract
AbstractWound closure with 2-octyl cyanoacrylate (Dermabond; Ethicon, Somerville, New Jersey USA) has recently increased in popularity across a wide spectrum of physicians ranging from surgeons to emergency medicine practitioners. Generally, very few complications are associated with Dermabond and are usually related to application techniques. Uncommonly, patients present with allergic reactions to the adhesive compounds; these allergies are often misdiagnosed as cellulitis or another infectious process, and are incorrectly treated. This report describes a rare case of a diffuse cutaneous allergic reaction to Dermabond following its use to close a surgical incision, its prompt identification, and treatment after presentation to an emergency department.RicciJA, ParekhNN, DesaiNS. Diffuse cutaneous allergic reaction to Dermabond. Prehosp Disaster Med. 2014;29(5):1-3.
Collapse
|
|
33
|
Woo KY, Chakravarthy D. A laboratory comparison between two liquid skin barrier products. Int Wound J 2014; 11:561-6. [PMID: 25040947 DOI: 10.1111/iwj.12325] [Citation(s) in RCA: 8] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/15/2014] [Revised: 05/27/2014] [Accepted: 06/05/2014] [Indexed: 11/29/2022] Open
Abstract
Exposure of skin to friction and moisture is detrimental to skin health. The purpose of this experimental study was to investigate the ability of a cyanoacrylate polymer film to protect human skin against moisture and abrasion. A secondary purpose of this study was to compare this cyanoacrylate material to a traditional barrier film. Twelve healthy subjects participated in the wash-off resistance test to determine the percentage of dye that was left on the skin after repeated washing. Ten subjects participated in the abrasion test. Transepidermal water loss (TEWL) was measured before and after abrasion to determine the level of skin damage, as high water loss seen post-abrasion is indicative of skin damage post-abrasion. Skin treated with cyanoacrylate had significantly more dye remaining than sites treated with traditional film barrier or control sites. The change in TEWL was statistically lower for cyanoacrylate-treated areas.
Collapse
Affiliation(s)
- Kevin Y Woo
- School of Nursing, Queen's University, Kingston, Ontario, Canada
| | | |
Collapse
|
|
34
|
Allergic Contact Dermatitis to Dermabond (2-Octyl Cyanoacrylate) After Total Knee Arthroplasty. Dermatitis 2014; 25:99-100. [DOI: 10.1097/der.0000000000000018] [Citation(s) in RCA: 27] [Impact Index Per Article: 2.5] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/15/2023]
|
|
35
|
Sachse MM, Junghans T, Rose C, Wagner G. Allergic contact dermatitis caused by topical 2-octyl-cyanoacrylate. Contact Dermatitis 2013; 68:317-9. [DOI: 10.1111/cod.12027] [Citation(s) in RCA: 18] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/28/2022]
|
|
36
|
Pope JFA, Knowles T. The efficacy of n-butyl-cyanoacrylate tissue adhesive for closure of canine laparoscopic ovariectomy port site incisions. J Small Anim Pract 2013; 54:190-4. [DOI: 10.1111/jsap.12047] [Citation(s) in RCA: 8] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/29/2022]
Affiliation(s)
- J. F. A. Pope
- Highcroft Veterinary Group; Whitchurch Bristol BS14 9BE
| | - T. Knowles
- Highcroft Veterinary Group; Whitchurch Bristol BS14 9BE
| |
Collapse
|
|
37
|
|
|
38
|
Potential contamination of the surgical site caused by leakage from an interscalene catheter with the patient in a seated position: a case report. Can J Anaesth 2012; 59:1125-9. [PMID: 23055036 DOI: 10.1007/s12630-012-9798-1] [Citation(s) in RCA: 8] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/05/2012] [Accepted: 09/18/2012] [Indexed: 10/27/2022] Open
Abstract
PURPOSE Continuous catheterized nerve blockade has been used for many years to provide effective analgesia postoperatively. We report a potential complication of interscalene nerve block performed with the traditional catheter-through-needle insertion technique. Specifically, leakage from the catheter insertion site posed a risk of contamination to the sterile surgical field. We also describe an alternative catheter design to overcome this leakage problem. CLINICAL FEATURES We present a case of leakage from the catheter insertion site during the course of an interscalene nerve block with the patient in a beach chair position for shoulder arthroplasty. Using the traditional catheter-through-needle technique, an 18G 100-mm Tuohy needle was inserted between the C6 and C7 roots under ultrasound guidance. After confirming the needle tip position, 20 mL of local anesthetic (1% ropivacaine and 0.25% bupivacaine 1:1) were injected. A 20G catheter was then threaded through the Tuohy needle and carefully secured with tape and dressing. In the operating room, leakage from the catheter insertion site started to disturb the adhesives of the surgical drapes and threatened the sterility of the surgical field. The catheter was removed prior to surgery upon the surgeon's request. Upon completion of the operation, a catheter was reinserted using an alternative catheter-over-needle method. Postoperatively, no leakage was seen at or around the catheter entry site. CONCLUSION This case report serves as a reminder that leakage from the catheter entry site remains a troublesome and hazardous issue during continuous peripheral nerve block. Leakage from the catheter insertion site often occurs due to the loose fit of the catheter in the larger diameter hole left by the Tuohy needle. We have also shown the successful use of an alternative catheter-over-needle design to minimize the risk of leakage from the catheter entry site. This technique resulted in being particularly vital for shoulder surgery with the patient in the beach chair position.
Collapse
|
|
39
|
Huemer GM, Schmidt M, Helml GH, Shafighi M, Dunst-Huemer KM. Effective wound closure with a new two-component wound closure device (Prineo™) in excisional body-contouring surgery: experience in over 200 procedures. Aesthetic Plast Surg 2012; 36:382-6. [PMID: 21964746 DOI: 10.1007/s00266-011-9819-4] [Citation(s) in RCA: 23] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/28/2011] [Accepted: 09/03/2011] [Indexed: 12/27/2022]
Abstract
BACKGROUND In excisional body-contouring surgery the surgeon is often confronted with time-consuming closure of long wounds. Recently, a new combination of a self-adhering mesh together with a liquid 2-octyl cyanoacrylate adhesive (Prineo™; Ethicon, Inc., Somerville, NJ, USA) has been introduced to replace intracutaneous running suture. METHODS An observational study was undertaken to evaluate the efficacy of the new wound closure device in excisional body-contouring procedures between January 2008 and November 2010. Wound characteristics were recorded in a prospectively maintained database. RESULTS During the study period, 224 procedures in 180 patients were undertaken. Twenty-seven patients had two subsequent operations and four patients had three subsequent operations. Application of the new device was easy and safe and patient satisfaction with the results was generally high. However, intense local allergic reactions were seen in 4 patients (1.8%), which necessitated early removal and topical corticosteroid treatment. CONCLUSIONS Prineo™ enables the surgeon to perform a quick and smooth skin closure, especially in long incisions frequently encountered in excisional body-contouring surgery. The application is fast and easy if basic guidelines are respected. Operating time is saved by eliminating the need for time-consuming intracutaneous running sutures. Removal is easy and painless for the patient. However, there is a potential for local allergic adverse effects of which the surgeon must be aware.
Collapse
|
|
40
|
|
|
41
|
Jagannathan N, Hallman M. Complications associated with 2-octyl cyanoacrylate (Dermabond): considerations for the anesthesiologist. J Clin Anesth 2010; 22:71-2. [PMID: 20206857 DOI: 10.1016/j.jclinane.2009.03.012] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/13/2008] [Revised: 03/23/2009] [Accepted: 03/25/2009] [Indexed: 11/19/2022]
|
|
42
|
Dunst KM, Auboeck J, Zahel B, Raffier B, Huemer GM. Extensive allergic reaction to a new wound closure device (Prineo). Allergy 2010; 65:798-9. [PMID: 19909297 DOI: 10.1111/j.1398-9995.2009.02243.x] [Citation(s) in RCA: 21] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/05/2023]
Affiliation(s)
- K M Dunst
- Department of Dermatology, General Hospital Linz, Krankenhausstrasse 9, Linz, Austria.
| | | | | | | | | |
Collapse
|
|
43
|
|
|
44
|
El-Dars LD, Chaudhury W, Hughes TM, Stone NM. Allergic contact dermatitis to Dermabond® after orthopaedic joint replacement. Contact Dermatitis 2010; 62:315-7. [DOI: 10.1111/j.1600-0536.2010.01720.x] [Citation(s) in RCA: 39] [Impact Index Per Article: 2.6] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/18/2022]
|
|
45
|
Studer M, Pouget-Jasson C, Waton J, Schmutz JL, Barbaud A. Comment tester l’allergie de contact à la colle tissulaire au 2-octylcyanoacrylate (Dermabond®) ? REVUE FRANCAISE D ALLERGOLOGIE 2010. [DOI: 10.1016/j.reval.2009.09.005] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 11/25/2022]
|
|
46
|
Gonzalo-Garijo MA, Pérez-Calderón R, Pérez-Rangel I, Sánchez-Vega S, Constantino JA, Zambonino MA, Arroyo J. Contact dermatitis after orthopaedic surgery. Contact Dermatitis 2009; 61:299-300. [DOI: 10.1111/j.1600-0536.2009.01632.x] [Citation(s) in RCA: 22] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/29/2022]
|