Copyright
©The Author(s) 2018.
World J Clin Oncol. Apr 10, 2018; 9(2): 33-41
Published online Apr 10, 2018. doi: 10.5306/wjco.v9.i2.33
Published online Apr 10, 2018. doi: 10.5306/wjco.v9.i2.33
Cases | sTIL ≥ 50% | P value | pCR | P value | Overall Survival at 5 yr(OS = 50.1%) | P value | Progression free survival at 5 yr(DFS = 57.8%) | P value | |
435 | 181 | 48 | |||||||
Age (yr), median (range) | 49 (24-84) | 49 (24-84) | 0.923 | 47 (28-80) | 0.472 | 0.512 | 0.833 | ||
< 50 | 231 (53.1) | 96 (35.2) | 28 (12.1) | 48.8% | 59.7% | ||||
≥ 50 | 204 (46.9) | 85 (36.7) | 20 (9.8) | 51.7% | 55.9% | ||||
Histological subtypes | 0.928 | 0.234 | 0.512 | 0.497 | |||||
Ductal | 406 (93.3) | 169 (43.6) | 43 (10.6) | 49.0% | 57.5% | ||||
Lobular | 21 (4.8) | 7 (36.8) | 2 (9.5) | 61.0% | 55.2% | ||||
Others | 8 (1.8) | 5 (62.5) | 3 (37.5) | - | - | ||||
Histological grade | < 0.001 | 0.170 | 0.001 | 0.006 | |||||
G1-G2 | 200 (46.0) | 59 (32.6) | 17 (8.5) | 57.1% | 64.6% | ||||
G3 | 227 (52.2) | 119 (65.7) | 29 (12.8) | 42.8% | 52.2% | ||||
NR | 8 (1.8) | 3 (1.7) | 2 (25) | 83.3% | 45.7% | ||||
ER | < 0.001 | 0.098 | < 0.001 | 0.000 | |||||
No | 162 (37.2) | 89 (57.8) | 23 (14.2) | 36.1% | 47.1% | ||||
Yes | 273 (62.8) | 92 (35.2) | 25 (9.2) | 58.2% | 64.3% | ||||
PgR | 0.003 | 0.246 | < 0.001 | 0.000 | |||||
No | 213 (49) | 104 (51.0) | 27 (12.7) | 41.0% | 50.0% | ||||
Yes | 222 (51) | 77 (36.5) | 21 (9.5) | 58.4% | 64.8% | ||||
HER2 | 0.002 | 0.135 | 0.334 | 0.135 | |||||
No | 294 (67.6) | 106 (38.3) | 28 (9.5) | 53.7% | 60.4% | ||||
Yes | 141 (32.4) | 75 (54.3) | 20 (14.2) | 40.8% | 52.3% | ||||
Molecular subtypes | < 0.001 | 0.233 | < 0.001 | < 0.001 | |||||
Luminal A | 107 (24.6) | 30 (29.7) | 13 (12) | 72.0% | 76.1% | ||||
Luminal B | 165 (37.9) | 61 (38.4) | 12 (7) | 50.6% | 57.7% | ||||
HER2-enriched | 77 (17.7) | 50 (66.7) | 10 (13) | 41.5% | 54.9% | ||||
Triple-Negative | 86 (19.8) | 40 (50.0) | 13 (15) | 32.5% | 40.3% | ||||
Tumor size (cm) | 0.183 | 0.019 | 0.490 | 0.250 | |||||
Median (range) | 6.5 (1-24) | 6.5 (1-16) | 6.0 (2-15) | ||||||
cT | |||||||||
cT1-cT2 | 36 (8.3) | 19 (54.3) | 8 (22.2) | 55.0% | 69.2% | ||||
cT3-cT4 | 399 (91.7) | 162 (42.6) | 40 (10) | 49.6% | 56.8% | ||||
cN | 0.084 | 0.743 | 0.007 | 0.001 | |||||
cN0 | 83 (19.1) | 28 (35.0) | 10 (12) | 65.8% | 77.0% | ||||
cN1-cN2-cN3 | 352 (80.9) | 153 (45.7) | 38 (10.8) | 47.2% | 54.2% | ||||
Clinical stage | 0.192 | 0.088 | 0.155 | 0.004 | |||||
II | 72 (16.6) | 26 (36.6) | 12 (16.7) | 62.1% | 74.3% | ||||
III | 363 (83.4) | 155 (45.1) | 36 (9.9) | 48.1% | 55.4% | ||||
sTIL% | 0.002 | 0.598 | 0.747 | ||||||
Median (range) | 40 (2-95) | 70 (60-95) | 65 (5-95) | ||||||
< 50% | 266 (61.1) | 0 (0) | 20 (7.5) | 49.6% | 55.7% | ||||
≥ 50% | 149 (34.3) | 181 (100) | 26 (17.4) | 53.9% | 63.1% | ||||
Missing data | 20 (4.6) | 20 (0) | 2 (10) | - | - | ||||
TLCS (d) | 0.411 | 0.633 | 0.317 | 0.156 | |||||
Median (range) | 63 (5-982) | 58 (8-982) | 65 (8-281) | ||||||
Shorter than median | 207 (47.6) | 91 (45.5) | 22 (10.6) | 48.5% | 55.0% | ||||
Longer than median | 211 (48.5) | 82 (41.4) | 26 (12.3) | 56.7% | 61.2% | ||||
Missing data | 17 (3.9) | 8 (47.1) | 0 (0) | 17.6% | 46.3% | ||||
pCR | 0.029 | 0.002 | 0.002 | ||||||
No | 387 (89) | 154 (41.7) | 0 (0) | 47.4% | 55.1% | ||||
Yes | 48 (11) | 27 (58.7) | 48 (100) | 85.1% | 84.9% | ||||
Relapse | 0.895 | < 0.001 | < 0.001 | ||||||
No | 284 (65.3) | 118 (43.4) | 42 (14.8) | 81.6% | - | ||||
Yes | 151 (34.7) | 63 (44.1) | 6 (4) | 8.58% | - |
Lum A | Lum B | HER2 | TN | |||||||||
Total | pCR | P value | Total | pCR | P value | Total | pCR | P value | Total | pCR | P value | |
107 | 13 | 165 | 12 | 77 | 10 | 86 | 13 | |||||
Age (yr) | 1.000 | 0.315 | 0.507 | 0.157 | ||||||||
median (range) | 47 (28-75) | 46 (28-62) | 51 (25-84) | 52 (39-69) | 51 (28-80) | 46 (29-80) | 49 (26-73) | 45 (28-68) | ||||
< 50 | 72 (67) | 9 (13) | 78 (48) | 4 (5) | 37 (48) | 6 (16.2) | 44 (48) | 9 (20) | ||||
≥ 50 | 35 (33) | 4 (11) | 87 (52) | 8 (9) | 40 (52) | 4 (10) | 42 (52) | 4 (10) | ||||
Histological subtypes | 0.349 | 1.000 | 0.434 | 0.392 | ||||||||
Ductal | 97 (91) | 11 (11) | 153 (93) | 11 (7) | 73 (95) | 9 (12.3) | 83 (97) | 12 (14) | ||||
Lobular and others | 10 (9) | 2 (20) | 12 (7) | 1 (8) | 4 (5) | 1 (25) | 3 (3) | 1 (33) | ||||
Histological grade | - | 0.213 | 0.266 | 1.000 | ||||||||
G1-G2 | 103 (97) | 12 (12) | 61 (39) | 2 (3) | 23 (30) | 1 (4.3) | 13 (15) | 2 (15) | ||||
G3 | - | - | 102 (61) | 10 (10) | 53 (69) | 9 (17) | 72 (85) | 10 (14) | ||||
NR | 4 (3) | 1 (25) | 2 (1) | 0 (0) | 1 (1) | 0 (0) | 1 (0) | 1 (100) | ||||
Tumor size (cm) | 0.102 | 0.213 | 0.511 | 0.620 | ||||||||
Median (range) | 6 (2-15) | 5 (2-9) | 7 (2-20) | 6 (2-12) | 7 (2.5-14) | 6 (4-12) | 7 (1-24) | 8 (3-15) | ||||
cT1-cT2 | 10 (7) | 3 (30) | 12 (7) | 2 (17) | 5 (6) | 1 (20) | 9 (10) | 2 (22) | ||||
cT3-cT4 | 97 (93) | 10 (10) | 153 (93) | 10 (7) | 72 (94) | 9 (12.5) | 77 (90) | 11 (14) | ||||
cN | 0.306 | 0.222 | 0.270 | 0.021 | ||||||||
cN0 | 27 (23) | 5 (19) | 28 (18) | 0 (0) | 53 (69) | 5 (9.4) | 14 (14) | 4 (29) | ||||
cN1-cN2–cN3 | 80 (77) | 8 (10) | 137 (82) | 12 (9) | 24 (31) | 5 (20.8) | 72 (86) | 9 (13) | ||||
Clinical stage | 0.471 | 0.652 | 1.000 | 0.122 | ||||||||
EC II | 23 (20) | 4 (17) | 21 (12) | 2 (10) | 11 (14) | 1 (9.1) | 17 (16) | 5 (29) | ||||
EC III | 84 (80) | 9 (11) | 144 (88) | 10 (7) | 66 (86) | 9 (13.6) | 69 (84) | 8 (12) | ||||
sTIL% | 0.054 | 0.750 | 0.150 | 1.000 | ||||||||
Median (range) | 30 (2-90) | 50 (10-90) | 40 (5-90) | 30 (8-90) | 60 (5-95) | 80 (30-95) | 45 (2-90) | 50 (5-80) | ||||
< 50 | 71 (69) | 6 (8) | 98 (60) | 6 (6) | 25 (32) | 1 (4) | 40 (47) | 6 (15) | ||||
≥ 50 | 30 (24) | 7 (23) | 61 (37) | 5 (8) | 50 (66) | 9 (18) | 40 (47) | 6 (15) | ||||
Missing data | 6 (6) | 0 (0) | 6 (3) | 1 (17) | 2 (3) | 0 (0) | 6 (7) | 1 (17) | ||||
TLCS (d) | 0.233 | 0.238 | 0.744 | 0.500 | ||||||||
Median (range) | 67 (14-458) | 80 (16-281) | 61 (5-412) | 54 (8-140) | 60 (11-240) | 66 (37-106) | 64 (8-982) | 66 (14-122) | ||||
Shorter than median | 49 (48) | 4 (8) | 77 (45) | 8 (10) | 41 (53) | 5 (12.2) | 40 (48) | 5 (13) | ||||
Longer than median | 57 (51) | 9 (16) | 76 (47) | 4 (5) | 33 (43) | 5 (15.2) | 45 (51) | 8 (18) | ||||
Missing data | 1 (1) | 0 (0) | 12 (8) | 0 (0) | 3 (4) | 0 (0) | 1 (1) | 0 (0) | ||||
Relapse | 0.121 | 0.753 | 0.300 | < 0.001 | ||||||||
No | 87 (79) | 13 (15) | 109 (65) | 9 (8) | 46 (60) | 8 (17.4) | 42 (41) | 12 (29) | ||||
Yes | 20 (21) | 0 (0) | 56 (35) | 3 (5) | 31 (40) | 2 (6.5) | 44 (59) | 1 (2) |
Lum A | Lum B | HER2 | TN | |||||||||
< 50% | ≥ 50% | P value | < 50% | ≥ 50% | P value | < 50% | ≥ 50% | P value | < 50% | ≥ 50% | P value | |
71 | 30 | 98 | 61 | 25 | 50 | 40 | 40 | |||||
Age (yr) | 0.181 | 0.783 | 0.624 | 0.074 | ||||||||
Median (range) | 47 (28-75) | 47 (36-74) | 52 (28-73) | 50 (25-84) | 52 (28-66) | 49 (29-80) | 51 (26-73) | 45 (27-73) | ||||
< 50 | 50 (70) | 17 (57) | 46 (47) | 30 (49) | 11 (44) | 25 (50) | 16 (40) | 24 (60) | ||||
≥ 50 | 21 (30) | 13 (43) | 52 (53) | 31 (51) | 14 (56) | 25 (50) | 24 (60) | 16 (40) | ||||
Histological subtypes | 0.445 | 1.000 | 0.597 | 1.000 | ||||||||
Ductal | 66 (93) | 26 (87) | 91 (93) | 57 (93) | 23 (92) | 48 (96) | 39 (98) | 38 (95) | ||||
Lobular and others | 5 (7) | 4 (13) | 7 (7) | 4 (7) | 2 (8) | 2 (4) | 1 (3) | 2 (5) | ||||
Histological grade | - | 0.011 | 0.514 | 0.006 | ||||||||
G1-G2 | 69 (97) | 28 (93) | 43 (44) | 15 (25) | 9 (36) | 14 (28) | 11 (28) | 2 (5) | ||||
G3 | 0 (0) | 0 (0) | 53 (54) | 46 (75) | 16 (64) | 35 (71) | 29 (73) | 38 (95) | ||||
NR | 2 (3) | 2 (7) | 2 (2) | 0 (0) | 0 (0) | 1 (2) | 0 (0) | 0 (0) | ||||
Tumor size (cm) | ||||||||||||
Median (range) | 6 (3-13) | 6 (2-15) | 6 (3-20) | 7 (2-15) | 7 (3-14) | 7 (3-14) | 7 (4-24) | 7 (1-16) | ||||
cT | 1.000 | 0.538 | 0.659 | 0.263 | ||||||||
cT1-cT2 | 7 (10) | 3 (10) | 6 (6) | 6 (10) | 1 (4) | 4 (8) | 2 (5) | 6 (15) | ||||
cT3-cT4 | 64 (90) | 27 (90) | 92 (94) | 55 (90) | 24 (96) | 46 (92) | 38 (95) | 34 (85) | ||||
cN | 0.890 | 0.020 | 0.631 | 0.762 | ||||||||
cN0 | 18 (25) | 8 (27) | 22 (22) | 5 (8) | 6 (24) | 8 (16) | 6 (15) | 7 (18) | ||||
cN1-cN2-cN3 | 53 (75) | 22 (73) | 76 (78) | 56 (92) | 11 (44) | 27 (54) | 34 (85) | 33 (83) | ||||
Clinical Stage | 0.666 | 0.141 | 0.742 | 0.576 | ||||||||
EC II | 17 (24) | 6 (20) | 16 (16) | 5 (8) | 3 (12) | 8 (16) | 9 (23) | 7 (18) | ||||
EC III | 54 (76) | 24 (80) | 82 (84) | 56 (92) | 22 (88) | 42 (84) | 31 (78) | 33 (83) | ||||
TLCS (d) | 0.631 | 0.882 | 0.502 | 0.141 | ||||||||
Median (range) | 64 (14-449) | 70 (19-458) | 61 (5-412) | 58 (8-285) | 68 (16-234) | 56 (11-240) | 74 (24-230) | 51 (14-982) | ||||
Shorter than median | 34 (48) | 13 (43) | 48 (49) | 28 (46) | 12 (48) | 28 (56) | 15 (38) | 22 (55) | ||||
Longer than median | 36 (51) | 17 (57) | 44 (45) | 27 (44) | 12 (48) | 20 (40) | 24 (60) | 18 (45) | ||||
Missing data | 1 (1) | 0 (0) | 6 (6) | 6 (10) | 1 (4) | 2 (4) | 1 (3) | 0 (0) | ||||
pCR | 0.054 | 0.750 | 0.150 | 1.000 | ||||||||
No | 65 (92) | 23 (77) | 92 (94) | 56 (92) | 24 (96) | 41 (82) | 34 (85) | 34 (85) | ||||
Yes | 6 (8) | 7 (23) | 6 (6) | 5 (8) | 1 (4) | 9 (18) | 6 (15) | 6 (15) | ||||
Relapse | 0.450 | 0.201 | 0.737 | 0.502 | ||||||||
No | 59 (83) | 23 (77) | 61 (62) | 44 (72) | 16 (64) | 30 (60) | 18 (45) | 21 (53) | ||||
Yes | 12 (17) | 7 (23) | 37 (38) | 17 (28) | 9 (36) | 20 (40) | 22 (55) | 19 (48) |
- Citation: Galvez M, Castaneda CA, Sanchez J, Castillo M, Rebaza LP, Calderon G, Cruz MDL, Cotrina JM, Abugattas J, Dunstan J, Guerra H, Mejia O, Gomez HL. Clinicopathological predictors of long-term benefit in breast cancer treated with neoadjuvant chemotherapy. World J Clin Oncol 2018; 9(2): 33-41
- URL: https://www.wjgnet.com/2218-4333/full/v9/i2/33.htm
- DOI: https://dx.doi.org/10.5306/wjco.v9.i2.33