Genomic era diagnosis and management of hereditary and sporadic colon cancer

doi:10.5306/wjco.v5.i5.1036

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Dec 10, 2014 (publication date) through Nov 22, 2024

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Dec 10, 2014; 5(5): 1036-1047
Published online Dec 10, 2014. doi: 10.5306/wjco.v5.i5.1036

Table 1 Evolving genomic tools for management of colon cancer

	Detection	Diagnosis	Management
Clinically available	Fecal occult blood test	Single gene sequencing (APC) Multigene panel next generation sequencing	Targeted gene analysis for therapeutic contraindications (KRAS, UGT1A1)
Research basis	Fecal genomic DNA analysis	Tumor genome sequencing for prognosis
Future application	Cell free genomic DNA sequencing		Development of gene pathway directed therapeutics (e.g., small molecule inhibitors)

APC: Adenomatous polyposis coli; KRAS: Kirsten rat sarcoma viral oncogene homolog; UGT1A1: Uridine diphosphate-glucuronosyl transferase 1A1.

Citation: Esplin ED, Snyder MP. Genomic era diagnosis and management of hereditary and sporadic colon cancer. World J Clin Oncol 2014; 5(5): 1036-1047
URL: https://www.wjgnet.com/2218-4333/full/v5/i5/1036.htm
DOI: https://dx.doi.org/10.5306/wjco.v5.i5.1036