Regulation of the mRNA half-life in breast cancer

doi:10.5306/wjco.v5.i3.323

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Aug 10, 2014; 5(3): 323-334
Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.323

Table 1 mRNA half-life modulators in breast cancer

mRNA half-life modulators	Main target	Prognostic factor	Ref.
RBPs
TTP	GM-CSF, cox2, VEGF, IL8, HIF1a, TNF-α	Yes	Griseri and Pagès
HuR	GM-CSF, cox2, VEGF, IL8, TGFB, TNF-α	Yes	Griseri and Pagès
microRNA
miR125a, miR125b	HER2, HER3, cRAF, HuR	Possible	[115-117]
miR206	ER	Unknown	[118,119]
miR200	Zfhx1b	Yes	[120,137,138]
miR506	cdh1	Unknown	[121]
miR34	Fra1	Unknown	[122]
miR31	Fzd3, ITGA5, MMP16, RDX, RhoA	Unknown	[123]
miR203	BIRC5, LASP1	Unknown	[124]
miR21	PDC4	Unknown	[125]
miR26b	PTGS2	Unknown	[126]
miR124	cd151	Unknown	[127]
miR29a	TTP	Unknown	[128]
miR3134	SOX9, VEGFA, EGFR	Unknown	[130]
miR125	HuR	Unknown	[115]
lncRNA
aHIF		Possible	[132,133]

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Citation: Griseri P, Pagès G. Regulation of the mRNA half-life in breast cancer. World J Clin Oncol 2014; 5(3): 323-334
URL: https://www.wjgnet.com/2218-4333/full/v5/i3/323.htm
DOI: https://dx.doi.org/10.5306/wjco.v5.i3.323