Large cell neuroendocrine carcinoma of the ovary: A pathologic entity in search of clinical identity

Table 1 Summary of basic characteristics of ovarian large cell neuroendocrine carcinoma

Pathologically distinct entity from epithelial ovarian cancers

Clinically similar presentation with common epithelial ovarian cancers

Often co-exists with non-neuroendocrine components

Several lines of data argue for a common origin of neuroendocrine and epithelial components (common co-existence, monoclonality analysis, neuroendocrine features arising in epithelial prostate cancer following treatment)

Treatment; suggested to be addressing the epithelial component except if neuroendocrine component is clearly dominant