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©2013 Baishideng Publishing Group Co.
World J Clin Oncol. Aug 10, 2013; 4(3): 58-69
Published online Aug 10, 2013. doi: 10.5306/wjco.v4.i3.58
Published online Aug 10, 2013. doi: 10.5306/wjco.v4.i3.58
Process | E3 ubiquitin ligase | Substrate | Ref. |
Cell proliferation | c-Cbl | EGFR | 61, 62 |
Nedd4 | PTEN | 65 | |
Siah2 | HIPK2 | 56, 128 | |
Cell cycle regulation | APC | OLC1 | 37, 68 |
Cul3-based ligase | Rho GTPase; Rho BTB2 | 96 | |
CCNB1IP1 | Cyclin B | 93 | |
Parkin | Parkin, CDCrel-1 | 86, 88 | |
SCF component: Fbxo7 | 79, 80 | ||
SCF component: Skp2 | CdK: p27, p21, p53 | 72, 73, 74 | |
Apoptosis | MDM2 | P53, pRb | 108, 117, 118, 161 |
Parkin | 90, 91 | ||
Pirh2 | P53 | 115, 162 | |
SCF component: SAG | c-Jun | 132, 134, 136, 137 | |
Siah2 | HIPK2 | 128, 129 | |
Topors | P53 | 123 | |
TRAF2 | RIP1 | 127, 163 | |
XIAP | XIAP, AIF | 104 | |
Gene regulation | Cul3-based ligase | IKBKb | 140 |
DNA repair | FANCL | FANCD2 | 143-145 |
- Citation: Snoek BC, Wilt LH, Jansen G, Peters GJ. Role of E3 ubiquitin ligases in lung cancer. World J Clin Oncol 2013; 4(3): 58-69
- URL: https://www.wjgnet.com/2218-4333/full/v4/i3/58.htm
- DOI: https://dx.doi.org/10.5306/wjco.v4.i3.58