Lymph node extramedullary hematopoiesis in breast cancer patients receiving neoadjuvant chemotherapy combined with immunotherapy: A case report

Table 1 Studies have described a total of 10 extramedullary hematopoiesis cases featuring megakaryocytes in breast axillary lymph nodes

Ref.	Neoadjuvant chemotherapy	Immunotherapy	Node procedure	pCR
Hoda et al[23], 2002	No therapy	No	Sentinel lymphadenectomy	No
Wang and Darvishian[24], 2006	Yes (cyclophosphamide and doxorubicin followed by paclitaxel)	No	EMH was seen in mastectomy specimens, not dissected lymph nodes	No
Millar et al[7], 2009	Yes (cyclophosphamide, doxorubicin followed by docetaxel with G-CSF)	No	Axillary node dissection	No
Prieto-Granada et al[16], 2013	Yes (chemotherapy regimen was not mentioned)	No	1 patient with sentinel lymph node; 1 patient with axillary node dissection; 1 patient with a core biopsy of an enlarged axillary lymph node	Yes
Takhar et al[18], 2013	Yes (chemotherapy regimen was not mentioned)	No	Sentinel lymphadenectomy/sentinel lymphadenectomy	Yes
Badr et al[25], 2019	Yes (docetaxel-FEC concurrent trastuzumab)	No	The sentinel lymph node	No

G-CSF: Granulocyte colony-stimulating factor; EMH: Extramedullary hematopoiesis; pCR: Pathological complete response.