Demographic trends in mortality due to ovarian cancer in the United States, 1999-2020

Table 1 Ovarian carcinoma-related deaths, stratified by race, in females in the United States, 1999 to 2020

Year	Overall	NH White	NH Black or African American	NH Asian or Pacific Islander	NH American Indian or Alaska Native	Hispanic or Latino	Population
1999	14726	12739	1154	230	35	516	94123092
2000	15170	13109	1153	236	34	608	94864102
2001	15480	13255	1229	257	69	640	95984408
2002	15767	13485	1256	285	51	657	96927703
2003	15696	13373	1256	285	65	686	97893297
2004	15713	13292	1322	289	60	729	98921524
2005	15791	13322	1290	336	54	779	100097839
2006	15922	13438	1266	329	69	801	101328442
2007	15673	13214	1243	336	55	814	102513830
2008	15429	12859	1265	379	69	837	103688156
2009	15444	12792	1320	361	78	881	104834186
2010	15581	12821	1345	400	76	906	105717426
2011	15371	12579	1390	399	71	908	107004480
2012	15424	12453	1427	410	78	1021	108088829
2013	15314	12469	1326	431	79	984	109172782
2014	15207	12177	1462	429	67	1041	110581619
2015	14937	11863	1411	466	103	1060	111947362
2016	15295	12125	1410	550	83	1080	112990913
2017	15325	12019	1489	523	90	1184	114358026
2018	14912	11624	1481	526	65	1188	115265998
2019	14600	11259	1508	543	60	1200	116084432
2020	14842	11423	1517	591	94	1197	116909132
Total	337619	277690	29520	8591	1505	19717	2319297578

NH: Non-Hispanic.

Table 2 Ovarian carcinoma-related mortality, stratified by place of death in females in the United States, 1999 to 2020

Year	Medical facility	Nursing home/long-term care facility	Hospices	Home
1999	5617	2315	Missing	5810
2000	5761	2486	Missing	5910
2001	5834	2500	Missing	6007
2002	5739	2515	Missing	6251
2003	5518	2511	125	6269
2004	5293	2461	187	6433
2005	5227	2421	548	6419
2006	5288	2481	737	6305
2007	4950	2463	977	6139
2008	4696	2354	1164	5943
2009	4519	2343	1148	5989
2010	4381	2193	1501	6411
2011	4234	2082	1703	6330
2012	4048	1966	1982	6362
2013	3850	1848	1920	6651
2014	3744	1848	2271	6556
2015	3674	1798	2423	6448
2016	3768	1635	2511	6755
2017	3753	1725	2444	6767
2018	3647	1493	2436	6684
2019	3598	1452	2305	6573
2020	3308	1130	1920	7784
Total	100447	46020	28302	140796

Table 3 Annual percent change of ovarian carcinoma-related age-adjusted mortality rates per 100000 in females in the United States, 1999 to 2020

Year interval	APC (95%CI)
Overall
1999-2003	0.41 (-0.48 to 1.79)
2003-2020	-2.28a (-2.39 to -2.16)
NH White
1999-2002	0.66 (-0.49 to 2.36)
2002-2006	-1.34a (-2.67 to -0.60)
2006-2020	-2.4034a (-3.30 to -1.95)
NH Black or African American
1999-2002	1.16 (-1.48 to 6.05)
2002-2020	-1.71a (-3.26 to -1.46)
NH American Indian or Alaska Native
1999-2020	-1.00 (-2.18 to 0.42)
Hispanic or Latino
1999-2005	0.30 (-1.10 to 5.47)
2005-2020	-1.72a (-2.77 to -1.41)
NH Asian or Pacific Islander
1999-2020	-0.85a (-1.16 to -0.46)
Young aged (25-44 years)
1999-2020	-1.83a (-2.20 to -1.46)
Middle aged (45-64 years)
1999-2020	-2.17a (-2.41 to -1.92)
Old aged (65 to > 85 years)
1999-2001	2.31 (-0.09 to 4.28)
2001-2007	-0.90a (-2.80 to -0.45)
2007-2020	-2.88a (-3.12 to -2.67)
Non-metropolitan areas
1999-2004	0.50 (-0.56 to 2.55)
2004-2020	-2.20a (-2.47 to -1.98)
Metropolitan areas
1999-2003	0.27 (-0.69 to 1.79)
2003-2020	-2.31a (-2.45 to -2.19)
Northeast region
1999-2002	1.15 (-0.84 to 4.52)
2002-2020	-2.39a (-2.60 to -2.22)
Midwest region
1999-2003	0.62 (-0.85 to 3.62)
2003-2020	-2.37a (-2.64 to -2.17)
South region
1999-2005	-0.37 (-1.02 to 0.81)
2005-2020	-2.29a (-2.50 to -2.11)
West region
1999-2004	0.12 (-0.51 to 1.09)
2004-2008	-3.18a (-4.24 to -2.32)
2008-2016	-1.64a (-1.93 to -0.29)
2016-2020	-3.58a (-5.02 to -2.76)

^aP value < 0.05, statistically significant annual percent change values.

APC: Annual percent change; CI: Confidence interval; NH: Non-Hispanic.

Table 4 Overall ovarian carcinoma-related age-adjusted mortality rates per 100000 in females in the United States, 1999 to 2020

Year	Overall AAMR (95%CI)
1999	14.62 (14.38-14.86)
2000	14.87 (14.64-15.11)
2001	14.95 (14.72-15.19)
2002	14.99 (14.75-15.22)
2003	14.7 (14.47-14.93)
2004	14.51 (14.28-14.74)
2005	14.3 (14.07-14.52)
2006	14.15 (13.93-14.38)
2007	13.67 (13.45-13.89)
2008	13.26 (13.05-13.47)
2009	13 (12.79-13.21)
2010	12.98 (12.78-13.19)
2011	12.51 (12.31-12.71)
2012	12.26 (12.06-12.46)
2013	11.94 (11.75-12.13)
2014	11.64 (11.46-11.83)
2015	11.19 (11.01-11.37)
2016	11.24 (11.06-11.42)
2017	10.99 (10.82-11.17)
2018	10.54 (10.37-10.72)
2019	10.09 (9.92-10.26)
2020	10.15 (9.98-10.31)
Total	12.63 (12.59-12.68)

AAMR: Age-adjusted mortality rate; CI: Confidence interval.

Table 5 Ovarian carcinoma-related age-adjusted mortality rates per 100000, stratified by age groups in females in the United States, 1999 to 2020

Year	AAMR (95%CI) in young aged (25-44 years)	AAMR (95%CI) in middle aged (45-64 years)	AAMR (95%CI) in old aged (65 to > 85 years)
1999	1.44 (1.321.55)	13.49 (13.09-13.9)	47.71 (46.76-48.65)
2000	1.43 (1.31-1.54)	13.35 (12.95-13.75)	49.27 (48.32-50.22)
2001	1.43 (1.31-1.54)	13.49 (13.09-13.88)	49.44 (48.48-50.39)
2002	1.43 (1.31-1.54)	13.55 (13.17-13.94)	49.5 (48.54-50.45)
2003	1.37 (1.26-1.49)	13.15 (12.77-13.53)	48.85 (47.91-49.79)
2004	1.43 (1.31-1.54)	12.54 (12.18-12.9)	48.85 (47.91-49.79)
2005	1.27 (1.16-1.38)	12.85 (12.5-13.21)	47.56 (46.63-48.48)
2006	1.22 (1.11-1.32)	12.44 (12.09-12.79)	47.69 (46.77-48.61)
2007	1.11 (1.01-1.21)	11.6 (11.27-11.93)	46.94 (46.04-47.85)
2008	1.26 (1.15-1.38)	11.11 (10.79-11.43)	45.35 (44.46-46.23)
2009	1.15 (1.05-1.26)	11.46 (11.14-11.78)	43.65 (42.79-44.51)
2010	1.21 (1.1-1.32)	10.99 (10.67-11.3)	44.28 (43.42-45.14)
2011	1.16 (1.06-1.27)	10.71 (10.41-11.02)	42.42 (41.58-43.25)
2012	1.11 (1-1.21)	10.63 (10.33-10.94)	41.43 (40.62-42.24)
2013	1.01 (0.91-1.11)	10.22 (9.92-10.52)	40.74 (39.95-41.54)
2014	1.16 (1.06-1.27)	9.9 (9.61-10.19)	39.44 (38.66-40.21)
2015	1.05 (0.95-1.16)	9.58 (9.29-9.86)	37.94 (37.19-38.69)
2016	1.15 (1.05-1.26)	9.66 (9.37-9.94)	37.83 (37.09-38.57)
2017	1 (0.9-1.1)	9.65 (9.37-9.94)	36.93 (36.21-37.65)
2018	1 (0.9-1.1)	9.5 (9.21-9.79)	34.9 (34.21-35.59)
2019	1 (0.9-1.1)	8.8 (8.53-9.07)	33.81 (33.14-34.48)
2020	1.05 (0.94-1.15)	9 (8.72-9.28)	33.64 (32.98-34.29)
Total	1.16 (1.14-1.19)	11.09 (11.02-11.16)	42.41 (42.23-42.59)

AAMR: Age-adjusted mortality rate; CI: Confidence interval.

Table 6 Ovarian carcinoma-related age-adjusted mortality rates per 100000 (95% confidence interval), stratified by race in females in the United States, 1999 to 2020

Year	AAMR (95%CI) in NH White	AAMR (95%CI) in NH Black or African American	AAMR (95%CI) in NH American Indian or Alaska Native	AAMR (95%CI) in Hispanic or Latino	AAMR (95%CI) in NH Asian or Pacific Islander
1999	15.47 (15.2-15.74)	12.45 (11.73-13.17)	8.43 (5.8-11.84)	9.26 (8.44-10.09)	8.16 (7.06-9.27)
2000	15.77 (15.5-16.04)	12.23 (11.52-12.93)	7.35 (5.03-10.38)	10.56 (9.69-11.42)	8.06 (6.99-9.13)
2001	15.79 (15.52-16.06)	12.71 (12-13.43)	13.6 (10.47-17.37)	10.14 (9.33-10.95)	8.2 (7.17-9.24)
2002	15.91 (15.63-16.18)	12.76 (12.06-13.47)	9.33 (6.85-12.41)	9.99 (9.2-10.77)	8.62 (7.59-9.66)
2003	15.61 (15.34-15.88)	12.46 (11.77-13.16)	12.44 (9.49-16.01)	10 (9.23-10.77)	8.2 (7.22-9.18)
2004	15.35 (15.08-15.61)	12.84 (12.14-13.53)	10.48 (7.9-13.64)	10.04 (9.29-10.8)	7.71 (6.8-8.62)
2005	15.21 (14.95-15.47)	12.24 (11.57-12.92)	8.87 (6.59-11.7)	10.11 (9.38-10.85)	8.56 (7.62-9.5)
2006	15.13 (14.88-15.39)	11.65 (11-12.3)	12.62 (9.7-16.15)	10.19 (9.47-10.92)	8.04 (7.15-8.93)
2007	14.68 (14.43-14.93)	11.18 (10.55-11.81)	9.81 (7.3-12.89)	9.56 (8.88-10.24)	7.86 (7-8.73)
2008	14.11 (13.86-14.35)	11.15 (10.53-11.77)	10.69 (8.21-13.67)	9.37 (8.71-10.02)	8.44 (7.57-9.31)
2009	13.85 (13.6-14.09)	11.27 (10.66-11.89)	11.61 (9.07-14.65)	9.43 (8.79-10.07)	7.51 (6.72-8.3)
2010	13.79 (13.55-14.04)	11.26 (10.65-11.87)	11 (8.56-13.92)	9.21 (8.59-9.83)	7.96 (7.17-8.76)
2011	13.34 (13.1-13.58)	11.31 (10.71-11.92)	9.99 (7.71-12.73)	8.82 (8.23-9.41)	7.47 (6.72-8.22)
2012	13.02 (12.78-13.25)	11.16 (10.57-11.75)	11.06 (8.65-13.92)	9.46 (8.86-10.06)	7.32 (6.6-8.05)
2013	12.84 (12.6-13.07)	10.13 (9.57-10.69)	10.42 (8.17-13.1)	8.69 (8.13-9.25)	7.44 (6.72-8.15)
2014	12.4 (12.17-12.63)	10.76 (10.2-11.33)	8.36 (6.41-10.72)	8.59 (8.05-9.12)	6.92 (6.25-7.58)
2015	11.92 (11.7-12.14)	10.06 (9.53-10.6)	12.16 (9.73-14.59)	8.43 (7.91-8.95)	7 (6.36-7.65)
2016	11.98 (11.76-12.2)	9.64 (9.13-10.16)	9.96 (7.87-12.43)	8.15 (7.65-8.65)	8.02 (7.34-8.7)
2017	11.69 (11.47-11.9)	10 (9.48-10.51)	9.74 (7.78-12.04)	8.54 (8.04-9.03)	7.16 (6.53-7.78)
2018	11.21 (10.99-11.42)	9.66 (9.16-10.16)	7 (5.36-9)	8.09 (7.62-8.56)	6.96 (6.36-7.56)
2019	10.68 (10.47-10.88)	9.49 (9-9.98)	6.38 (4.83-8.26)	8.01 (7.55-8.47)	6.95 (6.36-7.54)
2020	10.71 (10.51-10.92)	9.38 (8.9-9.86)	9.74 (7.82-11.98)	7.6 (7.16-8.04)	7.38 (6.78-7.98)
Total	13.53 (13.48-13.58)	11.02 (10.89-11.15)	9.85 (9.34-10.36)	8.94 (8.81-9.07)	7.56 (7.4-7.73)

AAMR: Age-adjusted mortality rate; CI: Confidence interval; NH: Non-Hispanic.

Table 7 Ovarian carcinoma-related age-adjusted mortality rates per 100000, stratified by urban-rural classification in females in the United States, 1999 to 2020

Year	AAMR (95%CI) in metropolitan	AAMR (95%CI) in nonmetropolitan
1999	14.73 (14.47-14.99)	14.25 (13.7-14.81)
2000	14.89 (14.62-15.15)	14.72 (14.16-15.28)
2001	15.07 (14.8-15.33)	14.5 (13.94-15.05)
2002	14.99 (14.73-15.24)	14.91 (14.35-15.47)
2003	14.75 (14.5-15.01)	14.36 (13.82-14.91)
2004	14.49 (14.24-14.74)	14.69 (14.14-15.24)
2005	14.32 (14.07-14.56)	14.2 (13.66-14.73)
2006	14.16 (13.91-14.4)	14.25 (13.72-14.79)
2007	13.63 (13.39-13.87)	14.1 (13.57-14.63)
2008	13.29 (13.06-13.53)	13.11 (12.6-13.61)
2009	12.94 (12.71-13.17)	13.34 (12.83-13.85)
2010	12.99 (12.76-13.21)	13.04 (12.54-13.54)
2011	12.47 (12.25-12.69)	12.84 (12.34-13.34)
2012	12.18 (11.97-12.4)	12.64 (12.15-13.13)
2013	11.83 (11.62-12.04)	12.49 (12-12.97)
2014	11.64 (11.44-11.85)	11.68 (11.21-12.14)
2015	11.1 (10.9-11.3)	11.62 (11.15-12.09)
2016	11.27 (11.07-11.47)	11.11 (10.65-11.57)
2017	10.96 (10.77-11.16)	11.25 (10.79-11.7)
2018	10.47 (10.28-10.66)	10.9 (10.46-11.35)
2019	10.11 (9.93-10.29)	10.13 (9.69-10.56)
2020	10.07 (9.89-10.25)	10.4 (9.96-10.83)
Total	12.61 (12.56-12.66)	12.84 (12.74-12.95)

AAMR: Age-adjusted mortality rate; CI: Confidence interval.

Table 8 Ovarian carcinoma-related age-adjusted mortality rates per 100000, stratified by census region in females in the United States, 1999 to 2020

Year	AAMR (95%CI) in Northeast	AAMR (95%CI) in Midwest	AAMR (95%CI) in South	AAMR (95%CI) in West
1999	15.31 (14.78-15.84)	14.94 (14.44-15.44)	13.94 (13.55-14.33)	14.89 (14.35-15.43)
2000	15.35 (14.82-15.88)	15.04 (14.55-15.54)	14.25 (13.86-14.64)	15.36 (14.82-15.9)
2001	15.89 (15.36-16.43)	15.17 (14.67-15.66)	14.2 (13.81-14.58)	15.2 (14.67-15.73)
2002	15.58 (15.05-16.11)	15.44 (14.95-15.94)	14.34 (13.95-14.72)	15.13 (14.6-15.65)
2003	15.33 (14.81-15.85)	15.04 (14.56-15.53)	13.89 (13.51-14.26)	15.11 (14.59-15.63)
2004	14.63 (14.12-15.13)	14.65 (14.18-15.13)	13.9 (13.52-14.27)	15.36 (14.84-15.87)
2005	14.61 (14.1-15.12)	14.57 (14.09-15.04)	13.81 (13.44-14.18)	14.6 (14.1-15.1)
2006	14.97 (14.46-15.48)	14.59 (14.12-15.06)	13.64 (13.28-14)	13.93 (13.45-14.42)
2007	14.16 (13.66-14.65)	13.82 (13.36-14.27)	13.2 (12.85-13.55)	14.03 (13.55-14.51)
2008	13.79 (13.31-14.28)	13.41 (12.96-13.86)	12.86 (12.52-13.21)	13.32 (12.86-13.78)
2009	13.21 (12.74-13.69)	13.39 (12.95-13.84)	12.54 (12.2-12.88)	13.2 (12.75-13.65)
2010	13.19 (12.72-13.66)	13.34 (12.9-13.78)	12.6 (12.27-12.94)	13.05 (12.61-13.5)
2011	13.01 (12.55-13.47)	12.63 (12.2-13.06)	12.21 (11.89-12.54)	12.54 (12.11-12.98)
2012	12.5 (12.05-12.95)	12.44 (12.02-12.86)	11.93 (11.61-12.25)	12.51 (12.09-12.94)
2013	12.22 (11.78-12.66)	12.45 (12.03-12.87)	11.41 (11.1-11.71)	12.14 (11.72-12.56)
2014	11.83 (11.39-12.26)	11.79 (11.39-12.2)	11.18 (10.88-11.48)	12.1 (11.69-12.51)
2015	11.5 (11.07-11.93)	11.32 (10.92-11.71)	10.56 (10.27-10.85)	11.91 (11.5-12.31)
2016	11.19 (10.77-11.61)	11.66 (11.26-12.06)	10.76 (10.47-11.05)	11.76 (11.37-12.16)
2017	11.2 (10.79-11.62)	11.07 (10.69-11.46)	10.64 (10.36-10.93)	11.33 (10.95-11.71)
2018	10.35 (9.95-10.74)	10.33 (9.96-10.7)	10.48 (10.2-10.76)	10.89 (10.51-11.26)
2019	10.26 (9.87-10.66)	10.08 (9.72-10.44)	9.93 (9.66-10.2)	10.29 (9.93-10.65)
2020	10.46 (10.06-10.86)	10.21 (9.85-10.58)	9.83 (9.56-10.09)	10.22 (9.87-10.58)
Total	13.06 (12.96-13.16)	12.94 (12.85-13.03)	12.16 (12.09-12.23)	12.86 (12.76-12.95)

AAMR: Age-adjusted mortality rate; CI: Confidence interval.

Table 9 Ovarian carcinoma-related age-adjusted mortality rates per 100000, stratified by states in females in the United States, 1999 to 2020

State	AAMR (95%CI)
AL	13.26 (12.92-13.61)
AK	10.06 (9.03-11.09)
AZ	12.12 (11.82-12.41)
AR	12.96 (12.52-13.4)
CA	12.81 (12.68-12.95)
CO	12.88 (12.52-13.25)
CT	12.37 (11.99-12.75)
DE	12.62 (11.85-13.39)
D.C.	12.6 (11.6-13.59)
FL	11.63 (11.48-11.79)
GA	12.62 (12.36-12.89)
HI	9.29 (8.74-9.85)
ID	13.08 (12.43-13.72)
IL	12.86 (12.64-13.07)
IN	13.24 (12.94-13.55)
IA	13.67 (13.23-14.1)
KS	12.99 (12.54-13.45)
KY	12.31 (11.95-12.66)
LA	11.65 (11.31-12)
ME	12.58 (11.97-13.18)
MD	12.61 (12.29-12.92)
MA	12.82 (12.54-13.11)
MI	13.35 (13.11-13.59)
MN	12.39 (12.06-12.72)
MS	11.94 (11.51-12.36)
MO	12.08 (11.79-12.38)
MT	13.26 (12.51-14.01)
NE	12.37 (11.82-12.93)
NV	11.95 (11.47-12.43)
NH	12.68 (12.04-13.33)
NJ	13.16 (12.9-13.41)
NM	12.36 (11.83-12.89)
NY	13 (12.83-13.17)
NC	11.88 (11.65-12.12)
ND	11.55 (10.68-12.42)
OH	12.98 (12.76-13.2)
OK	13.35 (12.95-13.75)
OR	14.66 (14.25-15.07)
PA	13.62 (13.42-13.83)
RI	12.28 (11.59-12.97)
SC	11.69 (11.36-12.02)
SD	13.3 (12.45-14.15)
TN	12.96 (12.66-13.27)
TX	11.58 (11.42-11.73)
UT	12.41 (11.87-12.95)
VT	12.09 (11.19-12.99)
VA	12.73 (12.46-13.01)
WA	14.46 (14.14-14.78)
WV	13.89 (13.35-14.44)
WI	13.09 (12.77-13.4)
WY	12.99 (11.93-14.06)
Total	12.63 (12.59-12.68)

AAMR: Age-adjusted mortality rate; CI: Confidence interval.