Angioimmunoblastic T-cell lymphoma accompanied by pure red cell aplasia: A case report

Table 1 Laboratory examinations

Complete blood count	Reference range
White blood cells	3000-9700	4000	/μL
Neutrophils	36.6-79.9	72.8	%
Red blood cells	394-542	315	× 106/μL
Hemoglobin	13.1-17.6	9.7	g/dL
Hematocrit	38.1-50.8	29.2	%
Mean corpuscular volume	84.6-100.6	92.7	fl
Mean corpuscular hemoglobin	28.0-34.6	30.8	pg
Mean corpuscular hemoglobin concentration	31.6-36.0	33.2	%
Platelets	12.4-30.5	14.9	× 104/μL
Biochemical	Reference range
AST	12-35	21	IU/L
ALT	6-40	9	IU/L
Total bilirubin	0.1-1.2	1.2	mg/dL
Lactate dehydrogenase	119-229	344	IU/L
Total protein	6.4-8.3	8.7	g/dL
Albumin	3.8-5.2	2.6	g/dL
Blood urea nitrogen	7.4-19.5	20	mg/dL
Creatine	0.5-1.2	0.67	mg/dL
Sodium	134-147	133	mEq/L
Potassium	3.4-4.8	4.1	mEq/L
Chloride	98-110	99	mEq/L
Calcium	8.3-10.4	7.4	mEq/L
Glucose	70-110	77	mg/L
C-reactive protein	0.0-0.3	2.217	mg/dL
Serum iron	50-170	144	μg/mL
Ferritin	5-152	353	ng/mg
TIBC	270-460	199	μg/mL
Haptoglobin	19-170	56	mg/dL
IgG	820-1740	3917	mg/dL
IgA	90-400	844	mg/dL
IgM	52-270	187	mg/dL
C3	65-135	20	mg/dL
C4	13-35	2	mg/dL
PR3-ANCA	0-3.5	1.2	U/mL
MPO-ANCA	0-3.5	0.1	U/mL
Folic Acid	3.89-26.8	3.7	ng/mg
sIL-2R	127-582	3412	U/mL
Direct coombs test		Positive
Indirect coombs test		Negative
Cryoglobulin		Negative
Coagulation	Reference range
PT-Sec	10.7-13.5	13.4	s
PT-%	77.8-130.0	71	%
PT-INR	0.89-1.12	1.17
APTT	23.6-31.3	27.4	s
Infection
CMV		IgG(+)/IgM(-)
HSV		IgG(+)/IgM(-)
HZV		IgG(+)/IgM(-)
EBV		EBV-VCAIgG(+)/EBV-VCAIgM(-)/PCR(-)
HIV 1+2 antibody		Negative
Parvovirus B19		IgG(+)/IgM(-)

AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; TIBC: Total iron binding capacity; CMV: Cytomegalovirus; HSV: Herpes simplex virus; EBV: Epstein-Barr virus; HIV: Human immunodeficiency virus; APTT: Activated partial thromboplastin time; PT-INR: Prothrombin time-international standardized ratio.

Table 2 Summaries of previous case reports of pure red cell aplasia associated with angioimmunoblastic T-cell lymphoma

No.	Ref.	Age (yr)	Sex	Hemoglobin on admission	Reticulocytes on admission	Direct coombs test	Indirect coombs test	Treatment	Outcome (AITL)	Outcome (PRCA)	Other complications
1	Vitorino et al[10], 2020	72	Female	2.6 g/dL	0.70%	Positive	Positive	Chemotherapy	Remission	Remission	None
2	Tao et al[6], 2013	71	Female	5.0 g/dL	0.10%	NA	NA	Sequential therapy	NA	NA	none
3	Choi et al[11], 2010	43	Female	6.9 g/dL	0.20%	Positive	Positive	Chemotherapy	Remission	Remission	None
4	Wang et al[12], 2007	37	Male	NA	NA	Positive	Positive	Chemotherapy	"Give some effect to cure"	NA	Warm-type autoimmu-ne hemolytic anemia
5	Mizobe et al[13], 2005	71	Female	5.5 g/dL	1%	Positive	Positive	Chemotherapy	Remission	Remission	None
6	Tsujimura et al[14], 1999	46	Male	7.8 g/dL	0%	NA	NA	Chemotherapy	NA	NA	None
7	Al Hilali et al[15], 1983	79	Female	6.5 g/dL	Less than 1%	NA	NA	NA	NA	NA	None

NA: Not available; AITL: Angioimmunoblastic T-cell lymphoma; PRCA: Pure red cell aplasia.