Overall and cause-specific survival for mucoepidermoid carcinoma of the major salivary glands: Analysis of 2210 patients

doi:10.5306/wjco.v11.i12.1029

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 11, Issue 12

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (5590)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-3) series, Tables (1-2) series.

Item

Count

PDF

239

WORD

176

HTML

3069

Figures (1-3)

216

Tables (1-2)

239

Sum=3939

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

556

Download

1095

Sum=1651

Dec 24, 2020 (publication date) through Nov 22, 2024

Times Cited of This Article

Times Cited (12)

Journal Information of This Article

Publication Name

World Journal of Clinical Oncology

ISSN

2218-4333

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Clin Oncol. Dec 24, 2020; 11(12): 1029-1044
Published online Dec 24, 2020. doi: 10.5306/wjco.v11.i12.1029

Table 1 Overall survival analysis of mucoepidermoid carcinoma of the major salivary glands

	n	Median survival	Univariate hazard ratio		Multivariate hazard ratio
	n	95%CI	Estimate	95%CI	Estimate	95%CI
Age bands
00-09	11	Cannot estimate	Cannot estimate		Cannot estimate
10-19	86	Cannot estimate	0.12^a	0.02-0.37	0.13^c	0.06-0.32
20-29	174	Cannot estimate	0.16^a	0.07-0.32	0.18^c	0.12-0.26
30-39	275	Cannot estimate	0.62^b	0.42-0.92	0.73^c	0.68-0.78
40-49	319	401 ± 38.42	Reference		Reference
50-59	431	248 ± 13.93	2.55^a	1.93-3.39	2.51^c	2.33-2.69
60-69	381	167 ± 26.25	5.00^a	3.75-6.75	4.31^c	3.28-5.67
70-79	336	70 ± 17.94	11.38^a	8.25-15.95	7.52^c	6.91-8.18
80+	197	35 ± 6.87	20.02^a	13.67-29.92	12.24^c	11.58-12.95
Stage
Localized	1344	342 ± 26.24	Reference		Reference
Regional	591	99 ± 19.59	3.07^a	2.66-3.54	1.95^c	1.95-1.96
Distant	143	29 ± 9.64	6.96^a	5.51-8.75	2.84^c	2.73-2.95
Unknown	132	118 ± 61.69	2.69^a	1.86-3.80	1.6^b	1.11-2.31
Primary tumor size (mm)
0-10	209	Cannot estimate	Reference		Reference
11-20	576	331 ± 59.73	1.95^c	1.30-3.01	1.64^c	1.39-1.94
21-30	355	248 ± 54.66	3.15^a	2.08-4.91	2.07^c	1.36-3.13
31-40	150	141 ± 57.38	4.63^a	2.97-7.40	2.23^c	1.98-2.52
41-50	57	46 ± 38.76	9.26^a	5.56-15.59	2.66^c	1.52-2.81
> 50	87	52 ± 36.21	9.14^a	5.67-15.05	2.87^c	2.63-3.13
Unknown/unspecific	776	220 ± 26.3	3.43^a	2.35-5.18	2.09^c	1.73-2.51
Grade
I	403	401 ± 48.25	Reference		Reference
II	850	340 ± 33.68	1.26	0.98-1.63	1.30^b	1.02-1.67
III/IV	538	55 ± 11.05	5.44^a	4.27-6.99	2.10^c	1.98-2.23
Unknown	419	201 ± 39.44	2.49^a	1.94-3.20	1.61^c	1.52-1.70
Race
American Indian/Alaska Native	16	Cannot estimate	0.47	0.13-1.20	1.64	0.61-4.45
Asian or Pacific Islander	206	308 ± 66.3	0.70^b	0.53-0.91	0.93	0.71-1.21
Black	239	Cannot estimate	0.59^a	0.45-0.76	1.00	0.78-1.29
Unknown	23	Cannot estimate	0.10^c	0.00-0.54	0.31	0.04-2.26
White	1726	226 ± 21.22	Reference		Reference
Sex
Female	1093	327 ± 31.14	Reference		Reference
Male	1117	187 ± 22.69	1.76^a	1.54-2.01	1.26^b	1.10-1.44
Radiation
No/unknown	1200	340 ± 34.89	0.46^a	0.40-0.53	1.07	0.70-1.63
Yes	1010	147 ± 23.39	Reference		Reference
Sequence
Not applicable	1260	327 ± 29.07	Reference		Reference
Radiation after surgery	902	162 ± 25.62	1.82^a	1.59-2.08	1.18	0.76-1.83
Radiation before surgery	48	162 ± 56.48	1.67^b	1.12-2.40	1.17^c	1.10-1.25
Surgery
No	77	27 ± 11.81	4.26^a	3.16-5.64	2.09^c	1.40-3.10
Unknown	28	16 ± 10.37	4.43^a	2.87-6.57	2.41^c	1.43-4.05
Yes	2105	263 ± 23.24	Reference		Reference
Diagnosis year
1975-1995	960	221 ± 23.77	1.31^c	1.13-1.52	1.38^c	1.16-1.64
1996-2016	1250	Cannot estimate	Reference		Reference
Surgery type
Excision	2085	261 ± 23.23	Reference		Variable not used in multivariate analysis
Limited surgical procedure/biopsy	20	Cannot estimate	1.01	0.52-1.96
None	77	27 ± 11.81	4.28^a	3.17-5.67
Unknown	28	16 ± 10.37	4.44^a	2.88-6.59
Diagnosis year
1975-1984	405	207 ± 31.31	1.77^a	1.39-2.26	Variable not used in multivariate analysis
1985-1994	497	230 ± 36.99	1.50^c	1.18-1.91
1995-2004	564	Cannot estimate	1.32^b	1.04-1.68
2005-2016	744	Cannot estimate	Reference

^aP < 0.0001.

^bP < 0.05.

^cP < 0.001.

Table 2 Cause-specific survival analysis of mucoepidermoid carcinoma of the major salivary glands

	n	Median survival	Univariate hazard ratio		Multivariate hazard ratio
	n	95%CI	Estimate	95%CI	Estimate	95%CI
Age bands
00-09	11	Cannot estimate	Cannot estimate		Cannot estimate
10-19	86	Cannot estimate	0.23^b	0.03-0.90	0.28^b	0.10-0.74
20-29	174	Cannot estimate	0.23^b	0.06-0.67	0.29^c	0.16--0.51
30-39	275	Cannot estimate	0.71	0.37-1.34	0.95	0.85-1.06
40-49	319	Cannot estimate	Reference		Reference
50-59	431	Cannot estimate	2.50^a	1.62-3.96	1.99^c	1.30-3.06
60-69	381	Cannot estimate	3.34^a	2.17-5.29	2.47^c	2.18-2.80
70-79	336	Cannot estimate	5.41^a	3.48-8.67	3.00^c	2.63-3.43
80+	197	Cannot estimate	7.67^a	4.69-12.92	3.47^c	3.17-3.79
Stage
Localized	1344	Cannot estimate	Reference
Regional	591	Cannot estimate	7.46^a	5.78-9.70	3.90^c	3.77-4.04
Distant	143	41 ± 23.43	16.71^a	11.95-23.34	5.79^c	5.77-5.81
Unknown	132	Cannot estimate	6.27^a	3.62-10.38	3.01^c	1.79-5.05
Primary tumor size (mm)
0-10	209	Cannot estimate	Reference		Reference
11-20	576	Cannot estimate	1.87	0.86-4.62	1.4^b	1.01-1.92
21-30	355	Cannot estimate	5.08^a	2.41-12.34	2.13^c	1.48-3.06
31-40	150	Cannot estimate	8.18^a	3.75-20.31	2.27^b	1.04-4.95
41-50	57	Cannot estimate	17.24^a	7.48-44-63	3.19^c	2.44-4.17
> 50	87	89 ± 108.69	18.24^a	8.30-45.63	3.53^c	2.58-4.83
Unknown/unspecific	776	Cannot estimate	6.25^a	3.10-14.69	2.57^c	1.73-3.82
Grade
I	403	Cannot estimate	Reference		Reference
II	850	Cannot estimate	1.75	0.98-3.33	1.56	0.88-2.76
III/IV	538	Cannot estimate	15.48^a	9.17-28.16	4.35^c	2.52-7.52
Unknown	419	Cannot estimate	7.02^a	4.06-13.01	2.92^c	1.67-5.10
Race
American Indian/Alaska Native	16	Cannot estimate	1.24	0.33-3.20	4.29^c	2.18-8.48
Asian or Pacific Islander	206	Cannot estimate	0.64^b	0.41-0.96	0.79	0.52-1.19
Black	239	Cannot estimate	0.66^b	0.44-0.95	1.06	0.94-1.19
Unknown	23	Cannot estimate	0.00^b	0.00-0.90	Cannot estimate
White	1726	Cannot estimate	Reference		Reference
Sex
Female	1093	Cannot estimate	Reference		Reference
Male	1117	Cannot estimate	2.38^a	1.92-2.96	1.36^b	1.09-1.69
Radiation
No/unknown	1200	Cannot estimate	0.27^a	0.22-0.34	2.10	0.43-1.49
Yes	1010	Cannot estimate	Reference		Reference
Sequence
Not applicable	1260	Cannot estimate	Reference		Reference
Radiation after surgery	902	Cannot estimate	2.66^a	2.15-3.30	0.96	0.50-1.84
Radiation before surgery	48	Cannot estimate	2.79^c	1.55-4.70	1.05	0.47-2.33
Surgery
No	77	Cannot estimate	4.37^a	2.89-6.38	2.17^b	1.18-3.98
Unknown	28	74 ± 7.67	4.84^a	2.54-8.44	1.62^c	1.49-1.76
Yes	2105	Cannot estimate	Reference		Reference
Diagnosis year
1975-1995	960	Cannot estimate	1.40^b	1.14-1.73	1.33^b	1.03-1.72
1996-2016	1250	Cannot estimate	Reference		Reference
Surgery type					Variable not used in multivariate analysis
Excision	2085	Cannot estimate	Reference
Limited surgical procedure/biopsy	20	Cannot estimate	1.50	0.48-3.55
None	77	Cannot estimate	4.41^a	2.92-6.44
Unknown	28	74 ± 7.67	4.89^a	2.57-8.53
Diagnosis year					Variable not used in multivariate analysis
1975-1984	405	Cannot estimate	2.09^a	1.53-2.88
1985-1994	497	Cannot estimate	1.47^b	1.06-2.04
1995-2004	564	Cannot estimate	1.44^b	1.05-1.98
2005-2016	744	Cannot estimate	Reference

^aP < 0.0001.

^bP < 0.05.

^cP < 0.001.

Citation: Taylor ZC, Kaya EA, Bunn JD, Guss ZD, Mitchell BJ, Fairbanks RK, Lamoreaux WT, Wagner AE, Peressini BJ, Lee CM. Overall and cause-specific survival for mucoepidermoid carcinoma of the major salivary glands: Analysis of 2210 patients. World J Clin Oncol 2020; 11(12): 1029-1044
URL: https://www.wjgnet.com/2218-4333/full/v11/i12/1029.htm
DOI: https://dx.doi.org/10.5306/wjco.v11.i12.1029