Targeting metabolism in breast cancer: How far we can go?

doi:10.5306/wjco.v7.i1.122

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Feb 10, 2016 (publication date) through Nov 25, 2024

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Feb 10, 2016; 7(1): 122-130
Published online Feb 10, 2016. doi: 10.5306/wjco.v7.i1.122

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Figure 1 Metabolic reprogramming in malignant cells. Most malignant cells present with increased aerobic glycolysis, fatty acid synthesis and glutaminolysis. The pink circles in the figure show the possible metabolic targets of enzymes or receptors. GLUT: Glucose transporter proteins; HK: Hexokinase; PKM: Pyruvate kinase M; LDH: Lactate dehydrogenase; FASN: Fatty acid synthase; ACS: Acetyl-CoA synthase; IDH: Isocitrate dehydrogenase; GLS: Glutaminase.

Citation: Long JP, Li XN, Zhang F. Targeting metabolism in breast cancer: How far we can go? World J Clin Oncol 2016; 7(1): 122-130
URL: https://www.wjgnet.com/2218-4333/full/v7/i1/122.htm
DOI: https://dx.doi.org/10.5306/wjco.v7.i1.122