Association of survivin splice variants with prognosis and treatment of breast cancer

Figure 1 Survivin functions that contribute to tumor development and metastasis; chromosomal passenger complex, inner centromere protein, hepatitis B X-linked interacting protein and X-linked inhibitor of apoptosis protein, angiopoietin-1, vascular endothelial growth factor receptor, receptor tyrosine kinase 2 (modified from ref. [59]). CPC: Chromosomal passenger complex; INCEP: Inner centromere protein; HBXIP: Hepatitis B X-linked interacting protein; XIAP: X-linked inhibitor of apoptosis protein; Ang1: Angiopoietin-1; VEGFR: Vascular endothelial growth factor receptor; Tie2: Tyrosine kinase 2.

Figure 2 Illustrative diagram of survivin isoforms exon structure. b: Sequence originated from intron; 3’UTR: Untranslated region, the red lines represent the baculovirus inhibitors of apoptosis repeat domain (modified from ref. [4] and [20]).