Timing matters: Early vs late recurrence in nasopharyngeal carcinoma and its impact on survival

doi:10.5306/wjco.124227

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Oncol. Aug 24, 2026; 17(8): 124227
Published online Aug 24, 2026. doi: 10.5306/wjco.124227

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Figure 1 Chronological distribution of recurrence types. A: Local or regional recurrence; B: Local recurrence; C: Regional recurrence; D: Proportion of recurrence types among patients. Recurrence incidence peaked during the 2^nd year for local or regional, local, and regional recurrence. ENR: Early regional recurrence; ETNR: Early locoregional recurrence; ETR: Early local recurrence; LNR: Late regional recurrence; LTNR: Late locoregional recurrence; LTR: Late local recurrence.

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Figure 2 Post-recurrence overall survival between early and late recurrence. A: Overall cohort; B: Local recurrence cohort; C: Regional recurrence cohort; D: Locoregional recurrence cohort. No significant difference in post-recurrence overall survival (OS) was observed between early and late recurrence in the overall, local, and regional cohorts. However, late locoregional recurrence significantly improved post-recurrence OS. ENR: Early regional recurrence; ETNR: Early locoregional recurrence; ETR: Early local recurrence; LNR: Late regional recurrence; LTNR: Late locoregional recurrence; LTR: Late local recurrence.

Citation: Wang JB, Meng Y, He ML, Zhang SJ, Huang XD, Zhang Y, Wu RY, Wang K, Chen XS, Qu Y, Zhang JH, Liu QF, Luo JW, Gao L, Xiao JP, Li YX, Luo LH, Yi JL. Timing matters: Early vs late recurrence in nasopharyngeal carcinoma and its impact on survival. World J Clin Oncol 2026; 17(8): 124227
URL: https://www.wjgnet.com/2218-4333/full/v17/i8/124227.htm
DOI: https://dx.doi.org/10.5306/wjco.124227

Wang JB, Meng Y, He ML, Zhang SJ, Huang XD, Zhang Y, Wu RY, Wang K, Chen XS, Qu Y, Zhang JH, Liu QF, Luo JW, Gao L, Xiao JP, Li YX, Luo LH, Yi JL. Timing matters: Early vs late recurrence in nasopharyngeal carcinoma and its impact on survival. World J Clin Oncol 2026; 17(8): 124227 [DOI: 10.5306/wjco.124227]

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