Multidimensional mechanisms of drug resistance in non-small cell lung cancer and novel strategies for overcoming it

doi:10.5306/wjco.121766

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Oncol. Jul 24, 2026; 17(7): 121766
Published online Jul 24, 2026. doi: 10.5306/wjco.121766

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Figure 1 Multidimensional mechanisms of therapy resistance in non-small cell lung cancer and emerging strategies for overcoming resistance. NSCLC: Non-small cell lung cancer; EGFR-TKI: Epidermal growth factor receptor tyrosine kinase inhibitor; pAKT: Phosphorylated protein kinase B; pERK: Phosphorylated extracellular signal-regulated kinase; MET: Mesenchymal-epithelial transition factor; TME: Tumor microenvironment; PD-L1: Programmed death-ligand 1; TGF-β: Transforming growth factor-beta; IL-10: Interleukin-10; TAM: Tumor-associated macrophage; ctDNA: Circulating tumor DNA; ADC: Antibody-drug conjugate; BsAb: Bispecific antibody; PROTAC: Proteolysis-targeting chimera; TPD: Targeted protein degradation. Created in BioRender. Available from: https://BioRender.com/76ufua3 (see Supplementary material).

Citation: Zhang XY, Pan XY, Zhu Y, Hu M, Ma S, Zheng SY, Wu CH, Xie YL, Xie YC. Multidimensional mechanisms of drug resistance in non-small cell lung cancer and novel strategies for overcoming it. World J Clin Oncol 2026; 17(7): 121766
URL: https://www.wjgnet.com/2218-4333/full/v17/i7/121766.htm
DOI: https://dx.doi.org/10.5306/wjco.121766

Zhang XY, Pan XY, Zhu Y, Hu M, Ma S, Zheng SY, Wu CH, Xie YL, Xie YC. Multidimensional mechanisms of drug resistance in non-small cell lung cancer and novel strategies for overcoming it. World J Clin Oncol 2026; 17(7): 121766 [DOI: 10.5306/wjco.121766]

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