Radiation-induced cardiotoxicity in lung cancer: Current landscape and future directions

doi:10.5306/wjco.118494

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Oncol. Jun 24, 2026; 17(6): 118494
Published online Jun 24, 2026. doi: 10.5306/wjco.118494

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Figure 1 Schematic diagram of the pathophysiological cascade of radiation-induced heart disease. The illustration depicts the dynamic progression from acute injury to chronic cardiac dysfunction following thoracic radiotherapy, encompassing four interconnected stages. A: Initial injury and endothelial dysfunction; B: Chronic inflammation and immune activation; C: Fibrotic remodeling; D: Clinical phenotypes. VCAM: Vascular cell adhesion molecule; ICAM: Intercellular adhesion molecule; ROS: Reactive oxygen species; TNF-α: Tumor necrosis factor-alpha; TGF-β: Transforming growth factor-beta; IL-1β: Interleukin-1β; MCP-1: Monocyte chemoattractant protein-1; cGAS: Cyclic GMP-AMP synthase; STING: Stimulator of interferon genes.

Citation: Lin XL, Li JR, Xie RX. Radiation-induced cardiotoxicity in lung cancer: Current landscape and future directions. World J Clin Oncol 2026; 17(6): 118494
URL: https://www.wjgnet.com/2218-4333/full/v17/i6/118494.htm
DOI: https://dx.doi.org/10.5306/wjco.118494

Lin XL, Li JR, Xie RX. Radiation-induced cardiotoxicity in lung cancer: Current landscape and future directions. World J Clin Oncol 2026; 17(6): 118494 [DOI: 10.5306/wjco.118494]

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