Prognostic value and therapeutic efficacy of interstitial circulating tumor cells in patients with advanced gastric cancer

Figure 1 Screening flow chart of patients with advanced gastric cancer. I-CTC: Interstitial circulating tumor cells.

Figure 2 Immunofluorescent staining of interstitial circulating tumor cells in gastric cancer patients. Interstitial circulating tumor cells are identified as DAPI (blue) positive, CSV (FITC, green) positive, and CD45 (PE, orange) negative cells. Scale bar represents 10 μm, immunofluorescent staining, 20 ×.

Figure 3 Relationship between interstitial circulating tumor cells and gastric cancer. A: Interstitial circulating tumor cells (I-CTCs) expression status before treatment; B: I-CTCs and prognostic receiver operating characteristic curves of patients with advanced gastric cancer (GC); C: Two-year overall survival curves of I-CTCs-positive and negative groups of patients with advanced GC; D: Two-year disease-free survival curves of I-CTCs-positive and negative groups of patients with advanced GC. I-CTC: Interstitial circulating tumor cell; AUC: Area under the curve; OS: Overall survival; DFS: Disease-free survival.