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Beltran-Ontiveros SA, Contreras-Gutierrez JA, Lizarraga-Verdugo E, Gutierrez-Grijalva EP, Lopez-Lopez K, Lora-Fierro EH, Trujillo-Rojas MA, Moreno-Ortiz JM, Cardoso-Angulo DL, Leal-Leon E, Zatarain-Lopez JR, Cuen-Diaz HM, Montoya-Moreno M, Arce-Bojorquez B, Rochin-Teran JL, Cuen-Lazcano DE, Contreras-Rodriguez VA, Lascurain R, Carmona-Aparicio L, Coballase-Urrutia E, Gallardo-Vera F, Diaz D. National Burden and Trends for 29 Groups of Cancer in Mexico from 1990 to 2019: A Secondary Analysis of the Global Burden of Disease Study 2019. Cancers (Basel) 2023; 16:149. [PMID: 38201576 PMCID: PMC10778521 DOI: 10.3390/cancers16010149] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/04/2023] [Revised: 12/17/2023] [Accepted: 12/26/2023] [Indexed: 01/12/2024] Open
Abstract
The global burden of cancer is on the rise, with varying national patterns. To gain a better understanding and control of cancer, it is essential to provide national estimates. Therefore, we present a comparative description of cancer incidence and mortality rates in Mexico from 1990 to 2019, by age and sex for 29 different cancer groups. Based on public data from the Global Burden of Disease Study 2019, we evaluated the national burden of cancer by analyzing counts and crude and age-standardized rates per 100,000 people with 95% uncertainty intervals for 2019 and trends using the annual percentage change from 1990 to 2019. In 2019, cancer resulted in 222,060 incident cases and 105,591 deaths. In 2019, the highest incidence of cancer was observed in non-melanoma skin cancer, prostate cancer, and breast cancer. Additionally, 53% of deaths were attributed to six cancer groups (lung, colorectal, stomach, prostate, breast, and pancreatic). From 1990 to 2019, there was an increasing trend in incidence and mortality rates, which varied by 10-436% among cancer groups. Furthermore, there were cancer-specific sex differences in crude and age-standardized rates. The results show an increase in the national cancer burden with sex-specific patterns of change. These findings can guide national efforts to reduce health loss due to cancer.
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Affiliation(s)
- Saul A. Beltran-Ontiveros
- Centro de Investigación y Docencia en Salud, Universidad Autónoma de Sinaloa, Culiacán Rosales 80030, Sinaloa, Mexico; (S.A.B.-O.); (E.L.-V.); (D.L.C.-A.); (M.M.-M.); (B.A.-B.)
| | - Jose A. Contreras-Gutierrez
- Centro de Investigación y Docencia en Salud, Universidad Autónoma de Sinaloa, Culiacán Rosales 80030, Sinaloa, Mexico; (S.A.B.-O.); (E.L.-V.); (D.L.C.-A.); (M.M.-M.); (B.A.-B.)
| | - Erik Lizarraga-Verdugo
- Centro de Investigación y Docencia en Salud, Universidad Autónoma de Sinaloa, Culiacán Rosales 80030, Sinaloa, Mexico; (S.A.B.-O.); (E.L.-V.); (D.L.C.-A.); (M.M.-M.); (B.A.-B.)
| | - Erick P. Gutierrez-Grijalva
- Cátedras CONACYT, Centro de Investigación en Alimentación y Desarrollo, A.C., Culiacán Rosales 80110, Sinaloa, Mexico;
| | - Kenia Lopez-Lopez
- Laboratorio de Biomedicina Molecular, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Culiacán Rosales 80019, Sinaloa, Mexico;
| | - Emilio H. Lora-Fierro
- Centro de Investigación y Docencia en Salud, Universidad Autónoma de Sinaloa, Culiacán Rosales 80030, Sinaloa, Mexico; (S.A.B.-O.); (E.L.-V.); (D.L.C.-A.); (M.M.-M.); (B.A.-B.)
| | - Miguel A. Trujillo-Rojas
- Instituto de Genética Humana “Dr. Enrique Corona Rivera”, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico; (M.A.T.-R.); (J.M.M.-O.)
| | - Jose M. Moreno-Ortiz
- Instituto de Genética Humana “Dr. Enrique Corona Rivera”, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico; (M.A.T.-R.); (J.M.M.-O.)
| | - Diana L. Cardoso-Angulo
- Centro de Investigación y Docencia en Salud, Universidad Autónoma de Sinaloa, Culiacán Rosales 80030, Sinaloa, Mexico; (S.A.B.-O.); (E.L.-V.); (D.L.C.-A.); (M.M.-M.); (B.A.-B.)
| | - Emir Leal-Leon
- Laboratorio de Genética y Biología Molecular, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Culiacán Rosales 80019, Sinaloa, Mexico;
| | - Jose R. Zatarain-Lopez
- Centro de Investigación y Docencia en Salud, Universidad Autónoma de Sinaloa, Culiacán Rosales 80030, Sinaloa, Mexico; (S.A.B.-O.); (E.L.-V.); (D.L.C.-A.); (M.M.-M.); (B.A.-B.)
| | - Hector M. Cuen-Diaz
- Centro de Investigación y Docencia en Salud, Universidad Autónoma de Sinaloa, Culiacán Rosales 80030, Sinaloa, Mexico; (S.A.B.-O.); (E.L.-V.); (D.L.C.-A.); (M.M.-M.); (B.A.-B.)
| | - Marisol Montoya-Moreno
- Centro de Investigación y Docencia en Salud, Universidad Autónoma de Sinaloa, Culiacán Rosales 80030, Sinaloa, Mexico; (S.A.B.-O.); (E.L.-V.); (D.L.C.-A.); (M.M.-M.); (B.A.-B.)
| | - Brisceyda Arce-Bojorquez
- Centro de Investigación y Docencia en Salud, Universidad Autónoma de Sinaloa, Culiacán Rosales 80030, Sinaloa, Mexico; (S.A.B.-O.); (E.L.-V.); (D.L.C.-A.); (M.M.-M.); (B.A.-B.)
| | - Juan L. Rochin-Teran
- Centro de Investigación y Docencia en Salud, Universidad Autónoma de Sinaloa, Culiacán Rosales 80030, Sinaloa, Mexico; (S.A.B.-O.); (E.L.-V.); (D.L.C.-A.); (M.M.-M.); (B.A.-B.)
| | - Daniel E. Cuen-Lazcano
- Centro de Investigación y Docencia en Salud, Universidad Autónoma de Sinaloa, Culiacán Rosales 80030, Sinaloa, Mexico; (S.A.B.-O.); (E.L.-V.); (D.L.C.-A.); (M.M.-M.); (B.A.-B.)
| | - Victor A. Contreras-Rodriguez
- Unidad Académica de Criminalística, Criminología y Ciencias Forenses, Universidad Autónoma de Sinaloa, Culiacán Rosales 80040, Sinaloa, Mexico;
| | - Ricardo Lascurain
- Unidad de Vinculación Científica, Facultad de Medicina, Universidad Nacional Autónoma de México en el Instituto Nacional de Medicina Genómica, Tlalpan 14610, Ciudad de México, Mexico;
| | - Liliana Carmona-Aparicio
- Laboratorio de Neurociencias II, Instituto Nacional de Pediatría, Coyoacán 04530, Ciudad de México, Mexico; (L.C.-A.); (E.C.-U.)
| | - Elvia Coballase-Urrutia
- Laboratorio de Neurociencias II, Instituto Nacional de Pediatría, Coyoacán 04530, Ciudad de México, Mexico; (L.C.-A.); (E.C.-U.)
| | - Francisco Gallardo-Vera
- Laboratorio de Biología Molecular y Bioseguridad Nivel III, Centro Médico Naval, Coyoacán 04470, Ciudad de México, Mexico;
| | - Daniel Diaz
- Facultad de Ciencias, Universidad Nacional Autónoma de México, Coyoacán 04510, Ciudad de México, Mexico
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Sánchez-Valledor LF, Habermann TM, Murrieta-Alvarez I, Córdova-Ramírez AC, Rivera-Álvarez M, León-Peña A, Cantero-Fortiz Y, Olivares-Gazca JC, Ruiz-Delgado GJ, Ruiz-Argüelles GJ. Long-term results of the treatment of Hodgkin's lymphoma in a resource-constrained setting: Real-world data from a single center. World J Clin Oncol 2021; 12:800-807. [PMID: 34631443 PMCID: PMC8479346 DOI: 10.5306/wjco.v12.i9.800] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/04/2021] [Revised: 05/17/2021] [Accepted: 08/09/2021] [Indexed: 02/06/2023] Open
Abstract
BACKGROUND The outcomes of Hodgkin´s lymphoma (HL) in México have not been widely reported. Simplified and affordable treatments have been adopted in middle-income countries. AIM The aim was to evaluate long-used therapies for HL in México in a long-term basis. METHODS In a 34-year time period, 88 patients with HL were treated at a single institution in México. Patients were treated with adriamycin bleomycin vinblastine and dacarbazine (ABVD) or mechlorethamine, vincristine, procarbazine, and prednisone (MOPP). Relapsed or refractory patients were given ifosfamide, carboplatin, and etoposide (ICE) followed by autologous or allogeneic stem cell transplants. RESULTS Thirty-seven women and 51 men were included; the median age was 29 years. Patients were followed for a mean of 128 mo. The 310-mo overall survival (OS) was 83% for patients treated with MOPP and 88% for those treated with ABVD. The OS of patients who received autologous stem cell transplantation was 76% (330 mo) vs 93% (402 mo) in those who did not. CONCLUSION HL may be less aggressive in Mexican population than in Caucasians. Combined chemotherapy renders acceptable results, regardless of clinical stage.
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Affiliation(s)
| | - Thomas M Habermann
- Department of Medicine, Division of Hematology, Mayo Clinical and Mayo Foundation, Rochester, MN 55905, United States
| | | | | | | | - Andrés León-Peña
- Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla 72530, Mexico
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Cruz-Mora A, Murrieta-Alvarez I, Olivares-Gazca JC, León-Peña A, Cantero-Fortiz Y, García-Navarrete YI, Sánchez-Valledor LF, Khalaf D, Ruiz-Delgado GJ, Ruiz-Argüelles GJ. Up to half of patients diagnosed with chronic lymphocytic leukemia in México may not require treatment. ACTA ACUST UNITED AC 2020; 25:156-159. [PMID: 32268849 DOI: 10.1080/16078454.2020.1749473] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/31/2022]
Abstract
Introduction: Although therapeutic choices for patients with chronic lymphocytic leukemia (CLL) were once limited, treatment of this disease has vastly improved in the last decades.Patients and methods: Consecutive CLL patients diagnosed in a single institution were analyzed. Treatment was withheld in persons with CLL Rai stage 0 or 1, until progression and in persons with stages 2-4, with a negative expression of ZAP-70 until progression. Between 1983 and 1991, patients were give chlorambucil and prednisone (CP); after 1991 fludarabine and cyclophosphamide (FC) and after 1998, rituximab and FC (FCR).Results: 98 patients with CLL were identified; 49 were followed for >3 months. 21 persons (43%) did not require treatment nor progressed; 14 received CP, 6 FC, 7 FCR and one rituximab. Median overall survival (OS) has not been reached, being above 247 months; median OS for patients given CP was 115 months, for FC above 132 months and for FCR above 136 months (p > 0.5).Conclusion: CLL seems to be less aggressive in Mexican mestizos than in Caucasians; 43% of patients do not need treatment at all.
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Affiliation(s)
- Antonio Cruz-Mora
- Centro de Hematología y Medicina Interna de Puebla, Puebla, México.,Medical School, Benemérita Universidad Autónoma de Puebla, Puebla, México
| | - Iván Murrieta-Alvarez
- Centro de Hematología y Medicina Interna de Puebla, Puebla, México.,Medical School, Universidad Popular Autónoma del Estado de Puebla, Puebla, México
| | - Juan Carlos Olivares-Gazca
- Centro de Hematología y Medicina Interna de Puebla, Puebla, México.,Medical School, Universidad Popular Autónoma del Estado de Puebla, Puebla, México
| | - Andrés León-Peña
- Centro de Hematología y Medicina Interna de Puebla, Puebla, México.,Medical School, Universidad Popular Autónoma del Estado de Puebla, Puebla, México
| | - Yahveth Cantero-Fortiz
- Centro de Hematología y Medicina Interna de Puebla, Puebla, México.,Medical School, Universidad de las Américas Puebla, Puebla, México
| | - Yarely Itzayana García-Navarrete
- Centro de Hematología y Medicina Interna de Puebla, Puebla, México.,Medical School, Universidad Popular Autónoma del Estado de Puebla, Puebla, México
| | - Luisa Fernanda Sánchez-Valledor
- Centro de Hematología y Medicina Interna de Puebla, Puebla, México.,Medical School, Universidad de las Américas Puebla, Puebla, México
| | - Dina Khalaf
- Medical School, Mc Master University, Hamilton, Canada
| | - Guillermo José Ruiz-Delgado
- Centro de Hematología y Medicina Interna de Puebla, Puebla, México.,Medical School, Universidad Popular Autónoma del Estado de Puebla, Puebla, México.,Laboratorios Ruiz, Puebla, México
| | - Guillermo José Ruiz-Argüelles
- Centro de Hematología y Medicina Interna de Puebla, Puebla, México.,Medical School, Universidad Popular Autónoma del Estado de Puebla, Puebla, México.,Laboratorios Ruiz, Puebla, México
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Bello-López JM, Cisneros CB, Martínez-Albarrán A. HLA analysis of Mexican candidates for bone marrow transplantation and probability of finding compatible related donors. Transfus Apher Sci 2018; 57:82-87. [PMID: 29398509 DOI: 10.1016/j.transci.2017.12.004] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/06/2017] [Revised: 12/20/2017] [Accepted: 12/22/2017] [Indexed: 11/29/2022]
Abstract
INTRODUCTION Oncohematological disorders are the main cause of morbidity in the Mexican population from 1 to 19 years old, where megakaryoblastic and promyelocitic leukemias are more frequent. Considering that the success of a transplant is multifactorial, the criterion of compatibility in the HLA system is crucial and even more so when the source of HSC is bone marrow. OBJECTIVE To determine the frequency of the HLA genotype in Mexican candidates who require a bone marrow transplant from related donors and the probability to find donors. MATERIALS AND METHODS One hundred twenty-six candidates for bone marrow transplant and related donors were tested for HLA class I (-A*, -B* alleles) and class II (-DRB1* allele) in intermediate-resolution, as the first phase in the choice of the possible donor. The criteria to identify donors were determined by antigen-matched in each HLA haplotype as follows: 4/6, 5/6 and 6/6 at the HLA-A*, HLA-B*, and HLA-DRB1* alleles. RESULTS Of all the candidates analyzed, 57.93%, at least one bone marrow donor was identified; in 53 cases, no donor was found. The average size of the families was 4.79 ± 1.06 members. A higher percentage of compatibility with grade 6/6 (31.6%) was identified with brothers, followed by sisters in 25.3%. The probability to find at least one compatible potential donor was 1.51 ± 0.92 donors. CONCLUSION In the first phase to select donors, Mexican patients studied in this work, have a compatible donor, however the grade of resolution test influenced in the probability identified.
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Affiliation(s)
- J Manuel Bello-López
- Centro Nacional de la Transfusión Sanguínea, Av. Othón de Mendizábal 195, Zacatenco, Gustavo A. Madero, 07360, Mexico City, Mexico; Hospital Juárez de México, Av. Instituto Politécnico Nacional 5160, Zacatenco, Gustavo A. Madero, 07360, Mexico City, Mexico.
| | - Carlos Bonilla Cisneros
- Centro Nacional de la Transfusión Sanguínea, Av. Othón de Mendizábal 195, Zacatenco, Gustavo A. Madero, 07360, Mexico City, Mexico
| | - Angel Martínez-Albarrán
- Centro Nacional de la Transfusión Sanguínea, Av. Othón de Mendizábal 195, Zacatenco, Gustavo A. Madero, 07360, Mexico City, Mexico
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