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Yoshida S, Takeshita Y, Kawazu T, Hisatomi M, Okada S, Fujikura M, Obata K, Takabatake K, Yoshida S, Asaumi J. Central dentinogenic ghost cell tumor of the maxilla: a case report with new imaging findings and review of the literature. Oral Radiol 2024; 40:561-568. [PMID: 38969864 PMCID: PMC11379793 DOI: 10.1007/s11282-024-00764-4] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/13/2024] [Accepted: 06/30/2024] [Indexed: 07/07/2024]
Abstract
A dentinogenic ghost cell tumor (DGCT) is a rare benign odontogenic tumor that commonly shows characteristics of solid proliferation and has a relatively high risk of recurrence after surgical treatment. We herein report a case of a central DGCT that occurred in the maxilla and resulted in bone expansion. This study highlights new imaging findings (particularly magnetic resonance imaging) along with histopathological observations. In addition, we conducted a review of the existing literature on this rare tumor. A 37-year-old man developed swelling around the right cheek. A benign odontogenic tumor such as ameloblastoma was suspected based on the imaging examination findings (including bone expansion and the internal characteristics of the tumor) on panoramic imaging, computed tomography, and magnetic resonance imaging. The lesion was surgically excised from the right maxilla. Postoperative histopathological examination led to a definitive diagnosis of central DGCT. The tumor comprised epithelial neoplastic islands, resembling ameloblastoma, inside tight fibroconnective tissue; masses of ghost cells and formation of dentin were also observed. We had suspected that the minute high-density region around the molars on the imaging examinations represented alveolar bone change; however, it represented dentin formation. This led to difficulty diagnosing the lesion. Although DGCT may present characteristic findings on imaging examinations, its occurrence is infrequent, and in some cases, the findings may include the presence or absence of an impacted tooth without obvious calcification. The present case suggests that we should consider the possibility of an odontogenic tumor with calcification when high-density structures are observed inside the lesion.
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Affiliation(s)
- Suzuka Yoshida
- Department of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan
| | - Yohei Takeshita
- Department of Oral and Maxillofacial Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
| | - Toshiyuki Kawazu
- Department of Oral and Maxillofacial Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan
| | - Miki Hisatomi
- Department of Oral and Maxillofacial Radiology, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan
| | - Shunsuke Okada
- Department of Oral and Maxillofacial Radiology, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan
| | - Mamiko Fujikura
- Department of Oral and Maxillofacial Radiology, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan
| | - Kyoichi Obata
- Department of Oral and Maxillofacial Surgery, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan
| | - Kiyofumi Takabatake
- Department of Oral Pathology and Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan
| | - Saori Yoshida
- Preliminary Examination Room, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan
| | - Junichi Asaumi
- Department of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan
- Department of Oral and Maxillofacial Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan
- Department of Oral and Maxillofacial Radiology, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan
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Yadav J, Kamboj M, Devi A, Narwal A, Chhikara D, Saini B. Unravelling the mystery of the central dentinogenic ghost cell tumor- a rare case report and recurrent insights. Autops Case Rep 2024; 14:e2024510. [PMID: 39176105 PMCID: PMC11340818 DOI: 10.4322/acr.2024.510] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/01/2023] [Accepted: 06/28/2024] [Indexed: 08/24/2024]
Abstract
Dentinogenic ghost cell tumor (DGCT) is a rare benign neoplasm form of calcifying odontogenic cyst (COC) characterized by ghost cells. Although benign, it presents an aggressive behavior. DGCT accounts for 2% to 14% of all COCs and less than 0.5% of all odontogenic tumors. It is a benign odontogenic tumor despite its local invasion and the likelihood of recurrence. To detect recurrence, central DGCT patients must be monitored long-term. We present the case of a 51-year-old male who reported pain in the right upper back tooth region. On examination, a soft to firm, bright red swelling was present in the buccal vestibule and gingival margin of the maxillary right first and second molar, which extended up to the palate. Histopathological analysis confirmed the diagnosis of a DGCT, which occurred in a previously treated calcifying odontogenic cyst. The case is reported here, along with a review of the literature update of such recurred instances in the past.
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Affiliation(s)
- Jagveer Yadav
- Department of Oral Maxillofacial Pathology and Microbiology, Post Graduate Institute of Dental Sciences, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak, Haryana, India
| | - Mala Kamboj
- Department of Oral Maxillofacial Pathology and Microbiology, Post Graduate Institute of Dental Sciences, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak, Haryana, India
| | - Anju Devi
- Department of Oral Maxillofacial Pathology and Microbiology, Post Graduate Institute of Dental Sciences, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak, Haryana, India
| | - Anjali Narwal
- Department of Oral Maxillofacial Pathology and Microbiology, Post Graduate Institute of Dental Sciences, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak, Haryana, India
| | - Deepti Chhikara
- Department of Oral Maxillofacial Surgery, Post Graduate Institute of Dental Sciences, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak, Haryana, India
| | - Bhawna Saini
- Department of Oral Medicine and Radiology, Post Graduate Institute of Dental Sciences, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak, Haryana, India
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Kinoshita N, Hirai H, Fukawa Y, Yamagata Y, Kashima Y, Sato M, Ikeda T, Harada H. A case of dentinogenic ghost cell tumor of the mandible with a review of the literature. JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, MEDICINE, AND PATHOLOGY 2023. [DOI: 10.1016/j.ajoms.2023.03.014] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 04/08/2023]
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Toyodome S, Wakasa T, Hirose K, Iwamoto N, Suzuki S, Nemoto N, Toyosawa S, Nagata T. Dentinogenic ghost cell tumor treated with a combination of marsupialization and radical resection: a case report and review of the literature. J Med Case Rep 2023; 17:114. [PMID: 36991521 DOI: 10.1186/s13256-023-03861-w] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/05/2021] [Accepted: 02/28/2023] [Indexed: 03/31/2023] Open
Abstract
BACKGROUND Dentinogenic ghost cell tumor is a rare benign tumor that accounts for less than 3% of all cases and consists of the stellate reticulum, which is made up of enamel epithelioid and basaloid cells. Although DGCT is a benign tumor, the local infiltration of the odontogenic epithelium or recurrences have been reported, and its detailed pathology and treatments remain unclear. CASE PRESENTATION This report describes the case of a 60-year-old Japanese male diagnosed with a maxillary dentinogenic ghost cell tumor. Images showed well-circumscribed, multilocular cystic lesions with a calcified substance in the interior. Marsupialization was performed along with biopsy to prevent the expansion of the lesion, and a partial maxillectomy was performed 2 years after the initial examination. Histopathological findings showed ameloblastomatous proliferation containing clusters of ghost cells and dentinoid materials, resulting in the diagnosis of dentinogenic ghost cell tumor. This article also reviews recently reported cases of dentinogenic ghost cell tumor. CONCLUSION It is important to perform marsupialization, proper resection, and postoperative follow-up because of possible recurrence.
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Affiliation(s)
- Soichiro Toyodome
- Department of Oral and Maxillofacial Surgery, Kindai University Nara Hospital, 1248-1 Otodacho, Ikoma, Nara, 630-0293, Japan.
| | - Tomoko Wakasa
- Department of Diagnostic Pathology, Kindai University Nara Hospital, 1248-1 Otodacho, Ikoma, Nara, 630-0293, Japan
| | - Katsutoshi Hirose
- Department of Oral Pathology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan
| | - Noriko Iwamoto
- Department of Oral and Maxillofacial Surgery, Kindai University Nara Hospital, 1248-1 Otodacho, Ikoma, Nara, 630-0293, Japan
| | - Seiya Suzuki
- Department of Oral and Maxillofacial Surgery, Kindai University Nara Hospital, 1248-1 Otodacho, Ikoma, Nara, 630-0293, Japan
| | - Naoto Nemoto
- Department of Oral and Maxillofacial Surgery, Kindai University Nara Hospital, 1248-1 Otodacho, Ikoma, Nara, 630-0293, Japan
| | - Satoru Toyosawa
- Department of Oral Pathology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan
| | - Tetsuji Nagata
- Department of Oral and Maxillofacial Surgery, Kindai University Nara Hospital, 1248-1 Otodacho, Ikoma, Nara, 630-0293, Japan
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Peripheral dentinogenic ghost cell tumor of the maxilla: A case report and literature review. ORAL AND MAXILLOFACIAL SURGERY CASES 2022. [DOI: 10.1016/j.omsc.2022.100270] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/18/2022] Open
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Reddy V, Wadhwan V, Singh R, Bansal V. Dentinogenic ghost cell tumor: Case report of a rare central variant and literature review. J Oral Maxillofac Pathol 2022; 26:S68-S72. [PMID: 35450252 PMCID: PMC9017846 DOI: 10.4103/jomfp.jomfp_174_21] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/02/2021] [Revised: 11/23/2021] [Accepted: 11/24/2021] [Indexed: 11/18/2022] Open
Abstract
The dentinogenic ghost cell tumor (DGCT), a solid variant of the calcifying odontogenic cysts, is an uncommon odontogenic neoplasm which is aggressive and has a propensity for recurrence. It accounts for <0.5% of all odontogenic tumors which can exhibit intraosseous (central) or extraosseous (peripheral) localization. Till today, only 39 cases of central DGCT have been reported in English literature according to WHO 2017 Classification. Therapeutic intervention of central variant should be aggressive, local resection with adequate safety margins and monitoring the patient for recurrence as the lesions show recurrence rate up to 71%. The purpose of this paper is to describe a rare case report of central DGCT in a 57-year-old female patient with a brief review of literature which provides an update on the epidemiology, diagnostic and clinicopathological characteristics of the published cases.
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Affiliation(s)
- Vandana Reddy
- Department of Oral and Maxillofacial Pathology and Microbiology, Subharti Dental College, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India
| | - Vijay Wadhwan
- Department of Oral and Maxillofacial Pathology and Microbiology, Subharti Dental College, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India
| | - Roli Singh
- Department of Oral and Maxillofacial Pathology and Microbiology, Subharti Dental College, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India
| | - Vishal Bansal
- Department of Oral and Maxillofacial Surgery, Subharti Dental College, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India
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Cabo I, Saura A, Cardoso AR, Cardoso JA. Peripheral dentinogenic ghost cell tumour. BMJ Case Rep 2022; 15:e245513. [PMID: 35039348 PMCID: PMC8768483 DOI: 10.1136/bcr-2021-245513] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 11/07/2021] [Indexed: 11/04/2022] Open
Abstract
The dentinogenic ghost cell tumour (DGCT) is a rare benign neoplasm, which histologically presents itself as an aberrant keratinisation of the epithelium, ghost cells and dentinoid material. Depending on its location there are two different types of DGCT, central or peripheral, with different clinical characteristics. By 2019, there were only 57 cases of DGCT published: 39 of the central type and 18 of the peripheral type.In this clinical case, the authors describe the case of a 78-year-old man with a painless and slow growing mandibular lump. The diagnosis of peripheral DGCT was made by incisional biopsy and the treatment consisted of radical excision with upper marginal mandibulectomy.The aim of the article is to report a clinical case of a rare pathology and, consequently, to help diagnose and better understand its biological behaviour.
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Affiliation(s)
- Ivan Cabo
- Department of Stomatology, Centro Hospitalar e Universitário de Coimbra EPE, Coimbra, Portugal
| | - André Saura
- Department of Stomatology, Centro Hospitalar e Universitário de Coimbra EPE, Coimbra, Portugal
| | - Ana Rita Cardoso
- Department of Stomatology and Maxillofacial Surgery, Instituto Português de Oncologia de Coimbra Francisco Gentil EPE, Coimbra, Portugal
| | - José Azenha Cardoso
- Department of Stomatology and Maxillofacial Surgery, Instituto Português de Oncologia de Coimbra Francisco Gentil EPE, Coimbra, Portugal
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Novembre D, Giofrè E, Barca I, Ferragina F, Cristofaro MG. A rare case of mandibular dentinogenic ghost cell tumor: Histopathological, clinical and surgical management. J Oral Maxillofac Pathol 2021; 25:206. [PMID: 34349449 PMCID: PMC8272492 DOI: 10.4103/jomfp.jomfp_185_20] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/04/2020] [Revised: 11/30/2020] [Accepted: 01/19/2021] [Indexed: 11/09/2022] Open
Abstract
Dentinogenic ghost cell tumor (DGCT) is a rare benign tumorous form of calcifying odontogenic cyst (COC) characterized by the presence of ghost cells but it seems to have more aggressive behavior. It represents 11.5% of COCs. In this work, we report a case of a 60-year-old male patient with DGCT in the posterior region of the right mandible treated with surgical enucleation.
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Affiliation(s)
- Daniela Novembre
- Department of Experimental and Clinical Medicine, Maxillo-Facial Surgery Unit, Magna Graecia University, Catanzaro, Italy
| | - Elio Giofrè
- Department of Experimental and Clinical Medicine, Maxillo-Facial Surgery Unit, Magna Graecia University, Catanzaro, Italy
| | - Ida Barca
- Department of Experimental and Clinical Medicine, Maxillo-Facial Surgery Unit, Magna Graecia University, Catanzaro, Italy
| | - Francesco Ferragina
- Department of Experimental and Clinical Medicine, Maxillo-Facial Surgery Unit, Magna Graecia University, Catanzaro, Italy
| | - Maria Giulia Cristofaro
- Department of Experimental and Clinical Medicine, Maxillo-Facial Surgery Unit, Magna Graecia University, Catanzaro, Italy
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Variations in Aggressive and Indolent Behaviour of Central Dentinogenic Ghost Cell Tumor. Case Rep Dent 2020; 2020:8837507. [PMID: 33224534 PMCID: PMC7673946 DOI: 10.1155/2020/8837507] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/08/2020] [Revised: 10/01/2020] [Accepted: 10/20/2020] [Indexed: 11/17/2022] Open
Abstract
Among the aggressive odontogenic tumors, a few tumors generally ameloblastomas, carry a connotation of being aggressive. But, a rare tumor like central dentinogenic ghost cell tumor (DGCT) can be equally aggressive with a propensity for recurrence. The two cases discussed in this article are divergent in behaviour with features such as presentation, seen in early decades as central intraosseous tumors in the maxilla and mandible. The first case describes an aggressive DGCT, associated with impacted tooth and odontome which showed recurrence into a large solid tumor within a year. The second case arose in accordance with a partially erupted molar which was comparatively innocuous and less aggressive. Both the cases exhibited classic histopathological features. These two unconventional cases of DGCT with a follow-up are being reported here to highlight the variation in behaviour and presentation and also to understand the aggressive nature of the tumor.
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Bali A, Vanhoenacker FM, Vanhoenacker C, Bernaerts A. Imaging of Radiolucent Jaw Lesions. Semin Musculoskelet Radiol 2020; 24:549-557. [PMID: 33036042 DOI: 10.1055/s-0040-1705118] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/22/2022]
Abstract
Radiolucent lesions in the jaw bones comprise a whole spectrum of odontogenic and nonodontogenic lesions. Although the imaging appearance is not always specific, careful radiologic analysis may contribute to characterization of these lesions. A useful approach is to first analyze the absence or presence of a relationship of the lesion to the teeth. The relation may be either near the tooth apex or crown of the tooth. Other lesions may or may not show any specific anatomical location. After analysis of the primary location of the lesion, additional criteria that may help in further imaging characterization are lesion demarcation and morphology, involvement of the cortex and periosteum, and soft tissue changes. This article describes the most characteristic and prevalent radiolucent lesions of the jaws at each location. In routine clinical practice, cone beam computed tomography is sufficient for appropriate lesion characterization, although magnetic resonance imaging may be useful in selected cases.
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Affiliation(s)
- Abdellatif Bali
- Department of Radiology, Antwerp University Hospital, Edegem, Belgium
| | - Filip M Vanhoenacker
- Department of Radiology, Antwerp University Hospital, Edegem, Belgium.,Department of Radiology, AZ Sint-Maarten, Mechelen, Belgium.,Department of Radiology, Ghent University Hospital, Ghent, Belgium
| | | | - Anja Bernaerts
- Department of Radiology, GZA Sint-Augustinus, Antwerp, Belgium
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Vanhoenacker FM, Bosmans F, Vanhoenacker C, Bernaerts A. Imaging of Mixed and Radiopaque Jaw Lesions. Semin Musculoskelet Radiol 2020; 24:558-569. [PMID: 33036043 DOI: 10.1055/s-0039-3402766] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/22/2022]
Abstract
Radiopaque lesions and lesions of mixed density are less frequent than radiolucent lesions of the jawbones. They comprise a spectrum of odontogenic and non-odontogenic lesions. The latter group includes inherited and developmental disorders, osteomyelitis, and benign and malignant primary bone tumors and metastases. Most odontogenic radiopaque or mixed lesions are either related to the apex or more rarely to the crown of the tooth, although there are exceptions to this rule. Some lesions, such as a torus mandibularis and torus palatinus, have a characteristic location, whereas others show no relationship to the dentition. This article describes the most characteristic and prevalent radiopaque and mixed lesions of the jaws and their imaging characteristics. Paget's disease, fibrous dysplasia, and rare sclerotic bone diseases of the maxillofacial bones are discussed elsewhere in this issue. Careful correlation of clinical presentation, panoramic radiographs, cone beam computed tomography, and histopathology are the cornerstones for appropriate lesion characterization.
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Affiliation(s)
- Filip M Vanhoenacker
- Department of Radiology, Antwerp University Hospital, Edegem, Belgium.,Department of Radiology, AZ Sint-Maarten, Mechelen, Belgium.,Department of Radiology, Ghent University Hospital, Ghent, Belgium
| | - Frederik Bosmans
- Department of Radiology, Antwerp University Hospital, Edegem, Belgium.,Department of Radiology, AZ Sint-Maarten, Mechelen, Belgium
| | | | - Anja Bernaerts
- Department of Radiology, GZA Hospitals, Antwerp, Belgium
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Abstract
RATIONALE The dentinogenic ghost cell tumor (DGCT), a locally invasive benign neoplasm, is one of the rarest odontogenic tumors, usually developing in the maxilla or mandible. It can be classified into 2 types: intraosseous (central) and extraosseous (peripheral). Here, we describe the first case of a peripheral DGCT located in the ethmoid sinus. PATIENT CONCERNS An 8-year-old boy presented to our department with a longer than 7-month history of nasal obstruction, purulent secretion, and reduction in sense of smell in the right nasal cavity. DIAGNOSIS The patient was diagnosed with peripheral DGCT of the ethmoid sinus based on computed tomography scan and pathology. INTERVENTIONS Functional endoscopic sinus surgery was performed. OUTCOMES With 2 years of follow-up, there was no evidence of recurrence. LESSONS Peripheral DGCT can occur in the paranasal sinus and the need to consider this entity as a possible diagnosis by the clinicians.
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Affiliation(s)
- Guo Liu
- Department of Otolaryngology-Head and Neck Surgery
| | - Jin-nan Li
- Department of Pathology, West China Hospital of Sichuan University, Chengdu, China
| | - Feng Liu
- Department of Otolaryngology-Head and Neck Surgery
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Patankar SR, Khetan P, Choudhari SK, Suryavanshi H. Dentinogenic ghost cell tumor: A case report. World J Clin Oncol 2019; 10:192-200. [PMID: 31114751 PMCID: PMC6506423 DOI: 10.5306/wjco.v10.i4.192] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/09/2018] [Revised: 03/15/2019] [Accepted: 04/09/2019] [Indexed: 02/06/2023] Open
Abstract
BACKGROUND Dentinogenic ghost cell tumor (DGCT) is an uncommon locally invasive odontogenic neoplasm. It is considered to be a solid variant of calcifying odontogenic cyst (COC). This tumor makes up for only 2%-14% of all COCs and less than 0.5% of all odontogenic tumors which owes to its rarity. The purpose of this paper was to describe a case of DGCT and the treatment adopted in our case, and to provide a review of this case in the indexed literature.
CASE SUMMARY In this article, we discussed a case of 18 year old male who reported with a chief complaint of a recurrent swelling and dull aching pain in upper left back region of the jaw. Computed tomography scan was carried out which revealed hypodense lesion with a few hyperdense flecks within it suggesting the presence of calcification. On incisional biopsy, diagnosis of COC was given. After segmental resection of the lesion, histopathogically odontogenic epithelium was noted along with calcifications, ghost cells and dentinoid material. Special staining was done with van Gieson and it showed pink areas of dentinoid material and yellow colour represented ghost cells. Hence, amalgamation of careful clinical examination, use of advanced radiographic imaging and detailed histopathological examination confirmed the diagnosis of DGCT. The patient was followed up for one year and there was no recurrence of the lesion or signs of any residual tumor.
CONCLUSION Radical treatment should be carried out along with mandatory long-term follow up in order to avoid recurrence in aggressive lesions.
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Affiliation(s)
- Sangeeta R Patankar
- Department of Oral Pathology and Microbiology, Yerala Medical Trust’s Dental College and Hospital, Navi Mumbai 410210, Maharashtra, India
| | - Palak Khetan
- Department of Oral Pathology and Microbiology, Yerala Medical Trust’s Dental College and Hospital, Navi Mumbai 410210, Maharashtra, India
| | - Sheetal K Choudhari
- Department of Oral Pathology and Microbiology, Yerala Medical Trust’s Dental College and Hospital, Navi Mumbai 410210, Maharashtra, India
| | - Harshal Suryavanshi
- Department of Oral and Maxillofacial Surgery, Yerala Medical Trust’s Dental College and Hospital, Navi Mumbai 410210, Maharashtra, India
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Dentinogenic ghost cell tumor - a rare case report. JOURNAL OF STOMATOLOGY, ORAL AND MAXILLOFACIAL SURGERY 2019; 121:186-188. [PMID: 30858131 DOI: 10.1016/j.jormas.2019.02.025] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Received: 10/22/2018] [Revised: 02/23/2019] [Accepted: 02/25/2019] [Indexed: 01/04/2023]
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