• bridge-to-surgery
• colon cancer
• obstruction
• palliative interventional endoscopy
• self-expandable metal stents

• acute colon cancer obstruction
• bridge to surgery
• neoadjuvant chemotherapy
• self‐expanding metallic stent
• survival outcomes

• Humans
• Colonic Neoplasms/complications
• Colonic Neoplasms/mortality
• Colonic Neoplasms/surgery
• Self Expandable Metallic Stents
• Intestinal Obstruction/etiology
• Intestinal Obstruction/therapy
• Intestinal Obstruction/surgery
• Intestinal Obstruction/mortality
• Treatment Outcome
• Survival Rate
• Female
• Male

• 82070685 National Natural Science Foundation of China
• CYDXK202206 Multidisciplinary Clinical Research Innovation Team Project of Beijing Chaoyang Hospital
• PX2019012 Beijing Municipal Administration of Hospitals Incubating Program

• CT scan
• acute colonic obstruction
• antiangiogenic agents
• bridge to surgery
• colorectal cancer
• endoscopic stent
• self-expandable metal stent

The therapy of left-sided malignant colonic obstruction continues to be one of the largest problems in clinical practice. Numerous studies on colonic stenting for neoplastic colonic obstruction have been reported in the last decades. Thereby the role of self-expandable metal stents (SEMS) in the treatment of malignant colonic obstruction has become better defined. However, numerous prospective and retrospective investigations have highlighted serious concerns about a possible worse outcome after endoscopic colorectal stenting as a bridge to surgery, particularly in case of perforation. This review analyzes the most recent evidence in order to highlight pros and cons of SEMS placement in left-sided malignant colonic obstruction.

• Colorectal neoplasm
• Intestinal obstruction
• Endoscopy
• Self expandable metallic stents
• Colorectal surgery
• Chemotherapy

Endoscopic luminal stenting (ELS) represents a minimally invasive option for the management of malignant obstruction along the gastrointestinal tract. Previous studies have shown that ELS can provide rapid relief of symptoms related to esophageal, gastric, small intestinal, colorectal, biliary, and pancreatic neoplastic strictures without compromising cancer patients’ overall safety. As a result, in both palliative and neoadjuvant settings, ELS has largely surpassed radiotherapy and surgery as a first-line treatment modality. Following the abovementioned success, the indications for ELS have gradually expanded. To date, ELS is widely used in clinical practice by well-trained endoscopists in managing a wide variety of diseases and complications, such as relieving non-neoplastic obstructions, sealing iatrogenic and non-iatrogenic perforations, closing fistulae and treating post-sphincterotomy bleeding. The abovementioned development would not have been achieved without corresponding advances and innovations in stent technology. However, the technological landscape changes rapidly, making clinicians’ adaptation to new technologies a real challenge. In our mini-review article, by systematically reviewing the relevant literature, we discuss current developments in ELS with regard to stent design, accessories, techniques, and applications, expanding the research basis that was set by previous studies and highlighting areas that need to be further investigated.

• Endoscopic luminal stenting
• Obstruction
• Stricture
• Stenting
• Leak
• Cancer
• Inflammatory bowel disease
• Bariatric surgery

• Colorectal obstruction
• Complication
• Endoscopy
• Self-expandable metal stent

Approximately 7%-29% of patients with colorectal cancer present with colonic obstruction. The concept of self-expandable metal stent (SEMS) insertion as a bridge to surgery (BTS) is appealing. However, concerns on colonic stenting possibly impairing oncologic outcomes have been raised. This study aimed to review current evidence on the short- and long-term oncologic outcomes of SEMS insertion as BTS for left-sided malignant colonic obstruction. For short-term outcomes, colonic stenting facilitates a laparoscopic approach, increases the likelihood of primary anastomosis without a stoma, and may decrease postoperative morbidity. However, SEMS-related perforation also increases local recurrence and impairs overall survival. Moreover, colonic stenting may cause negative oncologic outcomes even without perforation. SEMS can induce shear forces on the tumor, leading to increased circulating cancer cells and aggressive pathological characteristics, including perineural and lymphovascular invasion. The conflicting evidence has led to discordant guidelines. Well-designed collaborative studies that integrate both oncologic outcomes and data on basic research (e.g., alteration of circulating tumors) are needed to clarify the actual benefit of colonic stenting as BTS.

• Bridge to surgery
• Colon cancer
• Colorectal surgery
• Emergency treatment
• Intestinal obstruction
• Self-expandable metal stent

• MIS-C
• free thyroxine
• thyroid function
• free triiodothyronine

• Gastroenterostomy
• Gastrointestinal tract
• Gastrojejunostomy
• Stenoses
• Stents

• Endoscopy
• Endoscopy, Gastrointestinal
• Enteral Nutrition
• Gastrostomy
• Humans
• Jejunostomy
• Palliative Care

• bevacizumab
• chemotherapy
• malignant large bowel obstruction
• obstructive colorectal cancer
• self-expandable metallic stent

• intestinal obstruction
• other cancer
• supportive care

• Colon cancer
• Colonic obstruction
• Cost-effectiveness
• Palliative surgery
• Stents

Case-based reasoning is a proven method that relies on learned cases from the past for decision support of a new case. The accuracy of such a system depends on the applied similarity measure, which quantifies the similarity between two cases. This work proposes a collection of methods for similarity measures especially for comparison of clinical cases based on survival data, as they are available for example from clinical trials.

Our approach is intended to be used in scenarios, where it is of interest to use longitudinal data, such as survival data, for a case-based reasoning approach. This might be especially important, where uncertainty about the ideal therapy decision exists. The collection of methods consists of definitions of the local similarity of nominal as well as numeric attributes, a calculation of attribute weights, a feature selection method and finally a global similarity measure. All of them use survival time (consisting of survival status and overall survival) as a reference of similarity. As a baseline, we calculate a survival function for each value of any given clinical attribute.

We define the similarity between values of the same attribute by putting the estimated survival functions in relation to each other. Finally, we quantify the similarity by determining the area between corresponding curves of survival functions. The proposed global similarity measure is designed especially for cases from randomized clinical trials or other collections of clinical data with survival information. Overall survival can be considered as an eligible and alternative solution for similarity calculations. It is especially useful, when similarity measures that depend on the classic solution-describing attribute “applied therapy” are not applicable. This is often the case for data from clinical trials containing randomized arms.

In silico evaluation scenarios showed that the mean accuracy of biomarker detection in k = 10 most similar cases is higher (0.909–0.998) than for competing similarity measures, such as Heterogeneous Euclidian-Overlap Metric (0.657–0.831) and Discretized Value Difference Metric (0.535–0.671). The weight calculation method showed a more than six times (6.59–6.95) higher weight for biomarker attributes over non-biomarker attributes. These results suggest that the similarity measure described here is suitable for applications based on survival data.

• Case-based reasoning
• Clinical decision support
• Similarity measure
• Survival data

• Colon
• Colorectal carcinoma
• Computed tomography (CT)
• Magnetic resonance imaging (MRI)
• Stent

There is still controversy on the surgical treatment of obstructive colorectal cancer worldwide. No accurate research has been reported to propose which method is the most suitable for patients with obstructive colorectal cancer. Therefore, comparison of efficacy of intestinal stent and trans-anal ileus catheter combined with laparoscopic surgery and neoadjuvant chemotherapy respectively in patients with obstructive colorectal cancer was carried out to provide reference and guidance for the selection of surgical schemes for patients with obstructive colorectal cancer. In total 89 patients with obstructive colorectal cancer treated in the Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, from February 2016 to March 2017 were selected for retrospective analysis. Forty-nine cases treated with intestinal metal stent implantation combined with laparoscopic surgery and neoadjuvant chemotherapy were the stent group. The other 40 cases treated with trans-anal ileus catheter combined with laparoscopic surgery and neoadjuvant chemotherapy were the catheter group. The intestinal preparation time, surgical duration, intraoperative blood loss, open surgery rate, postoperative exhaust time and adverse reaction rate were compared between the two groups. All the patients were followed up with reexamination at 1 year in hospital to record the local recurrence rate and tumor implantation rate of incision. The intestinal preparation time in the stent group was shorter than that in the catheter group (P<0.001). The surgical duration in the stent group was longer than that in the catheter group (P<0.001). The intraoperative blood loss in the stent group was higher than that in the catheter group (P<0.001). However, there was no significant difference in open surgery rate, postoperative exhaust time, adverse reaction rate, local recurrence rate or incision tumor implantation rate between the two groups (all P>0.05). Therefore, intestinal metal stent implantation can effectively relieve intestinal obstruction, while trans-anal ileus catheter has higher safety in laparoscopic surgery. Their combination with neoadjuvant chemotherapy and laparoscopic surgery for obstructive colorectal cancer has high value and clinical effect. The best treatment plan should be selected according to the patient's condition.

• Tran-sanal ileus catheter
• intestinal obstruction stent
• laparoscopy
• neoadjuvant chemotherapy
• obstructive colorectal cancer

恶性肠梗阻(malignant bowel obstruction, MBO)是晚期肿瘤常见并发症之一, 严重影响患者的生活质量. 恶性肿瘤本身的复杂性导致肠梗阻治疗的复杂性、难治性. 近年来, 随着腹腔镜、内镜技术及介入技术的发展以及对姑息手术适应证的把握, 肠梗阻患者的生存质量及治疗率得以提高, 但尚存在一定争议, 且在药物治疗方面暂无显著进展. 另外, 中医药在该领域亦有较多研究, 显示出一定的效果, 但尚缺乏前瞻性的随机对照研究. 临床处理要充分考虑治疗可能带来的益处及风险, 慎重选择个性化的治疗方案. 本文对国内外近年来MBO的中西医诊疗进展进行系统综述, 以期对临床诊疗具有一定的指导意义.

• 恶性肠梗阻
• 姑息性治疗
• 自扩张金属支架
• 全肠外营养
• 中医药疗法

• Colorectal cancer
• bowel obstruction
• bridge to surgery
• colonoscopy
• emergency surgery
• endoscopy
• palliation
• self-expandable metal stent