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Sun J, Li HL, Zhou WJ, Ma ZX, Huang XP, Li C. Current status and recent progress of nanomaterials in transcatheter arterial chemoembolization therapy for hepatocellular carcinoma. World J Clin Oncol 2025; 16:104435. [PMID: 40290691 PMCID: PMC12019268 DOI: 10.5306/wjco.v16.i4.104435] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/23/2024] [Revised: 02/06/2025] [Accepted: 03/05/2025] [Indexed: 03/26/2025] Open
Abstract
Hepatocellular carcinoma (HCC) remains one of the most common cancers worldwide. Transcatheter arterial chemoembolization has become a common treatment modality for some patients with unresectable advanced HCC. Since the introduction of nanomaterials in 1974, their use in various fields has evolved rapidly. In medical applications, nanomaterials can serve as carriers for the delivery of chemotherapeutic drugs to tumour tissues. Additionally, nanomaterials have potential for in vivo tumour imaging. This article covers the properties and uses of several kinds of nanomaterials, focusing on their use in transcatheter arterial chemoembolization for HCC treatment. This paper also discusses the limitations currently associated with the use of nanomaterials.
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Affiliation(s)
- Jia Sun
- Department of Hepatobiliary Pancreatic Hernia Surgery, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, Guangdong Province, China
| | - Hai-Liang Li
- Department of Hepatobiliary Pancreatic Hernia Surgery, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, Guangdong Province, China
| | - Wen-Jun Zhou
- Department of Hepatobiliary Pancreatic Hernia Surgery, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, Guangdong Province, China
| | - Zeng-Xin Ma
- Department of Hepatobiliary Pancreatic Hernia Surgery, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, Guangdong Province, China
| | - Xiao-Pei Huang
- Department of Hepatobiliary Pancreatic Hernia Surgery, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, Guangdong Province, China
| | - Cheng Li
- Department of Hepatobiliary Pancreatic Hernia Surgery, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, Guangdong Province, China
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Thirumavalavan M, Sukumar K, Sabarimuthu SQ. Trends in green synthesis, pharmaceutical and medical applications of nano ZnO: A review. INORG CHEM COMMUN 2024; 169:113002. [DOI: 10.1016/j.inoche.2024.113002] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/09/2024]
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3
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Praharaj R, Rautray TR. Polymer Composites for Biomedical Applications. ENGINEERING MATERIALS 2024:489-532. [DOI: 10.1007/978-981-97-2075-0_16] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 01/06/2025]
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Lai C, Lin S, Liu W, Jin Y. Research Progress of Chitosan-based Multifunctional Nanoparticles in Cancer Targeted Therapy. Curr Med Chem 2024; 31:3074-3092. [PMID: 37062062 DOI: 10.2174/0929867330666230416153352] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/20/2022] [Revised: 03/01/2023] [Accepted: 03/03/2023] [Indexed: 04/17/2023]
Abstract
Conventional tumor therapeutic modalities, such as radiotherapy, chemotherapy, and surgery, involve low tumor inhibition efficiency, non-targeted drug delivery, and side effects. The development of novel and practical nano-drug delivery systems (DDSs) for targeted tumor therapy has become particularly important. Among various bioactive nanoparticles, chitosan is considered a suitable candidate for drug delivery due to its nontoxicity, good biocompatibility, and biodegradability. The amino and hydroxyl groups of chitosan endow it with the diverse function of chemical modification, thereby improving its physical and biological properties to meet the requirements of advanced biomedical applications. Therefore, it is necessary to review the property and applications of chitosan- based materials in biomedicine. In this review, the characteristics of chitosan related to its applications are first introduced, and then the preparation and modification of chitosan-based nanoparticles, including the function tailoring of chitosan-modified nanoparticles, are demonstrated and discussed. Finally, the opportunities and challenges of chitosan- based nanomaterials in this emerging field are proposed from the perspective of the rational and systematic design for the biomedicine field.
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Affiliation(s)
- Chunmei Lai
- College of Materials Science and Engineering, Fuzhou University, Fuzhou, 350108, China
- College of Chemistry, Fuzhou University, Fuzhou, 350108, China
| | - Simin Lin
- College of Materials Science and Engineering, Fuzhou University, Fuzhou, 350108, China
| | - Wei Liu
- Fujian College Association Instrumental Analysis Center of Fuzhou University, Fuzhou University, Fuzhou, 350108, China
| | - Yanqiao Jin
- College of Materials Science and Engineering, Fuzhou University, Fuzhou, 350108, China
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Raut J, Sarkar O, Das T, Mandal SM, Chattopadhyay A, Sahoo P. Efficient delivery of methotrexate to MDA-MB-231 breast cancer cells by a pH-responsive ZnO nanocarrier. Sci Rep 2023; 13:21899. [PMID: 38081993 PMCID: PMC10713526 DOI: 10.1038/s41598-023-49464-9] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/12/2023] [Accepted: 12/08/2023] [Indexed: 12/18/2023] Open
Abstract
Methotrexate (MTX), an efficient chemotherapy medication is used in treating various malignancies. However, the breast cancer cell line MDA-MB-231 has developed resistance to it due to low levels of the MTX transport protein, and reduced folate carrier (RFC), making it less effective against these cancer cells. Here we designed a very simple, biocompatible, and non-toxic amine-capped ZnO quantum dots to overcome the MTX resistance on the MDA-MB-231 breast cancer cell line. The QD was characterized by HRTEM, DLS EDX, FT-IR, UV-Vis, and Fluorescence spectroscopy. MTX loading onto the QD was confirmed through fluorescence and UV-Vis spectroscopy. Additionally, extensive confocal microscopic investigations were carried out to determine whether the MTX was successfully released on the MDA-MB-231 cell line. It was discovered that QD is a better pH-responsive delivery system than the previous ones because it successfully delivers MTX to the MDA-MB-231 at a higher rate on an acidic pH than it does at a physiological pH. QD also has anticancer activity and can eradicate cancer cells on its own. These factors make the QD to be an effective pH-responsive delivery system that can improve the efficacy of the medication in therapeutic diagnosis.
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Affiliation(s)
- Jiko Raut
- Department of Chemistry, Visva-Bharati University, Santiniketan, 731235, India
| | - Olivia Sarkar
- Department of Zoology, Visva-Bharati University, Santiniketan, 731235, India
| | - Tanmoy Das
- Department of Zoology, Visva-Bharati University, Santiniketan, 731235, India
| | - Santi M Mandal
- Central Research Facility, Indian Institute of Technology Kharagpur, Kharagpur, 721302, India
| | | | - Prithidipa Sahoo
- Department of Chemistry, Visva-Bharati University, Santiniketan, 731235, India.
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Araiza-Campos A, Herrera-Pérez G, Salas-Leiva JS, Chávez-Beltrán de Río M, Aguirre-Hernández A, Luna-Velasco A, Salas-Leiva D, Campos-Chávez E, Tovar-Ramírez D, Romo-Chacón A, Orrantia-Borunda E, Paraguay-Delgado F. Quasi-Diamond Platelet-Shaped Zinc Oxide Nanostructures Display Enhanced Antibacterial Activity. Chembiochem 2023; 24:e202300542. [PMID: 37743259 DOI: 10.1002/cbic.202300542] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/08/2023] [Revised: 09/20/2023] [Accepted: 09/21/2023] [Indexed: 09/26/2023]
Abstract
The current study compares the antibacterial activity of zinc oxide nanostructures (neZnO). For this purpose, two bacterial strains, Escherichia coli (ATCC 4157) and Staphylococcus aureus (ATCC 29213) were challenged in room light conditions with the aforementioned materials. Colloidal and hydrothermal methods were used to obtain the quasi-round and quasi-diamond platelet-shape nanostructures. Thus, the oxygen vacancy (VO ) effects on the surface of neZnO are also considered to assess its effects on antibacterial activity. The neZnO characterization was achieved by X-ray diffraction (XRD), a selected area electron diffraction (SAED) and Raman spectroscopy. The microstructural effects were monitored by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Furthermore, optical absorption ultraviolet visible spectrophotometry (UV-Vis) and X-ray photoelectron spectroscopy (XPS) analyses complement the physical characterization of these nanostructures; neZnO caused 50 % inhibition (IC50 ) at concentrations from 0.064 to 0.072 mg/mL for S. aureus and from 0.083 to 0.104 mg/mL for E. coli, indicating an increase in activity against S. aureus compared to E. coli. Consequently, quasi-diamond platelet-shaped nanostructures (average particle size of 377.6±10 nm) showed enhanced antibacterial activity compared to quasi-round agglomerated particles (average size of 442.8±12 nm), regardless of Vo presence or absence.
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Affiliation(s)
- Aurora Araiza-Campos
- Centro de Investigación en Materiales Avanzados S.C., (CIMAV), Miguel de Cervantes 120. Parque Industrial, 31136, Chihuahua, Mexico
| | - Guillermo Herrera-Pérez
- CONAHCYT, Centro de Investigación en Materiales Avanzados S.C., (CIMAV), Miguel de Cervantes 120. Parque Industrial, 31136, Chihuahua, Mexico
| | - Joan S Salas-Leiva
- CONAHCYT, Centro de Investigación en Materiales Avanzados S.C., (CIMAV), Miguel de Cervantes 120. Parque Industrial, 31136, Chihuahua, Mexico
| | - Margarita Chávez-Beltrán de Río
- Ingeniería en Biotecnología, Instituto Tecnológico y de Estudios Superiores de Monterrey, Av. Heroico Colegio Militar 4700, Nombre de Dios., 31300, Chihuahua, México
| | - Alejandro Aguirre-Hernández
- Ingeniería en Biotecnología, Instituto Tecnológico y de Estudios Superiores de Monterrey, Av. Heroico Colegio Militar 4700, Nombre de Dios., 31300, Chihuahua, México
| | - Antonia Luna-Velasco
- Centro de Investigación en Materiales Avanzados S.C., (CIMAV), Miguel de Cervantes 120. Parque Industrial, 31136, Chihuahua, Mexico
| | - Dayana Salas-Leiva
- Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
| | - Eduardo Campos-Chávez
- Department of Molecular Biosciences, Northwestern University, Evanston, IL, 60208, USA
| | - Dariel Tovar-Ramírez
- Centro de Investigaciones Biológicas del Noroeste (CIBNOR), Instituto Politécnico Nacional s/n, Playa Palo de Santa Rita Sur, 23096, La Paz, B.C.S, Mexico
| | - Alejandro Romo-Chacón
- Centro de Investigación en Alimentación y Desarrollo, A.C., (CIAD) Campus Cuauhtémoc, Chihuahua, Avenida Rio Conchos S/N, Parque Industrial, 31570, Cuauhtémoc, Mexico
| | - Erasmo Orrantia-Borunda
- Centro de Investigación en Materiales Avanzados S.C., (CIMAV), Miguel de Cervantes 120. Parque Industrial, 31136, Chihuahua, Mexico
| | - Francisco Paraguay-Delgado
- Centro de Investigación en Materiales Avanzados S.C., (CIMAV), Miguel de Cervantes 120. Parque Industrial, 31136, Chihuahua, Mexico
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Lustig DR, Buz E, Mulvey JT, Patterson JP, Kittilstved KR, Sambur JB. Characterizing the Ligand Shell Morphology of PEG-Coated ZnO Nanocrystals Using FRET Spectroscopy. J Phys Chem B 2023; 127:8961-8973. [PMID: 37802098 DOI: 10.1021/acs.jpcb.3c04900] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/08/2023]
Abstract
Poly(ethylene glycol) (PEG) ligands can inhibit proteins and other biomolecules from adhering to underlying surfaces, making them excellent surface ligands for nanocrystal (NC)-based drug carriers. Quantifying the PEG ligand shell morphology is important because its structure determines the permeability of biomolecules through the shell to the NC surface. However, few in situ analytical tools can reveal whether the PEG ligands form either an impenetrable barrier or a porous coating surrounding the NC. Here, we present a Förster resonance energy transfer (FRET) spectroscopy-based approach that can assess the permeability of molecules through PEG-coated ZnO NCs. In this approach, ZnO NCs serve as FRET donors, and freely diffusing molecules in the bulk solution are FRET acceptors. We synthesized a series of variable chain length PEG-silane-coated ZnO NCs such that the longest chain length ligands far exceed the Förster radius (R0), where the energy transfer (EnT) efficiency is 50%. We quantified the EnT efficiency as a function of the ligand chain length using time-resolved photoluminescence lifetime (TRPL) spectroscopy within the framework of FRET theory. Unexpectedly, the longest PEG-silane ligand showed equivalent EnT efficiency as that of bare, hydroxyl-passivated ZnO NCs. These results indicate that the "rigid shell" model fails and the PEG ligand shell morphology is more likely porous or in a patchy "mushroom state", consistent with transmission electron microscopy data. While the spectroscopic measurements and data analysis procedures discussed herein cannot directly visualize the ligand shell morphology in real space, the in situ spectroscopy approach can provide researchers with valuable information regarding the permeability of species through the ligand shell under practical biological conditions.
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Affiliation(s)
- Danielle R Lustig
- Department of Chemistry, Colorado State University, 200 West Lake Street, Fort Collins, Colorado 80523-1872, United States
| | - Enes Buz
- Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States
| | - Justin T Mulvey
- Center for Complex and Active Materials, University of California, Irvine, Irvine, California 92697-2025, United States
- Department of Materials Science and Engineering, University of California, Irvine, Irvine, California 92697-2025, United States
| | - Joseph P Patterson
- Center for Complex and Active Materials, University of California, Irvine, Irvine, California 92697-2025, United States
- Department of Chemistry, University of California, Irvine, Irvine, California 92697-2025, United States
- Department of Materials Science and Engineering, University of California, Irvine, Irvine, California 92697-2025, United States
| | - Kevin R Kittilstved
- Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States
| | - Justin B Sambur
- Department of Chemistry, Colorado State University, 200 West Lake Street, Fort Collins, Colorado 80523-1872, United States
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Asif N, Amir M, Fatma T. Recent advances in the synthesis, characterization and biomedical applications of zinc oxide nanoparticles. Bioprocess Biosyst Eng 2023; 46:1377-1398. [PMID: 37294320 PMCID: PMC10251335 DOI: 10.1007/s00449-023-02886-1] [Citation(s) in RCA: 10] [Impact Index Per Article: 5.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/18/2023] [Accepted: 05/23/2023] [Indexed: 06/10/2023]
Abstract
Zinc oxide nanoparticles (ZnONPs) have become the widely used metal oxide nanoparticles and drawn the interest of global researchers due to their biocompatibility, low toxicity, sustainability and cost-effective properties. Due to their unique optical and chemical properties, it emerges as a potential candidate in the fields of optical, electrical, food packaging and biomedical applications. Biological methods using green or natural routes are more environmentally friendly, simple and less use of hazardous techniques than chemical and/or physical methods in the long run. In addition, ZnONPs are less harmful and biodegradable while having the ability to greatly boost pharmacophore bioactivity. They play an important role in cell apoptosis because they enhance the generation of reactive oxygen species (ROS) and release zinc ions (Zn2+), causing cell death. Furthermore, these ZnONPs work well in conjunction with components that aid in wound healing and biosensing to track minute amounts of biomarkers connected to a variety of illnesses. Overall, the present review discusses the synthesis and most recent developments of ZnONPs from green sources including leaves, stems, bark, roots, fruits, flowers, bacteria, fungi, algae and protein, as well as put lights on their biomedical applications such as antimicrobial, antioxidant, antidiabetic, anticancer, anti-inflammatory, antiviral, wound healing, and drug delivery, and modes of action associated. Finally, the future perspectives of biosynthesized ZnONPs in research and biomedical applications are discussed.
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Affiliation(s)
- Nida Asif
- Department of Biosciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India
| | - Mohammad Amir
- Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India
| | - Tasneem Fatma
- Department of Biosciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India.
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Aslam J, Zehra S, Mobin M, Quraishi MA, Verma C, Aslam R. Metal/metal oxide-carbohydrate polymers framework for industrial and biological applications: Current advancements and future directions. Carbohydr Polym 2023; 314:120936. [PMID: 37173012 DOI: 10.1016/j.carbpol.2023.120936] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/08/2023] [Revised: 04/09/2023] [Accepted: 04/17/2023] [Indexed: 05/15/2023]
Abstract
Recently, the development and consumption of metal/metal oxide carbohydrate polymer nanocomposites (M/MOCPNs) are withdrawing significant attention because of their numerous salient features. Metal/metal oxide carbohydrate polymer nanocomposites are being used as environmentally friendly alternatives for traditional metal/metal oxide carbohydrate polymer nanocomposites exhibit variable properties that make them excellent prospects for a variety of biological and industrial uses. In metal/metal oxide carbohydrate polymer nanocomposites, carbohydrate polymers bind with metallic atoms and ions using coordination bonding in which heteroatoms of polar functional groups behave as adsorption centers. Metal/metal oxide carbohydrate polymer nanocomposites are widely used in woundhealing, additional biological uses and drug delivery, heavy ions removal or metal decontamination, and dye removal. The present review article features the collection of some major biological and industrial applications of metal/metal oxide carbohydrate polymer nanocomposites. The binding affinity of carbohydrate polymers with metal atoms and ions in metal/metal oxide carbohydrate polymer nanocomposites has also been described.
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Affiliation(s)
- Jeenat Aslam
- Department of Chemistry, College of Science, Taibah University, Yanbu 30799, Al-Madina, Saudi Arabia.
| | - Saman Zehra
- Corrosion Research Laboratory, Department of Applied Chemistry, Faculty of Engineering and Technology, Aligarh Muslim University, Aligarh 202002, India
| | - Mohammad Mobin
- Corrosion Research Laboratory, Department of Applied Chemistry, Faculty of Engineering and Technology, Aligarh Muslim University, Aligarh 202002, India
| | - M A Quraishi
- Interdisciplinary Research Centre for Advanced Materials, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia
| | - Chandrabhan Verma
- Department of Chemical Engineering, Khalifa University of Science and Technology, P.O. Box 2533, Abu Dhabi, United Arab Emirates.
| | - Ruby Aslam
- Corrosion Research Laboratory, Department of Applied Chemistry, Faculty of Engineering and Technology, Aligarh Muslim University, Aligarh 202002, India
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Fazal T, Murtaza BN, Shah M, Iqbal S, Rehman MU, Jaber F, Dera AA, Awwad NS, Ibrahium HA. Recent developments in natural biopolymer based drug delivery systems. RSC Adv 2023; 13:23087-23121. [PMID: 37529365 PMCID: PMC10388836 DOI: 10.1039/d3ra03369d] [Citation(s) in RCA: 35] [Impact Index Per Article: 17.5] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/20/2023] [Accepted: 07/24/2023] [Indexed: 08/03/2023] Open
Abstract
Targeted delivery of drug molecules to diseased sites is a great challenge in pharmaceutical and biomedical sciences. Fabrication of drug delivery systems (DDS) to target and/or diagnose sick cells is an effective means to achieve good therapeutic results along with a minimal toxicological impact on healthy cells. Biopolymers are becoming an important class of materials owing to their biodegradability, good compatibility, non-toxicity, non-immunogenicity, and long blood circulation time and high drug loading ratio for both macros as well as micro-sized drug molecules. This review summarizes the recent trends in biopolymer-based DDS, forecasting their broad future clinical applications. Cellulose chitosan, starch, silk fibroins, collagen, albumin, gelatin, alginate, agar, proteins and peptides have shown potential applications in DDS. A range of synthetic techniques have been reported to design the DDS and are discussed in the current study which is being successfully employed in ocular, dental, transdermal and intranasal delivery systems. Different formulations of DDS are also overviewed in this review article along with synthesis techniques employed for designing the DDS. The possibility of these biopolymer applications points to a new route for creating unique DDS with enhanced therapeutic qualities for scaling up creative formulations up to the clinical level.
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Affiliation(s)
- Tanzeela Fazal
- Department of Chemistry, Abbottabad University of Science and Technology Pakistan
| | - Bibi Nazia Murtaza
- Department of Zoology, Abbottabad University of Science and Technology Pakistan
| | - Mazloom Shah
- Department of Chemistry, Faculty of Science, Grand Asian University Sialkot Pakistan
| | - Shahid Iqbal
- Department of Chemistry, School of Natural Sciences (SNS), National University of Science and Technology (NUST) H-12 Islamabad 46000 Pakistan
| | - Mujaddad-Ur Rehman
- Department of Microbiology, Abbottabad University of Science & Technology Pakistan
| | - Fadi Jaber
- Department of Biomedical Engineering, Ajman University Ajman UAE
- Center of Medical and Bio-Allied Health Sciences Research, Ajman University Ajman UAE
| | - Ayed A Dera
- Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University Abha Saudi Arabia
| | - Nasser S Awwad
- Chemistry Department, Faculty of Science, King Khalid University P.O. Box 9004 Abha 61413 Saudi Arabia
| | - Hala A Ibrahium
- Biology Department, Faculty of Science, King Khalid University P.O. Box 9004 Abha 61413 Saudi Arabia
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Rai RS, P GJ, Bajpai V, Khan MI, Elboughdiri N, Shanableh A, Luque R. An eco-friendly approach on green synthesis, bio-engineering applications, and future outlook of ZnO nanomaterial: A critical review. ENVIRONMENTAL RESEARCH 2023; 221:114807. [PMID: 36455633 DOI: 10.1016/j.envres.2022.114807] [Citation(s) in RCA: 21] [Impact Index Per Article: 10.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 09/20/2022] [Revised: 11/07/2022] [Accepted: 11/11/2022] [Indexed: 06/17/2023]
Abstract
Synthesizing ZnO nanostructures ranging from 1 nm to 4 nm confines the electron cloud and exhibits a quantum effect generally called as quantum confinement effect attracting many researchers in the field of electronics and optics. ZnO nanostructures are used in medical applications to formulate antioxidant, antibacterial, antifungal, anti-inflammatory, wound healing, and anti-diabetic medications. This work is a comprehensive study of green synthesis of ZnO nanomaterials using different biological sources and highlights different processes able to produce nanostructures including nanowires, nanorods, nanotubes and other nano shapes of ZnO nanostructures. Different properties of ZnO nanostructures and their targeted bioengineering applications are also described. The strategies and challenges of the eco-friendly approach to enhance the application span of ZnO nanomaterials are also summarized, with future prospects for greener design of ZnO nanomaterials are also suggested.
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Affiliation(s)
- Ravi Shankar Rai
- Department of Mechanical Engineering, Indian Institute of Technology (Indian School of Mines), Dhanbad, Jharkhand, India.
| | - Girish J P
- Department of Mechanical Engineering with Specialization in Design and Manufacturing, Indian Institute of Information Technology Design and Manufacturing, Kurnool, A.P, India.
| | - Vivek Bajpai
- Department of Mechanical Engineering, Indian Institute of Technology (Indian School of Mines), Dhanbad, Jharkhand, India
| | - Muhammad Imran Khan
- Research Institute of Sciences and Engineering (RISE), University of Sharjah, Sharjah, 27272, United Arab Emirates.
| | - Noureddine Elboughdiri
- Chemical Engineering Department, College of Engineering, University of Ha'il, Ha'il, 81441, Saudi Arabia; Chemical Engineering Process Department, National School of Engineers Gabes, University of Gabes, Gabes, 6029, Tunisia.
| | - Abdallah Shanableh
- Research Institute of Sciences and Engineering (RISE), University of Sharjah, Sharjah, 27272, United Arab Emirates.
| | - Rafael Luque
- Peoples Friendship University of Russia (RUDN University), 6 Miklukho Maklaya Str., 117198, Moscow, Russian Federation; Universidad ECOTEC, Km 13.5 Samborondón, Samborondón, EC092302, Ecuador
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12
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Misra KP, Misra RDK. ZnO-Based Quantum Dots for Biosensing, Cancer Imaging and Therapy: An Overview. BIOMEDICAL MATERIALS & DEVICES 2023; 1:99-107. [DOI: 10.1007/s44174-022-00033-0] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Received: 06/07/2022] [Accepted: 09/01/2022] [Indexed: 01/04/2025]
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13
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Kadhim MM, Taban TZ, Abdullaha SA, Alnasoud N, Hachim SK, Alomar S. Application of zinc oxide nano-tube as drug-delivery vehicles of anticancer drug. J Mol Model 2023; 29:47. [PMID: 36656400 DOI: 10.1007/s00894-022-05426-y] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/16/2022] [Accepted: 12/16/2022] [Indexed: 01/20/2023]
Abstract
CONTEXT Zinc oxide nano-tube (ZnONT) nano-structures, which possess chemical stability and non-toxicity in the human body, are considered promising for delivering different drugs. Within this work, we scrutinized the drug delivery capability of the ZnONT and its adsorptional properties as a drug delivery vehicle (DDV) for hydroxyurea (HU) as an anti-cancer drug through density functional theory along with the solvent impacts. Based on the optimized structures, it can be suggested that Zn atoms of ZnONT are the ideal sites on this nano-tube for the adsorption of HU. HU had a strong physical adsorption through the O atom of carbonyl groups onto the local pyramidal site of the ZnONT. At 1.96 Å and Ead of -39.28 kcal/mol, in the configuration which was favorable in terms of energy, there was an interaction between the O atoms of -C=O group of the drug and a Zn atom of the ZnONT. In order to scrutinize the excited state properties of the HU-ZnONT complex, we also examined the UV/Vis data of the HU/ZnONT interaction system. Following the adsorption of HU onto the surface of the ZnONT, there was a significant red-shift based on the maximum absorption wavelength, showing that the ZnONT is an ideal candidate for optic sensors in order to detect and monitor the drug molecule. HU could be released in the cancer tissues where pH was low based on the drug release mechanism. The current work thoroughly investigated the mechanism of interaction between the ZnONT and HU, showing that ZnONT can be used for the smart drug delivery of HU. Overall, the findings suggest that ZnONT could be used as an efficient drug-delivery system for the HU drug to treat various types of cancer. METHODS In this work we used B3LYP-gCP-D3 functional and the basis set LANL2DZ on the transition metal (Zn) and the basis set cc-pVDZ on the others. GAMESS software program was employed for performing the calculations. we performed analyses, including charge transport, molecular electrostatic potential surface (MEP), energetic, electronic, natural bond orbitals (NBOs), and structural optimizations.
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Affiliation(s)
- Mustafa M Kadhim
- Medical Laboratory Techniques Department, Al-Farahidi University, Baghdad, 10022, Iraq.
| | - Taleeb Zedan Taban
- Laser and Optoelectronics Engineering Department, Kut University College, Kut, Wasit, 52001, Iraq
| | | | | | - Safa K Hachim
- College of Technical Engineering, The Islamic University, Najaf, Iraq
- Medical Laboratory Techniques Department, Al-Turath University College, Baghdad, Iraq
| | - S Alomar
- Independent Researcher, Baghdad, Iraq
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Aanish Ali M, Rehman N, Park TJ, Basit MA. Antiviral role of nanomaterials: a material scientist's perspective. RSC Adv 2022; 13:47-79. [PMID: 36605642 PMCID: PMC9769549 DOI: 10.1039/d2ra06410c] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/11/2022] [Accepted: 12/09/2022] [Indexed: 12/24/2022] Open
Abstract
The present world continues to face unprecedented challenges caused by the COVID-19 pandemic. Collaboration between researchers of multiple disciplines is the need of the hour. There is a need to develop antiviral agents capable of inhibiting viruses and tailoring existing antiviral drugs for efficient delivery to prevent a surge in deaths caused by viruses globally. Biocompatible systems have been designed using nanotechnological principles which showed appreciable results against a wide range of viruses. Many nanoparticles can act as antiviral therapeutic agents if synthesized by the correct approach. Moreover, nanoparticles can act as carriers of antiviral drugs while overcoming their inherent drawbacks such as low solubility, poor bioavailability, uncontrolled release, and side effects. This review highlights the potential of nanomaterials in antiviral applications by discussing various studies and their results regarding antiviral potential of nanoparticles while also suggesting future directions to researchers.
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Affiliation(s)
- Muhammad Aanish Ali
- Department of Materials Science and Engineering, Institute of Space Technology Islamabad 44000 Pakistan
| | - Nagina Rehman
- Department of Zoology, Government College University Allama Iqbal Road Faisalabad 38000 Pakistan
| | - Tae Joo Park
- Department of Materials Science and Chemical Engineering, Hanyang University Ansan 15588 Republic of Korea
| | - Muhammad Abdul Basit
- Department of Materials Science and Engineering, Institute of Space Technology Islamabad 44000 Pakistan
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15
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J. A, P. A, M. SM, D. PA, Maria Packiam S, Balthazar JD. Preparation and characterization studies of chitosan encapsulated ZnO nanoparticles modified with folic acid and their antibacterial activity against selected bacterial species. PARTICULATE SCIENCE AND TECHNOLOGY 2022. [DOI: 10.1080/02726351.2022.2145587] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 11/22/2022]
Affiliation(s)
- Agnes J.
- Materials Research Centre, Department of Physics, St. Xavier’s College (Autonomous), Palayamkottai, India
- Department of Physics, St. Xavier’s College (Autonomous), Palayamkottai, India
| | - Ajith P.
- Materials Research Centre, Department of Physics, St. Xavier’s College (Autonomous), Palayamkottai, India
| | - Sappani Muthu M.
- Materials Research Centre, Department of Physics, St. Xavier’s College (Autonomous), Palayamkottai, India
| | - Prem Anand D.
- Manonmaniam Sundaranar University, Abishekapatti, India
| | - Soosaimanickam Maria Packiam
- Entomology Research Institute (ERI), Loyola College, Chennai, India
- Department of Advanced Zoology and Biotechnology, Loyola College, Chennai, India
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16
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Li Z, Zhang S, Liu M, Zhong T, Li H, Wang J, Zhao H, Tian Y, Wang H, Wang J, Xu M, Wang S, Zhang X. Antitumor Activity of the Zinc Oxide Nanoparticles Coated with Low-Molecular-Weight Heparin and Doxorubicin Complex In Vitro and In Vivo. Mol Pharm 2022; 19:4179-4190. [PMID: 36223494 DOI: 10.1021/acs.molpharmaceut.2c00553] [Citation(s) in RCA: 7] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/28/2022]
Abstract
Various metal oxide nanomaterials have been widely used as carriers to prepare pH-sensitive nanomedicines to respond to the acidic tumor microenvironment promoting antitumor efficiency. Herein, we used zinc oxide nanoparticles (ZnO NPs) as metal oxide nanomaterial coated with low-molecular-weight heparin (LMHP) and doxorubicin (DOX) complex (LMHP-DOX) to prepare ZnO-LD NPs for controllable pH-triggered DOX release on the targeted site. Our results indicated that the released DOX from ZnO-LD NPs was pH-sensitive. The oxygen produced by ZnO-LD NPs in H2O2 solution was observed in in vitro experiment. The ZnO-LD NPs entered into both PC-3M and 4T1 tumor cells via clathrin-mediated endocytosis and micropinocytosis pathway. The intracellular reactive oxygen species (ROS) generated by ZnO-LD NPs could significantly increase the caspase 3/7 level, leading to tumor cell apoptosis. The in vitro and in vivo antitumor activity was confirmed in PC-3M and 4T1 cell lines or tumor-bearing mice models. The in vivo and in vitro tumor images via second-order nonlinearity of ZnO-LD NPs indicated that ZnO-LD NPs could penetrate deep into the tumor tissues. Therefore, the ZnO-LD NPs developed in our study could provide an efficient approach for the preparation of pH-sensitive nano delivery systems suitable for tumor therapy and imaging.
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Affiliation(s)
- Zhuoyue Li
- Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China.,Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China
| | - Shuang Zhang
- Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China.,Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China
| | - Man Liu
- Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China.,Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China
| | - Ting Zhong
- Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China.,Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China
| | - Hui Li
- Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China.,Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China
| | - Jingru Wang
- Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China.,Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China
| | - Heng Zhao
- Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China.,Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China
| | - Yubo Tian
- Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China.,Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China
| | - Hui Wang
- Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China.,Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China
| | - Jingwen Wang
- Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China.,Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China
| | - Meiqi Xu
- Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China.,Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China
| | - Shumin Wang
- Department of Ultrasound, Peking University Third Hospital, Peking University, Xueyuan Road 38, Beijing 100191, China
| | - Xuan Zhang
- Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China.,Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China
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17
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Al-luhaibi AA, Sendi RK. Synthesis, potential of hydrogen activity, biological and chemical stability of zinc oxide nanoparticle preparation by sol–gel: A review. JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES 2022. [DOI: 10.1016/j.jrras.2022.07.008] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 10/16/2022]
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18
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Sharma P, Hasan MR, Mehto NK, Deepak, Bishoyi A, Narang J. 92 years of zinc oxide: has been studied by the scientific community since the 1930s- An overview. SENSORS INTERNATIONAL 2022. [DOI: 10.1016/j.sintl.2022.100182] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 12/17/2022] Open
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19
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Sarkar S, Debnath SK, Srivastava R, Kulkarni AR. Continuous flow scale-up of biofunctionalized defective ZnO quantum dots: A safer inorganic ingredient for skin UV protection. Acta Biomater 2022; 147:377-390. [PMID: 35609802 DOI: 10.1016/j.actbio.2022.05.032] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/11/2022] [Revised: 05/11/2022] [Accepted: 05/17/2022] [Indexed: 11/01/2022]
Abstract
The versatility of ZnO quantum dots (QDs) exhibiting size-tunable visible photoluminescence has propelled them to the forefront of leading-edge innovations in healthcare. At the nano-bio interface, enhancing the singly-ionized oxygen vacancy defects (VO•) through holistic, sustainable synthesis protocols driven by the synergistic influence of QDs' nucleation-growth kinetics has implications on their bioactivity, physiochemical, and optical performance. Recently, robust continuous flow platforms have transcended the conventional batch reactors by alleviating the concerns of "hot-spot" formation due to inhomogeneous heat distribution, acute energy consumption, poor quality, and yield. However, complexities exist in translating batch chemistries into flow processes. Here, a unique, rationally designed continuous flow synthesis of luminescent defect-engineered ZnO QDs (E-QDs) via helical-reactor assembly that can adequately synthesize on a large scale is reported. The crux of this lies in the amalgamation of "green chemistry" and flow synthesis, which results in Lamer-mechanism mediated monodispersed E-QDs demonstrating high photoluminescence quantum yield (PLQY) of 89% under an accurately regulated synthesis environment. Process intensification corroborated that the bio-stable E-QDs manifested admirable photostability, broad-spectrum UV-shielding (400-250 nm), colloidal stability, in vitro biocompatibility against L929 and HaCaT cells, and antioxidant activity. These attributes were better compared to the commercial ZnO nanoparticles (ZnOC-NPs) used for skin UV protection. Delving deeper, the main drivers for the high density of intrinsic VO• formation (Iv/Io∼42.5) were revealed to be the reactor's hydrodynamic performance and the improvised heating rate (2.5°C/sec). Hence, these E-QDs have potential as a new, safe, and economical multifunctional active ingredient for skin UV protection and antioxidants for treating ROS-mediated disorders. STATEMENT OF SIGNIFICANCE: UV filters exhibiting questionable UV-attenuation efficacy and phototoxicity are significant impediments to the healthcare industry emphasizing skin cancer prevention. Although least explored, VO•-governed aberrant photoactive, biological, and surface-reactive qualities of engineered ZnO QDs (E-QDs) have created ample room to investigate these hallmarks for skin UV protection. However, the bottlenecks in stereotypical ZnO QDs production confined by inefficient process control are annihilated by continuous flow strategies. Herein, the high-throughput continuous flow helical reactor assembly was designed and fabricated to successfully showcase optimized transport properties, reproducibility, yield, and quality E-QDs. Anticipating a skyrocketing demand for E-QDs as bioactive-sunscreen components, the comprehensive investigation has demonstrated unprecedented biofunctionality and ROS-scavenging behaviour, even upon UVR exposure, contrary to the traditional nanoparticulate ZnO UV filters.
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20
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Raha S, Ahmaruzzaman M. ZnO nanostructured materials and their potential applications: progress, challenges and perspectives. NANOSCALE ADVANCES 2022; 4:1868-1925. [PMID: 36133407 PMCID: PMC9419838 DOI: 10.1039/d1na00880c] [Citation(s) in RCA: 139] [Impact Index Per Article: 46.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Subscribe] [Scholar Register] [Received: 12/22/2021] [Accepted: 03/07/2022] [Indexed: 05/22/2023]
Abstract
Extensive research in nanotechnology has been conducted to investigate new behaviours and properties of materials with nanoscale dimensions. ZnO NPs owing to their distinct physical and chemical properties have gained considerable importance and are hence investigated to a detailed degree for exploitation of these properties. This communication, at the outset, elaborates the various chemical methods of preparation of ZnO NPs, viz., the mechanochemical process, controlled precipitation, sol-gel method, vapour transport method, solvothermal and hydrothermal methods, and methods using emulsion and micro-emulsion environments. The paper further describes the green methods employing the use of plant extracts, in particular, for the synthesis of ZnO NPs. The modifications of ZnO with organic (carboxylic acid, silanes) and inorganic (metal oxides) compounds and polymer matrices have then been described. The multitudinous applications of ZnO NPs across a variety of fields such as the rubber industry, pharmaceutical industry, cosmetics, textile industry, opto-electronics and agriculture have been presented. Elaborative narratives on the photocatalytic and a variety of biomedical applications of ZnO have also been included. The ecotoxic impacts of ZnO NPs have additionally been briefly highlighted. Finally, efforts have been made to examine the current challenges and future scope of the synthetic modes and applications of ZnO NPs.
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Affiliation(s)
- Sauvik Raha
- Department of Chemistry, National Institute of Technology Silchar 788010 Assam India
| | - Md Ahmaruzzaman
- Department of Chemistry, National Institute of Technology Silchar 788010 Assam India
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21
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Artunduaga Bonilla JJ, Honorato L, Guimarães AJ, Miranda K, Nimrichter L. Silver Chitosan Nanocomposites are Effective to Combat Sporotrichosis. FRONTIERS IN NANOTECHNOLOGY 2022. [DOI: 10.3389/fnano.2022.857681] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/13/2022] Open
Abstract
The use of silver nanoparticles (AgNPs) embedded in polymeric matrix has acquired special attention as a strategy to reduce metal toxicity without losing its antimicrobial effect. In this work, the green synthesis of AgNPs and their functionalization with chitosan (AgNPs@Chi) was performed, and their antifungal activity investigated against the foremost species responsible for causing sporotrichosis, Sporothrix brasiliensis and Sporothrix schenckii. In vitro studies revealed inhibitory concentrations ranging from 0.12–1 μg/ml for both nanocomposites (NCs). Silver release in suspension displayed chitosan as a potential vehicle for continuous silver discharge, with a complete release after 52 days. No synergistic effects were observed in vitro when the NCs were combined with itraconazole or amphotericin B. Treatment of S. brasiliensis with NCs caused morphological deformities, cell membrane discontinuity and an intense cytoplasmic degeneration. Remarkably, both NCs induced the growth and migration of keratinocytes and fibroblasts when compared to control conditions. In addition, functionalization of AgNPs with chitosan significantly reduced its hemolytic activity, suggesting their potential use in vivo. Finally, silver nanocomposites were used as a daily topical treatment in a murine model of subcutaneous sporotrichosis, showing the ability to reduce the Sporothrix infection and stimulate tissue repair. In combination, our results demonstrate that AgNPs@Chi can be a non-toxic and efficient alternative for sporotrichosis.
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22
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Graphene-tethered 5-fluorouracil-loaded ZnO nanocomposites for pH-responsive enhanced efficacy in drug delivery on MCF-7 cells. Prog Biomater 2022; 11:193-205. [PMID: 35294982 DOI: 10.1007/s40204-022-00184-9] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/27/2021] [Accepted: 02/25/2022] [Indexed: 10/18/2022] Open
Abstract
Graphene-tethered ZnO nanocomposites with rod shapes and oval-shaped 5-fluorouracil-loaded graphene-supported ZnO nanohybrids were synthesized using one pot wet chemical bottom up coprecipitation method. The presence of hexagonal nanophase of ZnO lattice with surface-tethered graphene sheets were confirmed using XRD pattern and supportive UV-Vis and FTIR spectrum. XRD data of these nanocomposites were matched with TEM images which proved the hexagonal ZnO core maintained even after surface tailoring with graphene and drug loading. These porous nanocomposites were loaded with anticancer drug 5-fluorouracil for enhancement in anticancer activity on breast cancer MCF-7 cells. The optical, morphological and phase physicochemical characterizations of the nanohybrids were performed using techniques as UV-Vis, FTIR, XRD spectrometry, and TEM microscopic analysis. The nanocomposites did not only exhibit biocompatibility but also pH responsive in vitro delivery applied for anticancer therapy on the basis of spectrometric MTT assay following sustained drug release with zero-order Peppas release kinetics. These nanocomposites exhibited higher anticancer activity on MCF-7 cells than free drug after in vitro MTT assay. On the basis of these demonstrations, these newer nanocomposites find future biomedical applications in pH-responsive drug delivery.
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23
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Islam F, Shohag S, Uddin MJ, Islam MR, Nafady MH, Akter A, Mitra S, Roy A, Emran TB, Cavalu S. Exploring the Journey of Zinc Oxide Nanoparticles (ZnO-NPs) toward Biomedical Applications. MATERIALS (BASEL, SWITZERLAND) 2022; 15:2160. [PMID: 35329610 PMCID: PMC8951444 DOI: 10.3390/ma15062160] [Citation(s) in RCA: 82] [Impact Index Per Article: 27.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 02/02/2022] [Revised: 02/28/2022] [Accepted: 03/03/2022] [Indexed: 12/24/2022]
Abstract
The field of nanotechnology is concerned with the creation and application of materials having a nanoscale spatial dimensioning. Having a considerable surface area to volume ratio, nanoparticles have particularly unique properties. Several chemical and physical strategies have been used to prepare zinc oxide nanoparticles (ZnO-NPs). Still, biological methods using green or natural routes in various underlying substances (e.g., plant extracts, enzymes, and microorganisms) can be more environmentally friendly and cost-effective than chemical and/or physical methods in the long run. ZnO-NPs are now being studied as antibacterial agents in nanoscale and microscale formulations. The purpose of this study is to analyze the prevalent traditional method of generating ZnO-NPs, as well as its harmful side effects, and how it might be addressed utilizing an eco-friendly green approach. The study's primary focus is on the potential biomedical applications of green synthesized ZnO-NPs. Biocompatibility and biomedical qualities have been improved in green-synthesized ZnO-NPs over their traditionally produced counterparts, making them excellent antibacterial and cancer-fighting drugs. Additionally, these ZnO-NPs are beneficial when combined with the healing processes of wounds and biosensing components to trace small portions of biomarkers linked with various disorders. It has also been discovered that ZnO-NPs can distribute and sense drugs. Green-synthesized ZnO-NPs are compared to traditionally synthesized ones in this review, which shows that they have outstanding potential as a potent biological agent, as well as related hazardous properties.
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Affiliation(s)
- Fahadul Islam
- Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh; (F.I.); (M.R.I.); (A.A.)
| | - Sheikh Shohag
- Department of Biochemistry and Molecular Biology, Faculty of Life Science, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh; (S.S.); (M.J.U.)
| | - Md. Jalal Uddin
- Department of Biochemistry and Molecular Biology, Faculty of Life Science, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh; (S.S.); (M.J.U.)
| | - Md. Rezaul Islam
- Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh; (F.I.); (M.R.I.); (A.A.)
| | - Mohamed H. Nafady
- Faculty of Applied Health Science Technology, Misr University for Science and Technology, Giza 12568, Egypt;
| | - Aklima Akter
- Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh; (F.I.); (M.R.I.); (A.A.)
| | - Saikat Mitra
- Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh;
| | - Arpita Roy
- Department of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida 201310, India;
| | - Talha Bin Emran
- Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh; (F.I.); (M.R.I.); (A.A.)
- Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh
| | - Simona Cavalu
- Faculty of Medicine and Pharmacy, University of Oradea, 400087 Oradea, Romania
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24
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Sugashini S, Gomathi T, Devi RA, Sudha PN, Rambabu K, Banat F. Nanochitosan/carboxymethyl cellulose/TiO 2 biocomposite for visible-light-induced photocatalytic degradation of crystal violet dye. ENVIRONMENTAL RESEARCH 2022; 204:112047. [PMID: 34529967 DOI: 10.1016/j.envres.2021.112047] [Citation(s) in RCA: 25] [Impact Index Per Article: 8.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 05/31/2021] [Revised: 08/22/2021] [Accepted: 08/26/2021] [Indexed: 06/13/2023]
Abstract
Development of novel bionanomaterials for water and wastewater treatment has gained increased attraction and attention in recent times. The present study reports an effective biocomposite-based nano-photocatalyst comprised of nanochitosan (NCS), carboxymethyl cellulose (CMC), and titanium dioxide (TiO2) synthesized by sol-gel technique. The as-prepared NCS/CMC/TiO2 photocatalyst was systematically characterized by X-ray diffraction, Fourier Transform Infrared spectroscopy, Scanning Electron Microscopy with energy dispersive X-beam spectroscopy, Differential scanning calorimetry (DSC), and Thermogravimetric analysis (TGA). Photocatalytic degradation of the crystal violet (CV) dye using this nano photocatalyst was studied by varying the irradiation time, catalyst dosage, feed pH, and initial dye concentration. Further, the kinetic analysis of dye degradation was explored using the Langmuir-Hinshelwood model, and a plausible photocatalytic mechanism was proposed. The modification of TiO2 using NCS and CMC accelerated photocurrent transport by increasing the number of photogenerated electrons and holes. Overall, the study indicated the excellent photocatalytic performance of 95% CV dye degradation by NCS/CMC/TiO2 than the bare inorganic TiO2 photocatalyst under visible light irradiation.
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Affiliation(s)
- S Sugashini
- Biomaterials Research Lab, Department of Chemistry, DKM College for Women (Autonomous), Vellore, India
| | - T Gomathi
- Biomaterials Research Lab, Department of Chemistry, DKM College for Women (Autonomous), Vellore, India
| | - R Aruna Devi
- Biomaterials Research Lab, Department of Chemistry, DKM College for Women (Autonomous), Vellore, India
| | - P N Sudha
- Biomaterials Research Lab, Department of Chemistry, DKM College for Women (Autonomous), Vellore, India.
| | - K Rambabu
- Department of Chemical Engineering, Khalifa University, P.O. Box 127788, Abu Dhabi, United Arab Emirates.
| | - Fawzi Banat
- Department of Chemical Engineering, Khalifa University, P.O. Box 127788, Abu Dhabi, United Arab Emirates
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Gunasangkaran G, Ravi AK, Arumugam VA, Muthukrishnan S. Preparation, Characterization, and Anticancer Efficacy of Chitosan, Chitosan Encapsulated Piperine and Probiotics (Lactobacillus plantarum (MTCC-1407), and Lactobacillus rhamnosus (MTCC-1423) Nanoparticles. BIONANOSCIENCE 2022. [DOI: 10.1007/s12668-022-00961-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/28/2022]
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26
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Liang W, Cheng J, Zhang J, Xiong Q, Jin M, Zhao J. pH-Responsive On-Demand Alkaloids Release from Core-Shell ZnO@ZIF-8 Nanosphere for Synergistic Control of Bacterial Wilt Disease. ACS NANO 2022; 16:2762-2773. [PMID: 35135193 DOI: 10.1021/acsnano.1c09724] [Citation(s) in RCA: 72] [Impact Index Per Article: 24.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 06/14/2023]
Abstract
Developing an effective and safe technology to control severe bacterial diseases in agriculture has attracted significant attention. Here, ZnO nanosphere and ZIF-8 are employed as core and shell, respectively, and then a pH-responsive core-shell nanocarrier (ZnO-Z) was prepared by in situ crystal growth strategy. The bactericide berberine (Ber) was further loaded to form Ber-loaded ZnO-Z (Ber@ZnO-Z) for control of tomato bacterial wilt disease. Results demonstrated that Ber@ZnO-Z could release Ber rapidly in an acidic environment, which corresponded to the pH of the soil where the tomato bacterial wilt disease often outbreak. In vitro experiments showed that the antibacterial activity of Ber@ZnO-Z was about 4.5 times and 1.8 times higher than that of Ber and ZnO-Z, respectively. It was because Ber@ZnO-Z could induce ROS generation, resulting in DNA damage, cytoplasm leakage, and membrane permeability changes so the released Ber without penetrability more easily penetrated the bacteria to achieve an efficient synergistic bactericidal effect with ZnO-Z carriers after combining with DNA. Pot experiments also showed that Ber@ZnO-Z significantly reduced disease severity with a wilt index of 45.8% on day 14 after inoculation, compared to 94.4% for the commercial berberine aqueous solution. More importantly, ZnO-Z carriers did not accumulate in aboveground parts of plants and did not affect plant growth in a short period. This work provides guidance for the effective control of soil-borne bacterial diseases and the development of sustainable agriculture.
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Affiliation(s)
- Wenlong Liang
- Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou 310058, P.R. China
| | - Jingli Cheng
- Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou 310058, P.R. China
| | - Jiadong Zhang
- Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou 310058, P.R. China
| | - Qiuyu Xiong
- Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou 310058, P.R. China
| | - Maojun Jin
- Institute of Quality Standard and Testing Technology for Agro-Products, Key Laboratory of Agro-Product Quality and Safety, Chinese Academy of Agricultural Sciences, Beijing 100081, P.R. China
| | - Jinhao Zhao
- Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou 310058, P.R. China
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27
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Sewid FA, Annas KI, Dubavik A, Veniaminov AV, Maslov VG, Orlova AO. Chitosan nanocomposites with CdSe/ZnS quantum dots and porphyrin. RSC Adv 2021; 12:899-906. [PMID: 35425094 PMCID: PMC8978810 DOI: 10.1039/d1ra08148a] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/06/2021] [Accepted: 12/21/2021] [Indexed: 12/26/2022] Open
Abstract
Water-soluble nanocomposites based on CdSe/ZnS quantum dots (QDs) and hydrophobic tetraphenylporphyrin (TPP) molecules passivated by chitosan (CS) have been formed. Magnetic circular dichroism (MCD) spectra evidence TPP presence in both monomeric and agglomerated forms in the nanocomposites. The nanocomposites demonstrate more pronounced singlet oxygen generation compared to free TPP in CS at the same concentration due to the intracomplex Förster resonance energy transfer (FRET) with a 45% average efficiency.
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Affiliation(s)
- F A Sewid
- ITMO University St. Petersburg 197101 Russia
- Faculty of Science, Mansoura University Egypt
| | - K I Annas
- ITMO University St. Petersburg 197101 Russia
| | - A Dubavik
- ITMO University St. Petersburg 197101 Russia
| | | | - V G Maslov
- ITMO University St. Petersburg 197101 Russia
| | - A O Orlova
- ITMO University St. Petersburg 197101 Russia
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Kumar N, Tyeb S, Verma V. Recent advances on Metal oxide-polymer systems in targeted therapy and diagnosis: Applications and toxicological perspective. J Drug Deliv Sci Technol 2021. [DOI: 10.1016/j.jddst.2021.102814] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/19/2022]
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Demirbolat GM, Altintas L, Yilmaz S, Arsoy T, Sözmen M, Degim IT. Nanodesigning of multifunctional quantum dots and nanoparticles for the treatment of fibrosarcoma. J Microencapsul 2021; 39:210-225. [PMID: 34796787 DOI: 10.1080/02652048.2021.1990423] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/19/2022]
Abstract
AIM An effective, dual drug(DD) loaded nanocarrier system (nano particle(NP), quantum dots(QDs)) having two active substances was aimed to develop for the treatment of fibrosarcoma. METHODS Zinc oxide(ZnO) QDs were produced using zinc acetate dehydrate as a precursor, were incorporated with chitosan(Ch), and finally decorated with PEG-linked folic acid and were found to be effective after imatinib mesylate(IM) and dexketoprofen trometamol(DT) were loaded. Characterizations, invitro drug releases, cell toxicities, penetrations through cell lines and in-vivo animal tests of the prepared nanosystems were performed. RESULTS The size of hybrid nanoparticles were 168.6 ± 48.8nm, surface charge was -35.8 ± 0.26mV. The encapsulation efficiency was 75% for IM and 99% for DT. DD-functionalized QDChNPs and lyophilized functionalized QDChNPs in capsules slowed down tumor growth by up to 76.5 % and 88.7 %. CONCLUSIONS Our results demonstrate that developed hybrid nanoparticles are highly effective. This hybrid system gathers many of the advantages of nanotechnology into one form.
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Affiliation(s)
- Gulen Melike Demirbolat
- Department of Pharmaceutical Technology, Biruni University Faculty of Pharmacy, 34010, Topkapi, Istanbul, Turkey.,Department of Pharmaceutical Technology, Gazi University Faculty of Pharmacy, 06330, Yenimahalle, Ankara, Turkey
| | - Levent Altintas
- Department of Pharmacology and Toxicology, Ankara University Faculty of Veterinary Medicine, 06110, Ankara, Turkey
| | - Sukran Yilmaz
- Food and Mouth Diseases Institute, 06520, Ankara, Turkey
| | - Taibe Arsoy
- Food and Mouth Diseases Institute, 06520, Ankara, Turkey
| | - Mahmut Sözmen
- Department of Preclinical Sciences, Ondokuz Mayıs University Faculty of Veterinary, Samsun, Turkey
| | - Ismail Tuncer Degim
- Department of Pharmaceutical Technology, Biruni University Faculty of Pharmacy, 34010, Topkapi, Istanbul, Turkey.,Department of Pharmaceutical Technology, Gazi University Faculty of Pharmacy, 06330, Yenimahalle, Ankara, Turkey
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Hematian H, Ukraintsev E, Rezek B. Strong Structural and Electronic Binding of Bovine Serum Albumin to ZnO via Specific Amino Acid Residues and Zinc Atoms. Chemphyschem 2021; 23:e202100639. [PMID: 34755930 DOI: 10.1002/cphc.202100639] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/01/2021] [Revised: 10/24/2021] [Indexed: 11/08/2022]
Abstract
ZnO biointerfaces with serum albumin have attracted noticeable attention due to the increasing interest in developing ZnO-based materials for biomedical applications. ZnO surface morphology and chemistry are expected to play a critical role on the structural, optical, and electronic properties of albumin-ZnO complexes. Yet there are still large gaps in the understanding of these biological interfaces. Herein we comprehensively elucidate the interactions at such interfaces by using atomic force microscopy and nanoshaving experiments to determine roughness, thickness, and adhesion properties of BSA layers adsorbed on the most typical polar and non-polar ZnO single-crystal facets. These experiments are corroborated by force field (FF) and density-functional tight-binding (DFTB) calculations on ZnO-BSA interfaces. We show that BSA adsorbs on all the studied ZnO surfaces while interactions of BSA with ZnO are found to be considerably affected by the atomic surface structure of ZnO. BSA layers on the ( 000 1 ‾ ) surface have the highest roughness and thickness, hinting at a specific upright BSA arrangement. BSA layers on ( 10 1 ‾ 0 ) surface have the strongest binding, which is well correlated with DFTB simulations showing atomic rearrangement and bonding between specific amino acids (AAs) and ZnO. Besides the structural properties, the ZnO interaction with these AAs also controls the charge transfer and HOMO-LUMO energy positions in the BSA-ZnO complexes. This ZnO facet-specific protein binding and related structural and electronic effects can be useful for improving the design and functionality of ZnO-based materials and devices.
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Affiliation(s)
- Hadi Hematian
- Department of Physics, Faculty of Electrical Engineering, CTU in Prague, Technická 2, 166 27, Prague 6, Czech Republic
| | - Egor Ukraintsev
- Institute of Physics, Czech Academy of Sciences, Cukrovarnická 10, 162 00, Prague 6, Czech Republic
| | - Bohuslav Rezek
- Department of Physics, Faculty of Electrical Engineering, CTU in Prague, Technická 2, 166 27, Prague 6, Czech Republic
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Yadav KK, Ojha M, Pariary R, Arakha M, Bhunia A, Jha S. Zinc oxide nanoparticle interface moderation with tyrosine and tryptophan reverses the pro-amyloidogenic property of the particle. Biochimie 2021; 193:64-77. [PMID: 34699915 DOI: 10.1016/j.biochi.2021.10.011] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/09/2021] [Revised: 09/23/2021] [Accepted: 10/19/2021] [Indexed: 11/28/2022]
Abstract
Zinc oxide nanoparticle with negative surface potential (ZnONP) enhances bovine insulin fibrillation. Here, we are exploring ZnONP with positive surface potential (ZnONPUnc) and surface functionalized with tyrosine and tryptophan amino acids to observe the effects of surface potential and surface functional groups on the fibrillation. ZnONPUnc, despite of inversed surface potential, enhances the insulin fibrillation with increase in the interface concentration at physiological pH. Whereas, the interface moderation with the amino acids mitigates the surface-mediated insulin fibrillation propensity. Additionally, the study indicates that the change in interfacial functional groups at ZnONPUnc significantly reverses the interface-mediated destabilization of insulin conformation. The functional groups from the amino acids, like CO, N-H and aromatic functional groups, are anticipated to further stabilize the insulin conformation by forming hydrogen bond and van der Waals interactions with the key amyloidogenic sequences of insulin, A13-A20 from A-chain and B9-B20 from B-chain. Hence, the altered interaction profile, with change in interfacial functional groups, mitigates the interface-mediated insulin fibrillation and the ZnONPUnc-/fibril-mediated cytotoxicity.
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Affiliation(s)
- Kanti Kusum Yadav
- Department of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela, Odisha, 769008, India; Department of Biotechnology, School of Agriculture and Biosciences, Karunya Institute of Technology and Sciences, Coimbatore, Tamil Nadu, 641114, India
| | - Monalisha Ojha
- Department of Life Science, National Institute of Technology, Rourkela, Odisha, 769008, India
| | - Ranit Pariary
- Department of Biophysics, Bose Institute, Kolkata, West Bengal, 700054, India
| | - Manoranjan Arakha
- Centre for Biotechnology, Siksha 'O' Anusandhan, Bhubaneswar, Odisha, 751003, India
| | - Anirban Bhunia
- Department of Biophysics, Bose Institute, Kolkata, West Bengal, 700054, India
| | - Suman Jha
- Department of Life Science, National Institute of Technology, Rourkela, Odisha, 769008, India.
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Artunduaga Bonilla JJ, Honorato L, Cordeiro de Oliveira DF, Araújo Gonçalves R, Guimarães A, Miranda K, Nimrichter L. Silver chitosan nanocomposites as a potential treatment for superficial candidiasis. Med Mycol 2021; 59:993-1005. [PMID: 34036352 DOI: 10.1093/mmy/myab028] [Citation(s) in RCA: 14] [Impact Index Per Article: 3.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/10/2021] [Revised: 04/14/2021] [Accepted: 04/29/2021] [Indexed: 11/14/2022] Open
Abstract
Silver compounds are widely known for their antimicrobial activity, but can exert toxic effects to the host. Among the strategies to reduce its toxicity, incorporation into biopolymers has shown promising results. We investigated the green syntheses of silver nanoparticles (AgNPs) and their functionalization in a chitosan matrix (AgNPs@Chi) as a potential treatment against Candida spp. Inhibitory concentrations ranging between 0.06 and 1 μg/ml were observed against distinct Candida species. Nanocomposite-treated cells displayed cytoplasmic degeneration and a cell membrane and wall disruption. Silver nanocomposites in combination with fluconazole and amphotericin B showed an additive effect when analyzed by the Bliss method. The low cytotoxicity displayed in mammalian cells and in the Galleria mellonella larvae suggested their potential use in vivo. When tested as a topical treatment against murine cutaneous candidiasis, silver nanocomposites reduced the skin fungal burden in a dose-response behavior and favored tissue repair. In addition, the anti-biofilm effect of AgNPs@Chi in human nail model was demonstrated, suggesting that the polymeric formulation of AgNPs does not affect antifungal activity even against sessile cells. Our results suggest that AgNPs@Chi seems to be a less toxic and effective topical treatment for superficial candidiasis. LAY SUMMARY This study demonstrated the efficacy of silver nanoparticles (AgNPs) in inhibiting the growth of Candida. AgNPs incorporated in chitosan displayed a reduced toxicity. Tests in infected mice showed the effectiveness of the treatment. AgNPs-chitosan could be an alternative to combat candidiasis.
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Affiliation(s)
- Jhon Jhamilton Artunduaga Bonilla
- Laboratório de Glicobiología de Eucariotos (LaGE), Depto. Microbiologia Geral, Instituto de Microbiologia Paulo de Góes (IMPG), Universidade Federal do Rio de Janeiro, 21941-590, Rio de Janeiro, Brazil
| | - Leandro Honorato
- Laboratório de Glicobiología de Eucariotos (LaGE), Depto. Microbiologia Geral, Instituto de Microbiologia Paulo de Góes (IMPG), Universidade Federal do Rio de Janeiro, 21941-590, Rio de Janeiro, Brazil
| | | | - Rodrigo Araújo Gonçalves
- Depto de Química, Pontifícia Universidade Católica do Rio de Janeiro, 22451-900, Rio de Janeiro, Brazil
| | - Allan Guimarães
- Laboratório de Bioquímica e Imunologia das Micoses, Depto de Microbiologia e Parasitologia, Universidade Federal Fluminense, Niterói, 24220-900, Brazil
| | - Kildare Miranda
- Laboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filho and Centro Nacional de Biologia Estrutural e Bioimagem, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-590, Brazil
| | - Leonardo Nimrichter
- Laboratório de Glicobiología de Eucariotos (LaGE), Depto. Microbiologia Geral, Instituto de Microbiologia Paulo de Góes (IMPG), Universidade Federal do Rio de Janeiro, 21941-590, Rio de Janeiro, Brazil
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Rostami M, Nasab AS, Fasihi-Ramandi M, Badiei A, Ganjali MR, Rahimi-Nasrabadi M, Ahmadi F. Cur-loaded magnetic ZnFe2O4@mZnO-Ox-p-g-C3N4 composites as dual pH- and ultrasound responsive nano-carriers for controlled and targeted cancer chemotherapy. MATERIALS CHEMISTRY AND PHYSICS 2021; 271:124863. [DOI: 10.1016/j.matchemphys.2021.124863] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 06/19/2023]
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Anjum S, Hashim M, Malik SA, Khan M, Lorenzo JM, Abbasi BH, Hano C. Recent Advances in Zinc Oxide Nanoparticles (ZnO NPs) for Cancer Diagnosis, Target Drug Delivery, and Treatment. Cancers (Basel) 2021; 13:4570. [PMID: 34572797 PMCID: PMC8468934 DOI: 10.3390/cancers13184570] [Citation(s) in RCA: 157] [Impact Index Per Article: 39.3] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/20/2021] [Revised: 09/09/2021] [Accepted: 09/10/2021] [Indexed: 12/24/2022] Open
Abstract
Cancer is regarded as one of the most deadly and mirthless diseases and it develops due to the uncontrolled proliferation of cells. To date, varieties of traditional medications and chemotherapies have been utilized to fight tumors. However, their immense drawbacks, such as reduced bioavailability, insufficient supply, and significant adverse effects, make their use limited. Nanotechnology has evolved rapidly in recent years and offers a wide spectrum of applications in the healthcare sectors. Nanoscale materials offer strong potential for curing cancer as they pose low risk and fewer complications. Several metal oxide NPs are being developed to diagnose or treat malignancies, but zinc oxide nanoparticles (ZnO NPs) have remarkably demonstrated their potential in the diagnosis and treatment of various types of cancers due to their biocompatibility, biodegradability, and unique physico-chemical attributes. ZnO NPs showed cancer cell specific toxicity via generation of reactive oxygen species and destruction of mitochondrial membrane potential, which leads to the activation of caspase cascades followed by apoptosis of cancerous cells. ZnO NPs have also been used as an effective carrier for targeted and sustained delivery of various plant bioactive and chemotherapeutic anticancerous drugs into tumor cells. In this review, at first we have discussed the role of ZnO NPs in diagnosis and bio-imaging of cancer cells. Secondly, we have extensively reviewed the capability of ZnO NPs as carriers of anticancerous drugs for targeted drug delivery into tumor cells, with a special focus on surface functionalization, drug-loading mechanism, and stimuli-responsive controlled release of drugs. Finally, we have critically discussed the anticancerous activity of ZnO NPs on different types of cancers along with their mode of actions. Furthermore, this review also highlights the limitations and future prospects of ZnO NPs in cancer theranostic.
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Affiliation(s)
- Sumaira Anjum
- Department of Biotechnology, Kinnaird College for Women, Jail Road, Lahore 54000, Pakistan; (M.H.); (S.A.M.); (M.K.)
| | - Mariam Hashim
- Department of Biotechnology, Kinnaird College for Women, Jail Road, Lahore 54000, Pakistan; (M.H.); (S.A.M.); (M.K.)
| | - Sara Asad Malik
- Department of Biotechnology, Kinnaird College for Women, Jail Road, Lahore 54000, Pakistan; (M.H.); (S.A.M.); (M.K.)
| | - Maha Khan
- Department of Biotechnology, Kinnaird College for Women, Jail Road, Lahore 54000, Pakistan; (M.H.); (S.A.M.); (M.K.)
| | - José M. Lorenzo
- Centro Tecnológico de la Carne de Galicia, Avenida de Galicia 4, Parque Tecnológico de Galicia, 32900 San Cibrao das Viñas, Ourense, Spain;
- Área de Tecnología de los Alimentos, Facultad de Ciencias de Ourense, Universidad de Vigo, 32004 Ourense, Spain
| | - Bilal Haider Abbasi
- Department of Biotechnology, Quaid-i-Azam University, Islamabad 15320, Pakistan;
| | - Christophe Hano
- Laboratoire de Biologie des Ligneux et des Grandes Cultures, INRAE USC1328, Eure & Loir Campus, University of Orleans, 28000 Chartres, France;
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Gour A, Ramteke S, Jain NK. Pharmaceutical Applications of Quantum Dots. AAPS PharmSciTech 2021; 22:233. [PMID: 34476619 DOI: 10.1208/s12249-021-02103-w] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/02/2020] [Accepted: 07/20/2021] [Indexed: 12/12/2022] Open
Abstract
Nanotechnology has been utilized in developing novel drug formulations with minimal adverse effects. Nanoparticles in a lower size range with great surface area, increased potency, and easy permeability could be an approach for the treatment of cancer and other diseases. Unlike other nanoparticles, quantum dots have specific functional groups, have charges over their surface, and are extremely small in size (2-10nm), which makes them more permeable through tight junctions. Quantum dots are interesting materials that offer diagnosis and treatment concurrently. Quantum dots are reported to have several applications in pharmaceuticals as well as drug delivery, diagnosis, immunolabeling, and cell labeling tools. However, the existence of heavy metals in quantum dots such as cadmium poses a potential challenge for future medical applications, where quantum dots may be deliberately injected into the body. In this review, we are focusing on various pharmaceutical applications of quantum dots. Graphical Abstract.
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Vijayakumar S, González-Sánchez ZI, Malaikozhundan B, Saravanakumar K, Divya M, Vaseeharan B, Durán-Lara EF, Wang MH. Biogenic Synthesis of Rod Shaped ZnO Nanoparticles Using Red Paprika (Capsicum annuum L. var. grossum (L.) Sendt) and Their in Vitro Evaluation. J CLUST SCI 2021. [DOI: 10.1007/s10876-020-01870-z] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/19/2023]
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Arab-Bafrani Z, Zabihi E, Jafari SM, Khoshbin-Khoshnazar A, Mousavi E, Khalili M, Babaei A. Enhanced radiotherapy efficacy of breast cancer multi cellular tumor spheroids through in-situ fabricated chitosan-zinc oxide bio-nanocomposites as radio-sensitizing agents. Int J Pharm 2021; 605:120828. [PMID: 34174360 DOI: 10.1016/j.ijpharm.2021.120828] [Citation(s) in RCA: 9] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/28/2021] [Revised: 06/19/2021] [Accepted: 06/21/2021] [Indexed: 01/06/2023]
Abstract
Overwhelming evidence has shown that three-dimensional multicellular tumor spheroids (MCTSs) as a mimic of in-vivo tumor can accurately exhibit cellular responses to treatments. So, we compared the capability of pure zinc oxide nanoparticles (ZnO-NPs) and chitosan-ZnO bio-nanocomposites (CS-ZnO BNCs) for enhancing the radiosensitization of MDA-MB-231 breast cancer cells (BCCs) in the 3D-MCTSs model. ZnO-NPs and CS-ZnO BNCs were synthesized by a facile co-precipitation method. FE-SEM images revealed that the uniform spherical ZnO-NPs with an average diameter of 35 nm were successfully dispersed on chitosan. MDA-MB-231 MCTSs which were formed in a non-adherent culture plate, possessed functional features of in-vivo tumor. The priority of such culture method to conventionally used 2D monolayer (or parental) cell culture is the mimicking of tumor microenvironment. The toxicity of CS-ZnO BNCs and ZnO-NPs against the MDA-M-231 BCCs was evaluated using MTT-colorimetric assay, which demonstrated superior biocompatibility of CS-ZnO BNCs compared to pure ZnO-NPs (even at high concentration of 100 μg/mL). Survival fraction analysis of cells under clinical X-ray irradiation (6 MV) showed that MCTSs had a higher radioresistance compared to parental cells. Besides, the clonogenic potential of irradiated MCTSs was significantly decreased by the addition of CS-ZnO BNCs similar to that of monolayer cells. The sensitivity enhancement ratios (SER) for MCTSs and monolayer cells were calculated 1.5 and 1.63, respectively. Further, tracking of radiobiological properties and apoptosis induction of MCTSs showed that CS-ZnO BNCs not only could lead to the creation of higher radiation-induced complex DNA break and apoptosis death in MCTSs, but also weakened DNA repair mechanisms. It was found that non-toxic concentration of CS-ZnO BNCs has promising potential to enhance radiosensitivity of resistant-MCTSs as a superior in-vitro tumor model. So, CS-ZnO BNCs can be a prominent candidate for overcoming the resistance of BCCs to radiotherapy.
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Affiliation(s)
- Zahra Arab-Bafrani
- Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran; Department of Biochemistry and Biophysics, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
| | - Erfan Zabihi
- Cancer Research Center, Golestan University of Medical Sciences, Gorgan, Iran; Department of Polymer Engineering, Faculty of Engineering, Golestan University, Gorgan, Iran
| | - Seid Mahdi Jafari
- Cancer Research Center, Golestan University of Medical Sciences, Gorgan, Iran; Faculty of Food Science and Technology, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.
| | - Alireza Khoshbin-Khoshnazar
- Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran; Department of Biochemistry and Biophysics, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
| | - Elham Mousavi
- Medical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences, Kerman, Iran; Department of Microbiology and Virology, School of Medicine, Kerman University of Medical Sciences. Kerman, Iran
| | - Mohsen Khalili
- Medical Cellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran
| | - Amir Babaei
- Department of Polymer Engineering, Faculty of Engineering, Golestan University, Gorgan, Iran
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Andleeb A, Andleeb A, Asghar S, Zaman G, Tariq M, Mehmood A, Nadeem M, Hano C, Lorenzo JM, Abbasi BH. A Systematic Review of Biosynthesized Metallic Nanoparticles as a Promising Anti-Cancer-Strategy. Cancers (Basel) 2021; 13:cancers13112818. [PMID: 34198769 PMCID: PMC8201057 DOI: 10.3390/cancers13112818] [Citation(s) in RCA: 65] [Impact Index Per Article: 16.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/09/2021] [Revised: 05/29/2021] [Accepted: 05/30/2021] [Indexed: 12/24/2022] Open
Abstract
Cancer is one of the foremost causes of death worldwide. Cancer develops because of mutation in genes that regulate normal cell cycle and cell division, thereby resulting in uncontrolled division and proliferation of cells. Various drugs have been used to treat cancer thus far; however, conventional chemotherapeutic drugs have lower bioavailability, rapid renal clearance, unequal delivery, and severe side effects. In the recent years, nanotechnology has flourished rapidly and has a multitude of applications in the biomedical field. Bio-mediated nanoparticles (NPs) are cost effective, safe, and biocompatible and have got substantial attention from researchers around the globe. Due to their safe profile and fewer side effects, these nanoscale materials offer a promising cure for cancer. Currently, various metallic NPs have been designed to cure or diagnose cancer; among these, silver (Ag), gold (Au), zinc (Zn) and copper (Cu) are the leading anti-cancer NPs. The anticancer potential of these NPs is attributed to the production of reactive oxygen species (ROS) in cellular compartments that eventually leads to activation of autophagic, apoptotic and necrotic death pathways. In this review, we summarized the recent advancements in the biosynthesis of Ag, Au, Zn and Cu NPs with emphasis on their mechanism of action. Moreover, nanotoxicity, as well as the future prospects and opportunities of nano-therapeutics, are also highlighted.
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Affiliation(s)
- Anisa Andleeb
- Plant Cell and Tissue Culture Lab, Department of Biotechnology, Quaid-i-Azam University, Islamabad 45320, Pakistan; (A.A.); (G.Z.)
| | - Aneeta Andleeb
- Proteomics Lab, School of Biochemistry & Biotechnology, University of the Punjab, Lahore 54590, Pakistan;
| | - Salman Asghar
- Media and Production Group, Centre for Media and Communication Studies, University of Gujrat, Gujrat 50700, Pakistan;
| | - Gouhar Zaman
- Plant Cell and Tissue Culture Lab, Department of Biotechnology, Quaid-i-Azam University, Islamabad 45320, Pakistan; (A.A.); (G.Z.)
| | - Muhammad Tariq
- Nanobiotechnology Group, Department of Biotechnology, Mirpur University of Science and Technology, Mirpur 10250, Pakistan;
| | - Azra Mehmood
- Stem Cell & Regenerative Medicine Lab, National Centre of Excellence in Molecular Biology, University of Punjab, 87-West Canal Bank Road, Lahore 53700, Pakistan;
| | - Muhammad Nadeem
- Department of Biotechnology, Institute of Integrative Biosciences, Peshawar 25100, Pakistan;
| | - Christophe Hano
- Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC), INRA USC1328 Université ď Orléans, CEDEX 2, 45067 Orléans, France;
| | - Jose M. Lorenzo
- Centro Tecnológico de la Carne de Galicia, Avd. Galicia no 4, Parque Tecnológico de Galicia, San Cibrao das Viñas, 32900 Ourense, Spain;
- Área de Tecnología de los Alimentos, Facultad de Ciencias de Ourense, Universidad de Vigo, 32004 Ourense, Spain
| | - Bilal Haider Abbasi
- Plant Cell and Tissue Culture Lab, Department of Biotechnology, Quaid-i-Azam University, Islamabad 45320, Pakistan; (A.A.); (G.Z.)
- Correspondence: ; Tel./Fax: +92-51-9064-4121
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Nawrot KC, Zareba JK, Toporkiewicz M, Chodaczek G, Wawrzynczyk D, Kulbacka J, Bazylinska U, Nyk M. Polymeric Nanocarriers with Luminescent Colloidal Nanoplatelets as Hydrophilic and Non-Toxic Two-Photon Bioimaging Agents. Int J Nanomedicine 2021; 16:3649-3660. [PMID: 34079255 PMCID: PMC8166280 DOI: 10.2147/ijn.s298300] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/20/2020] [Accepted: 03/12/2021] [Indexed: 11/23/2022] Open
Abstract
Introduction Semiconductor nanoplatelets (NPLs) are promising materials for nonlinear optical microscopy since they feature good two-photon absorption (TPA) properties, narrow photoluminescence spectra and high quantum yields of luminescence. Nevertheless, the use of semiconductor NPLs is inevitably connected with concerns about heavy metal ion toxicity and their intrinsically hydrophobic character. Methods Our contribution focuses on the design and engineering of coloidal bionanomaterial consisting of two-dimensional highly luminescent CdSe semiconductor NPLs loaded into spherical and homogeneous polymeric nanocarriers (NCs) based on poly(ethylene oxide) and poly(propylene oxide) block co-polymer. The biocompatibility and usefulness of the NPLs-loaded polymeric NCs in two-photon induced bioimaging was demonstrated invitroby cytotoxicity and two-photon microscopic studies using eukaryotic (normal fibroblasts and cancer ovarian) cells. Results The encapsulated NPLs maintain their intensive and spectrally narrow photoluminescence, as well as preserve good TPA properties, while the surrounding polymer shell imparts hydrophilic character and non-toxicity towards eukaryotic cells. Specifically, TPA cross-sections of the colloidal NCs loaded with NPLs show large values reaching up to 2.0 × 108 GM, with simultaneously two-photon brightness reaching 2.2 × 107 GM at 870 nm. MTT proliferation assay performed on cell lines treated with encapsulated NPLs revealed at least 70% viability of normal human gingival fibroblast (HGF) and cancer ovarian (MDAH-2774) cells, while the results of multiphoton imaging of murine (L-929) fibroblasts suggest that the encapsulated NPLs are capable of labelling the target cells enabling their visualization. Conclusion As a result, we obtained water dispersible and temporally stable hydrophilic NPLs-loaded NCs that offer excellent, both one- and two-photon excited fluorescence preserving optical properties of the raw hydrophobic and colloidal NPLs. The biological responses upon eukaryotic cells indicate that the encapsulation process protects cells from the toxic influence of cadmium simultaneously preserving the unique multiphoton properties of the active cargo which opens a promising perspective for its application in multiphoton cancer bioimaging excited at the “optical transmission window” of biological tissues in near-infrared range.
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Affiliation(s)
- Katarzyna Celina Nawrot
- Advanced Materials Engineering and Modelling Group, Faculty of Chemistry, Wroclaw University of Science and Technology, Wroclaw, 50-370, Poland
| | - Jan Kazimierz Zareba
- Advanced Materials Engineering and Modelling Group, Faculty of Chemistry, Wroclaw University of Science and Technology, Wroclaw, 50-370, Poland
| | - Monika Toporkiewicz
- Łukasiewicz Research Network - PORT Polish Center for Technology Development, Wroclaw, 54-066, Poland
| | - Grzegorz Chodaczek
- Łukasiewicz Research Network - PORT Polish Center for Technology Development, Wroclaw, 54-066, Poland
| | - Dominika Wawrzynczyk
- Advanced Materials Engineering and Modelling Group, Faculty of Chemistry, Wroclaw University of Science and Technology, Wroclaw, 50-370, Poland
| | - Julita Kulbacka
- Department of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, 50-556, Poland
| | - Urszula Bazylinska
- Department of Physical and Quantum Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wroclaw, 50-370, Poland
| | - Marcin Nyk
- Advanced Materials Engineering and Modelling Group, Faculty of Chemistry, Wroclaw University of Science and Technology, Wroclaw, 50-370, Poland
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Lim MJ, Shahri NNM, Taha H, Mahadi AH, Kusrini E, Lim JW, Usman A. Biocompatible chitin-encapsulated CdS quantum dots: Fabrication and antibacterial screening. Carbohydr Polym 2021; 260:117806. [PMID: 33712152 DOI: 10.1016/j.carbpol.2021.117806] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/21/2020] [Revised: 01/27/2021] [Accepted: 02/08/2021] [Indexed: 10/22/2022]
Abstract
Chitin-encapsulated cadmium sulfide quantum dots (CdS@CTN QDs) were successfully synthesized from chitin and Cd(NO3)2 precursor using the colloidal chemistry method, toward the development of biocompatible and biodegradable QDs for biomedical applications. CdS@CTN QDs exhibited the nanocrystalline cubic CdS encapsulated by α-chitin. The average particle size of CdS@CTN QDs was estimated using empirical Henglein model to be 3.9 nm, while their crystallite size was predicted using Scherrer equation to be 4.3 nm, slightly larger compared to 3-mercaptopropionic acid-capped CdS QDs (3.2 and 3.6 nm, respectively). The mechanism of formation was interpreted based on the spectroscopic data and X-ray crystal structures of CdS@CTN QDs fabricated at different pH values and mass ratios of chitin to Cd(NO3)2 precursor. As an important step to explore potential biomolecular and biological applications of CdS@CTN QDs, their antibacterial activities were tested against four different bacterial strains; i.e. Escherichia coli, Bacillus subtillus, Staphylococcus aureus and Pseudomonas aeruginosa.
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Affiliation(s)
- Matin Jasli Lim
- Department of Chemistry, Faculty of Science, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong BE1410, Brunei Darussalam
| | - Nurulizzatul Ningsheh M Shahri
- Department of Chemistry, Faculty of Science, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong BE1410, Brunei Darussalam
| | - Hussein Taha
- Environmental and Life Sciences, Faculty of Science, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong BE1410, Brunei Darussalam
| | - Abdul Hanif Mahadi
- Centre for Advanced Material and Energy Sciences, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong BE1410, Brunei Darussalam
| | - Eny Kusrini
- Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus Baru UI-Depok, 16424, Indonesia
| | - Jun Wei Lim
- Department of Fundamental and Applied Sciences, HICoE-Centre for Biofuel and Biochemical Research, Institute of Self-Sustainable Building, Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak Darul Ridzuan, Malaysia
| | - Anwar Usman
- Department of Chemistry, Faculty of Science, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong BE1410, Brunei Darussalam.
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Gomathi R, Suhana H, Paradesi D. Characterization Study of Cytotoxicity of Green Synthesized ZnO Nanoparticles Loaded with Anti‐Cancer Doxorubicin Drug. ChemistrySelect 2021. [DOI: 10.1002/slct.202100358] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/07/2022]
Affiliation(s)
- Rajagopal Gomathi
- Department of Chemistry College of Engineering and Technology SRM Institute of Science and Technology, Chengalpattu District 603203 Tamilnadu India
| | - Harindran Suhana
- Department of Chemistry College of Engineering and Technology SRM Institute of Science and Technology, Chengalpattu District 603203 Tamilnadu India
| | - Deivanayagam Paradesi
- Department of Chemistry College of Engineering and Technology SRM Institute of Science and Technology, Chengalpattu District 603203 Tamilnadu India
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Yan K, Xu F, Wei W, Yang C, Wang D, Shi X. Electrochemical synthesis of chitosan/silver nanoparticles multilayer hydrogel coating with pH-dependent controlled release capability and antibacterial property. Colloids Surf B Biointerfaces 2021; 202:111711. [PMID: 33773171 DOI: 10.1016/j.colsurfb.2021.111711] [Citation(s) in RCA: 22] [Impact Index Per Article: 5.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/02/2020] [Revised: 01/25/2021] [Accepted: 03/16/2021] [Indexed: 12/23/2022]
Abstract
By coupling in situ electrochemical synthesis of silver nanoparticles (AgNPs) with the pre-deposited chitosan multilayer hydrogel, a novel type of nanocomposite coating was successfully fabricated on the stainless-steel needle electrode. Experimental results demonstrated the chitosan film can serve as a versatile medium for metal salt adsorption and stabilization, and finally electrochemical reduction of loaded silver ions to nanoparticles. The AgNPs were fabricated with a spherical shape and an average size of ∼15 nm endowing considerable antibacterial property to the hydrogel. Furthermore, the unique layered architecture consisted of porous segments and compact boundaries is almost retained, resulting in a pH-dependent and staged release pattern of silver nanoparticles based on acid triggered dissolution of the multi-membrane layer by layer. Thus, considering the mild synthesizing approach, multi-functionalities and relatively low cytotoxicity, this antibacterial hydrogel would show great potential either to be used as a newly coating material for interfacial improvement of implants or as a free-standing film after being peeled off for wound dressing.
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Affiliation(s)
- Kun Yan
- School of Resource and Environmental Science, Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and Energy, Hubei Engineering Center of Natural Polymers-Based Medical Materials, Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan, 430079, China; Hubei Key Laboratory of Advanced Textile Materials & Application, Hubei International Scientific and Technological Cooperation Base of Intelligent Textile Materials & Application, Key Laboratory of Textile Fiber & Product, Ministry of Education, Wuhan Textile University, Wuhan, 430200, China
| | - Feiyang Xu
- Hubei Key Laboratory of Advanced Textile Materials & Application, Hubei International Scientific and Technological Cooperation Base of Intelligent Textile Materials & Application, Key Laboratory of Textile Fiber & Product, Ministry of Education, Wuhan Textile University, Wuhan, 430200, China
| | - Wei Wei
- Hubei Key Laboratory of Advanced Textile Materials & Application, Hubei International Scientific and Technological Cooperation Base of Intelligent Textile Materials & Application, Key Laboratory of Textile Fiber & Product, Ministry of Education, Wuhan Textile University, Wuhan, 430200, China
| | - Chenguang Yang
- Hubei Key Laboratory of Advanced Textile Materials & Application, Hubei International Scientific and Technological Cooperation Base of Intelligent Textile Materials & Application, Key Laboratory of Textile Fiber & Product, Ministry of Education, Wuhan Textile University, Wuhan, 430200, China
| | - Dong Wang
- Hubei Key Laboratory of Advanced Textile Materials & Application, Hubei International Scientific and Technological Cooperation Base of Intelligent Textile Materials & Application, Key Laboratory of Textile Fiber & Product, Ministry of Education, Wuhan Textile University, Wuhan, 430200, China.
| | - Xiaowen Shi
- School of Resource and Environmental Science, Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and Energy, Hubei Engineering Center of Natural Polymers-Based Medical Materials, Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan, 430079, China.
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43
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LDL receptors and their role in targeted therapy for glioma: a review. Drug Discov Today 2021; 26:1212-1225. [PMID: 33609780 DOI: 10.1016/j.drudis.2021.02.008] [Citation(s) in RCA: 23] [Impact Index Per Article: 5.8] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/16/2020] [Revised: 01/15/2021] [Accepted: 02/06/2021] [Indexed: 11/22/2022]
Abstract
Gliomas are highly lethal forms of cancers occurring in the brain. Delivering the drugs into the brain is a major challenge to the treatment of gliomas because of the highly selectively permeable blood-brain barrier (BBB). Tapping the potential of receptor-mediated drug delivery systems using targeted nanoparticles (NPs) is a sought-after step forward toward successful glioma treatment. Several receptors are the focus of research for application in drug delivery. Low-density lipoprotein receptors (LDLR) are abundantly expressed in both healthy brains and diseased brains with a disrupted BBB. In this review, we discuss the LDLR and the types of NPs that have been used to target the brain via this receptor.
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Nivethaa EAK, Dhanavel S, Narayanan V, Narayana Kalkura S, Sivasankari J, Sivanandham N, Stephen A. CS/Au/MWCNT nanohybrid as an efficient carrier for the sustained release of 5-FU and a study of its cytotoxicity on MCF-7. RSC Adv 2021; 11:4584-4592. [PMID: 35424384 PMCID: PMC8694463 DOI: 10.1039/d0ra08537e] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/07/2020] [Accepted: 11/15/2020] [Indexed: 12/03/2022] Open
Abstract
The chemical reduction method has been used to adeptly synthesize a CS/Au/MWCNT nanocomposite, to be used as a carrier for the effectual delivery of the anticancer drug 5-Fluorouracil. The work aims at utilizing the less investigated ternary nanocomposite system containing chitosan (CS), gold (Au) and MWCNT's to attain higher encapsulation efficiency and to enable a more sustained and prolonged release of 5-FU. This system has improved cytotoxicity when compared to the CS/Au binary system. The prepared sample has been characterized using various techniques that confirm the formation of the nanocomposite, encapsulation of 5-FU into the nanocomposite, the structure of 5-FU and Au in the nanocomposite and the formation of the polymer matrix nanocomposite. An increase in the encapsulation efficiency to 98% and loading efficiency to 43% is observed when compared to the binary composite, elucidating the importance of incorporation of carbon nanotubes into the nanocomposite. A reduction in the release percentage of 5-FU by 40% indicates a more prolonged release, which will enable a reduction of the number of dosages that need to be administered. This in turn leads to a reduction in the side effects posed by the drug 5-FU. Moreover, the effectiveness of the drug loaded nanocomposite system towards the inhibition of breast cancer cells, apparent from the attainment of 50% cell viability while taking sample concentrations as low as 25 μg ml-1, makes this ternary nanocomposite superior and significant.
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Affiliation(s)
- E A K Nivethaa
- Department of Physics, Anna University Guindy Chennai-25 India
- Department of Nuclear Physics, University of Madras Guindy Campus Chennai-25 India +044-22351269 +044-22202802
| | - S Dhanavel
- Materials Chemistry & Metal Fuel Cycle Group, Indira Gandhi Centre for Atomic Research Kalpakkam India
- Department of Nuclear Physics, University of Madras Guindy Campus Chennai-25 India +044-22351269 +044-22202802
| | - V Narayanan
- Department of Inorganic Chemistry, University of Madras Guindy Campus Chennai 600 025 India
| | | | - J Sivasankari
- Department of Physics, Anna University Guindy Chennai-25 India
| | - N Sivanandham
- Department of Physics, Anna University Guindy Chennai-25 India
| | - A Stephen
- Department of Nuclear Physics, University of Madras Guindy Campus Chennai-25 India +044-22351269 +044-22202802
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45
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Tetraselmis indica Mediated Green Synthesis of Zinc Oxide (ZnO) Nanoparticles and Evaluating Its Antibacterial, Antioxidant, and Hemolytic Activity. BIONANOSCIENCE 2021. [DOI: 10.1007/s12668-020-00817-y] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/22/2022]
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46
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Hassan T, Salam A, Khan A, Khan SU, Khanzada H, Wasim M, Khan MQ, Kim IS. Functional nanocomposites and their potential applications: A review. JOURNAL OF POLYMER RESEARCH 2021. [DOI: 10.1007/s10965-021-02408-1] [Citation(s) in RCA: 39] [Impact Index Per Article: 9.8] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 02/07/2023]
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47
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Nanoparticles of two ZnO Precursors as an Encapsulating Matrix of Mangiferin: Associated Studies to Cytotoxic Effects on Liver Cancer Cells Hep-G2 and Healthy Lung Cell Beas-2B. J CLUST SCI 2021. [DOI: 10.1007/s10876-020-01957-7] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/22/2022]
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48
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Bagherzadeh M, Rabiee N, Fatahi Y, Dinarvand R. Zn-rich (GaN)1−x(ZnO)x: a biomedical friend? NEW J CHEM 2021. [DOI: 10.1039/d0nj06310j] [Citation(s) in RCA: 21] [Impact Index Per Article: 5.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/18/2022]
Abstract
The synthesis of (GaN)1−x(ZnO)x with the assistance of high-gravity using a green approach for the first time, with the application of delivering pCRISPR.
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Affiliation(s)
| | - Navid Rabiee
- Department of Chemistry
- Sharif University of Technology
- Tehran
- Iran
| | - Yousef Fatahi
- Department of Pharmaceutical Nanotechnology
- Faculty of Pharmacy
- Tehran University of Medical Sciences
- Tehran 14155-6451
- Iran
| | - Rassoul Dinarvand
- Department of Pharmaceutical Nanotechnology
- Faculty of Pharmacy
- Tehran University of Medical Sciences
- Tehran 14155-6451
- Iran
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49
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Sakthivel S, Periakaruppan R, Chandrasekaran R, Abd-Elsalam KA. Zinc nanomaterials: Synthesis, antifungal activity, and mechanisms. ZINC-BASED NANOSTRUCTURES FOR ENVIRONMENTAL AND AGRICULTURAL APPLICATIONS 2021:139-165. [DOI: 10.1016/b978-0-12-822836-4.00009-4] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 09/01/2023]
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50
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Primo JDO, Bittencourt C, Acosta S, Sierra-Castillo A, Colomer JF, Jaerger S, Teixeira VC, Anaissi FJ. Synthesis of Zinc Oxide Nanoparticles by Ecofriendly Routes: Adsorbent for Copper Removal From Wastewater. Front Chem 2020; 8:571790. [PMID: 33330360 PMCID: PMC7732540 DOI: 10.3389/fchem.2020.571790] [Citation(s) in RCA: 45] [Impact Index Per Article: 9.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/11/2020] [Accepted: 10/26/2020] [Indexed: 11/16/2022] Open
Abstract
Zinc Oxide nanoparticles have been synthesized by two simple routes using Aloe vera (green synthesis, route I) or Cassava starch (gelatinization, route II). The XRD patterns and Raman spectra show that both synthesis routes lead to single-phase ZnO. XPS results indicate the presence of zinc atoms with oxidation state Zn2+. SEM images of the ZnO nanoparticles synthesized using Cassava starch show the presence of pseudo-spherical nanoparticles and nanosheets, while just pseudo-spherical nanoparticles were observed when Aloe vera was used. The UV-Vis spectra showed a slight difference in the absorption edge of the ZnO particles obtained using Aloe vera (3.18 eV) and Cassava starch (3.24 eV). The ZnO nanoparticles were tested as adsorbents for the removal of copper in wastewater, it is shown that at low Cu2+ ion concentration (~40 mg/L) the nanoparticles synthesized by both routes have the same removal efficiency, however, increasing the absorbate concentration (> 80 mg/L) the ZnO nanoparticles synthesized using Aloe vera have a higher removal efficiency. The synthesized ZnO nanoparticles can be used as effective and environmental-friendly metal trace absorbers in wastewater.
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Affiliation(s)
- Julia de O Primo
- Laboratório de Materiais e Compostos Inorgânicos (LabMat), Departamento de Química, Universidade Estadual Do Centro-Oeste, Guarapuava, Brazil
| | - Carla Bittencourt
- Chimie des Interactions Plasma-Surface (ChIPS), Research Institute for Materials Science and Engineering, Université de Mons, Mons, Belgium
| | - Selene Acosta
- Chimie des Interactions Plasma-Surface (ChIPS), Research Institute for Materials Science and Engineering, Université de Mons, Mons, Belgium
| | - Ayrton Sierra-Castillo
- Research Group on Carbon Nanostructures (CARBONNAGe), Université de Namur, Namur, Belgium
| | - Jean-François Colomer
- Research Group on Carbon Nanostructures (CARBONNAGe), Université de Namur, Namur, Belgium
| | - Silvia Jaerger
- Laboratório de Materiais e Compostos Inorgânicos (LabMat), Departamento de Química, Universidade Estadual Do Centro-Oeste, Guarapuava, Brazil
| | - Verônica C Teixeira
- Laboratório Nacional de Luz Síncrotron (LNLS), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas, Brazil
| | - Fauze J Anaissi
- Laboratório de Materiais e Compostos Inorgânicos (LabMat), Departamento de Química, Universidade Estadual Do Centro-Oeste, Guarapuava, Brazil
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