Shared changes in angiogenic factors across gastrointestinal vascular conditions: A pilot study

Table 1 Characteristics of study population

Factor	Controls	SBA	PHG	GAVE	Controls vs cases
Number	15	10	11	8
mean age (range)	49 (20-74)	68 (53-79)	60 (38-81)	68 (58-85)	P < 0.0005
Male gender, n (%)	7 (47)	5 (50)	3 (27%)	5 (63)	NS
mean haemoglobin, g/dL	12.5	11.4	11.2	11.5	NS
Anaemia, n (%)1	1 (20)	4 (40)	6 (75)	3/5 (60)	P < 0.05

¹Anaemia defined as Hb < 11.5 g/dL in females and < 13 g/dL in males. SBA: Small bowel angiodysplasia; PHG: Portal hypertensive gastropathy; GAVE: Gastric antral vascular ectasia; NS: Not significant.

Table 2 Levels of serum angiogenic factors according to group

	SBA	PHG	GAVE	Control
Ang-1 (ng/mL), mean (range)	35696 (12466-54338)	23111 (1950-72445)	30753 (9773-72609)	53115 (28624-82066)
P value vs controls	0.01	0.0003	0.01
Ang-2 (ng/mL), mean (range)	2803 (125-13141)	4298 (1299-8702)	4232 (1253-6081)	1899 (742-3693)
P value vs controls	0.4	0.0008	0.003
VEGF (ng/mL), mean (range)	443 (273-964)	316 (51-600)	435 (288-637)	421 (250-678)
P value vs controls	0.8	0.08	0.8
Ang-1/Ang-2 ratios by group	13	5	7	28
Median Ang-1/Ang-2 ratios	8			28
P value vs controls	0.001

SBA: Small bowel angiodysplasia; PHG: Portal hypertensive gastropathy; GAVE: Gastric antral vascular ectasia; VEGF: Vascular endothelial growth factor; Ang-1: Angiopoietin 1; Ang-2: Angiopoietin 2.