Risk factors for recurrence after bowel resection for Crohn’s disease

Table 1 Demographic and clinical characteristics of the patients, n (%)

Variables	Number of patients
Gender
Male	47 (73.4)
Female	17 (26.6)
Age at diagnosis	27.5 (8, 78)
Disease period before operation	9.5 (2.0, 48.0)
Montreal classification
Age, yr
A1 (≤ 16)	6 (9.4)
A2 (17-40)	49 (76.6)
A3 (> 40)	9 (14.1)
Behavior
B1 (Inflammatory)	2 (3.1)
B2 (Stricturing)	25 (39.1)
B3 (Penetrating)	37 (57.8)
Location
L1 (Terminal ileum)	9 (14.1)
L2 (Colon)	1 (1.6)
L3 (Ileocolon)	47 (73.4)
L4 (Upper disease)	7 (10.9)
Perianal disease	22 (34.4)
Preoperative use of medication	29 (45.3)
Steroid	23 (35.9)
Immunomodulator	24 (37.5)
Anti-TNF	4 (6.2)

TNF: Tumor necrosis factor.

Table 2 Surgical details, n (%)

Variables	Number of patients
Indication of surgery
Intestinal obstruction	27 (42.3)
Intestinal fistula	34 (53.1)
Abscess	2 (3.2)
Bleeding	1 (1.6)
Site of resection
Ileocolon	47 (73.4)
Intestine	15 (23.4)
Colon	1 (1.6)

Table 3 Univariate and multivariate analysis of factors associated with endoscopic recurrence and clinical recurrence

Variable	Endoscopic recurrence		Clinical recurrence
	Univariate	Multivariate	Univariate	Multivariate
Gender	0.683		0.939
Diagnostic age	0.000b	0.004b	0.422
Disease behavior	0.044a	0.041a	0.686
Disease location	0.146		0.315
Perianal disease	0.357		0.032a	0.023a
Preoperative use of steroid	0.739		0.700
Preoperative use of immunomodulator	0.085		0.031a	0.092
Preoperative use of anti-TNF	0.020a	0.010a	0.438
Preoperative body mass index level	0.230		0.705
Preoperative leukocytosis	0.760		0.627
Preoperative C-reactive protein level	0.290		0.917
Preoperative erythrocyte sedimentation rate level	0.078		0.247
Preoperative albumin level	0.368		0.271

^aP < 0.05,

^bP < 0.01. TNF: Tumor necrosis factor.