Reduced esophageal cancer incidence in statin users, particularly with cyclo-oxygenase inhibition

Figure 1 Flow chart showing process of study selection and data extraction.

Figure 2 Meta-analysis. A: Meta-analysis of pooled unadjusted odds ratios for the effect of statin use on the development of esophageal adenocarcinoma in patients with Barrett’s esophagus; B: Meta-analysis of pooled adjusted odds ratios for the effect of statin use on the development of esophageal adenocarcinoma in patients with Barrett’s esophagus; C: Meta-analysis of pooled adjusted odds ratios for the cyclo-oxygenase inhibitor [aspirin, non-steroidal anti-inflammatory drug (NSAID) or coxib] use on the development of esophageal adenocarcinoma in patients with Barrett’s esophagus; D: Meta-analysis of pooled adjusted odds ratios for the effect of combined statin and cyclo-oxygenase inhibitor (aspirin, NSAID or coxib) use on the development of esophageal adenocarcinoma in patients with Barrett’s esophagus; E: Meta-analysis of pooled unadjusted odds ratios for the effect of statin use on the development of all esophageal carcinomas in population-based studies; F: Meta-analysis of pooled unadjusted odds ratios for the effect of statin use on the development of all esophageal carcinomas in population-based studies.