Ileal bile acid transporter inhibitors for chronic constipation in the elderly

doi:10.4292/wjgpt.v17.i1.112327

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Mar 5, 2026 (publication date) through Feb 11, 2026

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World Journal of Gastrointestinal Pharmacology and Therapeutics

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2150-5349

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pharmacol Ther. Mar 5, 2026; 17(1): 112327
Published online Mar 5, 2026. doi: 10.4292/wjgpt.v17.i1.112327

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Figure 1 Flow chart for evaluation of chronic constipation in the elderly. ARM: Anorectal manometry; BET: Balloon expulsion test; CC: Chronic constipation; CTT: Colonic transit time; DD: Defecatory disorders; IBS-C: Irritable bowel syndrome with constipation; MOM: Milk of magnesia; NTC: Normal transit constipation; PEG: Polyethylene glycol; STC: Slow transit constipation.

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Figure 2 Mechanism of action of elobixibat (ileal bile acid transporter inhibitor) and effect of increased bile acid pool on colonocytes. ASBT: Apical sodium-dependent bile acid transporter; CFTR: Cystic fibrosis transmembrane conductance regulator; cAMP: Cyclic adenosine monophosphate; OSTα/β: Organic solute transporter alpha/beta; TGR5: Takeda G-protein coupled receptor.

Citation: Aneesh PSR, Vaithiyam V, Reddy RT, Dalal A, Sachdeva S. Ileal bile acid transporter inhibitors for chronic constipation in the elderly. World J Gastrointest Pharmacol Ther 2026; 17(1): 112327
URL: https://www.wjgnet.com/2150-5349/full/v17/i1/112327.htm
DOI: https://dx.doi.org/10.4292/wjgpt.v17.i1.112327