Glucagon-like peptide-1 receptor agonists: Evolution, gastrointestinal adverse effects, and future directions

Figure 1 Distribution plod of global prevalence of obesity. Data on global trends in the prevalence of obesity (body mass index ≥ 30 kg/m²) in adults aged 20 years and older in 1990, 2000, 2010, and 2022 from selected regions of the world show an increase in obesity across the world.

Figure 2  Schematic representation of the domino effect triggered by globalization, rapid urbanization, and economic growth which led to substantial lifestyle changes from diets to day-life activities promoting a state of positive energy balance through increased consumption of empty caloric food with more sugar and fats than nutrients and reduced physical activity.