Kamrul-Hasan ABM, Borozan S, Jena S, Nagendra L, Dutta D, Bhattacharya S, Islam MS, Pappachan JM. Safety and efficacy of efruxifermin in metabolic dysfunction-associated steatohepatitis: A systematic review. World J Gastrointest Pharmacol Ther 2025; 16(3): 110709 [PMID: 40937291 DOI: 10.4292/wjgpt.v16.i3.110709]
Reader's ID:
03769692
Submitted on:
September 09, 2025, 11:03
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Reader Comments:
EFX, a fibroblast growth factor 21 analogue, shows promising potential for improving liver fat, liver injury markers, fibrosis, and several metabolic parameters in individuals with MASH. The paper offers significant insights, especially given the limited therapeutic options available for MASH. From a clinical standpoint, the review highlights the dual benefits of EFX in addressing both liver and metabolic dysfunctions, including improvements in hepatic fat content, liver enzymes, fibrosis markers, and insulin resistance. The finding that EFX significantly reduces liver fat while improving metabolic outcomes such as HbA1c and triglycerides is particularly relevant in the management of MASH, which often coexists with metabolic syndrome and type 2 diabetes. In conclusion, this review emphasizes EFX’s potential as a promising treatment for MASH, particularly in managing both hepatic and metabolic dysfunctions. This paper is a timely contribution to the field, providing a comprehensive understanding of EFX's role in MASH management.
Reply from the Editorial Office:
Thank you very much for your comments.
Author's Reply:
Replied on September 09, 2025, 18:49
Thanks for your comments and appreciation.
Best wishes,
JM Pappachan