Ismail A, Amer MS, Tawheed A. Glucagon-like peptide-1 receptor agonists: Evolution, gastrointestinal adverse effects, and future directions. World J Gastrointest Pharmacol Ther 2025; 16(3): 107148 [PMID: 40937289 DOI: 10.4292/wjgpt.v16.i3.107148]
Reader's ID:
08628847
Submitted on:
September 09, 2025, 11:01
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Reader Comments:
The article is comprehensive, presenting both the beneficial effects and the challenges associated with GLP-1RAs, especially their gastrointestinal adverse events such as nausea, vomiting, and diarrhea.From a clinical perspective, the paper underscores the need for personalized approaches in prescribing GLP-1RAs, considering the varying responses to treatment and the potential risks in certain patient populations. The authors also provide practical management strategies for these side effects, which is highly relevant for clinical practice. In summary, this paper offers a balanced view of the evolving landscape of obesity management with GLP-1RAs. It is a timely contribution to the field, especially for healthcare providers looking to enhance treatment outcomes while managing side effects effectively.
Reply from the Editorial Office:
Thank you very much for your comments.