Copyright
©The Author(s) 2015.
World J Gastrointest Pathophysiol. Nov 15, 2015; 6(4): 131-139
Published online Nov 15, 2015. doi: 10.4291/wjgp.v6.i4.131
Published online Nov 15, 2015. doi: 10.4291/wjgp.v6.i4.131
Gene symbol | mRNA description | GO biological process term | Fold increase |
Cdkn1a | Cyclin-dependent kinase inhibitor 1A (P21), transcript variant 1 | Response to DNA damage stimulus/cell cycle/cell cycle arrest/negative regulation of cell proliferation | 5.6 |
Igfbp1 | Insulin-like growth factor binding protein 1 | Regulation of cell growth | 5.5 |
Defb1 | Defensin beta 1 | Defense response/response to bacterium/defense response to bacterium/innate immune response | 5.2 |
Gpr64 | G protein-coupled receptor 64, transcript variant 1 | Signal transduction/cell surface receptor linked signaling pathway/G-protein coupled receptor protein signaling pathway/neuropeptide signaling pathway | 5.1 |
Serpina7 | Serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 | Post-embryonic development/response to vitamin A/response to drug | 4.9 |
Cpt1b | Carnitine palmitoyltransferase 1b, muscle, nuclear gene encoding mitochondrial protein | Lipid metabolic process/fatty acid metabolic process/transport/long-chain fatty acid transport/long-chain fatty acid transport | 4.6 |
Chac1 | ChaC, cation transport regulator-like 1 (E. coli) | Apoptosis/response to unfolded protein/biological_process | 4.3 |
Npas2 | Neuronal PAS domain protein 2 | Transcription/regulation of transcription, DNA-dependent/signal transduction/circadian sleep/wake cycle/regulation of transcription/locomotor rhythm/positive regulation of transcription from RNA polymerase II promoter/rhythmic process | 3.9 |
Slc34a2 | Solute carrier family 34 (sodium phosphate), member 2 | In utero embryonic development/transport/ion transport/sodium ion transport/phosphate transport/phosphate transport/phosphate transport | 3.6 |
Fabp5 | Fatty acid binding protein 5, epidermal | Glucose metabolic process/lipid metabolic process/phosphatidylcholine biosynthetic process/transport/glucose transport | 3.5 |
BC023105 | cDNA sequence BC023105 | Unknown | 3.1 |
Cav1 | Caveolin 1, caveolae protein | MAPKKK cascade/inactivation of MAPK activity/vasculogenesis/response to hypoxia/negative regulation of endothelial cell proliferation/negative regulation of cytokine-mediated signaling pathway/triglyceride metabolic process/calcium ion transport/cellular calcium ion homeostasis/cellular calcium ion homeostasis/endocytosis/regulation of smooth muscle contraction | 2.8 |
Lpl | Lipoprotein lipase | Lipid metabolic process/positive regulation of macrophage derived foam cell differentiation/lipid catabolic process/triglyceride biosynthetic process/triglyceride catabolic process | 2.7 |
Il22ra1 | Interleukin 22 receptor, alpha 1 | Blood coagulation | 2.6 |
Acaca | Acetyl-Coenzyme A carboxylase alpha | Tissue homeostasis/acetyl-CoA metabolic process/lipid metabolic process/fatty acid biosynthetic process/metabolic process/lipid biosynthetic process/response to organic cyclic substance/multicellular organismal protein metabolic process | 2.6 |
Inhba | Inhibin beta-A | Mesoderm formation/hemopoietic progenitor cell differentiation/growth/positive regulation of transcription from RNA polymerase II promoter/mesodermal cell differentiation/negative regulation of hair follicle development | 2.6 |
Gadd45b | Growth arrest and DNA-damage-inducible 45 beta | Activation of MAPKK activity/negative regulation of protein kinase activity/apoptosis/multicellular organismal development/cell differentiation/regulation of cell cycle | 2.4 |
Tgtp1 | T-cell specific GTPase 1 | Immune response/response to virus | 2.4 |
Rassf4 | Ras association (RalGDS/AF-6) domain family member 4 | Cell cycle/signal transduction | 2.4 |
Cxcl13 | Chemokine (C-X-C motif) ligand 13 | Chemotaxis/inflammatory response/immune response/lymph node development | 2.4 |
Il1b | Interleukin 1 beta | Angiogenesis/fever/inflammatory response/immune response/elevation of cytosolic calcium ion concentration/aging | 2.4 |
Tgtp1 | T-cell specific GTPase 1 | Immune response/response to virus | 2.3 |
Asns | Asparagine synthetase | Asparagine biosynthetic process/glutamine metabolic process/metabolic process/cellular amino acid biosynthetic process | 2.3 |
Socs2 | Suppressor of cytokine signaling 2, transcript variant 1 | Lactation/regulation of growth/regulation of multicellular organism growth/negative regulation of multicellular organism growth/negative regulation of multicellular organism growth/positive regulation of neuron differentiation/negative regulation of JAK-STAT cascade/mammary gland alveolus development | 2.3 |
Meig1 | Meiosis expressed gene 1 | Meiosis | 2.3 |
Cxcl9 | Chemokine (C-X-C motif) ligand 9 | Inflammatory response/immune response | 2.2 |
Vtcn1 | V-set domain containing T cell activation inhibitor 1 | Negative regulation of T cell activation | 2.2 |
H2-Ab1 | Histocompatibility 2, class II antigen A, beta 1 | Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II/immune response/antigen processing and presentation/antigen processing and presentation of exogenous peptide antigen via MHC class II | 2.2 |
Spon2 | Spondin 2, extracellular matrix protein | Cell adhesion/innate immune response | 2.2 |
Rgs16 | Regulator of G-protein signaling 16 | G-protein coupled receptor protein signaling pathway/negative regulation of signal transduction | 2.1 |
Il2rg | Interleukin 2 receptor, gamma chain | Regulation of gene expression/positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation/positive regulation of T cell differentiation in the thymus/positive regulation of B cell differentiation | 2.1 |
Wdr67 | WD repeat domain 67, transcript variant 1 | Regulation of Rab GTPase activity | 2.1 |
Prss8 | Protease, serine, 8 (prostasin) | Hair follicle development/proteolysis | 2.1 |
Bach2 | BTB and CNC homology 2 | Transcription/regulation of transcription, DNA-dependent/regulation of transcription | 2.0 |
Serpina12 | Serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 | Unknown | 2.0 |
Gene symbol | mRNA description | GO biological process term | Fold decrease |
Mmd2 | Monocyte to macrophage differentiation-associated 2 | Cytolysis | 9.7 |
Nnmt | Nicotinamide N-methyltransferase | Unknown | 6.2 |
Gcgr | Glucagon receptor | Exocytosis/signal transduction/cell surface receptor linked signaling pathway/G-protein coupled receptor protein signaling pathway/G-protein signaling, coupled to cAMP nucleotide second messenger/activation of adenylate cyclase activity by G-protein signaling pathway | 5.3 |
Mfsd2a | Major facilitator superfamily domain containing 2A | Transport/transmembrane transport | 4.2 |
Oat | Ornithine aminotransferase, nuclear gene encoding mitochondrial protein | Unknown | 4.1 |
Slc10a2 | Solute carrier family 10, member 2 | Transport/ion transport/sodium ion transport/organic anion transport/bile acid and bile salt transport | 3.9 |
A1bg | Alpha-1-B glycoprotein | Unknown | 3.5 |
Gm129 | Gene model 129 (NCBI) | Unknown | 3.3 |
Sds | Serine dehydratase | Gluconeogenesis/cellular amino acid metabolic process/metabolic process | 3.1 |
Pck1 | Phosphoenolpyruvate carboxykinase 1, cytosolic | Gluconeogenesis/gluconeogenesis/oxaloacetate metabolic process/lipid metabolic process/glycerol biosynthetic process from pyruvate | 3.0 |
Lrtm1 | Leucine-rich repeats and transmembrane domains 1 | Unknown | 3.0 |
Ntrk2 | Neurotrophic tyrosine kinase, receptor, type 2, transcript variant 1 | Vasculogenesis/protein amino acid phosphorylation/transmembrane receptor protein tyrosine kinase signaling pathway/multicellular organismal development/nervous system development/feeding behavior/glutamate secretion/regulation of metabolic process/cell differentiation/brain-derived neurotrophic factor receptor signaling pathway/mechanoreceptor differentiation | 3.0 |
Gls2 | Glutaminase 2 (liver, mitochondrial), nuclear gene encoding mitochondrial protein | Gutamine metabolic process | 3.0 |
Susd4 | Sushi domain containing 4 | Unknown | 2.9 |
Slc16a5 | Solute carrier family 16 (monocarboxylic acid transporters), member 5 | Unknown | 2.9 |
Ccrn4l | CCR4 carbon catabolite repression 4-like (S. cerevisiae) | Rhythmic process | 2.9 |
Lhpp | Phospholysine phosphohistidine inorganic pyrophosphate phosphatase | Metabolic process | 2.7 |
Neb | Nebulin | Regulation of actin filament length/sarcomere organization | 2.6 |
Got1 | Glutamate oxaloacetate transaminase 1, soluble | Oxaloacetate metabolic process/glycerol biosynthetic process/cellular amino acid metabolic process/aspartate metabolic process/aspartate biosynthetic process/biosynthetic process/glutamate catabolic process to aspartate/glutamate catabolic process to 2-oxoglutarate/dicarboxylic acid metabolic process/fatty acid homeostasis | 2.6 |
Sult5a1 | Sulfotransferase family 5A, member 1 | Unknown | 2.6 |
Hapln1 | Hyaluronan and proteoglycan link protein 1 | Cell adhesion | 2.5 |
Mt2 | Metallothionein 2 | Cellular zinc ion homeostasis/nitric oxide mediated signal transduction/detoxification of copper ion | 2.5 |
Mt1 | Metallothionein 1 | Cellular metal ion homeostasis/cellular zinc ion homeostasis/nitric oxide mediated signal transduction/detoxification of copper ion | 2.4 |
Slc3a1 | Solute carrier family 3, member 1 | Amino acid transport | 2.4 |
Trdn | Triadin | Cellular calcium ion homeostasis/regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum/negative regulation of calcium ion transport via store-operated calcium channel activity | 2.4 |
Bhlhe41 | Basic helix-loop-helix family, member e41 | Negative regulation of transcription from RNA polymerase II promoter/transcription/regulation of transcription, DNA-dependent/circadian rhythm/entrainment of circadian clock/regulation of transcription | 2.3 |
Usp2 | Ubiquitin specific peptidase 2, transcript variant 3 | Ubiquitin-dependent protein catabolic process | 2.3 |
Derl3 | Der1-like domain family, member 3 | Unknown | 2.3 |
Mrap2 | Melanocortin 2 receptor accessory protein 2, transcript variant 1 | Unknown | 2.2 |
Ncam2 | Neural cell adhesion molecule 2, transcript variant 1 | Cell adhesion | 2.2 |
S1pr5 | Sphingosine-1-phosphate receptor 5 | Signal transduction/G-protein coupled receptor protein signaling pathway | 2.2 |
1810046K07Rik | RIKEN cDNA 1810046K07 gene | Unknown | 2.2 |
Nrg4 | Neuregulin 4 | Unknown | 2.2 |
Gas2 | Growth arrest specific 2 | Apoptosis/cell cycle/cell cycle arrest/regulation of cell shape | 2.2 |
Ttc39b | Tetratricopeptide repeat domain 39B | Unknown | 2.2 |
Cyp17a1 | Cytochrome P450, family 17, subfamily a, polypeptide 1 | Steroid biosynthetic process/glucocorticoid biosynthetic process/oxidation reduction | 2.1 |
Creld2 | cysteine-rich with EGF-like domains 2 | Unknown | 2.1 |
Upp2 | Uridine phosphorylase 2 | Nucleoside metabolic process/nucleotide catabolic process | 2.1 |
Ar | Androgen receptor | In utero embryonic development/transcription/regulation of transcription, DNA-dependent/regulation of transcription from RNA polymerase II promoter/male gonad development/cellular process/regulation of gene expression/male somatic sex determination/androgen receptor signaling pathway/androgen receptor signaling pathway/positive regulation of estrogen receptor signaling pathway/positive regulation of MAPKKK cascade/positive regulation of insulin-like growth factor receptor signaling pathway | 2.1 |
Gm10419 | Lung RCB-0558 LLC cDNA, RIKEN full-length enriched library, clone:G730014J15 product: Hypothetical protein | Unknown | 2.1 |
Sdf2l1 | Stromal cell-derived factor 2-like 1 | Unknown | 2.0 |
Trdn | Triadin | Cellular calcium ion homeostasis/regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum/negative regulation of calcium ion transport via store-operated calcium channel activity | 2.0 |
Antxr2 | Anthrax toxin receptor 2 | Unknown | 2.0 |
Glucose homeostasis | Inflammation | Cell proliferation | Metabolism | |
Underexpressed in Gcgr-/- mouse liver | Nnmt, Got1, Sds, Pck1 | Gas2 | Slc10a2, Ntrk2, Gls2, Lhpp, Sult5a1, Mt2, Mt1, Slc3a1, Trdn, Usp2, Cyp17a1, Upp2 | |
Overexpressed in Gcgr-/- mouse liver | Il1b, Cxcl13, Tgtp1, Cxcl9, Defb1, Vtcn1, H2-Ab1, Spon2, Il2rg | Cdkn1a, Igfbp1, Chac1, Cav1, Inhba, Gadd45b, Rassf4, Socs2, Meig1 | Serpina7, Cpt1b, Slc34a2, Fabp5, Lpl, Acaca, Asns |
- Citation: Yu R, Zheng Y, Lucas MB, Tong YG. Elusive liver factor that causes pancreatic α cell hyperplasia: A review of literature. World J Gastrointest Pathophysiol 2015; 6(4): 131-139
- URL: https://www.wjgnet.com/2150-5330/full/v6/i4/131.htm
- DOI: https://dx.doi.org/10.4291/wjgp.v6.i4.131