Low grade dysplasia in Barrett’s esophagus: Should we worry?

Table 1 Molecular biomarkers predicting progression of dysplastic Barrett’s esophagus

Molecular biomarker	Technique	Ref.
Overexpression of p53	IHC	[24-27]
Loss of heterozygosity (17p)	PCR	[28-30]
Hypermethylation of genes	PCR	[32]
Aneuploidy (2N)/Tetraploidy (4N)	Flow cytometry	[33-35]
Ki-671	IHC	[23]

¹Facilitates differentiation between non-dysplastic and dysplastic mucosa. IHC: Immunohistochemistry; PCR: Polymerase chain reaction.