Review
Copyright ©2011 Baishideng Publishing Group Co.
World J Gastrointest Pathophysiol. Dec 15, 2011; 2(6): 114-122
Published online Dec 15, 2011. doi: 10.4291/wjgp.v2.i6.114
Table 1 Overview of the gene therapy based treatment strategies for inflammatory bowel diseases as discussed in this review
Viral vectorGut targetingReference for gut targetingStatus of developmentReference for status of development
Gene therapyRetro- and lentiviralYes[24-27]Not performedN/A
AdenoviralYes[28-30]Preclinical[28-30]
AAVYes[31,32]Not performedN/A
Table 3 Overview of the combined gene and cell therapy based treatment strategies for inflammatory bowel diseases as discussed in this review
Applied strategyViral vector usedReference for viral vector usedStatus of developmentReference for status of development
Combined gene and cell therapyEx vivo generated Treg/Tr1Retrovirus[113,115]Preclinical[113,115]
T cell receptor transgenic TregRetrovirus[116]Preclinical[116]