Non-erosive and uncomplicated erosive reflux diseases: Difference in physiopathological and symptom pattern

Table 1 Description of the study population n(%)

Population	NERD+	ERD	P value
Gender
Males	39 (36.5)	35 (32.8)	NS
Females	68 (63.5)	72 (67.2)
Age
mean ± SD	52.08 ± 13	52.8 ± 14	NS
Median	55	54
Hiatal hernia	53 (43.4)	69 (56.6)	0.02

NERD+: Non-erosive reflux disease positive on pH monitoring; ERD: Erosive reflux disease; NS: Non-statistically significative.

Table 2 NERD+ vs ERD: manometry study

Manometry	NERD+	ERD	P value
LES
Pressure (mmHg)
mean ± SD	11.18 ± 6.5	9.4 ± 5.3	0.03
Median	9.33	8.5
Total length (cm)
mean ± SD	2.57 ± 0.7	2.44 ± 0.8	NS
Median	3	3
Abdominal length (cm)
mean ± SD	1.13 ± 0.8	1.05 ± 0.9	NS
Median	1	1
Esophageal body
Distal wave amplitude (mmHg)
mean ± SD	80.38 ± 45	75.55 ± 40	NS
Median	70.2	68.3
Proximal wave amplitude (mmHg)
mean ± SD	50.61 ± 20	50.74 ± 21	NS
Median	50	48.65
Distal wave duration (s)
mean ± SD	3.58 ± 1	3.64 ± 0.9	NS
Median	3.45	3.4
Proximal wave duration (s)
mean ± SD	2.83 ± 1	2.92 ± 0.6	NS
Median	2.75	2.75
Effective peristalsis (%)	41 (47.7%)	45 (52.3%)	NS

LES: Lower esophageal sphincter; NERD+: Non-erosive reflux disease positive on pH monitoring; ERD: Erosive reflux disease; NS: Non-statistically significative.

Table 3 NERD+ vs ERD: pH monitoring

24 h pH monitoring	NERD+	ERD	P value
Number of reflux episodes
Total
mean ± SD	125.67 ± 74.49	162.93 ± 128.1	0.01
Median	118	131
Lasting > 5 min
mean ± SD	4.42 ± 4.9	8.19 ± 7.7	0
Median	3	6
pH < 4
Total time (%)
mean ± SD	9.24 ± 8.1	15.80 ± 14	0
Median	6.8	11
Upright time (%)
mean ± SD	10.20 ± 7.9a	14.20 ± 13b	0.007
Median	7.8	10.7
Supine time (%)
mean ± SD	7.6 ± 12.2a	18.20 ± 20.6b	0
Median	4.1	11.1
DeMeester score
mean ± SD	37.24 ± 32.63	63.38 ± 48.70	0
Median	30.4	48.7

NERD+: Non-erosive reflux disease positive on pH monitoring; ERD: Erosive reflux disease; NS: Non-statistically significative;

^aNERD+: Upright vs supine (P = 0.02);

^bERD Supine vs upright (P = 0.01).

Table 4 Clinical presentation of NERD+ and ERD patients n(%)

Clinical presentation	NERD+ (88/107)	ERD (102/107)	P value
Typical symptoms only	52 (59.1)	76 (74.5)	0.01
Typical and atypical symptoms	36 (40.9)	26 (25.5)	0.01

NERD+: Non erosive reflux disease positive on pH monitoring; ERD: Erosive reflux disease.