Fatty acid binding receptors in intestinal physiology and pathophysiology

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Dec 15, 2010 (publication date) through Oct 31, 2025

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World Journal of Gastrointestinal Pathophysiology

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2150-5330

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pathophysiol. Dec 15, 2010; 1(5): 147-153
Published online Dec 15, 2010. doi: 10.4291/wjgp.v1.i5.147

Table 1 Molecular and biochemical characteristics of free fatty acid receptors and GPR120

Receptor	Localization	Ligand	Signaling
FFAR1	19q13.1	> C6; medium to long chain	Insulin, GLP-1, GIP
FFAR2	19q13.1	C2-C6; acetate, propionate, butyrate	PYY, 5-HT
FFAR3	19q13.1	C2-C6; propionate > butyrate > acetate	Leptin, PYY
GPR120	10q23.33	Medium and long chain; alpha-linolenic acid, docosa- hexadienic acid, palmitoleic acid	GLP-1, CKK

FFAR: free fatty acid receptor.

Table 2 Important cell types expressing free fatty acid receptors or GPR120

FFAR: free fatty acid receptor.

Citation: Kaemmerer E, Plum P, Klaus C, Weiskirchen R, Liedtke C, Adolf M, Schippers A, Wagner N, Reinartz A, Gassler N. Fatty acid binding receptors in intestinal physiology and pathophysiology. World J Gastrointest Pathophysiol 2010; 1(5): 147-153
URL: https://www.wjgnet.com/2150-5330/full/v1/i5/147.htm
DOI: https://dx.doi.org/10.4291/wjgp.v1.i5.147