Intestinal barrier: Molecular pathways and modifiers

doi:10.4291/wjgp.v4.i4.94

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Nov 15, 2013 (publication date) through Apr 29, 2026

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World Journal of Gastrointestinal Pathophysiology

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2150-5330

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pathophysiol. Nov 15, 2013; 4(4): 94-99
Published online Nov 15, 2013. doi: 10.4291/wjgp.v4.i4.94

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Figure 1 The molecular regulatory pathways in intestinal epithelial homeostasis. Wnt signaling promotes the proliferation of TA/stem cells and drives Paneth cell maturation. Notch signaling cooperates with Wnt to drive proliferation of intestinal stem cells and regulates maintenance of undifferentiated TA/stem cells. Hippo and bone morphogenetic protein (BMP) signaling inhibits proliferation and induces maturation of all secretory cell types. Hedgehog signaling activates the expression of BMP in the mesenchyme.

Citation: Jeon MK, Klaus C, Kaemmerer E, Gassler N. Intestinal barrier: Molecular pathways and modifiers. World J Gastrointest Pathophysiol 2013; 4(4): 94-99
URL: https://www.wjgnet.com/2150-5330/full/v4/i4/94.htm
DOI: https://dx.doi.org/10.4291/wjgp.v4.i4.94

Jeon MK, Klaus C, Kaemmerer E, Gassler N. Intestinal barrier: Molecular pathways and modifiers. World J Gastrointest Pathophysiol 2013; 4(4): 94-99 [PMID: 24244877 DOI: 10.4291/wjgp.v4.i4.94]

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